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Developing the Artifacts Removing System for OCTA using generative adversarial network

Research Project

Project/Area Number 20K18332
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56060:Ophthalmology-related
Research InstitutionAsahikawa Medical College

Principal Investigator

Takahashi Kengo  旭川医科大学, 大学病院, 助教 (40646064)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2020: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords光干渉断層計 / SRF / IRF / セグメンテーション / AI / OCT / U-net / 人工知能 / 網膜下液 / アーチファクト / 敵対的生成ネットワーク / GAN / VQ-VAE-2 / 眼科 / 光干渉断層血管撮影
Outline of Research at the Start

光干渉断層血管撮影撮影時に特にセグメンテーションエラーが問題になりやすい加齢黄斑 変性を対象に、アーチファ クト除去システムの開発を行い。市販機器の自動のセグメテーションライン生成システムでの正確性を比較検討する。

Outline of Final Research Achievements

Retinal specialists pointed out that the artifact removal system using a generative adversarial network predicted images that differed from the facts and that applying the system to clinical practice would be difficult. After that, we performed automatic segmentation of optical coherence tomography (OCT) using U-net, a type of Convolutional neural network, to evaluate the activity of retinal disease by automatically segmenting sub-retinal fluid (SRF) and intraretinal fluid (IRF) and evaluating them as subretinal fluid scores. We developed a system for predicting and preventing SRF and IRF and for tailored medicine. We summarized the results and submitted them as a paper. We are currently considering applying the system to clinical practice.

Academic Significance and Societal Importance of the Research Achievements

糖尿病網膜症(DR)および進出型加齢黄斑変性(wAMD)は、それぞれ、本邦における失明原因の2位と4位を占めており、その個別管理・治療は重要である。DRおよびwAMDは黄斑部に網膜下液を生じ、光干渉断層計を用いた病状管理が重要である。本研究では、網膜下液を下液スコアとして評価し、それを用いて、予防・予測観点で個別管理するシステムの開発に寄与した。今後はこのシステムの実臨床への応用について検討の上、本邦における失明者を減らすことに貢献する。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (9 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (2 results) Journal Article (6 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] Singapore Eye Research Institute/Singapore National Eye Centre(シンガポール)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] Singapore Eye Research Institute(シンガポール)

    • Related Report
      2020 Research-status Report
  • [Journal Article] PATTERN AND CHARACTERISTICS OF DRUSEN SUBTYPES IN CHINESE AND INDIAN POPULATIONS IN SINGAPORE2023

    • Author(s)
      Takahashi Kengo、Song Youngseok、Cheong Kai Xiong、Fenner Beau J.、Teo Kelvin Yi Chong、Chee Miao Li、Li Hengtong、Tham Yih-Chung、Cheung Chui Ming Gemmy、Cheng Ching-Yu、Wong Tien Yin、Yanagi Yasuo、Tan Anna C. S.
    • Journal Title

      Retina

      Volume: 43 Issue: 2 Pages: 303-312

    • DOI

      10.1097/iae.0000000000003651

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Predictive, preventive, and personalized management of retinal fluid via computer-aided detection app for optical coherence tomography scans2022

    • Author(s)
      Quek Ten Cheer、Takahashi Kengo、Kang Hyun Goo、Thakur Sahil、Deshmukh Mihir、Tseng Rachel Marjorie Wei Wen、Nguyen Helen、Tham Yih-Chung、Rim Tyler Hyungtaek、Kim Sung Soo、Yanagi Yasuo、Liew Gerald、Cheng Ching-Yu
    • Journal Title

      EPMA Journal

      Volume: 13 Issue: 4 Pages: 547-560

    • DOI

      10.1007/s13167-022-00301-5

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Glaucoma Diagnostic Performance of Retinal Blood Flow Measurement With Doppler Optical Coherence Tomography2022

    • Author(s)
      Abe Tsubasa、Yoshioka Takafumi、Song Youngseok、Tani Tomofumi、Kawai Motofumi、Omae Tsuneaki、Takahashi Kengo、Takizawa Yoshitaka、Ro-Mase Tomoko、Ishiko Satoshi、Minamide Kana、Sakai Jun、Akiba Masahiro、Hashimoto Yohei、Yoshida Akitoshi
    • Journal Title

      Translational Vision Science & Technology

      Volume: 11 Issue: 10 Pages: 11-11

    • DOI

      10.1167/tvst.11.10.11

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Normative Data and Associations of OCT Angiography Measurements of the Macula2022

    • Author(s)
      Teo Zhen Ling、Sun Christopher Ziyu、Chong Crystal Chun Yuen、Tham Yih-Chung、Takahashi Kengo、Majithia Shivani、Teo Cong Ling、Rim Tyler Hyungtaek、Chua Jacqueline、Schmetterer Leopold、Cheung Chui Ming Gemmy、Wong Tien Yin、Cheng Ching-Yu、Tan Anna Cheng Sim
    • Journal Title

      Ophthalmology Retina

      Volume: 6 Issue: 11 Pages: 1080-1088

    • DOI

      10.1016/j.oret.2022.05.010

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Computer-aided detection and abnormality score for the outer retinal layer in optical coherence tomography2021

    • Author(s)
      Rim Tyler Hyungtaek、Lee Aaron Yuntai、Ting Daniel S、Teo Kelvin Yi Chong、Yang Hee Seung、KIM Hyeonmin、Lee Geunyoung、Teo Zhen Ling、Teo Wei Jun Alvin、Takahashi Kengo、Yoo Tea Keun、Kim Sung Eun、Yanagi Yasuo、Cheng Ching-Yu、Kim Sung Soo、Wong Tien Yin、Cheung Chui Ming Gemmy
    • Journal Title

      British Journal of Ophthalmology

      Volume: - Issue: 9 Pages: 317817-317817

    • DOI

      10.1136/bjophthalmol-2020-317817

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Deterioration of Retinal Blood Flow Parameters in Branch Retinal Vein Occlusion Measured by Doppler Optical Coherence Tomography Flowmeter.2020

    • Author(s)
      Takahashi K, Song YS*, Sogawa K, Yoshioka T, Tani T, Ishiko S, Yoshida A
    • Journal Title

      J. Clin. Med

      Volume: 13;9(6) Issue: 6 Pages: 1847-1847

    • DOI

      10.3390/jcm9061847

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Computer-Aided Detection (CADe) of Treatable Retinal Fluid in OCT2021

    • Author(s)
      Quek Ten Cheer, Tyler Hyungtaek Rim, Kengo Takahashi, Tham Yih-Chung, Cheng Ching-Yu
    • Organizer
      SingHealth Duke-NUS Scientific Congress 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research

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Published: 2020-04-28   Modified: 2025-01-30  

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