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The elucidation the mechanism through which exercise improves adipose tissue metabolism

Research Project

Project/Area Number 20K19532
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionDepartment of Clinical Research, National Hospital Organization Kyoto Medical Center

Principal Investigator

Nirengi Shinsuke  独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究員 (70741156)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords褐色脂肪組織 / 運動 / オキシリピン / 寒冷曝露 / リピドミクス / 皮下脂肪組織 / Ca2+ / GPCR / カルシウム代謝 / UCP1
Outline of Research at the Start

これまで、運動が褐色脂肪組織(BAT)の熱産生機能を改善するかについては、脱共役タンパク質(UCP1)が中心に検討されきているが、一定の見解を得ていない。
そこで、本研究では、運動による影響について、UCP1非依存性の熱産生機構およびに着目して、BATのみならず、近年注目されはじめている皮下脂肪(ベージュ脂肪組織)を対象に研究を行う。また同組織からの内分泌因子についての検討も行う。本研究では、齧歯類を対象にメカニズムの研究、さらにはヒトを対象に臨床的な観点で研究を行う。

Outline of Final Research Achievements

We performed a lipidomics test and measured brown adipose tissue activity in college athletic non-athletic students. Interestingly, college athletes with high brown adipose tissue activity had elevated blood oxylipin levels after cold exposure. Next, we performed lipidomics and gene expression analysis of brown adipose tissue in mice after exercise and cold exposure. The results were presented at three international conferences.

Other things, A review paper on brown adipose tissue was accepted by Experimental Gerontology (published)

Academic Significance and Societal Importance of the Research Achievements

運動をすることによる褐色脂肪組織への変化について検討を行った。
運動による健康増進効果への知見を深めることができた。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (20 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (1 results) Journal Article (10 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 10 results,  Open Access: 10 results) Presentation (9 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Int'l Joint Research] オハイオ州立大学(米国)

    • Related Report
      2021 Research-status Report
  • [Journal Article] Brown adipose tissue and aging: potential benefits of exercise2023

    • Author(s)
      Nirengi S, Stanford KI.
    • Journal Title

      Experimental Gerontology

      Volume: 発行中

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of serum fibroblast growth factor 21 with diabetic complications and insulin dose in patients with type 1 diabetes mellitus2022

    • Author(s)
      Taniguchi H, Nirengi S, Ishihara K, Sakane N.
    • Journal Title

      PLoS One

      Volume: 17 Issue: 2 Pages: e0263774-e0263774

    • DOI

      10.1371/journal.pone.0263774

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of Prolonged Sitting with or without Elastic Garments on Limb Volume, Arterial Blood Flow, and Muscle Oxygenation2021

    • Author(s)
      KUROSAWA YUKO、NIRENGI SHINSUKE、TABATA IZUMI、ISAKA TADAO、CLARK JOSEPH F.、HAMAOKA TAKAFUMI
    • Journal Title

      Medicine and Science in Sports and Exercise

      Volume: 54 Issue: 3 Pages: 399-407

    • DOI

      10.1249/mss.0000000000002822

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Hepcidin-25/Ferritin Ratio Is Increased in University Rugby Players with Lower Fat Mass2021

    • Author(s)
      Nirengi Shinsuke、Fujibayashi Mami、Furuno Sachiko、Sukino Shin、Suganuma Akiko、Kawaguchi Yaeko、Kawase Yasuharu、Kotani Kazuhiko、Sakane Naoki
    • Journal Title

      Nutrients

      Volume: 13 Issue: 9 Pages: 2993-2993

    • DOI

      10.3390/nu13092993

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diurnal variations of brown fat thermogenesis and fat oxidation in humans2021

    • Author(s)
      Matsushita Mami、Nirengi Shinsuke、Hibi Masanobu、Wakabayashi Hitoshi、Lee Sang-il、Domichi Masayuki、Sakane Naoki、Saito Masayuki
    • Journal Title

      International Journal of Obesity

      Volume: 45 Issue: 11 Pages: 2499-2505

    • DOI

      10.1038/s41366-021-00927-x

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparisons Between Serum Levels of Hepcidin and Leptin in Male College-Level Endurance Runners and Sprinters2021

    • Author(s)
      Nirengi Shinsuke、Taniguchi Hirokazu、Ishibashi Aya、Fujibayashi Mami、Akiyama Nao、Kotani Kazuhiko、Ishihara Kengo、Sakane Naoki
    • Journal Title

      Frontiers in Nutrition

      Volume: 8 Pages: 1-6

    • DOI

      10.3389/fnut.2021.657789

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lower bone mineral density and higher bone resorption marker levels in premenopausal women with type 1 diabetes in Japan2021

