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Quantitative analysis of changes in biophysical properties of sclera during myopia progress

Research Project

Project/Area Number 20K18357
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56060:Ophthalmology-related
Research InstitutionKeio University

Principal Investigator

Jeong Heonuk  慶應義塾大学, 医学部(信濃町), 特任助教 (90868613)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords近視 / 強膜 / 脈絡膜 / バイオレットライト / ブナゾシン / 菲薄化 / 眼軸長 / 脈絡膜厚 / 眼圧 / 物性変化 / 組織弾性
Outline of Research at the Start

眼の構造的変化による近視は遺伝や環境からの影響がある中、様々な生理的要因から眼球の形を維持する強膜の弾性が落ちることで、眼軸伸長による近視になると報告されている。しかし、近視進歩と伴い、弾性を含めた強膜組織の物性変化を定量的解析は行われていないため、生体物理的観点で強膜を評価する必要がある。本研究では近視誘導のマウスモデルと非侵襲的測定法を用いて時系列に強膜組織の生体物理的特性を定量的評価を行い、近視の進行と強膜の変化の関係を明確に示すことを目指す。本研究の結果から近視による眼の物理的変化を理解し、さらに近視進行を予防するための指標として臨床的に応用されることを期待する。

Outline of Final Research Achievements

The purpose of this study is to quantitatively evaluate the biophysical characteristics of the eye tissue in the progression of myopia, and to clarify the relationship with the elongation of the axial length of the eye tissue. The properties of choroid in myopia progression and inhibition were measured non-invasively. We reported that the loss of vascular endothelial growth factor derived from the retinal pigment epithelium causes choroidal thinning, resulting in axial elongation and myopic refraction. It was clarified that violet light transmittance and bunazosin eye drops affected the progression of myopia accompanied by changes in axial length and choroidal thickness.

Academic Significance and Societal Importance of the Research Achievements

VEGF欠損マウスから脈絡膜菲薄化が生じた後、眼軸長伸長が見られた。強膜の物性値変化において脈絡膜の厚さ、血流の変化が原因であり、近視進行を予防、予測するためには、強膜の特性より脈絡膜の変化を捉えることが優先する必要があることを示した。VEGFの適切な制御が新たな軸性近視の進行予防と治療法となることが期待できる。
近視進行及び抑制過程において脈絡膜厚の変化との関連性を示した。さらに、脈絡膜厚を維持するバイオレットライト照射、ブナゾシン点眼で近視進行を抑制したことから急増する近視人口に対する予防方法を提案したことに社会的意義をもつ。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (19 results)

All 2023 2022 2021

All Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (13 results) (of which Int'l Joint Research: 8 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Contralateral effect in progression and recovery of lens‐induced myopia in mice2023

    • Author(s)
      Ma Ziyan、Jeong Heonuk、Yang Yajing、Jiang Xiaoyan、Ikeda Shin‐ichi、Negishi Kazuno、Kurihara Toshihide、Tsubota Kazuo
    • Journal Title

      Ophthalmic and Physiological Optics

      Volume: 43 Issue: 3 Pages: 1-8

    • DOI

      10.1111/opo.13125

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Suppressive effects of violet light transmission on myopia progression in a mouse model of lens-induced myopia2023

    • Author(s)
      Jeong Heonuk、Kurihara Toshihide、Jiang Xiaoyan、Kondo Shinichiro、Ueno Yusuke、Hayashi Yuki、Lee Deokho、Ikeda Shin-Ichi、Mori Kiwako、Torii Hidemasa、Negishi Kazuno、Tsubota Kazuo
    • Journal Title

      Experimental Eye Research

      Volume: 228 Pages: 109414-109414

    • DOI

      10.1016/j.exer.2023.109414

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Vascular endothelial growth factor from retinal pigment epithelium is essential in choriocapillaris and axial length maintenance2022

    • Author(s)
      Zhang Yan、Jeong Heonuk、Mori Kiwako、Ikeda Shin-Ichi、Shoda Chiho、Miwa Yukihiro、Nakai Ayaka、Chen Junhan、Ma Ziyan、Jiang Xiaoyan、Torii Hidemasa、Kubota Yoshiaki、Negishi Kazuno、Kurihara Toshihide、Tsubota Kazuo
    • Journal Title

      PNAS Nexus

      Volume: 1 Issue: 4 Pages: 1-13

    • DOI

      10.1093/pnasnexus/pgac166

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Retinal dysfunction induced in a mouse model of unilateral common carotid artery occlusion2021

    • Author(s)
      Lee Deokho、Jeong Heonuk、Miwa Yukihiro、Shinojima Ari、Katada Yusaku、Tsubota Kazuo、Kurihara Toshihide
    • Journal Title

      PeerJ

      Volume: 9 Pages: e11665-e11665

    • DOI

      10.7717/peerj.11665

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Role of VEGF secreted from Retinal Pigment Epithelium in Choriocapillaris and Axial Length Maintenance2022

