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Development of a novel direct dental pulp-capping material using 4-META/MMA-TBB resin with nano hydroxyapatite

Research Project

Project/Area Number 20K18538
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57030:Conservative dentistry-related
Research InstitutionKyushu University

Principal Investigator

Yoshida Shinichiro  九州大学, 大学病院, 助教 (30778866)

Project Period (FY) 2020-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords4-META/MMA-TBB resin / Nano hydroxyapatite / dental pulp stem cells / reparative dentin / direct pulp capping / 4-META/MMA-TBBレジン / nano hydroxyapatite / 歯髄幹細胞 / 修復象牙質 / 直接覆髄 / ナノハイドロキシアパタイト / naHAp
Outline of Research at the Start

本研究では、4-META/MMA-TBBレジンとnaHApの特性を生かして、広範囲の露髄面に象牙芽細胞分化を生物学的に促し、緻密な修復象牙質形成を促進することができる新規直接覆髄材の開発を企図している。本研究から得られる結果は、これまでにない理想的な治癒を導く直接覆髄材創生の基盤となるものであり、将来的に歯髄を健康的に保ち歯牙の長期維持を可能とする新規直接覆髄材の開発へと繋がるものであると考えている。

Outline of Final Research Achievements

This study was to evaluate the dentin-adhesive 4-META/MMA-TBB resin including osteo-conductive nano hydroxyapatite as a novel direct pulp capping material. The 30% naHAp/SB showed a good sealing ability and biocompatibility as SB does, and also induced odontoblastic differentiation of human dental pulp stem cells through a CaSR-MEK/ERK pathway. In addition, 30% naHAp/SB sealed the pulp exposure site by inducing reparative dentin with dentin tubules in a rat artificail pulp exposure model. These results indicate that 30% naHAp/SB can be used as a novel direct pulp capping material.

Academic Significance and Societal Importance of the Research Achievements

これまでに歯質接着性を有した直接覆髄材は存在せず、辺縁漏洩による術後感染のリスクが存在する。本研究で開発した新規直接覆髄材は歯質接着性を有しており、辺縁漏洩のリスクを抑え長期的な予後を見込むことができる。また、材料の諸性質の解析に加えて、修復象牙質形成の主役となる歯髄幹細胞の象牙芽細胞様分化に及ぼす影響ならびにその細胞内シグナル経路の解明を行った。さらに、動物実験モデルでは良好な修復象牙質形成効果を認めており、今後臨床応用へと繋げていくことができると考えている。

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • Research Products

    (3 results)

All 2021

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Development of a novel direct dental pulp-capping material using 4-META/MMA-TBB resin with nano hydroxyapatite2021

    • Author(s)
      Yoshida S, Sugii H, Itoyama T, Kadowaki M, Hasegawa D, Tomokiyo A, Hamano S, Ipposhi K, Yamashita K, Maeda H.
    • Journal Title

      Materials Science & Engineering C: Materials for Biological Applications.

      Volume: 130 Pages: 112426-112426

    • DOI

      10.1016/j.msec.2021.112426

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Presentation] 4-META/MMA-TBB resin including Nano-hydroxyapatite as a direct pulp capping material.2021

    • Author(s)
      Shinichiro Yoshida, Hideki Sugii, Masataka Kadowaki, Tomohiro Itoyama, Daigaku Hasegawa, Atsushi Tomokiyo, Sayuri Hamano, Keita Ipposhi, Kozue Yamashita, Hidefumi Maeda.
    • Organizer
      The 99th General Session & Exhibition of the IADR.
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nano Hydroxyapatite 含有 4-META/MMA-TBB レジンは、Calcium-sensing receptor-MEK/ERK 経路を介してヒト歯髄幹細胞の象牙芽細胞様分化を促進する.2021

    • Author(s)
      吉田晋一郎、杉井英樹、糸山知宏、門脇正敬、一法師啓太、山下梢、友清淳、濱野さゆり、長谷 川大学、前田英史.
    • Organizer
      第 154 回日本歯科保存学会春季学術大会.
    • Related Report
      2021 Annual Research Report

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Published: 2020-04-28   Modified: 2023-01-30  

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