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The effects of nutritional/life-environmental factors during pregnancy on the maternal and fetal epigenome and their relationship to pregnancy progress and prognosis

Research Project

Project/Area Number 20K19635
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionUniversity of Yamanashi (2022-2023)
Tokyo Medical and Dental University (2020-2021)

Principal Investigator

Imai Chihiro  山梨大学, 大学院総合研究部, 准教授 (50778842)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords食事の質 / 妊娠期栄養 / DNAメチル化 / DOHaD / 母子コホート / 妊娠期環境要因 / エピゲノム / 複合的環境要因 / 妊娠転帰
Outline of Research at the Start

妊娠中の母体の栄養・生活環境は、妊娠期特有の身体的・生理的変化や心理的要因と相互に影響し合い、短期間で劇的に変化するとともに、母児のエピゲノムにも変化を与えると考えられる。そのため、母児の予後を規定し得る妊娠期の環境要因は、単一的な決定因子としてではなく、複合的に捉える必要がある。そこで本研究では、同一母児の妊娠中および産後の統合的情報を収集し、母児エピゲノムを潜在的指標として、妊娠期の動的な環境要因とエピゲノム状態、および母児の予後との関連を明らかにし、予防医療の観点から、次世代のための妊娠中の適切な栄養環境や修正可能な生活習慣へのアプローチ方法について検討する。

Outline of Final Research Achievements

To clarify the effects of nutritional/life-environmental factors during pregnancy on the maternal and fetal epigenome, pregnancy progress and prognosis, we conducted a follow-up study of the mother and child between early pregnancy and two years after childbirth. In this study, DNA methylation levels of the SKI gene in newborn umbilical cord blood were weakly associated with protein-energy intake ratio of pregnant women. Furthermore, we examined the relationship between NRF9.3 or Japanese Food Guide Spinning Top Score, which are assessing the diet quality and weight gain during pregnancy. The results showed that there are concerns that nutritional advice that focuses on weight only may actually lead to poor diet quality, so that the importance of assessing individual diet quality using appropriate metrics to prevent the deterioration of diet quality.

Academic Significance and Societal Importance of the Research Achievements

妊娠期(胎児期)の環境は、妊娠中から出産後にかけての短期的な母児の健康はもとより、母児の長期的な予後にまで影響を及ぼす。妊娠によって引き起こされる母体の身体的変化や心理的負荷が食事などの基本的な生活環境にも影響することを考慮すると、同一母児の環境要因を網羅的に収集し、エピゲノムや妊娠経過などとどのように関連するかを調べることは、予防医療・先制医療の観点から重要である。その点において本研究は、修正可能な栄養・環境要因について明らかにすることで、次世代のための適切な妊娠環境あるいは栄養環境についてさまざまな示唆を得ることができた。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (8 results)

All 2023 2022 2021 2020

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Diet Quality and Its Relationship with Weight Characteristics in Pregnant Japanese Women: A Single-Center Birth Cohort Study2023

    • Author(s)
      Imai Chihiro、Takimoto Hidemi、Kurotani Kayo、Fudono Ayako、Tarui Iori、Aoyama Tomoko、Yago Satoshi、Okamitsu Motoko、Miyasaka Naoyuki、Sato Noriko
    • Journal Title

      Nutrients

      Volume: 15 Issue: 8 Pages: 1827-1840

    • DOI

      10.3390/nu15081827

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Application of the Nutrient-Rich Food Index 9.3 and the Dietary Inflammatory Index for Assessing Maternal Dietary Quality in Japan: A Single-Center Birth Cohort Study2021

    • Author(s)
      Imai Chihiro、Takimoto Hidemi、Fudono Ayako、Tarui Iori、Aoyama Tomoko、Yago Satoshi、Okamitsu Motoko、Sasaki Satoshi、Mizutani Shuki、Miyasaka Naoyuki、Sato Noriko
    • Journal Title

      Nutrients

      Volume: 13 Issue: 8 Pages: 2854-2854

    • DOI

      10.3390/nu13082854

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trimester-specific associations between extracellular vesicle microRNAs and fetal growth2021

    • Author(s)
      Fudono Ayako、Imai Chihiro、Takimoto Hidemi、Tarui Iori、Aoyama Tomoko、Yago Satoshi、Okamitsu Motoko、Muramatsu Masaaki、Sato Noriko、Miyasaka Naoyuki
    • Journal Title

      The Journal of Maternal-Fetal & Neonatal Medicine

      Volume: - Issue: 25 Pages: 1-7

    • DOI

      10.1080/14767058.2021.2000598

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] 妊娠期の食事の質の評価と妊娠準備世代における食教育の意義2022

    • Author(s)
      今井千裕
    • Organizer
      第44回日本臨床栄養学会総会・第43回日本臨床栄養協会総会・第20回大連合大会
    • Related Report
      2022 Research-status Report
  • [Presentation] A prudent Japanese dietary pattern is associated with a reduced risk of metabolic diseases predicted by principal component analysis of the clinical parameters related to metabolic syndrome2022

    • Author(s)
      Toshinao Goda, Yuko Takeda, Saki Takeuchi, Chihiro Imai
    • Organizer
      22nd IUNS International Congress of Nutrition
    • Related Report
      2022 Research-status Report
  • [Presentation] Perinatal maternal mental health, sleep quality, and infant development: A Japanese prospective cohort study2021

    • Author(s)
      Satoshi Yago, Motoko Okamitsu, Noriko Sato, Hidemi Takimoto, Chihiro Imai, Ayako Fudono, Hiroshi Yomogida, Tomoko Aoyama, Naoyuki Miyasaka
    • Organizer
      17th WAIMH WORLD CONGRESS
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 33.Nutrient-Rich Food IndexおよびDietary Inflammatory Indexを用いた妊婦の食事の質の解析2021

    • Author(s)
      今井千裕, 藤原綾, 瀧本秀美, 不殿絢子, 樽井依織, 青山友子, 矢郷哲志, 岡光基子, 宮坂尚幸, 佐藤憲子
    • Organizer
      第75回日本栄養・食糧学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 妊婦のたんぱく質エネルギー比率と新生児DNAメチル化-疾患関連メチル化部位の解析2020

    • Author(s)
      今井千裕、飛知和尚美、中田ありさ、瀧本秀美、岡光基子、樽井依織、青山友子、矢郷哲志、不殿絢子、宮坂尚幸、佐藤憲子
    • Organizer
      第74回日本栄養・食糧学会大会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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