Novel anti-muscle atrophy signaling via the stress response molecule HO-1
| Project/Area Number |
20K19639
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | The University of Tokushima |
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Principal Investigator |
UCHIDA Takayuki 徳島大学, 大学院医歯薬学研究部(医学域), 講師 (00803561)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 筋萎縮 / 鉄代謝 / ミトコンドリア / HO-1 / 筋肉 / 酸化ストレス |
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| Outline of Research at the Start |
骨格筋量は加齢や運動負荷の減少(寝たきりなどのunloading環境)によって低下することが知られている。これら筋萎縮の誘導因子についてはミトコンドリアの機能低下や酸化ストレスの産生亢進、鉄代謝異常など様々な報告が為されている。しかし、未だ筋萎縮発生メカニズムの全容は不明な点が多く、筋萎縮に対する根本的な治療法は存在しない。そこで本研究では、抗酸化因子として知られるHO-1に着目して、これらの代謝異常が引き起こされるメカニズムを解明し、HO-1を介した筋萎縮治療法について検証する。
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| Outline of Final Research Achievements |
To maintain skeletal muscle mass, the relationship between iron metabolism and mitochondrial metabolism is crucial. Previous studies have demonstrated that iron deficiency leads to mitochondrial dysfunction and abnormalities in muscle cells. In this study, we investigated how fluctuations in iron levels affect muscle cell metabolism. The results revealed that treatment with the iron chelator DFO resulted in a decrease in mitochondrial proteins and an imbalance in protein synthesis in muscle cells, leading to reduced muscle function. Furthermore, in a muscle atrophy model, it was observed that changes in iron levels affected the expression of muscle atrophy-related genes. These findings suggest that the interplay between iron metabolism and mitochondrial metabolism in muscle cells may contribute to the development of muscle atrophy.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究を通して、鉄・エネルギー代謝異常から筋萎縮へと繋がる新規経路が明らかになり、大きな学術的意義を持つ。さらに、萎縮環境における鉄付加で筋萎縮抑制傾向がみられたことは、寝たきり状態や消耗性疾患等による筋萎縮を予防するために、食事やサプリメントとしての鉄付加が有効である可能性を示唆しており、社会的意義も大きい。
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Daily Dietary Supplementation with Steamed Soybean Improves Muscle Volume and Strength in Healthy People Lacking Exercise2022
Author(s)
Madoka Kohno, Anayt Ulla, Rina Taniguchi, Akane Ohishi, Kako Hirayama, Yuma, Takemura, Shoichiro Takao, Yuki Kanazawa, Yuki Matsumoto, Masafumi Harada, Tomoya Fukawa, Hiro-Omi Kanayama, Takayuki Uchida, Toshio Suzuki, Takeshi Nikawa.
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Journal Title
Journal of Nutritional Science and Vitaminology
Volume: 68
Issue: 6
Pages: 521-526
DOI
ISSN
0301-4800, 1881-7742
Year and Date
2022-12-31
Related Report
Peer Reviewed / Open Access
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[Journal Article] Morin improves dexamethasone-induced muscle atrophy by modulating atrophy-related genes and oxidative stress in female mice2022
Author(s)
Anayt Ulla, Kanae Osaki, Md Mizanur Rahman, Reiko Nakao, Takayuki Uchida, Isafumi Maru, Kazuaki Mawatari, Tomoya Fukawa, Hiro-Omi Kanayama, Iori Sakakibara, Katsuya Hirasaka, Takeshi Nikawa
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 86
Issue: 10
Pages: 1448-1458
DOI
Related Report
Peer Reviewed
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[Journal Article] Astaxanthin Prevents Atrophy in Slow Fiber Muscles by Inhibiting Mitochondrial Reactive Oxygen Species Via a Mitochondria-Mediated Apoptosis Pathwa2021
Author(s)
Luchuanyang Sun, Nobuyuki Miyaji, Min Yang, Edward M Mills, Shigeto Taniyama, Takayuki Uchida, Takeshi Nikawa, Jifeng Li, Jie Shi, Katsuyasu Tachibana, Katsuya Hirasaka
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Journal Title
Nutrients
Volume: 13
Issue: 2
Pages: 379-379
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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