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Comprehensive analysis of organic contaminants in the aquatic environment of Asian developing countries by using liquid chromatography-high resolution mass spectrometry

Research Project

Project/Area Number 20K19983
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 64010:Environmental load and risk assessment-related
Research InstitutionEhime University

Principal Investigator

Tanoue Rumi  愛媛大学, 沿岸環境科学研究センター, 助教 (60767226)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords水圏環境 / 化学汚染 / 生活関連化学物質 / 生態影響評価 / 南・東南アジア諸国 / 抗生物質 / 網羅分析 / 生活関連物質 / LC-MS/MS / LC-QToF-MS/MS / 表層水 / 魚類 / ターゲット分析 / サスペクトスクリーニング分析 / 水生生物 / 環境汚染物質 / 化学物質 / サスペクトスクリーニング / ノンターゲット分析 / 生物濃縮係数 / 途上国 / 数理モデル
Outline of Research at the Start

水質汚染が進行しているアジア途上国に注目し、水圏環境に残留する化学物質の網羅解析を試みる。優先的に調査すべき化学物質を特定し、それらの時空間分布と生態リスクの広がりを数理モデルにより可視化する。曝露影響が危惧される環境汚染物質が明らかになることに加え、監視が必要な地域および時期によってリスクが上昇する地点の情報提供も可能となり、効果的かつ効率的な化学物質管理対策の実現が期待できる。

Outline of Final Research Achievements

We conducted an analysis of 'down-the-drain' chemicals - including pharmaceuticals, personal care products, bisphenols, and artificial sweeteners - in surface water samples from rivers and canals across India, Vietnam, and Thailand, aiming to assess their potential ecological risks. Our approach involved a screening analysis of approximately 2,000 compounds, which we achieved using the MS/MS spectral database. To evaluate ecological risks, we compared the concentrations of these chemicals in surface water to the ecotoxicity values reported in earlier studies. Concentrations of parabens, saccharin, and acesulfame, which are removed by sewage treatment plants by more than 95%, in surface water of rivers were notably high, suggesting direct discharges of untreated domestic and human wastewater. Concentrations of bisphenol A and bisphenol S in surface water of India and Vietnam were in the range of concentrations that may cause adverse effects on wild fish.

Academic Significance and Societal Importance of the Research Achievements

南・東南アジア諸国では、都市人口増加率に対して下水処理システムの整備が遅れているため、未処理あるいは浄化処理の不十分な工場廃水・生活雑排水・し尿排水が都市河川へ流出することによる水質汚染が深刻である。しかし、化学汚染に関する情報は不足している。本研究では、生活雑排水・し尿排水・工場廃水に由来する人工化学物質を網羅的に測定することにより、優先的に調査すべき物質の特定および、それらの汚染レベルや生態リスクの広がり(時空間分布)の可視化に取り組んだ。監視すべき化学物質に加えて、時期によってリスクが上昇する水域などの情報を提供できたことから、効率的な化学物質管理対策に資する成果であると考えている。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (30 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (13 results) Journal Article (7 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 7 results,  Open Access: 1 results) Presentation (6 results) Remarks (4 results)

  • [Int'l Joint Research] Bharathidasan University/KLE Society's S. Nijalingappa College(インド)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] National Research and Innovation Agency(インドネシア)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Vietnam National University(ベトナム)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Burapha University(タイ)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Burapha University(タイ)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] Annamalai University(インド)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] VNU University of Science(ベトナム)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] BPPT(インドネシア)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] Bharathidasan University(インド)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] Burapha University(タイ)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Bharathidasan University(ベトナム)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] VNU University of Science, Hanoi(ベトナム)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] BPPT(インドネシア)

    • Related Report
      2020 Research-status Report
  • [Journal Article] Pharmaceuticals and personal care products (PPCPs) in surface water and fish from three Asian countries: Species-specific bioaccumulation and potential ecological risks2023

    • Author(s)
      Nozaki Kazusa、Tanoue Rumi、Kunisue Tatsuya、Tue Nguyen Minh、Fujii Sadahiko、Sudo Nao、Isobe Tomohiko、Nakayama Kei、Sudaryanto Agus、Subramanian Annamalai、Bulbule Keshav A.、Parthasarathy Peethambaram、Tuyen Le Huu、Viet Pham Hung、Kondo Masakazu、Tanabe Shinsuke、Nomiyama Kei
    • Journal Title

      Science of The Total Environment

      Volume: 866 Pages: 161258-161258

    • DOI

      10.1016/j.scitotenv.2022.161258

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Determination of six thyroid hormones in dog brain and liver using acidic extraction, mixed-mode cleanup, and liquid chromatography?tandem mass spectrometry2022

    • Author(s)
      Takaguchi Kohki、Ono Sumika、Tanoue Rumi、Kunisue Tatsuya、Tanabe Shinsuke、Nomiyama Kei
    • Journal Title

      Journal of Chromatography A

      Volume: 1661 Pages: 462686-462686

    • DOI

      10.1016/j.chroma.2021.462686

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] The association between antimicrobials and the antimicrobial-resistant phenotypes and resistance genes of Escherichia coli isolated from hospital wastewaters and adjacent surface waters in Sri Lanka2021

