慢性腎臓病へ歯周病が与える影響についての疫学調査ならびにメカニズムの基礎的解析

• Project/Area Number: 20K18497
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: 三上 理沙子 東京医科歯科大学, 東京医科歯科大学病院, 助教 (30822548)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 歯周病 / 慢性腎臓病 / 人工透析 / 糖尿病

Outline of Research at the Start

慢性腎臓病は重症化すると人工透析を余儀なくされ、心血管疾患発症の大きなリスクとなる。近年、慢性腎臓病と歯周病との関連が指摘され、疾患進行の因果関係の予測が報告されているものの、メカニズムの解明はなされていない。
本研究ではまず透析療法を受けている慢性腎臓病患者における全身状態と歯周病の関連性について横断的に調査し、さらに糖尿病腎症モデルマウスを用いた動物実験を行い、関連のメカニズムを明らかにすることである。
本研究成果は、慢性腎臓病の末期腎不全への重症化予防の一助となる可能性があり、医歯学臨床応用への発展、医療費削減などの波及効果にもつながる。

Outline of Annual Research Achievements

慢性腎臓病は重症化すると人工透析を余儀なくされ、心血管疾患発症の大きなリスクとなる。国内患者数は現在1300万人を超え、増加の一途をたどっている。
近年、慢性腎臓病と歯周病との関連が指摘され、腎機能悪化に対して歯周病が影響を与える可能性が報告されているものの、メカニズムの解明はなされていな
い。また、日本人を対象とした研究例は少ない。
現在までに、末期腎不全により人工透析が必要となった患者において、唾液中の歯周病原細菌(Porphyromonas gingivalis）の菌数と、慢性炎症のマーカーであるTumor Necrosis Factor Receptor (TNFR) 1,2 に有意な相関があることや、人工透析患者のうち糖尿病罹患者では歯周病がより重度であり、喪失歯数が有意に多いことを示した。また、同じ集団におけるコホート研究より、口腔内の衛生状況が悪い人工透析患者は有意に生存率が低いことを明らかにした。さらに、透析患者では低栄養や慢性的な炎症状態が生命予後の大きなリスクになることが知られ、両者を呈する患者では動脈硬化性病変を高頻度に発症することから、この病態はMalnutrition-inflammation-atherosclerosis (MIA)症候群と呼ばれる。我々は、歯周病がMIA症候群のうち、特に低栄養と炎症亢進に関与し、MIA症候群の増悪に加担する可能性を示した。

Research Products

• [Journal Article] Association between occlusal supports and nutritional status in older adults: A systematic review (2024)
  • Author(s): Mikami Risako、Komagamine Yuriko、Aoyama Norio、Mizutani Koji、Sasaki Yoshiyuki、Iwata Takanori、Minakuchi Shunsuke、Kanazawa Manabu
  • Journal Title: Journal of Dental Sciences Volume: 19 Issue: 2 Pages: 813-827
  • DOI: 10.1016/j.jds.2023.09.014
  • Peer Reviewed
• [Journal Article] Genetic analysis of impaired healing responses after periodontal therapy in type 2 diabetes: Clinical and in?vivo studies (2024)
  • Author(s): Nakagawa Keita、Watanabe Kazuki、Mizutani Koji、Takeda Kohei、Takemura Shu、Sakaniwa Eri、Mikami Risako、Kido Daisuke、Saito Natsumi、Kominato Hiromi、Hattori Atsuhiko、Iwata Takanori
  • Journal Title: Journal of Periodontal Research Volume: - Issue: 4 Pages: 1-16
  • DOI: 10.1111/jre.13249
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Improvement of periodontal parameters following intensive diabetes care and supragingival dental prophylaxis in patients with type 2 diabetes: A prospective cohort study (2024)
  • Author(s): Mizutani Koji、Minami Isao、Mikami Risako、Kido Daisuke、Takeda Kohei、Nakagawa Keita、Takemura Shu、Saito Natsumi、Kominato Hiromi、Sakaniwa Eri、Konuma Kuniha、Izumi Yuichi、Ogawa Yoshihiro、Iwata Takanori
  • Journal Title: Journal of Clinical Periodontology Volume: 51 Issue: 6 Pages: 733-741
  • DOI: 10.1111/jcpe.13958
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Current status of Er:YAG laser in periodontal surgery (2024)
  • Author(s): Aoki A, Mizutani K, Taniguchi Y, Lin T, Ohsugi Y, Mikami R, Katagiri S, Meinzer W, Iwata T.
