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Effect of tryptophan for sleep bruxism

Research Project

Project/Area Number 20K18805
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57080:Social dentistry-related
Research InstitutionOkayama University

Principal Investigator

Toyama Naoki  岡山大学, 医歯薬学域, 助教 (50803152)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords睡眠時ブラキシズム / 栄養素 / 栄養 / トリプトファン
Outline of Research at the Start

口腔内に破壊的な影響をもたらす睡眠時ブラキシズムは脳内セロトニンの不足と関連することが分かってきた。セロトニンはトリプトファンを材料に生合成されるが、トリプトファンは体内で生成できないため、食事を通じて摂取しなくてはならない。そこで応募者らは、トリプトファンの摂取は睡眠時ブラキシズムを改善させる可能性があると考えた。本研究は、横断研究で睡眠時ブラキシズムとトリプトファン摂取量との関連を調査し、次に睡眠時ブラキシズムを有する者を対象としたランダム化比較試験を実施し、トリプトファン摂取の介入効果を検討することを目的とした。本研究の結果は睡眠時ブラキシズムの新たな治療法を提供できる可能性がある。

Outline of Final Research Achievements

The purpose of the present research was to identify nutrients related to sleep bruxism and to establish a hypothesis regarding the relationship between sleep bruxism and nutrients.
We recruited 143 Japanese university students in 2021 and assigned them to sleep bruxism (n = 58) and non-sleep bruxism groups (n = 85. To investigate nutrient intakes, participants answered a food frequency questionnaire based on food groups. We assessed differences in nutrient intakes between the sleep bruxism and non-sleep bruxism groups. As a result, We showed that sleep bruxism tended to be associated with dietary fiber. In addition, a subgroup analysis showed that students with sleep bruxism had a significantly lower dietary fiber intake (10.4 ± 4.6 g) than those without sleep bruxism (13.4 ± 6.1 g; p = 0.022).
The present research showed that dietary fiber intake may be related to sleep bruxism. Therefore, we hypothesized that dietary fiber would improve sleep bruxism in young adults.

Academic Significance and Societal Importance of the Research Achievements

睡眠時ブラキシズムは多因子性であり,睡眠時ブラキシズムとの関連因子が多数報告されているが,栄養素と睡眠時ブラキシズムとの関連性を明らかにした研究は本研究が世界で初めてである.
本研究は睡眠時ブラキシズムと栄養との関連に関する今後の介入研究の方向性を決める研究であり,栄養学的に口腔保健を改善できることを示唆する学術的意義は大きい.今後は,食物繊維が睡眠時ブラキシズムに与える影響を明らかにすることが期待される.

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (3 results)

All 2023 Other

All Presentation (2 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Presentation] 睡眠時ブラキシズムと関連する栄養素の探索的研究2023

    • Author(s)
      外山直樹、江國大輔、福原大樹、澤田ななみ、森田学
    • Organizer
      口腔衛生学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Dietary fiber related to sleep bruxism: a exploratory study2023

    • Author(s)
      Naoki Toyama, Daisuke Ekuni, Daiki Fukuhara, Nanami Sawada, Manabu Morita
    • Organizer
      AAPD 15th International Conference 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 睡眠中の歯ぎしりは食物繊維摂取量と関連している可能性を世界で初めて発見

    • URL

      https://www.okayama-u.ac.jp/tp/release/release_id1093.html

    • Related Report
      2023 Annual Research Report

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Published: 2020-04-28   Modified: 2025-01-30  

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