    • Author(s)
      Yan Zhang, Heonuk Jeong, Kiwako Mori, Shin-Ichi Ikeda, Chiho Shoda, Yukihiro Miwa, Ayaka Nakai, Junhan Chen, Ziyan Ma, Yoshiaki Kubota, Kazuno Negishi, Toshihide Kurihara, Kazuo Tsubota
    • Organizer
      18th International Myopia Conference 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Alpha-1 blockers suppress lens-induced myopia in mice by maintenance of choroidal thickness2022

    • Author(s)
      Heonuk Jeong, Toshihide Kurihara, Xiaoyan Jiang, Kazuno Negishi, Kazuo Tsubota
    • Organizer
      18th International Myopia Conference 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ginkgo biloba Extracts Altered Choroidal Blood Perfusion in Mice2022

    • Author(s)
      Jing Hou, Kiwako Mori, Shin-ichi Ikeda, Heonuk Jeong, Hidemasa Torii, Kazuno Negishi, Toshihide Kurihara, Kazuo Tsubota
    • Organizer
      18th International Myopia Conference 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Omega 3 polyunsaturated fatty acids showed suppression of choroidal thinning and subsequent myopia inhibition by lipidomic analysis in murine experimental models2022

    • Author(s)
      Toshihide Kurihara, Kiwako Mori, Sayoko Kuroha, Hou Jing, Heonuk Jeong, Mamoru Ogawa, Shin-Ichi Ikeda, Jing X. Kang, Kazuno Negishi, Hidemasa Torii, Makoto Arita, Kazuo Tsubota
    • Organizer
      18th International Myopia Conference 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Post Lens-Induced-Myopia Emmetropization: Binocular Compensation in Progression and Recovery of Myopia2022

    • Author(s)
      Ziyan Ma, Heonuk Jeong, Xiaoyan Jiang, Shin-Ichi Ikeda, Kazuno Negishi, Toshihide Kurihara, Kazuo Tsubota
    • Organizer
      18th International Myopia Conference 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bunazosin inhibited axial elongation with an increase of the choroidal blood perfusion in a murine model of myopia2022

    • Author(s)
      Heonuk Jeong, Toshihide Kurihara, Xiaoyan Jiang, Kazuno Negishi, Kazuo Tsubota
    • Organizer
      2022 ARVO Annual Meeting
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ginkgo biloba Extracts Showed Myopia Suppressive Effects in a Lens-Induced Myopia Model in Mice2022

    • Author(s)
      Jing Hou, Kiwako Mori, Shin-ichi Ikeda, Heonuk Jeong, Hidemasa Torii, Kazuno Negishi, Toshihide Kurihara, Kazuo Tsubota
    • Organizer
      2022 ARVO Annual Meeting
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] レンズ誘導近視モデルマウスにおけるVL透過率による近視進行抑制効果の差異2022

    • Author(s)
      丁憲煜,栗原俊英,馬子妍,姜效炎,近藤眞一郎,植野雄介,林祐樹,池田真一,森紀和子,鳥居秀成,根岸一乃,坪田一男
    • Organizer
      第4回日本近視学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] EPA代謝物の脈絡膜菲薄化および近視抑制効果に与える影響2022

    • Author(s)
      森紀和子,黒羽小羊子,侯靖,丁憲煜,小川護,池田真一,ジンカン,鳥居秀成,根岸一乃,有田誠,栗原俊英,坪田一男
    • Organizer
      第126回日本眼科学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 網膜色素上皮特異的VEGF欠損マウスでの眼軸長伸長2022

    • Author(s)
      丁憲煜,栗原俊英,張エン,森紀和子,池田真一,馬子妍,久保田義顕,根岸一乃,坪田一男
    • Organizer
      第126回日本眼科学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Lrp2ノックアウトマウスが示す強度近視の分子機構解析2022

    • Author(s)
      張エン,栗原俊英,丁憲煜,森紀和子,池田真一,陳俊翰,根岸一乃,坪田一男
    • Organizer
      第126回日本眼科学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Establishment of scaffold-free choroid in vitro model2021

    • Author(s)
      Heonuk Jeong, Toshihide Kurihara, Kazuno Negishi, Kazuo Tsubota
    • Organizer
      The 11th APBiomech
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] OPN5 を介したバイオレットライトによる血管内皮増殖因子の発現,2021

    • Author(s)
      丁憲煜、池田真一、ジャンジョウエン、森紀和子、鳥居秀成、栗原俊英、坪田一男
    • Organizer
      第3回日本近視学会
    • Related Report
      2021 Research-status Report
  • [Patent(Industrial Property Rights)] α1ブロッカーを含む近視進行抑制用点眼剤2022

    • Inventor(s)
      ジョン ホヌク、栗原俊英、坪田一男
    • Industrial Property Rights Holder
      ジョン ホヌク、栗原俊英、坪田一男
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Related Report
      2022 Annual Research Report
  • [Patent(Industrial Property Rights)] 視抑制用点眼剤2021

    • Inventor(s)
      ジョンホヌク、栗原俊英、坪田一男
    • Industrial Property Rights Holder
      ジョンホヌク、栗原俊英、坪田一男
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Acquisition Date
      2021
    • Related Report
      2021 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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