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Hip osteoarthritis after spinopelvic fusion surgery

Research Project

Project/Area Number 20K18008
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionWakayama Medical University

Principal Investigator

Kozaki Takuhei  和歌山県立医科大学, 医学部, 博士研究員 (90838319)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords成人脊柱変形手術 / 変形性股関節症 / 隣接関節障害 / 成人脊柱変形 / 動作解析 / 有限要素解析 / 接関節障害
Outline of Research at the Start

脊柱変形手術(Long Fusion)は非生理的な生体力学環境を生み出すことによる合併症を引き起こしている。Long Fusionにより可動域を失った脊椎の代償として股関節に働く応力の増大があると考えている。本研究は動作解析、有限要素解析を用いて股関節に働く応力やその分布の変化をLong Fusion前後で3次元的に比較検討することで、本病態を解明することを目的としている。

Outline of Final Research Achievements

Hip osteoarthritis progresses rapidly after adult spinal deformity surgery, which is one of the complications of this procedure, but its pathology has not been clearly understood. In this study, we used two three-dimensional evaluation methods, finite element analysis and motion analysis, to compare the stress on the hip joint before and after adult spinal deformity surgery. The finite element analysis showed hip joint stress increased much more in a spinopelvic fixation than the other model. Motion analysis also showed hip joint moment increased after surgery. These results demonstrated that hip osteoarthritis that progresses after adult spinal deformity surgery is adjacent joint damage caused by pelvic fixation.

Academic Significance and Societal Importance of the Research Achievements

成人脊柱変形術後の股関節症は新規発生率が20%であるものの、有効な治療法が確立されていない。本研究結果より本病態は骨盤固定に伴う隣接関節障害であることが判明した。本研究をもとに今後予防法を開発することが期待される。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (12 results)

All 2023 2022 2021

All Journal Article (4 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (8 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Acetabular Rim Fracture after Adult Spinal Deformity Surgery-Induced Secondary Hip Osteoarthritis: Two Case Reports2023

    • Author(s)
      Takuhei Kozaki
    • Journal Title

      Spine Surgery and Related Research

      Volume: 7 Issue: 5 Pages: 464-467

    • DOI

      10.22603/ssrr.2023-0035

    • ISSN
      2432-261X
    • Year and Date
      2023-09-27
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of Lumbar Fusion and Pelvic Fixation Rigidity on Hip Joint Stress: A Finite Element Analysis2023

    • Author(s)
      Takuhei Kozaki
    • Journal Title

      Spine

      Volume: 48(20) Issue: 20 Pages: E355-E361

    • DOI

      10.1097/brs.0000000000004791

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Spinopelvic fusion surgery from lower thoracic spine to pelvis increased hip joint moment-motion analysis.2023

    • Author(s)
      Takuhei Kozaki
    • Journal Title

      Eur Spine J

      Volume: 32 Issue: 2 Pages: 727-733

    • DOI

      10.1007/s00586-022-07483-6

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lumbar Fusion including Sacroiliac Joint Fixation Increases the Stress and Angular Motion at the Hip Joint: A Finite Element Study2022

    • Author(s)
      Kozaki T, Hashizume H, Oka H, Ohashi S, Kumano Y, Yamamoto E, Minamide A, Yukawa Y, Iwasaki H, Tsutsui S, Takami M, Nakata K, Taniguchi T, Fukui D, Nishiyama D, Yamanaka M, Tamai H, Taiji R, Murata S, Murata A, Yamada H.
    • Journal Title

      Spine Surgery and Related Research

      Volume: 6 Issue: 6 Pages: 681-688

    • DOI

      10.22603/ssrr.2021-0231

    • ISSN
      2432-261X
    • Year and Date
      2022-11-27
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 成人脊柱変形術後に発症もしくは進行する股関節症は骨盤固定の影響がある2023

    • Author(s)
      神前拓平
    • Organizer
      日本脊椎脊髄病学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 成人脊柱変形術後に股関節に働くモーメントは増加する2023

    • Author(s)
      神前拓平
    • Organizer
      日本脊椎脊髄病学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 成人脊柱変形手術において骨盤固定強度があがると股関節に働く応力は増加する2023

    • Author(s)
      神前拓平
    • Organizer
      日本脊椎脊髄病学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] More rigid fixation of pelvis in adult spinal deformity increased the stress and angular motion at hip joint: finite element analysis.2022

    • Author(s)
      Takuhei Kozaki
    • Organizer
      Orthopaedic Research Society
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 成人脊柱変形術後に股関節に働くモーメントは増加する2022

    • Author(s)
      神前拓平
    • Organizer
      第52回日本脊椎脊髄病学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 強固な骨盤固定は股関節に働く角運動と相当応力を増加させる2022

    • Author(s)
      神前拓平
    • Organizer
      第52回日本脊椎脊髄病学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 成人脊柱変形術後に発症、進行する股関節症は骨盤固定の影響である2022

    • Author(s)
      神前拓平
    • Organizer
      日本整形外科学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 成人脊柱変形術後に股関節に働く応力は増加する 3次元有限要素解析を用いて2021

    • Author(s)
      神前拓平
    • Organizer
      日本脊椎脊髄病学会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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