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Study of a high-precision diagnostic imaging program for undiagnosed patients with chronic thromboembolic pulmonary hypertension

Research Project

Project/Area Number 20K17120
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53020:Cardiology-related
Research InstitutionKyushu University

Principal Investigator

Hosokawa Kazuya  九州大学, 先端医療オープンイノベーションセンター, 准教授 (40746872)

Project Period (FY) 2020-04-01 – 2025-03-31
Project Status Completed (Fiscal Year 2024)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordspulmonary embolism / pulmonry hypertension / diagnosis / imaging / Imaging / pulmonary hypertension / 慢性血栓塞栓性肺高血圧症 / 血栓塞栓症 / 機械学習 / 画像診断 / 肺高血圧
Outline of Research at the Start

・ディープラーニングは専門医の知識のみならず、経験や勘をプログラム上で再現でき、希少疾患で散見される知識・経験不足による見逃しや不十分な治療を克服することが期待される。
・希少疾患である慢性血栓塞栓性肺高血圧症(CTEPH)は適切な診断・治療により予後が劇的に改善する疾患である。そのため、スクリーニング検査である肺血流シンチグラムの診断精度が生死を分けるといっても過言ではない。現状では読影に習熟した専門医が限られており、約半数の・CTEPHが未診断のままとなっている。
・本研究では深層機械学習を用いて高精度の肺血流シンチグラム診断プログラムを確立することが目的である。

Outline of Final Research Achievements

Since 2020, the world has experienced the coronavirus pandemic, and between 2023 and 2024, breakthroughs in machine learning and artificial intelligence (AI) have emerged. Advanced technologies such as image recognition, speech recognition, large language models, and generative AI have become widespread. AI-related companies, particularly in the United States, have invested massive resources, driving technological innovation at a pace unimaginable at the start of this research. While this study initially aimed to focus on diagnostic imaging using lung perfusion scintigraphy, new challenges necessitated a shift in research direction. The principal investigator deepened their understanding of image recognition technologies and machine learning, applying this knowledge to research that will contribute to the next generation.

Academic Significance and Societal Importance of the Research Achievements

プログラム医療機器の開発が旺盛となっており、機械学習が組み込まれた医療機器の開発がより一般的となってきている。2020年に始まった本研究はこの流れの最先端であったが、AIの汎用化が米国を中心に国家レベルで取り組まれており、日々、技術革新が起こっている。先端技術を取り込んだより精度の高い医療機器研究の先駆けとして役割は果たした。

Report

(6 results)
  • 2024 Annual Research Report   Final Research Report ( PDF )
  • 2023 Research-status Report
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (17 results)

All 2025 2024 2023 2022 2021 2020

All Journal Article (15 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 14 results,  Open Access: 4 results) Presentation (1 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Milestones in therapeutic and antithrombotic strategies for chronic thromboembolic pulmonary hypertension2025

    • Author(s)
      細川和也、阿部弘太郎
    • Journal Title

      Journal of Cardiology

      Volume: 0 Issue: 2 Pages: 0-0

    • DOI

      10.1016/j.jjcc.2025.03.006

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Outcomes of Chronic Thromboembolic Pulmonary Hypertension After Balloon?Pulmonary Angioplasty and Pulmonary Endarterectomy2024

    • Author(s)
      眞崎耕平、細川和也ら
    • Journal Title

      JACC: Asia

      Volume: 4 Issue: 8 Pages: 577-589

    • DOI

      10.1016/j.jacasi.2024.05.007

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamic chest radiography for pulmonary vascular diseases: clinical applications and correlation with other imaging modalities2023

    • Author(s)
      Yamasaki Yuzo、Kamitani Takeshi、Sagiyama Koji、Hino Takuya、Kisanuki Megumi、Tabata Kosuke、Isoda Takuro、Kitamura Yoshiyuki、Abe Kohtaro、Hosokawa Kazuya、Toyomura Daisuke、Moriyama Shohei、Kawakubo Masateru、Yabuuchi Hidetake、Ishigami Kousei
    • Journal Title

