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Mutual control mechanism of masticatory function development and maxillofacial morphological growth

Research Project

Project/Area Number 20K18764
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57070:Developmental dentistry-related
Research InstitutionNagasaki University

Principal Investigator

Yoshimi Tomoko  長崎大学, 病院(歯学系), 医員 (20805973)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsマウス / 口腔機能低下 / ボツリヌストキシン / 成長発達期 / 歯科矯正学 / 顎運動
Outline of Research at the Start

軟食化ならびに社会の高齢化が急速に進むなか、「噛めない」「うまく飲み込めない」児童や、摂食機能障害を持つ高齢者が急増している。発達期に適切な機能の獲得が行われなかった場合、老年期まで摂食・嚥下機能に障害を残すことが考えられる。本研究は、顎口腔機能低下マウスおよび不正咬合マウスを用いて、成長発達期における咀嚼・嚥下機能と顎顔面形態パターンの相互制御機構を解明することを目的とする。本研究により、子どもたちの顎口腔機能の正常な発達を支援し、「口腔の健康から全身の健康」を体現化する『口腔成育』という新たな医療概念を社会に浸透させるための科学的エビデンスを提示する。

Outline of Final Research Achievements

The purpose of this study is to elucidate the mutual control mechanism of masticatory functions and maxillofacial morphological patterns during growth and development using mice with hypofunction and malocclusion.
In the mice induced masticatory hypofunction using BoNT/A, significant differences were observed in mandibular morphology such as the condyle. In the malocclusion model mice, a decrease in bone density of the condyle and mandibular angle and alveolar bone density was observed. In addition, the effect on jaw movement trajectory was observed, suggesting that malocclusion and masticatory dysfunction during the growth and development period affect not only normal morphological development but also the development of masticatory function later on.

Academic Significance and Societal Importance of the Research Achievements

現代において、摂食機能に障害を有する児童が増加傾向にあるとの報告があり、発育期における咀嚼・嚥下機能の発達や障害発症のメカニズムについての研究が注目されている。本研究では、発育期での顎口腔機能低下モデルや不正咬合モデルの顎顔面形態および機能において変化が認められた。本研究結果は子どもたちの顎口腔機能の正常な発達と咬合の成育のために、成長期における機能障害、不正咬合の早期治療や機能回復の検討に貢献するものである。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (1 results)

All 2021

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Visualization of mandibular movement relative to the maxilla during mastication in mice: integration of kinematic analysis and reconstruction of a three-dimensional model of the maxillofacial structure2021

    • Author(s)
      Yasuda Go、Moriuchi Emi、Hamanaka Ryo、Fujishita Ayumi、Yoshimi Tomoko、Yamamoto Kana、Hayashida Kaori、Koga Yoshiyuki、Yoshida Noriaki
    • Journal Title

      BMC Oral Health

      Volume: 21 Issue: 1

    • DOI

      10.1186/s12903-021-01879-4

    • NAID

      120007180587

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access

URL: 

Published: 2020-04-28   Modified: 2025-01-30  

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