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Establishment of objective and longitudinal sleep evaluation methods, including sleep-disordered breathing, in patients with acute respiratory failure.

Research Project

Project/Area Number 20K17860
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 55060:Emergency medicine-related
Research InstitutionKyoto University

Principal Investigator

Minami Takuma  京都大学, 医学研究科, 助教 (70866491)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords睡眠指標 / 睡眠時間 / 睡眠呼吸障害 / せん妄 / 呼吸不全 / 客観的睡眠時間 / デクスメデトミジン / ハロペリドール / 心房細動 / 睡眠時無呼吸 / 急性呼吸不全 / 睡眠 / 睡眠障害
Outline of Research at the Start

重症患者における睡眠障害とせん妄を始めとした合併症や予後との関連が注目されているが、臨床的に有用な睡眠指標の測定方法は未確立である。本研究においては客観的な睡眠指標を縦断的に測定可能な携帯型加速度計と酸素療法下でも睡眠呼吸障害を感知可能と考えられる睡眠評価装置で測定し、これらによって測定される指標と酸素療法下の急性呼吸不全患者の合併症発症や予後との関連を探索する。

Outline of Final Research Achievements

In patients who were urgently hospitalized for acute respiratory failure and had delirium, sleep efficiency evaluated by a portable accelerometer was higher than in patients without delirium. This was thought to be due to the effects of sleeping pills or sedatives administered for delirium. A randomized controlled trial comparing dexmedetomidine and haloperidol for sedation in patients with hyperactive delirium at night who were urgently hospitalized is being conducted. It was revealed that sleep apnea and long sleep duration are predictors of atrial fibrillation recurrence in patients who underwent radiofrequency catheter ablation for persistent atrial fibrillation.

Academic Significance and Societal Importance of the Research Achievements

携帯型加速度計を用いて評価した急性呼吸不全患者の睡眠指標はせん妄との直接との関連ではなく、せん妄に対する投薬の影響を受ける可能性がある。これは、せん妄に対する薬剤による鎮静が重要な課題であることを示唆すると同時に、携帯型加速度計を用いて評価した睡眠指標は鎮静の程度を評価する指標となり得ることを示した。また、睡眠時無呼吸に加えて、携帯型加速度計による長時間睡眠は心房細動患者において、今後の研究課題となり得る重要な予測因子であることを示した。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (6 results)

All 2023 2022 2021

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Dexmedetomidine versus haloperidol for sedation of non-intubated patients with hyperactive delirium during the night in a high dependency unit: study protocol for an open-label, parallel-group, randomized controlled trial (DEX-HD trial)2023

    • Author(s)
      Minami Takuma、Watanabe Hirotoshi、Kato Takao、Ikeda Kaori、Ueno Kentaro、Matsuyama Ai、Maeda Junya、Sakai Yoji、Harada Hisako、Kuriyama Akira、Yamaji Kyohei、Kitajima Naoki、Kamei Jun、Takatani Yudai、Sato Yuki、Yamashita Yugo、Mizota Toshiyuki、Ohtsuru Shigeru
    • Journal Title

      BMC Anesthesiology

      Volume: 23 Issue: 1 Pages: 193-193

    • DOI

      10.1186/s12871-023-02158-1

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-invasive ventilation using a novel ventilator and non-vented full-face mask for patients with respiratory failure during the COVID-19 pandemic: Report of three cases2022

    • Author(s)
      Minami Takuma、Kai Shinichi、Tanaka Tomoharu、Ito Isao、Kato Genta、Nagao Miki、Date Hiroshi、Hirai Toyohiro、Ohtsuru Shigeru、Chin Kazuo
    • Journal Title

      Respiratory Investigation

      Volume: 60 Issue: 4 Pages: 607-611

    • DOI

      10.1016/j.resinv.2022.03.005

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optimal Evidence Grading of Simultaneous Use of Hypertonic Saline and Furosemide for Fluid Overload2022

    • Author(s)
      Kitajima Naoki、Yamada Hiroyuki、Minami Takuma、Ohtsuru Shigeru
    • Journal Title

      Critical Care Medicine

      Volume: 50 Issue: 4 Pages: 405-406

    • DOI

      10.1097/ccm.0000000000005419

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of sleep-disordered breathing on glucose metabolism among individuals with a family history of diabetes: the Nagahama study2021

    • Author(s)
      Minami T、Matsumoto T、Tabara Y、Gozal D、Smith D、Murase K、Tanizawa K、Takahashi N、Nakatsuka Y、Hamada S、Handa T、Takeyama H、Oga T、Nakamoto I、Wakamura T、Komenami N、Setoh K、Tsutsumi T、Kawaguchi T、Kamatani Y、Takahashi Y、Morita S、Nakayama T、Hirai T、Matsuda F、Chin K、on behalf of the Nagahama Study Group
    • Journal Title

      Journal of Clinical Sleep Medicine

      Volume: 17 Issue: 2 Pages: 129-140

    • DOI

      10.5664/jcsm.8796

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Associations among sleep apnea, recurrence of atrial fibrillation, and objective sleep duration in patients who underwent radiofrequency catheter ablation for persistent atrial fibrillation2023

    • Author(s)
      Takuma Minami
    • Organizer
      ATS 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 持続性心房細動に対して高周波カテーテルアブレーションが 施行された患者群における睡眠時無呼吸、術後の心房細動の 再発および客観的睡眠時間の関連2023

    • Author(s)
      南 卓馬
    • Organizer
      第63回日本呼吸器学会学術講演会
    • Related Report
      2023 Annual Research Report

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Published: 2020-04-28   Modified: 2025-01-30  

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