    • Author(s)
      Guruge Keerthi S.、Tamamura Yukino A.、Goswami Prasun、Tanoue Rumi、Jinadasa K.B.S.N.、Nomiyama Kei、Ohura Takeshi、Kunisue Tatsuya、Tanabe Shinsuke、Akiba Masato
    • Journal Title

      Chemosphere

      Volume: 279 Pages: 130591-130591

    • DOI

      10.1016/j.chemosphere.2021.130591

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Transport and dilution of fluvial antibiotic in the Upper Gulf of Thailand2021

    • Author(s)
      Wang Aobo、Guo Xinyu、Morimoto Akihiko、Maetani Kana、Tanoue Rumi、Tong-U-Dom Siraporn、Buranapratheprat Anukul
    • Journal Title

      Environmental Pollution

      Volume: 288 Pages: 117779-117779

    • DOI

      10.1016/j.envpol.2021.117779

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Occurrence of Pharmaceutically Active Compounds and Potential Ecological Risks in Wastewater from Hospitals and Receiving Waters in Sri Lanka2021

    • Author(s)
      Goswami Prasun、Guruge Keerthi S.、Tanoue Rumi、Tamamura Yukino A.、Jinadasa K. B. S. N.、Nomiyama Kei、Kunisue Tatsuya、Tanabe Shinsuke
    • Journal Title

      Environmental Toxicology and Chemistry

      Volume: 41 Issue: 2 Pages: 298-311

    • DOI

      10.1002/etc.5212

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antibiotics in surface water of East and Southeast Asian countries: A focused review on contamination status, pollution sources, potential risks, and future perspectives2021

    • Author(s)
      Anh Hoang Quoc、Le Thi Phuong Quynh、Da Le Nhu et al.
    • Journal Title

      Science of The Total Environment

      Volume: 764 Pages: 142865-142865

    • DOI

      10.1016/j.scitotenv.2020.142865

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Rapid analysis of 65 pharmaceuticals and 7 personal care products in plasma and whole-body tissue samples of fish using acidic extraction, zirconia-coated silica cleanup, and liquid chromatography-tandem mass spectrometry2020

    • Author(s)
      Tanoue Rumi、Nozaki Kazusa、Nomiyama Kei、Kunisue Tatsuya、Tanabe Shinsuke
    • Journal Title

      Journal of Chromatography A

      Volume: 1631 Pages: 461586-461586

    • DOI

      10.1016/j.chroma.2020.461586

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] 魚類肝S9画分を用いた医薬品類の肝代謝速度定数の解析と生物濃縮性予測モデルへの適用2022

    • Author(s)
      甲斐奏、田上瑠美、近藤昌和、仲山慶、 小林淳、野見山桂、 国末達也
    • Organizer
      第57回日本水環境学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 下水処理水に残留する医薬品類及びパーソナルケア製品由来物質の魚類への取込と排泄2021

    • Author(s)
      田上瑠美,仲山 慶,近藤昌和,野見山 桂,国末達也
    • Organizer
      第29回環境化学討論会
    • Related Report
      2021 Research-status Report
  • [Presentation] 医薬品・パーソナルケア製品由来化学物質による汽水域魚類への移行・残留性2021

    • Author(s)
      須藤菜穂,田上瑠美,国末達也,野見山 桂
    • Organizer
      第29回環境化学討論会
    • Related Report
      2021 Research-status Report
  • [Presentation] Occurrence and fate of endocrine disrupting chemicals in surface water and fish from India and Vietnam2021

    • Author(s)
      Kwon,J., Tanoue,R., Tue,N.M., Tuyen,L.H., Viet, P.H., Krishnamoorthi, V., Subramanian,A., Tanabe,S., Kunisue, T
    • Organizer
      第29回環境化学討論会
    • Related Report
      2021 Research-status Report
  • [Presentation] 生活関連化学物質(PPCPs)の汽水域魚類への移行・残留性と脳移行2021

    • Author(s)
      須藤 菜穂,田上 瑠美,国末 達也,野見山 桂
    • Organizer
      第23回環境ホルモン学会研究発表会
    • Related Report
      2021 Research-status Report
  • [Presentation] 医薬品・パーソナルケア製品由来化学物質による汽水域魚類の曝露実態と脳移行2020

    • Author(s)
      須藤菜穂, 田上瑠美, 野見山桂
    • Organizer
      第55回日本水環境学会年会
    • Related Report
      2020 Research-status Report
  • [Remarks] 環境化学研究室

    • URL

      http://kanka.cmes.ehime-u.ac.jp

    • Related Report
      2022 Annual Research Report
  • [Remarks] 愛媛大学 沿岸環境科学研究センター 環境化学研究室

    • URL

      http://kanka.cmes.ehime-u.ac.jp

    • Related Report
      2021 Research-status Report 2020 Research-status Report
  • [Remarks] researchmap - 田上瑠美

    • URL

      https://researchmap.jp/tanoue_rumi

    • Related Report
      2021 Research-status Report 2020 Research-status Report
  • [Remarks] ORCID - Rumi Tanoue

    • URL

      https://orcid.org/0000-0003-2354-0694

    • Related Report
      2021 Research-status Report 2020 Research-status Report

URL: 

Published: 2020-04-28   Modified: 2024-01-30  

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