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The study on the oral sensations of patients with cleft lip and palate

Research Project

Project/Area Number 20K18656
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57060:Surgical dentistry-related
Research InstitutionTohoku University

Principal Investigator

Shimada Eriya  東北大学, 歯学研究科, 助教 (00822115)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords口唇口蓋裂 / 脳磁図計 / 口腔感覚 / 脳磁図形 / 口腔感覚特性 / 電気刺激 / 体性感覚 / 口唇裂・口蓋裂
Outline of Research at the Start

口唇裂・口蓋裂は、胎生期に組織欠損や癒合不全により上唇や口蓋に裂を生じる先天疾患である。口腔外科医、形成外科医、矯正歯科医らの連携により、形態的に大きく改善するが、口腔機能と深く関連する口腔感覚がどの程度回復しているかについては未だ不明な点が多い。
本研究では口唇口蓋裂患者の口腔感覚を、脳磁図計(Magnetoencephalography : MEG)にて測定することで、定量的かつ客観的に評価することにより口唇口蓋裂患者の口腔感覚の特性を解明し、口腔感覚と言語機能との相関性について明らかにすることを目的とする。本研究成果により、口唇口蓋裂患者に対する新たな手術法や言語訓練法の開発が期待できる。

Outline of Final Research Achievements

It is still not clear to what extent oral sensation is recovered in the patients with cleft lip and palate who have undergone cheiloplasty and palatoplasty. The purpose of this study was to quantitatively and objectively evaluate the oral sensory characteristics of the patients with cleft lip and palate by measuring somatosensory evoked magnetic fields (SEFs) using a magnetoencephalography. The results showed that the latency of SEFs during electrical stimulation of the upper lip and palate was significantly prolonged in the pathents with cleft lip and palate group compared to the healthy subject group. It was suggested that cheiloplasty or palatoplasty might have affected the sensory conduction pathways in the patients with cleft lip and palate.

Academic Significance and Societal Importance of the Research Achievements

口腔感覚は咀嚼や言語などの口腔機能と相関があるとされ、口腔感覚の改善が口腔機能の改善に繋がると考えられる。本研究では、脳磁図形を用いて口唇口蓋裂患者の口腔感覚伝達メカニズムの一端を明らかにした。この成果により、口唇口蓋裂患者の口腔形態のみならず、口腔感覚も考慮した新たな治療法の開発に繋がる可能性がある。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (7 results)

All 2022 2021 2020

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Somatosensory evoked magnetic fields induced by electrical palate stimulation in patients with unilateral cleft lip and palate after palatoplasty2022

    • Author(s)
      Shimada Eriya、Hihara Hiroki、Kitayama Chihiro、Kanno Akitake、Kawashima Ryuta、Sato Akimitsu、Imai Yoshimichi、Nakasato Nobukazu、Igarashi Kaoru、Kanetaka Hiroyasu
    • Journal Title

      Neuroscience Research

      Volume: 184 Pages: 30-37

    • DOI

      10.1016/j.neures.2022.08.002

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnetoencephalographic evaluation of repaired lip sensation in patients with cleft lip2022

    • Author(s)
      Kitayama Chihiro、Shimada Eriya、Hihara Hiroki、Kanno Akitake、Nakasato Nobukazu、Imai Yoshimichi、Sato Akimitsu、Kawashima Ryuta、Igarashi Kaoru、Kanetaka Hiroyasu
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 9 Pages: e0274405-e0274405

    • DOI

      10.1371/journal.pone.0274405

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Brain Functional Evaluation of Periodontal Sensation of Patients with Cleft Palate after Palatoplasty2022

    • Author(s)
      Shimada Eriya、Hihara Hiroki、Kitayama Chihiro、Sato Akimitsu、Imai Yoshimichi、Igarashi Kaoru、Kanetaka Hiroyasu
    • Organizer
      Cleft 2022 (14th International Cleft Congress)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Somatosensory evoked magnetic fields of lip sensation of patients with cleft lip after cheiloplasty2022

    • Author(s)
      Kitayama Chihiro、Shimada Eriya、Hihara Hiroki、Imai Yoshimichi、Sato Akimitsu、Igarashi Kaoru、Kanetaka Hiroyasu
    • Organizer
      Cleft 2022 (14th International Cleft Congress)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 口蓋形成術後の片側性唇顎口蓋裂患者の口蓋電気刺激による体性感覚誘導磁界反応2021

    • Author(s)
      島田 栄理遣, 日原 大貴, 北山 ちひろ, 菅野 彰剛, 中里 信和, 五十嵐 薫, 金高 弘恭
    • Organizer
      第80回日本矯正歯科学会学術大会&第5回国際会議
    • Related Report
      2021 Research-status Report
  • [Presentation] 体性感覚誘発磁界を用いた口唇形成術後の口唇感覚の客観的評価2020

    • Author(s)
      北山 ちひろ , 菅野 彰剛 , 日原 大貴 , 島田 栄理遣 , 金高 弘恭 , 中里 信和 , 五十嵐 薫
    • Organizer
      第44回 日本口蓋裂学会総会・学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Objective evaluation of sensation of cleft lip patients after cheiloplasty with somatosensory evoked magnetic fields2020

    • Author(s)
      Chihiro Kitayama , Akitake Kanno , Hiroki Hihara , Eriya Shimada , Hiroyasu Kanetaka , Nobukazu Nakasato , Kaoru Igarashi
    • Organizer
      第9回国際矯正歯科会議世界大会
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research

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Published: 2020-04-28   Modified: 2024-01-30  

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