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Developement of the novel rehabilitation and evaluation method in patients with disorder of consciousness

Research Project

Project/Area Number 20K19404
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionNational Rehabilitation Center for Persons with Disabilities

Principal Investigator

Yusaku Takamura  国立障害者リハビリテーションセンター(研究所), 研究所 運動機能系障害研究部, 研究員 (20846175)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2023: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2022: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords遷延性意識障害 / HMD-Eyetracking / EEG脳波 / Eye-tracking / 脳波 / 意識障害
Outline of Research at the Start

遷延性意識障害(PVS)は、交通事故後頭部外傷後などに視覚・聴覚・触覚や侵襲刺激に対
して持続的かつ再現可能性のある意図的/自発的な行動応答が3か月以上の間、持続的にも見られない状態として定義される。PVSと何らかの意思表示や刺激への応答が確認できる最小意識状態(MCS)の判断や、改善の予測は難しいことが知られる。
本研究では、PVS症例の潜在的残存機能の適切な把握のための評価手法として、視線計測システムの開発と活用を試みる。また、開発したシステムの現場実装とあわせて、脳波やMRIによる残存する神経ネットワーク同定を行い、PVS症例への有効なリハビリテーション手法の開発を目指す。

Outline of Final Research Achievements

Persistent disorder of consciousness (PDoC) is defined as the absence of reproducible responses to visual, auditory, tactile, and nociceptive stimuli following brain injury. A certain number of patients with DoC recover to the minimally conscious state (MCS), which is defined as the state of being able to respond to stimuli in a reproducible manner. However, it is difficult to unambiguously assess whether patients are in MCS or PVS and to predict recovery. Our research aimed to develop a more valid assessment using a head-mounted display with eye-tracking and electroencephalogram (EEG). Through diachronic analysis, we observed that EEG changes are related to the exploratory area of the eye movement. These results have the potential to improve the accuracy of the assessment and quality of medicine in the future.

Academic Significance and Societal Importance of the Research Achievements

遷延性意識障害、これはいわゆる植物状態ともいえる症状です。意識状態が残っているか否か、また回復するか否かを把握することは困難を極めます。そこで本研究では、視線計測と脳波という客観的指標によって、こうした状態を捉える可能性について模索しました。本研究を通じて将来的には、現在よりも詳細な理解が可能となり、精密なリハビリテーション医療の確立が可能となると考えています。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (4 results)

All 2023 2021

All Presentation (4 results) (of which Int'l Joint Research: 3 results)

  • [Presentation] Neurophysiological mechanisms of recovery after bilateral motor cortex transcranial direct current stimulation in a patient with persistence minimally conscious state: a case report.2023

    • Author(s)
      Takamura Y, Abe H, Seki S, Muraishi K, Kawashima N
    • Organizer
      American Congrenss of Rehabilitation Medicine meeting at Rehabweek 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel Evaluation Tool for Arousal, Awareness and Spatial Attention in Patients with Neuropsychological Disorders using Head Mounted Display with Eye Tracking.2023

    • Author(s)
      Takamura Y, Ohashi Y, Ohmatsu S, Kawashima N:
    • Organizer
      The International Neuropsychological Society Meeting
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel Evaluation Tool for Visuospatial Neglect by using eye tracker-implemented head mount display.2023

    • Author(s)
      Ohashi Y, Takamura Y, Yamamoto S, Noritaka K
    • Organizer
      8th Scientific meeting on the federation of the europian societies of neuropsychology.
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 磁気刺激位置と運動誘発電位の対応づけによる大脳皮質運動野の機能局在マッピング-刺激位置ナビゲーションによる高精度・短時間計測システムの構築-2021

    • Author(s)
      高村優作
    • Organizer
      第51回日本神経生理学会学術集会
    • Related Report
      2021 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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