Project/Area Number |
20K19700
|
Research Category |
Grant-in-Aid for Early-Career Scientists
|
Allocation Type | Multi-year Fund |
Review Section |
Basic Section 59040:Nutrition science and health science-related
|
Research Institution | National Institute of Advanced Industrial Science and Technology |
Principal Investigator |
Saiki Papawee 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 (10803934)
|
Project Period (FY) |
2020-04-01 – 2024-03-31
|
Project Status |
Granted (Fiscal Year 2022)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | stress / microflora / stress hormone / cytokines / hormone |
Outline of Research at the Start |
我々のグループでは慢性的にストレス負荷できるモデルマウス系を開発、詳細にストレスの影響を解析することに成功した。一方、微生物叢・脳腸相関が免疫系を通じてストレスが緩和されることが明らかになりつつある。そこで本研究では、ストレス評価モデルマウスを用いて微生物叢・脳腸相関と免疫系の連携を詳細に検討、新しいストレス対処法を見出すことを目的とする。さらに、我々が開発した免疫に関わる抗炎症作用評価のためのハイスループットクリーニング系を基本に、微生物叢・脳腸相関に連関するストレス緩和に関わる薬剤・化合物のアッセイ系を新規に開発し、そのスクリーニングを行うことを目標とする
|
Outline of Annual Research Achievements |
I took maternity leave during 2022/4~2023/3. Therefore, I do not have any new results.
|
Current Status of Research Progress |
Current Status of Research Progress
4: Progress in research has been delayed.
Reason
I took maternity leave for 1 year
|
Strategy for Future Research Activity |
I have to move to management section during 2023/5~2024/4. During this period, I could not do experiment. After that, I will treat good bacteria from microflora analysis and some herb from established cell-based assay into stress mice. I will also develop new cell-based bioassay. However, this year I will have a presentation of previous results.
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