| Project/Area Number |
20K18728
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Sjogren's syndrome / Salivary glands / Chronic inflammation / Cell therapy / Xerostomia / Inflammatory cytokines / Chemokines / Lymphocyte infiltration / Sjogren’s syndrome / Autoimmune disease / Salivary gland atrophy / Regenerative medicine |
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| Outline of Research at the Start |
Sjogren’s syndrome (SS) leads to salivary gland (SG) atrophy. There is no cure for SS, however, our approach using enhanced peripheral blood mononuclear cells (EMNC), improves radiation-injured SGs in mice. We aim to study if E-MNC transplantation can reduce SG inflammation in a mouse model of SS.
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| Outline of Final Research Achievements |
Sjogren’s syndrome (SS) affects the salivary glands leading to dry mouth and a reduced quality of life in many patients, therefore, many novel cell-based therapies to prevent or repair salivary gland function loss are being studied. The salivary glands of SS patients present chronic inflammation due to over production of inflammatory molecules. Many animal models are used to perform research on SS, including the MRL/lpr mouse and the non-obese diabetic (NOD) mouse. We have developed a therapy that consists of using anti-inflammatory cells called m2 macrophage-like cells. We aimed to study if M2 macrophage-like cell transplantation could reduce the inflammation in salivary glands in Sjogren’s syndrome mouse models. Our results showed that m2 macrophage-like cell transplantation in these mice reduced inflammatory gene expression.
This suggests that m2 macrophage-like cells are an effective therapy for alterations in salivary glands caused by immune disorders such as Sjogren's syndrome.
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| Academic Significance and Societal Importance of the Research Achievements |
これらの結果は、m2マクロファージが唾液腺の炎症を抑制するのに効果的であり、唾液腺組織の破壊を減らし、萎縮と口渇を防ぐことができることを示唆しています。 口渇は、嚥下困難、虫歯、口腔粘膜の炎症など、多くの口腔合併症を引き起こします。したがって、この治療法は、シェーグレン症候群の患者の生活の質を大幅に改善することができます。 将来的には、この治療法は唾液腺の変化以外の他の炎症性疾患にも適用される可能性があります。
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