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New therapeutic strategies for insulin resistance through bone and mineral metabolism

Research Project

Project/Area Number 20K17259
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53040:Nephrology-related
Research InstitutionJikei University School of Medicine

Principal Investigator

Nakashima Akio  東京慈恵会医科大学, 医学部, 助教 (20624688)

Project Period (FY) 2020-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsインスリン抵抗性 / 骨・ミネラル代謝 / 血液透析 / FGF23 / 糖尿病 / FGF-23 / klotho / Klotho
Outline of Research at the Start

インスリン抵抗性は糖尿病発症の主要な因子であり,心血管疾患の発症,全死亡に関与する.しかしながらインスリン抵抗性への介入方法は少なく,その治療法は限られている.本研究はリンやFGF-23などの骨・ミネラル代謝がインスリン抵抗性とどのような機序で関与するか,基礎研究,臨床研究の両面から明らかにすることを目的とする.本研究により骨・ミネラル代謝による糖尿病への新たな治療戦略が開かれる可能性がある.

Outline of Final Research Achievements

The number of diabetic patients is increasing all over the world, and therapeutic strategy are urgently needed for medical staffs. Insulin resistance is a major factor in the pathogenesis of diabetes mellitus and has been reassessed in recent years. However, there are few interventions for insulin resistance, and the treatments are limited. We have clarified that phosphorus and phosphorus excretion hormone FGF23 are involved in insulin resistance in diabetic patients, and also analyzed the prognosis of life. As a result, a significant correlation was found between insulin resistance and mineral-bone metabolism, demonstrating that both affect prognosis.

Academic Significance and Societal Importance of the Research Achievements

本研究課題ではリン代謝に関与するFGF23とインスリン抵抗性との関係性を明らかにし、骨・ミネラル代謝とインスリン抵抗性の両者が相まって腎不全患者/血液透析患者の生命予後や心血管疾患に関与することを示した。その機序として骨・ミネラル代謝による血管石灰化の進展が考えられた。今後、骨・ミネラル代謝を通じた新たなインスリン抵抗性や糖尿病への治療に結びつく可能性を秘めており、腎不全患者に与える影響は大きいと考えられる。

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • Research Products

    (9 results)

All 2022 2021 2020

All Journal Article (4 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (5 results)

  • [Journal Article] Higher Soluble ACE2 Levels and Increased Risk of Infection-Related Hospitalization in Patients on Maintenance Hemodialysis2022

    • Author(s)
      Kawabe Mayuko、Nakashima Akio、Yamamoto Izumi、Ohkido Ichiro、Yokoo Takashi、Urashima Mitsuyoshi
    • Journal Title

      Frontiers in Medicine

      Volume: 9 Pages: 791284-791284

    • DOI

      10.3389/fmed.2022.791284

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Role and Treatment of Insulin Resistance in Patients with Chronic Kidney Disease: A Review2021

    • Author(s)
      Nakashima Akio、Kato Kazuhiko、Ohkido Ichiro、Yokoo Takashi
    • Journal Title

      Nutrients

      Volume: 13 Issue: 12 Pages: 4349-4349

    • DOI

      10.3390/nu13124349

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long‐term changes in anemia‐related parameters among Japanese dialyzed patients assessed by newly developed web‐based system2021

    • Author(s)
      Maruyama Yukio、Niikura Takahito、Nakashima Akio、Yamamoto Hiroyasu、Yokoo Takashi
    • Journal Title

      Therapeutic Apheresis and Dialysis

      Volume: 26 Issue: 2 Pages: 362-367

    • DOI

      10.1111/1744-9987.13705

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Dysfunctional ABCG2 gene polymorphisms are associated with serum uric acid levels and all-cause mortality in hemodialysis patients2020

    • Author(s)
      Nakashima Akio、Ichida Kimiyoshi、Ohkido Ichiro、Yokoyama Keitaro、Matsuo Hirotaka、Ohashi Yuki、Takada Tappei、Nakayama Akiyoshi、Suzuki Hiroshi、Shinomiya Nariyoshi、Urashima Mitsuyoshi、Yokoo Takashi
    • Journal Title

      Human Cell

      Volume: epub ahead of print Issue: 3 Pages: 1-10

    • DOI

      10.1007/s13577-020-00342-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 血液透析患者におけるシナカルセトが骨折に与える影響についての検討2021

    • Author(s)
      中島章雄 大城戸一郎 横山啓太郎 浦島充佳 横尾隆
    • Organizer
      日本CKD-MBD研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 血液透析患者における25OHDが全死亡、骨折に与える影響についての検討2021

    • Author(s)
      中島章雄 大城戸一郎 横山啓太郎 浦島充佳 横尾隆
    • Organizer
      日本CKD-MBD研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 血液透析患者におけるSoluble Klothoと心血管疾患の発症および全死亡との関連調査2020

    • Author(s)
      中島章雄 大城戸一郎 横山啓太郎 浦島充佳 横尾隆
    • Organizer
      内科学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] プロトンポンプ阻害剤とCYP2C19遺伝子の血液透析患者に与える影響2020

    • Author(s)
      中島章雄 大城戸一郎 横山啓太郎 浦島充佳 横尾隆
    • Organizer
      日本透析医学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Serum soluble Klotho is associated with cardiovascular disease events and all-cause mortality in hemodialysis patients2020

    • Author(s)
      Akio Nakashima Ichiro Ohkido Keitaro Yokoyama Mitsuyoshi Urashima Takashi Yokoo
    • Organizer
      Asian pacific congress of nephrology
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2023-01-30  

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