  • Journal Title: Japanese Dental Science Review Volume: 60 Pages: 1-14
  • DOI: 10.1016/j.jdsr.2023.11.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Assessment of bone defect morphology for the adjunctive use of bone grafting combined with enamel matrix derivative: A 3‐year cohort study (2023)
  • Author(s): Matsuura Takanori、Mikami Risako、Mizutani Koji、Shioyama Hidehiro、Aoyama Norio、Suda Tomonari、Kusunoki Yukako、Takeda Kohei、Izumi Yuichi、Aida Jun、Aoki Akira、Iwata Takanori
  • Journal Title: Journal of Periodontology Volume: - Issue: 9 Pages: 1-12
  • DOI: 10.1002/jper.23-0538
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Enhanced periodontal tissue healing via vascular endothelial growth factor expression following low‐level erbium‐doped: yttrium, aluminum, and garnet laser irradiation: In vitro and in vivo studies (2023)
  • Author(s): Takemura Shu、Mizutani Koji、Mikami Risako、Nakagawa Keita、Hakariya Masahiro、Sakaniwa Eri、Saito Natsumi、Kominato Hiromi、Kido Daisuke、Takeda Kohei、Aoki Akira、Iwata Takanori
  • Journal Title: Journal of Periodontology Volume: - Issue: 9 Pages: 1-14
  • DOI: 10.1002/jper.23-0458
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Influence of Reactive Oxygen Species on Wound Healing and Tissue Regeneration in Periodontal and Peri-Implant Tissues in Diabetic Patients (2023)
  • Author(s): Buranasin Prima、Kominato Hiromi、Mizutani Koji、Mikami Risako、Saito Natsumi、Takeda Kohei、Iwata Takanori
  • Journal Title: Antioxidants Volume: 12 Issue: 9 Pages: 1787-1787
  • DOI: 10.3390/antiox12091787
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Malnutrition- inflammation- atherosclerosis (MIA) syndrome associates with periodontitis in end-stage renal disease patients undergoing hemodialysis: a cross-sectional study (2023)
  • Author(s): Mikami Risako、Mizutani Koji、Gohda Tomohito、Matsuyama Yusuke、Gotoh Hiromichi、Nakagawa Keita、Takemura Shu、Aoyama Norio、Matsuura Takanori、Kido Daisuke、Takeda Kohei、Saito Natsumi、Izumi Yuichi、Iwata Takanori
  • Journal Title: Scientific Reports Volume: 13 Issue: 1 Pages: 11805-11805
  • DOI: 10.1038/s41598-023-38959-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Potential of a Saliva Test for Screening of Alveolar Bone Resorption (2023)
  • Author(s): Ikeda Yuichi、Chigasaki Otofumi、Mizutani Koji、Sasaki Yoshiyuki、Aoyama Norio、Mikami Risako、Gokyu Misa、Umeda Makoto、Izumi Yuichi、Aoki Akira、Takeuchi Yasuo
  • Journal Title: Healthcare Volume: 11 Issue: 13 Pages: 1822-1822
  • DOI: 10.3390/healthcare11131822
  • Peer Reviewed / Open Access
• [Journal Article] Er:YAG laser‐assisted comprehensive periodontal pocket therapy for residual periodontal pocket treatment: A randomized controlled clinical trial (2023)
  • Author(s): Aoki Akira、Mizutani Koji、Mikami Risako、Ohsugi Yujin、Kobayashi Hiroaki、Akizuki Tatsuya、Taniguchi Yoichi、Takeuchi Yasuo、Katagiri Sayaka、Sasaki Yoshiyuki、Komaki Motohiro、Meinzer Walter、Izumi Yuichi、Iwata Takanori
  • Journal Title: Journal of Periodontology Volume: 94 Issue: 10 Pages: 1187-1199
  • DOI: 10.1002/jper.22-0552
  • Peer Reviewed
• [Journal Article] Association between chronic kidney disease and periodontal disease (2022)
  • Author(s): Mikami Risako、Arakawa Shinichi
  • Journal Title: Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) Volume: 64 Issue: 4 Pages: 136-141
  • DOI: 10.2329/perio.64.136
  • ISSN: 0385-0110, 1880-408X
  • Year and Date: 2022-12-28
  • Peer Reviewed / Open Access
