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A 9-year longitudinal study of the effect of oral function on the development of sarcopenia and frailty

Research Project

Project/Area Number 20K18598
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57050:Prosthodontics-related
Research InstitutionOsaka University

Principal Investigator

Murakami Hitomi  大阪大学, 歯学研究科, 招へい教員 (10845879)

Project Period (FY) 2020-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2020: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsサルコペニア・フレイル / 口腔機能 / 高齢者 / サルコペニア
Outline of Research at the Start

本研究は,大阪大学大学院歯学,医学系,人間科学研究科,東京都健康長寿医療センター研究所,慶応大学医学部,東京大学大学院医学系研究科の各研究者が,それぞれの立場から多角的に検討し,包括的に健康長寿の要因を探索する学際的な老年学研究の一部である.このような集学的な研究は,これまで類をみない独創的・先駆的なものである.また各専門家がレベルの高い検査を行うため,より目的に沿った,正確なデータとその結果が得られると考えられる.
これまで我々が蓄積してきた口腔機能検査法のノウハウを最大限利用し,口腔機能の客観的評価を行う.また,身体機能計測を行い,サルコペニア,フレイル発症の評価を行う.

Outline of Final Research Achievements

Prevention of sarcopenia and frailty as well as dementia is important for the prevention of long-term care in a super-aging society. In this study, we investigated the relationship between oral functions (oral wetness, occlusal force, tongue-lip motor function, tongue pressure, masticatory performance, and swallowing function) and the development of sarcopenia and frailty in elderly subjects aged 77 to 81 years. The results showed that tongue pressure and bite strength were significantly associated with muscle strength (grip strength). Swallowing function and tongue-lip motor function were significantly associated with physical performance (walking speed). The results suggest that these oral function indices may be useful as indicators of physical frailty.

Academic Significance and Societal Importance of the Research Achievements

要介護状態や寝たきりの原因とされているサルコペニア・フレイルの発症と口腔機能低下症との関連を明らかとし、介護予防につなげることが必要である。本研究の結果から、舌圧、咬合力、嚥下機能、舌口唇運動機能といった口腔機能指標は、高齢者の身体的フレイルのスクリーニングに有用である可能性が示された。さらに検討を進めることで、サルコペニア・フレイルを発症する基準値等の算出やサルコペニア・フレイルを予防するための口腔機能低下の診断基準を示し、口腔機能の維持・改善から介護予防につなげることで、医療費や社会費用の削減をもたらす可能性がある。

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • Research Products

    (6 results)

All 2021 2020

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Influence of mandibular distal extension implant-supported removable partial dentures on the force exerted on maxillary anterior teeth2021

    • Author(s)
      Arita Shuhei、Gonda Tomoya、Togawa Hitomi、Maeda Yoshinobu、Ikebe Kazunori
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 65 Issue: 4 Pages: 541-545

    • DOI

      10.2186/jpr.JPR_D_20_00077

    • NAID

      130008104545

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2021 Annual Research Report
  • [Journal Article] Oral Functions Are Associated with Muscle Strength and Physical Performance in Old-Old Japanese2021

    • Author(s)
      Murotani Yuki、Hatta Kodai、Takahashi Toshihito、Gondo Yasuyuki、Kamide Kei、Kabayama Mai、Masui Yukie、Ishizaki Tatsuro、Matsuda Ken-ichi、Mihara Yusuke、Fukutake Motoyoshi、Nishimura Yuichi、Akema Suzuna、Hagino Hiromasa、Higashi Kotaro、Togawa Hitomi、Maeda Yoshinobu、Ogata Soshiro、Moynihan Paula、Ikebe Kazunori
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 18 Issue: 24 Pages: 13199-13199

    • DOI

      10.3390/ijerph182413199

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of mandibular free-end partial edentulism on the force exerted on maxillary anterior teeth2020

    • Author(s)
      Arita Shuhei、Gonda Tomoya、Togawa Hitomi、Maeda Yoshinobu、Ikebe Kazunori
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 64 Issue: 4 Pages: 454-459

    • DOI

      10.1016/j.jpor.2019.12.004

    • NAID

      130007886258

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] Influence of wearing unilateral and bilateral distal extension removable partial denture on occlusal force to anterior teeth2021

    • Author(s)
      Gonda T, Togawa H, Ikebe K
    • Organizer
      19th Biennial Meeting of the International College of Prosthodontists
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 地域在住高齢者における口腔機能と身体的フレイルとの関連2021

    • Author(s)
      八田昂大、室谷有紀、高橋利士、福武元良、三原佑介、松田謙一、戸川瞳、萩野弘将、明間すずな、前田芳信、池邉一典
    • Organizer
      日本サルコペニアフレイル学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 臼歯部遊離端欠損ならびに義歯装着が支台歯に加わる咬合力に及ぼす影響2021

    • Author(s)
      狩野剛志,権田知也,戸川瞳,濱田匠,豊田理紗,小野高裕,池邉一典
    • Organizer
      令和3年度日本補綴歯科学会関西支部総会ならびに学術大会
    • Related Report
      2021 Annual Research Report

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Published: 2020-04-28   Modified: 2023-01-30  

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