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Risk genes involved in the development of temporomandibular joint osteoarthritis

Research Project

Project/Area Number 20K18600
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57050:Prosthodontics-related
Research InstitutionOsaka University

Principal Investigator

Takaoka Ryota  大阪大学, 大学院歯学研究科, 助教 (20733968)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords変形性顎関節症 / 遺伝的素因 / 遺伝 / 一塩基多型 / 顎関節症 / 遺伝子多型 / リスク遺伝子
Outline of Research at the Start

変形性顎関節症(TMJOA)は,顎の関節の変形により痛みや運動障害が生じる疾患である.TMJOAの発症の原因は十分に明らかにされておらず,発症を予知することができないのが現状である.一方で,全身のその他の関節における変形性関節症においては遺伝的要因の関与が報告されている.TMJOAの発症においても遺伝的要素が関与している可能性はあるが,今まで関連する遺伝子についての報告はない.
そこで本研究では,TMJOAに関与する遺伝子を探索し発症のメカニズムを明らかにするとともに,これらの遺伝的因子を指標とした治療前のリスク予知法および予防法の確立を目指す.

Outline of Final Research Achievements

Genetic polymorphisms involved in the development of osteoarthritis (OA) in the knee and hip joints have been reported. There were no studies investigating OA in the polymorphisms In the temporomandibular joint. The present multivariate analysis clarified the association between the single nucleotide polymorphism (rs8044769) and TMJOA even after adjusting for the effects of age, gender, and disc dynamics abnormalities, which have been reported to have a strong association with TMJOA. It was suggested that the FTO gene may promote the development of TMJOA with the onset of disc disc displacement as a trigger. This study is the first study to suggest an association between TMJOA and specific single nucleotide polymorphisms.

Academic Significance and Societal Importance of the Research Achievements

治療効果を左右し,変形性顎関節症の将来につながるリスク遺伝子の同定は,患者の遺伝的素因に合った最適の治療法を選択し,提供するための術前診断技術に繋がるものと期待される.さらに,変形性顎関節症の進行を加速させるをリスク遺伝子が明らかにされると,進行を予防するための治療薬が開発・立案されるための一助となる.今後,本研究の研究結果をもとに遺伝学的なアプローチによる研究が発展し,変形性顎関節症の術前のリスク診断を可能にするだけでなく,テーラーメイド治療の実現も可能になるのではないかと期待している.

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (11 results)

All 2023 2022 2021 2020

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results)

  • [Journal Article] Clinical identification of the stimulus intensity to measure temporal summation of second pain2022

    • Author(s)
      Moriguchi D, Ishigaki S, Lin X, Kuyama K, Koishi Y, Takaoka R, Svensson P, Yatani H
    • Journal Title

      Scientific Reports

      Volume: 12(1) Issue: 1 Pages: 12915-12915

    • DOI

      10.1038/s41598-022-17171-6

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cross-sectional and longitudinal assessment of subchondral cysts in temporomandibular joints: Clinical and MRI study with a mean follow-up of 66 months2022

    • Author(s)
      Takaoka Ryota、Koishi Yukiko、Kuyama Kotaro、Ueda You、Ishigaki Shoichi、Uchiyama Yuka、Shimamoto Hiroaki、Nakatani Atsutoshi、Yatani Hirofumi
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 67 Issue: 3 Pages: 392-399

    • DOI

      10.2186/jpr.JPR_D_22_00089

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of an FTO gene polymorphism in the temporomandibular joint osteoarthritis2021

    • Author(s)
      Takaoka Ryota、Kuyama Kotaro、Yatani Hirofumi、Ishigaki Shoichi、Kayashima Hiroki、Koishi Yukiko、Kato Takafumi、Egusa Hiroshi、Uchiyama Yuka、Nakatani Atsutoshi、Shimamoto Hiroaki
    • Journal Title

      Clinical Oral Investigations

      Volume: 26 Issue: 3 Pages: 2965-2973

    • DOI

      10.1007/s00784-021-04278-9

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 顎関節症患者の臨床症状に対する咀嚼筋痛、顎関節円板動態異常、変形性顎関節症の相対的影響度2021

    • Author(s)
      高岡 亮太, 石垣 尚一, 久山 晃太郎, 森口 大輔, 内山 百夏, 中谷 温紀, 島本 博彰, 矢谷 博文
    • Journal Title

      日本顎関節学会雑誌

      Volume: 33 Pages: 37-44

    • NAID

      130008161776

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] Relative risk of positional and dynamic temporomandibular disc abnormality for osteoarthritis -magnetic resonance imaging study2023

    • Author(s)
      高岡亮太
    • Organizer
      大阪大学歯学会第134回例会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 口腔内スキャナーを用いた下顎頭吸収に伴う顎位の経時的変化の評価2022

    • Author(s)
      森岡詞音,高岡亮太,森口大輔,久山晃太郎,林暁雨,植田陽,山本梨絵,奥田眞夫,石垣尚一.
    • Organizer
      日本補綴歯科学会第131回学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 縦断的調査による関節円板側方転位の病態解明2022

    • Author(s)
      植田陽,高岡亮太,森口大輔,久山晃太郎,林暁雨, 森岡詩音,山本梨絵,玉利秀樹,桑原俊也,島本博彰, 内山百夏,中谷温紀,石垣尚一.
    • Organizer
      第35回日本顎関節学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] IS AN FTO GENE POLYMORPHISM INVOLVED WITH THE TEMPOROMANDIBULAR JOINT OSTEOARTHRITIS THROUGH OBESITY EXISTS?2021

    • Author(s)
      Takaoka R, Kuyama K, Ishigaki S, Egusa H, Morioka S, Ueda Y, Yamamoto R, Lyn X, Yatani H
    • Organizer
      International College of Prosthodontists
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] FTO 遺伝子の一塩基多型(rs8044769)の変形性顎関節症への関与2021

    • Author(s)
      髙岡 亮太,久山晃太郎,小石由紀子,森口 大輔,石垣 尚一, 矢谷 博文,桑原 俊也,玉利 秀樹,内山 百夏,中谷 温紀,島本 博彰,植田 陽,森岡 詩音,山本 梨絵,林 暁雨.
    • Organizer
      日本顎関節学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 顎関節症のテーラーメイド医療に向けたMRIの応用-変形性顎関節症の遺伝的リスク因子の探索-2020

    • Author(s)
      高岡亮太
    • Organizer
      第33回日本顎関節学会学術大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 変形性顎関節症の発症に関与する遺伝子の探索2020

    • Author(s)
      久山晃太郎,高岡亮太,小石由紀子,林暁雨,森口大輔,石垣尚一,矢谷博文.
    • Organizer
      日本補綴歯科学会第129回学術大会
    • Related Report
      2020 Research-status Report
    • Invited

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Published: 2020-04-28   Modified: 2024-01-30  

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