    • Author(s)
      Yoshioka F, Nirengi S, Murata T, Kawaguchi Y, Watanabe T, Saeki K, Yoshioka M, Sakane N.
    • Journal Title

      J Diabetes Investig

      Volume: 12 Issue: 9 Pages: 1689-1696

    • DOI

      10.1111/jdi.13530

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Near-Infrared Time-Resolved Spectroscopy for Assessing Brown Adipose Tissue Density in Humans: A Review2020

    • Author(s)
      Hamaoka Takafumi、Nirengi Shinsuke、Fuse Sayuri、Amagasa Shiho、Kime Ryotaro、Kuroiwa Miyuki、Endo Tasuki、Sakane Naoki、Matsushita Mami、Saito Masayuki、Yoneshiro Takeshi、Kurosawa Yuko
    • Journal Title

      Frontiers in Endocrinology

      Volume: 11 Pages: 261-261

    • DOI

      10.3389/fendo.2020.00261

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of beta-conglycinin intake on circulating FGF21 levels and brown adipose tissue activity in Japanese young men: a single intake study and a randomized controlled trial2020

    • Author(s)
      Hirokazu Taniguchi, Keigo Shimizu, Sayori Wada, Shinsuke Nirengi, Haruki Kataoka, Akane Higashi.
    • Journal Title

      J Physiol Anthropol .

      Volume: 39 Issue: 1 Pages: 17-17

    • DOI

      10.1186/s40101-020-00226-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Disruption of energy utilization in diabetic cardiomyopathy; a mini review2020

    • Author(s)
      Shinsuke Nirengi, Carmem Peres Valgas da Silva, Kristin I Stanford
    • Journal Title

      Curr Opin Pharmacol .

      Volume: 54 Pages: 82-90

    • DOI

      10.1016/j.coph.2020.08.015

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 女子学生アスリートにおけるリン摂取量と貧血関連因子との関連2023

    • Author(s)
      織田奈央子, 藤林真美, 二連木晋輔, 坂根直樹
    • Organizer
      第77回日本栄養・食糧学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 女子大学生における隠れ貧血と食事との関係 ―アスリートとの比較より―2023

    • Author(s)
      品川真実, 坂根貞樹, 山方諒平, 二連木晋輔, 坂根直樹, 藤林真美
    • Organizer
      第77回 日本栄養・食糧学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 12,13-diHOME negates age-induced decline cardiac function2023

    • Author(s)
      Shinsuke Nirengi
    • Organizer
      Aging Interest Conference
    • Related Report
      2022 Annual Research Report
  • [Presentation] Prior exercise training increases oxylipins secretion from brown adipose tissue response to cold exposure2022

    • Author(s)
      Shinsuke Nirengi, Hirokazu Taniguchi, Kengo Ishihara, Diego Hernandez-Saavedra, Pablo Vidal, Lisa, Baer, Masayuki Domichi, Valerie Bussberg, Michael Kiebish, Hitoshi Wakabayashi, Mami Matsushita, Masayuki Saito, Naoki Sakane, Kristin Stanford
    • Organizer
      CPHBAT
    • Related Report
      2022 Annual Research Report
  • [Presentation] 燃える脂肪組織 - 褐色脂肪組織 - を活性化して体脂肪を減らすには?2021

    • Author(s)
      二連木晋輔
    • Organizer
      摂大農学セミナー
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Exercise improves BAT-released signaling lipids capacity in response to cold exposure2021

    • Author(s)
      Shinsuke Nirengi, Hirokazu Taniguchi, Kengo Ishihara, Hernandez-Saavedra, Masayuki Domichi, Kazuhiko Kotani, Valerie Bussberg, Michael Kiebish, Hitoshi Wakabayashi, Mami Matsushita, Masayuki Saito, Naoki Sakane, Kristin Stanford
    • Organizer
      Metabolism Month 2021
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Adrenic acid - A link between Type 2 Diabetes, Heart Disease and Liver metabolism?2021

    • Author(s)
      Carmem Peres Valgas da Silva, Lisa A. Baer, Diego Hernandez-Saavedra, Shinsuke Nirengi, Paul Coen, Kristin I. Stanford
    • Organizer
      Metabolism Month 2021
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 大学陸上競技選手における寒冷曝露中の呼気アセトン濃度の変化2020

    • Author(s)
      二連木晋輔, 谷口祐一, 同道正行, 鋤納心, 竹下尚男, 石原健吾, 坂根直樹
    • Organizer
      第75回 日本体力医学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 大学ラグビー選手におけるオメガ3系脂肪酸摂取量と血中濃度との関連2020

    • Author(s)
      藤林真美, 二連木晋輔, 瀬川智広, 古野幸子, 河瀬泰治, 坂根直樹
    • Organizer
      第75回 日本体力医学会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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