• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Pathophysiology of hearing loss and its effect on cognitive function

Research Project

Project/Area Number 20K18263
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56050:Otorhinolaryngology-related
Research InstitutionNational Defense Medical College

Principal Investigator

Kurioka Takaomi  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 耳鼻咽喉科学, 講師 (30842728)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords聴覚障害 / シナプス / 難聴 / 耳鳴 / 神経可塑性 / 髄鞘 / 認知機能 / 海馬 / 内耳 / 聴覚中枢 / 神経炎症 / 免疫反応
Outline of Research at the Start

本研究では、難聴が抑うつ・認知機能に及ぼす影響とその病態解明を目的とする。中枢での神経炎症や免疫細胞の活性化に着目し、難聴後の海馬や蝸牛神経核におけるミクログリアの遊走、炎症性サイトカインの発現について解析を行い、難聴とうつ・認知機能の関連について検討する。さらに、海馬の神経新生能を評価し、神経炎症や神経新生を中枢で制御することが難聴に対する新しい治療法となりうるかについて探究する。

Outline of Final Research Achievements

In this study, we investigated whether a decrease in sound level could induce impairment of hippocampal neurogenesis and examined the differences between unilateral conductive (uCHL) and bilateral CHL (bCHL).
Although hearing thresholds were significantly increased following CHL, CHL mice exhibited no significant loss of spiral ganglion or hippocampal neurons. Hippocampal neurogenesis was significantly and equally decreased in both sides following uCHL. More severe decreases in hippocampal neurogenesis were observed in both sides in bCHL mice compared with that in uCHL mice. Furthermore, microglial invasion significantly increased following CHL. Serum cortisol levels, which indicate stress response, significantly increased following bCHL. Therefore, auditory deprivation could lead to increased microglial invasion

Academic Significance and Societal Importance of the Research Achievements

伝音難聴による中耳から内耳への音響刺激の減少が蝸牛神経、脳に及ぼす影響と神経可塑性について検討した。耳栓により有意な聴力閾値の上昇を認めたが,耳栓解除後には聴力閾値は完全に回復した。組織学的には,有毛細胞や蝸牛神経の消失は認めなかったが,内有毛細胞と蝸牛神経の接合部シナプス数,蝸牛神経軸索径および髄鞘化が有意に低値となった。これらの組織学的変化は伝音難聴の解消により回復を示した。さらに海馬の神経新生能も低下を示した。以上のことから,聴覚刺激に依存して脳は可塑性を有すると考えられ,伝音難聴においても蝸牛神経への電気刺激を維持することが重要と考える。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (36 results)

All 2023 2022 2021 2020

All Journal Article (21 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 21 results,  Open Access: 9 results) Presentation (15 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results)

  • [Journal Article] Clinical Characteristics and Corticosteroid Responses of Acoustic Neuroma Treated as Idiopathic Sudden Sensorineural Hearing Loss2023

    • Author(s)
      Yoshinari Nakamura, Takaomi Kurioka, Hajime Sano, Shogo Furuki, Taku Yamashita
    • Journal Title

      The Journal of International Advanced Otology

      Volume: 19 Issue: 1 Pages: 5-9

    • DOI

      10.5152/iao.2023.22720

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Investigation of hearing aid fitting according to the National Acoustic Laboratories’ prescription for non-linear hearing aids and the Desired Sensation Level methods in Japanese speakers: a crossover-controlled trial.2023

    • Author(s)
      Shogo Furuki, Hajime Sano, Takaomi Kurioka, Yoshihiro Nitta, Sachie Umehara, Yuki Hara, Taku Yamashita
    • Journal Title

      Auris Nasus Larynx

      Volume: - Issue: 5 Pages: 708-713

    • DOI

      10.1016/j.anl.2023.01.004

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Unilateral Vagotomy on LPS-Induced Aspiration Pneumonia in Mice2023

    • Author(s)
      Tatsushima Daisuke、Kurioka Takaomi、Mizutari Kunio、Suzuki Jun、Ikeda Ryoukichi、Hisaoka Takuma、Koshiba Yasutoshi、Takahashi Hiyori、Hashimoto Hikaru、Katori Yukio、Shiotani Akihiro
    • Journal Title

      Dysphagia

      Volume: - Issue: 5 Pages: 1353-1362

    • DOI

      10.1007/s00455-023-10564-3

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of Blast-Induced Tympanic Membrane Perforation with Peripheral Cochlear Synaptopathy2022

    • Author(s)
      Kurioka Takaomi、Mizutari Kunio、Satoh Yasushi、Shiotani Akihiro
    • Journal Title

      Journal of Neurotrauma

      Volume: 39 Issue: 13-14 Pages: 999-1009

    • DOI

      10.1089/neu.2021.0487

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Factors affecting the incidence of chorda tympani nerve transection in middle ear surgery2022

    • Author(s)
      Takihata Saki、Kurioka Takaomi、Mizutari Kunio、Shiotani Akihiro
    • Journal Title

