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Prevention of allergic disease based on allergen-specific IgG4 levels in cord blood

Research Project

Project/Area Number 20K17457
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 54020:Connective tissue disease and allergy-related
Research InstitutionThe University of Tokushima (2021-2022)
National Center for Child Health and Development (2020)

Principal Investigator

IRAHARA, Makoto  徳島大学, 大学院医歯薬学研究部(医学域), 徳島大学専門研究員 (50767910)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywordsアレルゲン特異的IgG4 / アレルゲン特異的IgE / マイクロバイオーム / 臍帯血 / 便中マイクロバイオーム / 特異的IgG4抗体価 / 特異的IgE抗体価 / 食物アレルギー / ハイリスクコホート / 特異的igG4抗体価 / IgG4 / 感作
Outline of Research at the Start

ヒトの血液中のアレルゲンに対する特異的IgE抗体はアレルギー疾患を引き起こす要因である。我々は以前に臍帯血にある特異的IgG4抗体が多いと出生後の特異的IgE抗体が増加しにくい可能性を明らかにした。今回、臍帯血の特異的IgG4抗体価と生後2歳の特異的IgE抗体価を母の生活環境や皮膚や便の中にいる細菌叢などと一緒に検討することで①鶏卵以外のアレルゲンについても同様の傾向が認められるか。②臍帯血にある特異的IgG4抗体価を上昇させる要因にはどのようなものがあるか。の2点を明らかにして今後のアレルギー疾患の予防につなげる目的で研究を行う。

Outline of Final Research Achievements

We evaluated the association between fecal microbiomes of pregnant women and allergen-specific IgG4 levels in cord blood. A negative correlation was shown between egg white-specific IgG4 levels in cord blood and ovomucoids-specific IgE levels at 6 months of age in their children. Egg-white specific IgG4 levels in cord blood was positively correlated with Butyrate-producing bacterium M21.2, Coprococcus catus, and negatively correlated with Olsenella species 1832 in stools of pregnant mothers. This study suggests that the fecal microbiome of pregnant mothers is associated with allergen-specific IgG4 levels in cord blood and may be associated with developing of food allergy in their children.

Academic Significance and Societal Importance of the Research Achievements

研究代表者は、臍帯血中のアレルゲン特異的IgG4抗体価と出生した児のアレルゲン特異的IgE抗体価とに負の関連があることを報告した。このことは、臍帯血中のアレルゲン特異的IgG4抗体価に関連する因子の特定が、出生した児のアレルゲン特異的IgE抗体価の上昇の予防を通じて、アレルギー疾患の予防にもつながる研究になることを示している。そこで、近年の研究でアレルギー疾患との関連が示唆される便中マイクロバイオームに着目し、検討を行った。妊娠中の便中マイクロバイオームと臍帯血中のアレルゲン特異的抗体価との関連における報告はなく、アレルギー疾患の予防法確立の基礎として学術的意義、社会的意義のある研究である。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (12 results)

All 2023 2022

All Journal Article (9 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 9 results,  Open Access: 5 results) Presentation (3 results)

  • [Journal Article] Enhanced early skin treatment for atopic dermatitis in infants reduces food allergy2023

    • Author(s)
      Yamamoto-Hanada Kiwako、Kobayashi Tohru、Mikami Masashi、Williams Hywel C.、Saito Hirohisa、Ohya Yukihiro、et al
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: in press Issue: 1 Pages: 126-135

    • DOI

      10.1016/j.jaci.2023.03.008

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Relationship between Food Allergy and Endotoxin Concentration and the Toleration Status at 2 Years: The Japan Environment and Children’s Study2023

    • Author(s)
      Irahara Makoto、Yamamoto-Hanada Kiwako、Sato Miori、Saito-Abe Mayako、Miyaji Yumiko、Yang Limin、Nishizato Minaho、Kumasaka Natsuhiko、Mezawa Hidetoshi、Ohya Yukihiro、on behalf of the Japan Environment and Children’s Study (JECS) Group
    • Journal Title

      Nutrients

      Volume: 15 Issue: 4 Pages: 968-968

    • DOI

      10.3390/nu15040968

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] FLG mutations, eczema control, and respiratory symptom at one-year-old in early-onset atopic dermatitis infants (PACI-ON cohort study)2023

    • Author(s)
      Kumagai Fumiko、Yamamoto-Hanada Kiwako、Saito-Abe Mayako、Sato Miori、Ishikawa Fumi、Irahara Makoto、Miyaji Yumiko、Kabashima Shigenori、Ohya Yukihiro、Akiyama Masashi、Kono Michihiro
    • Journal Title

      Journal of Dermatological Science

      Volume: 109 Issue: 2 Pages: 99-101

    • DOI

      10.1016/j.jdermsci.2023.01.009

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tolerability and safety of a new elimination diet for pediatric eosinophilic gastritis and duodenitis2023

    • Author(s)
      Nagashima Saori、Yamamoto Mayu、Inuzuka Yusuke、Irahara Makoto、Miyaji Yumiko、Tadaki Hiromi、Ito Shuichi、Masuda Shizuka、Ito Yoshiyuki、Saito Yuri、Kobayashi Saeko、Morita Hideaki、Yoshioka Takako、Shimizu Hirotaka、Arai Katsuhiro、Ohya Yukihiro、Saito Hirohisa、Matsumoto Kenji、Nomura Ichiro
    • Journal Title