• [Journal Article] Morphological analysis of the impact of diabetes on gingival capillaries with non-invasive blood flow scope ? A preliminary study (2022)
  • Author(s): Takeda Kohei、Mizutani Koji、Mikami Risako、Fujino Aiko、Ito Yuri、Takeuchi Shunsuke、Saito Natsumi、Iwata Takanori
  • Journal Title: Journal of Dental Sciences Volume: 10 Issue: 3 Pages: 024-024
  • DOI: 10.1016/j.jds.2022.10.024
  • Peer Reviewed / Open Access
• [Journal Article] Income-related inequalities in the association of smoking with periodontitis: a cross-sectional analysis in Tokyo Metropolitan Districts (2022)
  • Author(s): Mikami Risako、Mizutani Koji、Aoyama Norio、Matsuura Takanori、Suda Tomonari、Takeda Kohei、Saito Natsumi、Arakawa Shinichi、Izumi Yuichi、Iwata Takanori、Aida Jun
  • Journal Title: Clinical Oral Investigations Volume: 27 Issue: 2 Pages: 519-528
  • DOI: 10.1007/s00784-022-04747-9
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic factors affecting periodontal regenerative therapy using recombinant human fibroblast growth factor-2: A 3-year cohort study (2022)
  • Author(s): Mikami Risako、Sudo Takeaki、Fukuba Shunsuke、Takeda Kohei、Matsuura Takanori、Kariya Tomoaki、Takeuchi Shunsuke、Ochiai Akane、Kawamoto Sakurako、Toyoshima Keita、Mizutani Koji、Arakawa Shinichi、Aoki Akira、Iwata Takanori
  • Journal Title: Regenerative Therapy Volume: 21 Pages: 271-276
  • DOI: 10.1016/j.reth.2022.07.006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association of type 2 diabetes with periodontitis and tooth loss in patients undergoing hemodialysis (2022)
  • Author(s): Mikami Risako、Mizutani Koji、Matsuyama Yusuke、Gohda Tomohito、Gotoh Hiromichi、Aoyama Norio、Matsuura Takanori、Kido Daisuke、Takeda Kohei、Saito Natsumi、Fujiwara Takeo、Izumi Yuichi、Iwata Takanori
  • Journal Title: PLOS ONE Volume: 17 Issue: 5 Pages: e0267494-e0267494
  • DOI: 10.1371/journal.pone.0267494
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impaired dental implant osseointegration in rat with streptozotocin‐induced diabetes (2022)
  • Author(s): Saito Natsumi、Mikami Risako、Mizutani Koji、Takeda Kohei、Kominato Hiromi、Kido Daisuke、Ikeda Yuichi、Buranasin Prima、Nakagawa Keita、Takemura Shu、Ueno Takeshi、Hosaka Keiichi、Hanawa Takao、Shinomura Tamayuki、Iwata Takanori
  • Journal Title: Journal of Periodontal Research Volume: 57 Issue: 2 Pages: 412-424
  • DOI: 10.1111/jre.12972
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Antioxidant effect of enamel matrix derivative for early phase of periodontal tissue regeneration in diabetes (2022)
  • Author(s): Takeda Kohei、Mizutani Koji、Matsuura Takanori、Kido Daisuke、Mikami Risako、Buranasin Prima、Saito Natsumi、Kominato Hiromi、Takemura Shu、Nakagawa Keita、Iwata Takanori
  • Journal Title: Journal of Periodontology Volume: － Issue: 8 Pages: 1206-1217
  • DOI: 10.1002/jper.21-0413
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Novel flapless esthetic procedure for the elimination of extended gingival metal tattoos adjacent to prosthetic teeth: Er:YAG laser micro-keyhole surgery (2022)
  • Author(s): Mizutani Koji、Mikami Risako、Tsukui Akira、Nagai Shigeyuki、Pavlic Verica、Komada Wataru、Iwata Takanori、Aoki Akira
  • Journal Title: Journal of Prosthodontic Research Volume: 66 Issue: 2 Pages: 346-352
  • DOI: 10.2186/jpr.JPR_D_21_00045
  • NAID: 130008089849
  • ISSN: 1883-1958, 1883-9207
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Periodontal Disease and Chronic Kidney Disease: the Impact of Oral Health on Inflammation and Nutrition in Patients Undergoing Hemodialysis (2022)
