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Investigation of motor engram with TMS and 7T-MRI

Research Project

Project/Area Number 20K19629
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59030:Physical education, and physical and health education-related
Research InstitutionWaseda University (2021-2023)
National Institute for Physiological Sciences (2020)

Principal Investigator

Hamano Yuki  早稲田大学, 理工学術院, 次席研究員 (00823254)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords運動記憶 / 系列運動学習 / 両手 / 機能的MRI / 超高磁場MRI / 系列運動 / 運動学習 / 両手協調動作 / 記憶痕跡 / 経頭蓋磁気刺激 / 超高磁場機能的MRI / 経頭蓋直流電気刺激 / fMRI
Outline of Research at the Start

運動技能の獲得における練習の重要性は一般に認識されている。繰り返し練習をすることで記憶痕跡が形成され、パフォーマンス向上をもたらす。しかし、ヒトの運動技能の獲得に伴う運動技能の記憶痕跡の神経機構は十分に理解されていない。
本研究の目的は、1)系列情報の運動記憶痕跡が左半球頭頂間溝の因果的役割、2)体側の一次運動野が系列運動記憶において必須の役割を果たしているかを立証することである。これまで左半球頭頂間溝にて系列内容を含む運動記憶痕跡の保持を報告しているが、本研究課題の完遂により、左半球頭頂間溝が系列情報記憶を形成し、一次運動野が運動情報の統合的役割を担っていること立証する。

Outline of Final Research Achievements

The purpose of this study was to investigate in which part of the brain the sequential motor learning forms its motor engram. Due to COVID-19 pandemic, under the circumstance of being restricted to perform the experiment, we modified the experiment plan to investigate the motor engram of bimanual sequential motor learning. To achieve a bimanual sequential motor learning, it was necessary to have separate sequential motor learnings with non-sequential component to independently control of bimanual hands, and a sequential component to achieve a motor sequential learning with actual sequences. By using a 7T-fMRI, we found that the motor engrams, which are formed through these two learning components within the bimanual sequential motor learning, are represented in the primary cortex controlling the dominant hand.

Academic Significance and Societal Importance of the Research Achievements

タイピングやピアノ演奏など日常には両手を用いた系列動作が数多く存在する。しかし、系列運動の神経機構を扱うほとんどの研究は、片手動作しか扱ってこなかった。日常で多くみられる両手を用いた系列動作についての記憶が、脳内でどのように形成されるかを明らかにしたという点で、本研究は社会的な意義を持つ。さらに本研究は、両手を用いた学習にも関わらず、その記憶痕跡が利き手を支配する脳領域に形成されることを発見した。この新たな発見は、脳がどのように系列運動を実現するかという神経機構の解明に対し重要な示唆を与えるという点で学術的意義を持つ。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (6 results)

All 2023 2022 2021

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (2 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] The dorsal premotor cortex encodes the step-by-step planning processes for goal-directed motor behavior in humans2022

    • Author(s)
      Yoshihisa Nakayama, Sho K. Sugawara, Masaki Fukunaga, Yuki H. Hamano, Norihiro Sadato, Yukio Nishimura
    • Journal Title

      NeuroImage

      Volume: 256 Pages: 119221-119221

    • DOI

      10.1016/j.neuroimage.2022.119221

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The integrative role of the M1 in motor sequence learning2021

    • Author(s)
      Hamano Yuki H.、Sugawara Sho K.、Fukunaga Masaki、Sadato Norihiro
    • Journal Title

      Neuroscience Letters

      Volume: 760 Pages: 136081-136081

    • DOI

      10.1016/j.neulet.2021.136081

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cognitive control affects motor learning through local variations in GABA within the primary motor cortex2021

    • Author(s)
      Maruyama Shuki、Fukunaga Masaki、Sugawara Sho K.、Hamano Yuki H.、Yamamoto Tetsuya、Sadato Norihiro
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 18566-18566

    • DOI

      10.1038/s41598-021-97974-1

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced structural connectivity within the motor loop in professional boxers prior to a match2021

    • Author(s)
      Yuichi Ogino, Hiroaki Kawamichi, Daisuke Takizawa, Sho K. Sugawara, Yuki H. Hamano, Masaki Fukunaga, Keiko Toyoda, Yusuke Watanabe, Osamu Abe, Norihiro Sadato, Shigeru Saito & Shigeru Furui
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 9015-9015

    • DOI

      10.1038/s41598-021-88368-4

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 学ぶとはどういうことか2023

    • Author(s)
      濱野友希
    • Organizer
      学び講座2023
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] The left primary motor cortex is a critical hub in bimanual sequential learning2022

    • Author(s)
      Yuki H. Hamano, Sho K. Sugawara, Masaki Fukunaga, Norihiro Sadato
    • Organizer
      The 51st annual meeting of the Society for Neuroscience
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research

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Published: 2020-04-28   Modified: 2025-01-30  

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