      Laryngoscope Investigative Otolaryngology

      Volume: 7 Issue: 6 Pages: 2088-2094

    • DOI

      10.1002/lio2.976

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immune-Nutritional Status as a Novel Prognostic Predictor of Bell’s Palsy2022

    • Author(s)
      Yamamoto Kengo、Kurioka Takaomi、Ohki Motofumi、Ohashi Kentaro、Harada Yuki、Asako Yukiko、Sano Hajime、Yamashita Taku
    • Journal Title

      Audiology and Neurotology

      Volume: 27 Issue: 5 Pages: 418-426

    • DOI

      10.1159/000524355

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroplasticity of auditory neurons in conductive hearing loss2021

    • Author(s)
      Kurioka Takaomi、Sano Hajime、Furuki Shogo、Yamashita Taku
    • Journal Title

      AUDIOLOGY JAPAN

      Volume: 64 Issue: 2 Pages: 163-169

    • DOI

      10.4295/audiology.64.163

    • NAID

      130008039288

    • ISSN
      0303-8106, 1883-7301
    • Year and Date
      2021-04-28
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Decreasing auditory input induces neurogenesis impairment in the hippocampus2021

    • Author(s)
      Kurioka Takaomi、Mogi Sachiyo、Yamashita Taku
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-020-80218-z

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of shock wave power spectrum on the inner ear pathophysiology in blast-induced hearing loss2021

    • Author(s)
      Kimura, E., Mizutari, K., Kurioka, T., Kawauchi, S., Satoh, Y., Sato, S. & Shiotani, A.
    • Journal Title

      Sci Rep

      Volume: 11 Issue: 1 Pages: 14704-14704

    • DOI

      10.1038/s41598-021-94080-0

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of extracellular signal-regulated kinase pathway suppresses tracheal stenosis in a novel mouse model2021

    • Author(s)
      Kimura Akari、Araki Koji、Satoh Yasushi、Mogi Sachiyo、Fujitani Kazuko、Kurioka Takaomi、Endo Shogo、Shiotani Akihiro、Yamashita Taku
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 9 Pages: 0256127-0256127

    • DOI

      10.1371/journal.pone.0256127

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Scar Formation and Debris Elimination during Hair Cell Degeneration in the Adult DTR Mouse2021

    • Author(s)
      Lee Sungsu、Kurioka Takaomi、Lee Min Young、Beyer Lisa A.、Swiderski Donald L.、Ritter K. Elaine、Raphael Yehoash
    • Journal Title

      Neuroscience

      Volume: 453 Pages: 57-68

    • DOI

      10.1016/j.neuroscience.2020.11.041

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical features and hearing prognosis of idiopathic sudden sensorineural hearing loss in patients undergoing hemodialysis: A retrospective study2021

    • Author(s)
      Yamamoto Kengo、Kurioka Takaomi、Furuki Shogo、Sano Hajime、Ohashi Kentaro、Ohki Motofumi、Yamashita Taku
    • Journal Title

      Laryngoscope Investigative Otolaryngology

      Volume: 6 Issue: 5 Pages: 1104-1109

    • DOI

      10.1002/lio2.630

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of real-ear insertion gains in Japanese-speaking individuals wearing hearing aids with DSL v5 and NAL-NL2.2021

    • Author(s)
      Shogo Furuki, Hajime Sano, Takaomi Kurioka, Atsuko Ogiwara, Tkahito Nakagawa, Rie Inoue, Sachie Umehara, Yuki Hara, Keiko Suzuki, Taku Yamashita
    • Journal Title

      Aris Nasus Larynx

      Volume: 48 Issue: 1 Pages: 75-81

    • DOI

      10.1016/j.anl.2020.07.010

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Iron deficiency is associated with poor prognosis in idiopathic sudden sensorineural hearing loss2021

    • Author(s)
      Kurioka Takaomi、Mogi Sachiyo、Yamashita Taku
    • Journal Title

      The Journal of Laryngology & Otology

      Volume: - Issue: 6 Pages: 508-512

    • DOI

      10.1017/s0022215121001079

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neural degeneration of auditory and hippocampal neurons in noise-induced hearing loss2021

    • Author(s)
      栗岡 隆臣
    • Journal Title

      Otology Japan

      Volume: 31 Issue: 3 Pages: 235-239

    • DOI

      10.11289/otoljpn.31.235

    • ISSN
      0917-2025, 1884-1457
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 伝音難聴が蝸牛神経に及ぼす影響と神経可塑性について2021

    • Author(s)
      栗岡隆臣,佐野 肇,古木省吾,山下 拓
    • Journal Title

      Audiology Japan

      Volume: Vol. 64, No. 2 Pages: 163-169

    • NAID

      130008039288

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Activity-Dependent Neurodegeneration and Neuroplasticity of Auditory Neurons Following Conductive Hearing Loss in Adult Mice2020

    • Author(s)
      Kurioka Takaomi、Mogi Sachiyo、Tanaka Manabu、Yamashita Taku
    • Journal Title

      Cellular and Molecular Neurobiology

      Volume: 41 Issue: 1 Pages: 31-42

    • DOI

      10.1007/s10571-020-00829-y

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Speech discrimination impairment of the worse-hearing ear in asymmetric hearing loss2020