  • Author(s): Mizutani Koji、Mikami Risako、Saito Natsumi、Sakaniwa Eri、Iwata Takanori
  • Journal Title: Current Oral Health Reports Volume: 9 Issue: 3 Pages: 81-88
  • DOI: 10.1007/s40496-022-00313-0
  • Peer Reviewed / Open Access
• [Journal Article] Metformin accelerates wound healing by Akt phosphorylation of gingival fibroblasts in insulin-resistant prediabetes mice (2022)
  • Author(s): 54.Hiromi Kominato, Kohei Takeda, Koji Mizutani, Risako Mikami, Daisuke Kido, Prima Buranasin, Natsumi Saito , Shu Takemura , Keita Nakagawa , Toshiyuki Nagasawa , Takanori Iwata
  • Journal Title: J Periodontol Volume: 93 Issue: 2 Pages: 256-158
  • DOI: 10.1002/jper.21-0362
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Influence of aging on periodontal regenerative therapy using enamel matrix derivative: A 3‐year prospective cohort study (2021)
  • Author(s): Mikami Risako、Mizutani Koji、Shioyama Hidehiro、Matsuura Takanori、Aoyama Norio、Suda Tomonari、Kusunoki Yukako、Takeda Kohei、Izumi Yuichi、Aida Jun、Aoki Akira、Iwata Takanori
  • Journal Title: Journal of Clinical Periodontology Volume: 49 Issue: 2 Pages: 123-133
  • DOI: 10.1111/jcpe.13552
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Residual periodontal pocket treatment with Er:YAG laser-assisted comprehensive periodontal pocket therapy: a retrospective study (2021)
  • Author(s): Aoki Akira、Mizutani Koji、Mikami Risako、Taniguchi Yoichi、Ohsugi Yujin、Meinzer Walter、Izumi Yuichi、Iwata Takanori
  • Journal Title: Clinical Oral Investigations Volume: 26 Issue: 1 Pages: 761-771
  • DOI: 10.1007/s00784-021-04054-9
  • Peer Reviewed
• [Journal Article] Association between periodontal inflammation and serum lipid profile in a healthy population: A cross‐sectional study (2021)
  • Author(s): Mikami Risako、Mizutani Koji、Matsuyama Yusuke、Matsuura Takanori、Kido Daisuke、Takeda Kohei、Takemura Shu、Nakagawa Keita、Mukaiyama Yuto、Suda Tomonari、Yasuda Takako、Ohta Syujiro、Takaya Norihide、Fujiwara Takeo、Izumi Yuichi、Iwata Takanori
  • Journal Title: Journal of Periodontal Research Volume: 56 Issue: 6 Pages: 1037-1045
  • DOI: 10.1111/jre.12917
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effect of night dentures on tooth mobility in denture wearers with sleep bruxism: A pilot randomized controlled trial (2021)
  • Author(s): Uchida Hirofumi、Wada Junichiro、Watanabe Chie、Nagayama Tomiharu、Mizutani Koji、Mikami Risako、Inukai Shusuke、Wakabayashi Noriyuki
  • Journal Title: Journal of Prosthodontic Research Volume: 66 Issue: 4 Pages: 564-571
  • DOI: 10.2186/jpr.JPR_D_21_00230
  • NAID: 130008117147
  • ISSN: 1883-1958, 1883-9207
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Periodontal regenerative therapy in patients with type 2 diabetes using minimally invasive surgical technique with enamel matrix derivative under 3‐year observation: A prospective cohort study (2021)
  • Author(s): Mizutani Koji、Shioyama Hidehiro、Matsuura Takanori、Mikami Risako、Takeda Kohei、Izumi Yuichi、Aoki Akira、Iwata Takanori
  • Journal Title: Journal of Periodontology Volume: online ahead Issue: 9 Pages: 1262-1273
  • DOI: 10.1002/jper.20-0590
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of Antioxidant in Adjunct with Periodontal Therapy in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis (2021)
  • Author(s): Koji Mizutani, Prima Buranasin, Risako Mikami, Kohei Takeda, Daisuke Kido, Kazuki Watanabe, Shu Takemura, Keita Nakagawa, Hiromi Kominato, Natsumi Saito, Atsuhiko Hattori, Takanori Iwata.
  • Journal Title: Antioxidants Volume: 10 Issue: 8 Pages: 1304-1304
  • DOI: 10.3390/antiox10081304
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A novel minimally‐invasive approach for metal tattoo removal with Er:YAG laser laser (2021)
  • Author(s): Mikami Risako、Mizutani Koji、Nagai Shigeyuki、Pavlic Verica、Iwata Takanori、Aoki Akira
  • Journal Title: Journal of Esthetic and Restorative Dentistry Volume: - Issue: 4 Pages: 550-559
  • DOI: 10.1111/jerd.12721
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association of periodontal pocket area with type 2 diabetes and obesity: a cross-sectional study (2021)
  • Author(s): Takeda Kohei、Mizutani Koji、Minami Isao、Kido Daisuke、Mikami Risako、Konuma Kuniha、Saito Natsumi、Kominato Hiromi、Takemura Shu、Nakagawa Keita、Izumi Yuichi、Ogawa Yoshihiro、Iwata Takanori
  • Journal Title: BMJ Open Diabetes Research & Care Volume: 9 Issue: 1 Pages: e002139-e002139
  • DOI: 10.1136/bmjdrc-2021-002139
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between circulating tumor necrosis factor receptors and oral bacterium in patients receiving hemodialysis: a cross-sectional study (2021)
  • Author(s): Mikami R, Mizutani K, Gohda T, Gotoh H, Matsuyama Y, Aoyama N, Matsuura T, Kido D, Takeda K, Izumi Y, Fujiwara T, Iwata T
  • Journal Title: Clinical and Experimental Nephrology Volume: 25 Issue: 1 Pages: 58-65
  • DOI: 10.1007/s10157-020-01952-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Poor oral hygiene and dental caries predict high mortality rate in hemodialysis: a 3-year cohort study. (2020)
  • Author(s): Mizutani K, Mikami R, Gohda T, Gotoh H, Aoyama N, Matsuura T, Kido D, Takeda K, Izumi Y, Sasaki Y, Iwata T
  • Journal Title: Scientific reports Volume: 10 Issue: 1 Pages: 21872-21872
  • DOI: 10.1038/s41598-020-78724-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 人間ドック受診者に対する歯周病スクリーニング方法の検討 単一施設横断研究 (2020)
  • Author(s): 水谷 幸嗣, 三上 理沙子, 佐々木 好幸, 高谷 典秀, 太田 秀二郎, 松浦 孝典, 城戸 大輔, 武田 浩平, 向山 雄人, 須田 智也, 和泉 雄一, 岩田 隆紀
  • Journal Title: 日本歯科保存学雑誌 Volume: 63 Pages: 245-253
  • NAID: 130007871266
  • Peer Reviewed
• [Presentation] Er:YAGレーザー照射歯根面の性状解析および歯周組織付着の組織学的解析 (2023)
  • Author(s): 宮田 和樹，水谷 幸嗣，大杉 勇人，三上 理沙子，髙木 徹，小田 茂，岩田 隆紀，青木 章
  • Organizer: 第35回日本レーザー歯学会総会・学術大会
• [Presentation] 乳癌既往歴から歯肉癌が疑われた根尖付近まで至る重度歯肉退縮に対して根面被覆術と歯根端切除術を行った一症例 (2023)
  • Author(s): 三上 理沙子, 岩田 隆紀
  • Organizer: 第66回秋季日本歯周病学会学術大会
• [Presentation] 低出力Er:YAGレーザー照射の血管内皮細胞への影響. (2023)
  • Author(s): 竹村修、水谷幸嗣、三上理沙子、中川佳太、秤屋雅弘、坂庭愛理、齋藤夏実、城戸大輔、武田浩平、小湊広美、青木章、岩田隆紀
  • Organizer: 第66回春季日本歯周病学会学術大会
• [Presentation] 糖尿病モデルラットにおける実験的歯周炎の治癒期の網羅的遺伝子発現解析 (2023)
  • Author(s): 中川佳太、水谷幸嗣、渡辺数基、齋藤夏実、竹村修、坂庭愛理、三上理沙子、城戸大輔、武田浩平、小湊広美、服部淳彦、岩田隆紀
  • Organizer: 第66回春季日本歯周病学会学術大会
• [Presentation] ビーグル犬におけるEr:YAGレーザー照射歯根面に対する歯周組織付着の組織学的解析 (2023)
  • Author(s): 宮田 和樹，水谷 幸嗣，大杉 勇人，三上 理沙子，髙木 徹，川勝 紀子，白方 良典，土岡 弘明，小田 茂，木下 淳博，岩田 隆紀，青木 章
  • Organizer: 第66回春季日本歯周病学会学術大会
• [Presentation] Porphyromonas gingivalis 由来LPSによる高血糖状態でのメサンギウム細胞の線維化への影響. (2023)
  • Author(s): 坂庭愛理,三上理沙子,水谷幸嗣,齋藤夏実,小湊広美,竹村修,中川佳太,秤屋雅弘,城戸大輔,武田浩平,美馬晶,岩田隆紀
  • Organizer: 第66回春季日本歯周病学会学術大会
• [Presentation] 人工透析患者と健常者・慢性腎臓病患者を比較した抜歯後の局所・全身感染の発症. (2023)
  • Author(s): 石丸 美穂, 大野 幸子, 岩上 将夫, 宮本 佳尚, 三上 理沙子, 相田 潤.
  • Organizer: 第33回日本疫学会学術総会
• [Presentation] FGF-2製剤を用いた歯周組織再生療法の臨床的評価 ─3年後ろ向きコホート研究─ (2022)
  • Author(s): 刈屋 友彰，須藤 毅顕，三上 理沙子，武田 浩平，福場 駿介，竹内 俊介， 落合 茜，川本 櫻子，豊嶋 啓汰，水谷 幸嗣，青木 章，岩田 隆紀
  • Organizer: 第65回春季日本歯周病学会学術大会
• [Presentation] 水谷 幸嗣，塩山 秀裕，松浦 孝典，三上 理沙子，武田 浩平，和泉 雄一， 青木 章，岩田 隆紀 (2022)
  • Author(s): 2型糖尿病患者へ低侵襲手術にてエナメルマトリックスデリバティブを応用した歯周再生療法の3 年経過：前向きコホート研究
  • Organizer: 第65回春季日本歯周病学会学術大会
• [Presentation] 三上 理沙子，水谷 幸嗣，塩山 秀裕，松浦 孝典，青山 典生，須田 智也， 楠 侑香子，武田 浩平，和泉 雄一，相田 潤，青木 章，荒川 真一， 岩田 隆紀 (2022)
  • Author(s): 加齢がエナメルマトリックスタンパクを用いた歯周組織再生療法に与える影響 ─3年前向き研究─
  • Organizer: 第65回春季日本歯周病学会学術大会
• [Presentation] 術後成績と患者報告アウトカムによるEr:YAGレーザーを用いた低侵襲なメタルタトゥー除去術の評価 (2021)
  • Author(s): 三上理沙子, 水谷幸嗣, 永井茂之, 岩田隆紀, 青木 章.
  • Organizer: 第33回日本レーザー歯学会学術大会
• [Presentation] 歯周炎および口腔衛生が人工透析患者の生存率に与える影響―前向きコホート研究― (2021)
  • Author(s): 三上理沙子
  • Organizer: 第64回秋季日本歯周病学会
• [Presentation] 歯周治療におけるレーザーの疼痛制御効果―システマティックレビューおよびメタ分析― (2021)
  • Author(s): 三上理沙子、水谷幸嗣、佐々木好幸、岩田隆紀、青木章
  • Organizer: 第24回日本歯科医学会学術大会
• [Presentation] 城戸 大輔, 池田 裕一, 中川 佳太, 竹村 修, 上野 剛史, 保坂 啓一, 塙 隆夫, 篠村 多摩之, 岩田 隆紀. 糖尿病による歯科用インプラントのオッセオインテグレーションの低下 (2021)
  • Author(s): 齋藤 夏実, 三上 理沙子, 水谷 幸嗣, 武田 浩平, 小湊 広美, 城戸 大輔, 池田 裕一, 中川 佳太, 竹村 修, 上野 剛史, 保坂 啓一, 塙 隆夫, 篠村 多摩之, 岩田 隆紀.
  • Organizer: 第64回春季日本歯周病学会
• [Presentation] 高脂肪食誘発型糖尿病マウスにおける歯肉創傷治癒に対するメトホルミン投与の効果 (2021)
  • Author(s): 小湊 広美, 水谷 幸嗣, 武田 浩平, 城戸 大輔, 三上 理沙子, 齋藤 夏実, 竹村 修, 中川 佳太, 岩田 隆紀
  • Organizer: 2021年度春季（第154回）日本歯科保存学会学術大会
• [Presentation] 2型糖尿病が歯肉毛細血管に及ぼす影響 (2020)
  • Author(s): 藤野愛子，武田浩平，水谷幸嗣，三上理沙子，石角 篤，木平成子，竹内俊介，伊藤裕理，岩田隆紀
  • Organizer: 第63回秋季日本歯周病学会学術大会