      Allergology International

      Volume: 72 Issue: 2 Pages: 306-315

    • DOI

      10.1016/j.alit.2022.11.001

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Two cases of pediatric eosinophilic esophagitis successfully treated by topical steroid therapy in addition to proton pump inhibitor2022

    • Author(s)
      Ogita Hiroya、Nomura Ichiro、Miyagi Yoshitsune、Kiguchi Tomoyuki、Inuzuka Yusuke、Toyokuni Kenji、Irahara Makoto、Ishikawa Fumi、Sato Miori、Saito-Abe Mayako、Miyaji Yumiko、Kabashima Shigenori、Yamamoto-Hanada Kiwako、Fukuie Tatsuki、Takeuchi Ichiro、Arai Katsuhiro、Ohya Yukihiro
    • Journal Title

      Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology

      Volume: 36 Issue: 3 Pages: 224-233

    • DOI

      10.3388/jspaci.36.224

    • ISSN
      0914-2649, 1882-2738
    • Year and Date
      2022-08-20
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Remission of Acute Food Protein-Induced Enterocolitis Syndrome Confirmed by Oral Food Challenges in Japan2022

    • Author(s)
      Nishimura Koji、Yamamoto-Hanada Kiwako、Sato Miori、Toyokuni Kenji、Ogita Hiroya、Kiguchi Tomoyuki、Miyagi Yoshitsune、Inuzuka Yusuke、Saito-Abe Mayako、Irahara Makoto、Ishikawa Fumi、Kabashima Shigenori、Miyaji Yumiko、Fukuie Tatsuki、Nomura Ichiro、Ohya Yukihiro
    • Journal Title

      Nutrients

      Volume: 14 Issue: 19 Pages: 4158-4158

    • DOI

      10.3390/nu14194158

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endotoxin concentration and persistent eczema in early childhood2022

    • Author(s)
      Irahara Makoto、Yamamoto‐Hanada Kiwako、Sato Miori、Saito‐Abe Mayako、Miyaji Yumiko、Yang Limin、Nishizato Minaho、Kumasaka Natsuhiko、Mezawa Hidetohi、Ohya Yukihiro、Kamijima Michihiro、Yamazaki Shin、Ohya Yukihiro、Kishi Reiko、Yaegashi Nobuo、Hashimoto Koichi、Mori Chisato、Ito Shuichi、Yamagata Zentaro
    • Journal Title

      The Journal of Dermatology

      Volume: 50 Issue: 5 Pages: 646-655

    • DOI

      10.1111/1346-8138.16686

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluctuations of aeroallergen-specific immunoglobulins and children's allergic profiles: Japan Environment & Children's Study of a pilot cohort2022

    • Author(s)
      Irahara Makoto、Yamamoto-Hanada Kiwako、Saito-Abe Mayako、Sato Miori、Miyaji Yumiko、Yang Limin、Mitsubuchi Hiroshi、Oda Masako、Sanefuji Masafumi、Ohga Shouichi、Ikegami Akihiko、Mise Nathan、Suga Reiko、Shimono Masayuki、Yamazaki Shin、Nakayama Shoji F.、Ohya Yukihiro
    • Journal Title

      Allergology International

      Volume: 71 Issue: 3 Pages: 335-344

    • DOI

      10.1016/j.alit.2022.01.002

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Is oral food challenge useful to avoid complete elimination in Japanese patients diagnosed with or suspected of having IgE-dependent hen's egg allergy? A systematic review2022

    • Author(s)
      Murai Hiroki、Irahara Makoto、Sugimoto Mayumi、Takaoka Yuri、Takahashi Kyohei、Wada Takuya、Yamamoto-Hanada Kiwako、Okafuji Ikuo、Yamada Yoshiyuki、Futamura Masaki、Ebisawa Motohiro
    • Journal Title

      Allergology International

      Volume: 71 Issue: 2 Pages: 221-229

    • DOI

      10.1016/j.alit.2021.09.005

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 特異的IgE抗体のAvidityによる即時型食物アレルギー症状誘発リスク評価の可能性2022

    • Author(s)
      苛原誠, 木戸博
    • Organizer
      日本小児アレルギー学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 食物アレルギーの診断・免疫療法 牛乳アレルギー経口免疫療法に対する加熱乳酸菌併用効果に関する第二相ランダム化比較試験2022

    • Author(s)
      佐藤未織, 山本 貴和子, 豊國 賢治, 苛原 誠, 上滝 恵利華, 水澤 直美, 森田 英明, 松本 健治, 大矢 幸弘
    • Organizer
      日本アレルギー学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 子どもの健康と環境に関する全国調査(エコチル調査)パイロット調査における8歳児の麻疹抗体陽性率とアレルギー疾患既往の関連(会議録)2022

    • Author(s)
      齋藤 麻耶子, 山本 貴和子, 庄司 健介, 佐藤 未織, 苛原 誠, 宮地 裕美子, 宮入 烈, 大矢 幸弘
    • Organizer
      日本小児科学会
    • Related Report
      2022 Annual Research Report

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Published: 2020-04-28   Modified: 2024-01-30  

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