    • Author(s)
      Kurioka Takaomi、Sano Hajime、Furuki Shogo、Yamashita Taku
    • Journal Title

      International Journal of Audiology

      Volume: 60 Issue: 1 Pages: 54-59

    • DOI

      10.1080/14992027.2020.1795282

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transient Conductive Hearing Loss Regulates Cross-Modal VGLUT Expression in the Cochlear Nucleus of C57BL/6 Mice2020

    • Author(s)
      Kurioka Takaomi、Mogi Sachiyo、Yamashita Taku
    • Journal Title

      Brain Sciences

      Volume: 10 Issue: 5 Pages: 260-260

    • DOI

      10.3390/brainsci10050260

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term administration of vitamin B12 and adenosine triphosphate for idiopathic sudden sensorineural hearing loss: a retrospective study2020

    • Author(s)
      Kurioka Takaomi、Sano Hajime、Furuki Shogo、Yamashita Taku
    • Journal Title

      PeerJ

      Volume: 8 Pages: e10406-e10406

    • DOI

      10.7717/peerj.10406

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of the Conductive Component of Hearing Loss on Speech Discrimination Ability2020

    • Author(s)
      Takaomi Kurioka, Hajime Sano, Shogo Furuki, Taku Yamashita
    • Journal Title

      The Journal of International Advanced Otology

      Volume: 16 Issue: 1 Pages: 93-97

    • DOI

      10.5152/iao.2020.7870

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Blast shockwaves cause central myelin defect and synapse degeneration, and its relevance to tinnitus development2023

    • Author(s)
      Takaomi Kurioka, Kunio Mizutari
    • Organizer
      46th Annual MidWinter Meeting of Association for Research in Otolaryngology
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 音響性聴覚障害における中枢変化について2022

    • Author(s)
      栗岡隆臣
    • Organizer
      第32回日本耳科学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 栄養状態・免疫能の評価による突発性難聴の予後予測に関する検討2022

    • Author(s)
      山本 賢吾, 栗岡 隆臣, 大木 幹文, 佐野 肇, 山下 拓
    • Organizer
      第32回日本耳科学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] スタチン製剤による突発性難聴の聴力予後の検討2022

    • Author(s)
      新田義洋, 栗岡隆臣, 古木省吾, 佐野 肇, 山下 拓
    • Organizer
      第32回日本耳科学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 内耳奇形が原因と考えられた細菌性髄膜炎に対しCO2レーザーでアブミ骨を摘出し内耳窓の補強を行った1例2022

    • Author(s)
      西野桂佑, 栗岡隆臣, 水足邦雄, 塩谷彰浩
    • Organizer
      第84回耳鼻咽喉科臨床学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 音響性聴覚障害におけるMyelinopathyの病態について -爆傷動物モデルを用いた検討-2022

    • Author(s)
      栗岡隆臣、水足邦雄、塩谷彰浩
    • Organizer
      第67回日本聴覚医学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 伝音難聴が蝸牛神経に及ぼす影響と神経可塑性について2022

    • Author(s)
      栗岡隆臣
    • Organizer
      第67回日本聴覚医学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 第Ⅶ・Ⅷ神経症状を認め肺小細胞癌の内耳道内転移が疑われた1症例2022

    • Author(s)
      中村吉成, 佐野 肇, 古木省吾, 新田義洋, 栗岡隆臣, 山下 拓
    • Organizer
      第67回日本聴覚医学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 急性感音難聴に対する全身ステロイド反復投与と聴力予後に関する検討2022

    • Author(s)
      山本賢吾, 栗岡隆臣, 大橋健太郎, 大木幹文, 佐野 肇, 山下 拓
    • Organizer
      第123回日本耳鼻咽喉科頭頸部外科学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Factors affecting the incidence of chorda tympani nerve transection in middle ear surgery2022

    • Author(s)
      Takaomi Kurioka, Saki Takihata, Kunio Mizutari, Akihiro Shiotani
    • Organizer
      4th world congress on endoscopic ear surgery
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 左右非対称性難聴における悪聴耳の語音聴取能低下について2020

    • Author(s)
      栗岡隆臣
    • Organizer
      第40回日本耳科学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 伝音難聴が蝸牛神経に及ぼす影響と神経可塑性について2020

    • Author(s)
      栗岡隆臣
    • Organizer
      日本聴覚医学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 難聴が海馬の神経新生に及ぼす影響について2020

    • Author(s)
      栗岡隆臣
    • Organizer
      日本耳鼻咽喉科学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Activity-dependent Synaptopathy and Demyelination of Auditory Neurons following Conductive Hearing Loss in Adult Mice2020

    • Author(s)
      Takaomi Kurioka
    • Organizer
      Association For Research In Otolaryngology 43rd Annual MidWinter Meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 音響性聴覚障害における 蝸牛神経と海馬の障害メカニズムについて2020

    • Author(s)
      栗岡隆臣
    • Organizer
      第40回日本耳科学会
    • Related Report
      2020 Research-status Report
    • Invited

URL: 

Published: 2020-04-28   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi