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The effect of resveratrol in mice periodontitis model

Research Project

Project/Area Number 20K18500
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57030:Conservative dentistry-related
Research InstitutionOsaka University (2023)
Tokyo Medical and Dental University (2020-2022)

Principal Investigator

Ikeda Eri  大阪大学, 大学院歯学研究科, 助教 (40822565)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsレスベラトロール / 歯周炎 / 糖尿病 / 抗酸化物質 / 炎症
Outline of Research at the Start

「歯周炎」と「糖尿病」の両疾患を同時に制御する創薬プラットフォームの構築することを目的として研究を行う。歯周炎は、糖尿病の双方向の関連が指摘されている。その関連メカニズムとして、高血糖により生成されるAGEs、炎症メディエーターであるHMGb1とその受容体であるRAGEの関与が示唆されている。ポリフェノールの一種であるレスベラトロール は「歯周炎」と「糖尿病」どちらにも改善効果が報告されており、レスベラトロール にはHMGB1, AGES-RAGE系への抑制作用があることから、レスベラトロール が歯周炎と糖尿病の関連に新たな治療戦略を提唱するものになり得ると考えてその検証を行う。

Outline of Final Research Achievements

The antioxidant and anti-inflammatory effects of resveratrol have been reported previously. Particularly, monomeric trans-resveratrol has been demonstrated to produce positive effects in various pathological processes. We reported previously that resveratrol dimer-rich melinjo extract, among others, caused bone healing, decreased local oxidative damage, and activated antioxidants nuclear factor erythroid 2-related factor 2 (Nrf2) pathways in a mouse model of experimentally induced periodontitis (EP). EP was induced experimentally in mice by placement of a 9-0 silk ligature around the left second molar. Mice received 10 mg/kg of resveratrol dimer intraperitoneally on day 0 and 3 after induction of EP. We couldn't find any difference of helper T cell compositions in cervical lymph nods.

Academic Significance and Societal Importance of the Research Achievements

レスベラトロールは抗酸化物質であり、抗炎症作用も有するポリフェノールである。レスベラトロールが歯周炎モデルマウスにおいて口腔免疫に与える影響を検討することで、レスベラトロールが炎症を緩和するメカニズム解明の一端になったと考えている。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (4 results)

All 2024 2022 2021

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (1 results)

  • [Journal Article] Gut microbiota-mediated alleviation of dextran sulfate sodium-induced colitis in mice.2024

    • Author(s)
      Ikeda Eri、Yamaguchi Masaya、Kawabata Shigetada
    • Journal Title

      Gastro Hep Advances

      Volume: 3(4) Issue: 4 Pages: 461-470

    • DOI

      10.1016/j.gastha.2024.01.016

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Healing effects of monomer and dimer resveratrol in a mouse periodontitis model2022

    • Author(s)
      Eri Ikeda , Daiki Tanaka , Michael Glogauer , Howard C Tenenbaum , Yuichi Ikeda
    • Journal Title

      BMC oral health

      Volume: 22 Issue: 1 Pages: 460-460

    • DOI

      10.1186/s12903-022-02499-2

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Overexpression of PD‐L1 in gingival basal keratinocytes reduces periodontal inflammation in a ligature‐induced periodontitis model2021

    • Author(s)
      Wongtim Keeratika、Ikeda Eri、Ohno Tatsukuni、Nagai Shigenori、Okuhara Shigeru、Kure Keitetsu、Azuma Miyuki
    • Journal Title

      Journal of Periodontology

      Volume: 93 Issue: 1 Pages: 146-155

    • DOI

      10.1002/jper.21-0017

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 重度歯周炎患者歯周プラーク構成異常細菌の同定と培養頻出菌投与によるマウス腸炎への影響(Frequently detectable severe human periodontitis bacteria cause gut immunity in a mouse model).2022

    • Author(s)
      池田 恵莉, 永井 重徳, 石原 和幸, 池田 裕一, 東 みゆき.
    • Organizer
      第64回歯科基礎医学会学術大会
    • Related Report
      2022 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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