      Japanese Journal of Radiology

      Volume: 42 Issue: 2 Pages: 126-144

    • DOI

      10.1007/s11604-023-01483-2

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of Dynamic Chest Radiography for Chronic Thromboembolic Pulmonary Hypertension2023

    • Author(s)
      Yamasaki Yuzo、Abe Kohtaro、Kamitani Takeshi、Hosokawa Kazuya、Hida Tomoyuki、Sagiyama Koji、Matsuura Yuko、Baba Shingo、Isoda Takuro、Maruoka Yasuhiro、Kitamura Yoshiyuki、Moriyama Shohei、Yoshikawa Hideki、Fukumoto Takenori、Yabuuchi Hidetake、Ishigami Kousei
    • Journal Title

      Radiology

      Volume: 306 Issue: 3

    • DOI

      10.1148/radiol.220908

    • Related Report
      2023 Research-status Report 2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Technical Considerations for Performing Safe and Effective Balloon Pulmonary Angioplasty in Patients with Chronic Thromboembolic Pulmonary Hypertension2023

    • Author(s)
      Hosokawa Kazuya、Yamasaki Yuzo、Abe Kohtaro
    • Journal Title

      Interventional Cardiology Clinics

      Volume: NA Issue: 3 Pages: 367-380

    • DOI

      10.1016/j.iccl.2023.02.003

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Long-term outcome of chronic thromboembolic pulmonary hypertension using direct oral anticoagulants and warfarin: a Japanese prospective cohort study2023

    • Author(s)
      Hosokawa Kazuya、Abe Kohtaro、Funakoshi Kouta、Tet al
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: in press Issue: 8 Pages: 2151-2162

    • DOI

      10.1016/j.jtha.2023.03.036

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Balloon pulmonary angioplasty versus riociguat in inoperable chronic thromboembolic pulmonary hypertension (MR BPA): an open-label, randomised controlled trial2022

    • Author(s)
      Kawakami Takashi、Matsubara Hiromi、Shinke Toshiro、Abe Kohtaro、Kohsaka Shun、Hosokawa Kazuya、Taniguchi Yu、Shimokawahara Hiroto、Yamada Yoshitake、Kataoka Masaharu、Ogawa Aiko、Murata Mitsushige、Jinzaki Masahiro、Hirata Kenichi、Tsutsui Hiroyuki、Sato Yasunori、Fukuda Keiichi
    • Journal Title

      The Lancet Respiratory Medicine

      Volume: 10 Issue: 10 Pages: 949-960

    • DOI

      10.1016/s2213-2600(22)00171-0

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of edoxaban in patients with chronic thromboembolic pulmonary hypertension: protocol for a multicentre, randomised, warfarin-controlled, parallel group trial - KABUKI trial2022

    • Author(s)
      Hosokawa Kazuya、Abe Kohtaro、Kishimoto Junji、Kobayakawa Yuko、Todaka Koji、Tamura Yuichi、Tatsumi Koichiro、Inami Takumi、Ikeda Nobutaka、Taniguchi Yu、Minatsuki Shun、Murohara Toyoaki、Yasuda Satoshi、Fukuda Keiichi、Tsutsui Hiroyuki
    • Journal Title

      BMJ Open

      Volume: 12 Issue: 7 Pages: e061225-e061225

    • DOI

      10.1136/bmjopen-2022-061225

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased Pulmonary Arterial Compliance after Balloon Pulmonary Angioplasty Predicts Exercise Tolerance Improvement in Inoperable CTEPH Patients with Lower Pulmonary Arterial Pressure2022

    • Author(s)
      Umemoto Shintaro、Abe Kohtaro、Hosokawa Kazuya、Horimoto Koshin、Saku Keita、Sakamoto Takafumi、Tsutsui Hiroyuki
    • Journal Title

      Heart & Lung

      Volume: 52 Pages: 8-15

    • DOI

      10.1016/j.hrtlng.2021.11.003

    • Related Report
      2021 Research-status Report
  • [Journal Article] Diagnosis of Pulmonary Hypertension Using Dynamic Chest Radiography2021

    • Author(s)
      Yamasaki Yuzo、Kamitani Takeshi、Abe Kohtaro、Hosokawa Kazuya、Sagiyama Koji、Hida Tomoyuki、Matsuura Yuko、Kitamura Yoshiyuki、Maruoka Yasuhiro、Isoda Takuro、Baba Shingo、Yoshikawa Hideki、Kuramoto Taku、Yabuuchi Hidetake、Ishigami Kousei
    • Journal Title

      American Journal of Respiratory and Critical Care Medicine

      Volume: 204 Issue: 11 Pages: 1336-1337

    • DOI

      10.1164/rccm.202102-0387im

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Right Ventricular Extracellular Volume with Dual-Layer Spectral Detector CT: Value in Chronic Thromboembolic Pulmonary Hypertension2021

    • Author(s)
      Yamasaki Yuzo、Abe Kohtaro、Kamitani Takeshi、Sagiyama Koji、Hida Tomoyuki、Hosokawa Kazuya、Matsuura Yuko、Hioki Kazuhito、Nagao Michinobu、Yabuuchi Hidetake、Ishigami Kousei
    • Journal Title

      Radiology

      Volume: 298 Issue: 3 Pages: 589-596

    • DOI

      10.1148/radiol.2020203719

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multistage Strategy With Perfusion SPECT and CT Pulmonary Angiogram in Balloon Pulmonary Angioplasty for Totally Occluded Lesions in CTEPH2020

    • Author(s)
      Kazuya Hosokawa, Kohtaro Abe, Yuzo Yamasaki, Hiroyuki Tsutsui
    • Journal Title

      EuroIntervention

      Volume: Online Issue: 2 Pages: 652-653

    • DOI

      10.4244/eij-d-20-00652

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pulmonary ventilation?perfusion mismatch demonstrated by dynamic chest radiography in giant cell arteritis2020

    • Author(s)
      Yamasaki Yuzo、Hosokawa Kazuya、Tsutsui Hiroyuki、Ishigami Kousei
    • Journal Title

      European Heart Journal

      Volume: 42 Issue: 2 Pages: 208-209

    • DOI

      10.1093/eurheartj/ehaa443

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Smart Baroreceptor Activation Therapy Strikingly Attenuates Blood Pressure Variability in Hypertensive Rats With Impaired Baroreceptor.2020

    • Author(s)
      Tohyama T, Hosokawa K, Saku K, Oga Y, Tsutsui H, Sunagawa K.
    • Journal Title

      Hypertension.

      Volume: 75 Issue: 3 Pages: 885-892

    • DOI

      10.1161/hypertensionaha.119.13673

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Balloon pulmonary angioplasty improves right atrial reservoir and conduit functions in chronic thromboembolic pulmonary hypertension2020

    • Author(s)
      Yamasaki Yuzo、Abe Kohtaro、Kamitani Takeshi、Hosokawa Kazuya、Kawakubo Masateru、Sagiyama Koji、Hida Tomoyuki、Matsuura Yuko、Murayama Yuriko、Funatsu Ryohei、Tsutsui Hiroyuki、Yabuuchi Hidetake
    • Journal Title

      European Heart Journal - Cardiovascular Imaging

      Volume: 21 Issue: 8 Pages: 855-862

    • DOI

      10.1093/ehjci/jeaa064

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] Seeking positioning of direct oral anticoagulants for the treatment of CTEPH2023

    • Author(s)
      細川 和也
    • Organizer
      第87回日本循環器学会学術集会
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Book] 循環器診療コンプリート 先天性心疾患・肺動脈疾患2021

    • Author(s)
      赤木禎治
    • Total Pages
      360
    • Publisher
      学研メディカル秀潤社
    • ISBN
      9784780904093
    • Related Report
      2021 Research-status Report

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Published: 2020-04-28   Modified: 2026-01-16  

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