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Development of multiscale forward finite element musculoskeletal model for rehabilitation and artificial prosthesis design

Research Project

Project/Area Number 20K20162
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 90110:Biomedical engineering-related
Research InstitutionThe University of Tokyo

Principal Investigator

SHU LIMING  東京大学, 大学院工学系研究科(工学部), 特任講師 (30838206)

Project Period (FY) 2020-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords筋骨格モデル / 有限要素 / 膝関節 / musculoskeletal model / Biomechanics / Ground reaction force / ground reaction force / motion capture system / knee joint / biomechanics / Musculoskeletal modeling
Outline of Research at the Start

We propose a new bioinspired multiscale forward finite element musculoskeletal model to deterministically investigate the individualized biofeedback of relevant mechanical signals to guide the design of rehabilitation and artificial prosthesis design.

Outline of Final Research Achievements

The whole body multi-scale finite element musculoskeletal (FE-MS) model of humans has been developed with the function of subject-specific.(1) An algorithm for the prediction of ground reaction force was developed and integrated with the FE-MS model. A super accuracy has been found in comparison with conventional approaches.(2) It has been applied to the clinical field and used to understand the effect of lower limb alignment on multi-scale dynamics from knee and body levels.(3) A wearable motion capture system has been developed for synchronously acquiring the kinematics and EMG of humans.

Academic Significance and Societal Importance of the Research Achievements

This research provides a deterministic way to insight into the relationship between physical behavior and tissue state, which significantly provided a fundamental understanding of human biomechanics and help treat musculoskeletal disease.

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • Research Products

    (14 results)

All 2022 2021 2020 Other

All Int'l Joint Research (2 results) Journal Article (7 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 7 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results)

  • [Int'l Joint Research] Cambridge University(英国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Southwest Jiaotong University(中国)

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Multiscale modelling for investigating the long-term time-dependent biphasic behaviour of the articular cartilage in the natural hip joint2022

    • Author(s)
      Hua Xijin、Shu Liming、Li Junyan
    • Journal Title

      Biomechanics and Modeling in Mechanobiology

      Volume: 12 Issue: 4 Pages: 450-480

    • DOI

      10.1007/s10237-022-01581-6

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Incremental Element Deletion-Based Finite Element Analysis of the Effects of Impact Speeds, Fall Postures, and Cortical Thicknesses on Femur Fracture2022

    • Author(s)
      Cui Yangyang、Xiang Dingding、Shu Liming、Duan Zhili、Liao Zhenhua、Wang Song、Liu Weiqiang
    • Journal Title

      Materials

      Volume: 15 Issue: 8 Pages: 2878-2878

    • DOI

      10.3390/ma15082878

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multiscale finite element musculoskeletal model for intact knee dynamics2022

    • Author(s)
      Shu Liming、Yamamoto Ko、Yoshizaki Reina、Yao Jiang、Sato Takashi、Sugita Naohiko
    • Journal Title

      Computers in Biology and Medicine

      Volume: 141 Pages: 105023-105023

    • DOI

      10.1016/j.compbiomed.2021.105023

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparison of Kinematics and Contact Mechanics in Normal Knee and Total Knee Replacements: A Computational Investigation2021

    • Author(s)
      Shu Liming、Sato Takashi、Hua Xijin、Sugita Naohiko
    • Journal Title

      Annals of Biomedical Engineering

      Volume: 49 Issue: 9 Pages: 2491-2502

    • DOI

      10.1007/s10439-021-02812-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In vivo Kinematical Validated Knee Model for Preclinical Testing of Total Knee Replacement2021

    • Author(s)
      Liming Shu, Jiang Yao, Ko Yamamoto, Takashi Sato and Naohiko Sugita
    • Journal Title

      Computers in Biology and Medicin

      Volume: 132 Pages: 104311-104311

    • DOI

      10.1016/j.compbiomed.2021.104311

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Enhanced In-Silico Polyethylene Wear Simulation of Total Knee Replacements During Daily Activities2020

    • Author(s)
      Shu Liming、Hashimoto Sho、Sugita Naohiko
    • Journal Title

      Annals of Biomedical Engineering

      Volume: 49 Issue: 1 Pages: 322-333

    • DOI

      10.1007/s10439-020-02555-4

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Systematic review of computational modelling for biomechanics analysis of total knee replacement2020

    • Author(s)
      Shu Liming、Li Shihao、Sugita Naohiko
    • Journal Title

      Biosurface and Biotribology

      Volume: 6 Issue: 1 Pages: 3-11

    • DOI

      10.1049/bsbt.2019.0012

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Important of posterior tibial slope on joint dynamics of intact and ACL deficient knee: a multiscale musculoskeletal analysis2021

    • Author(s)
      Shu, L., Abe, N., and Sugita, N
    • Organizer
      11th Asian-Pacific Conference on Biomechanics
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] How does normal knee work in the gait cycle: A finite element musculoskeletal investigation2021

    • Author(s)
      Shu L., Yao J., N. and Sugita N.,
    • Organizer
      Global 3DExperience Modeling & Simulation Virtual Conference
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] How does normal knee works in the gait cycle: A finite element musculoskeletal investigation2020

    • Author(s)
      L.Shu, J. Yao, and N. Sugita
    • Organizer
      Global 3DExperience Modeling & Simulation Virtual Conference
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] A Subject-Specific Finite-Element Musculoskeletal Model for Analysis of Lower Limb Biomechanics2020

    • Author(s)
      Li S., Shu, L., and Sugita, N
    • Organizer
      The 42nd Annual Meeting of the American Society of Biomechanics
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 下肢バイオメカニクスを解析するための有限要素ベース患者個別筋骨格モデル2020

    • Author(s)
      李 世豪,舒 利明,姚 江, 杉田 直彦
    • Organizer
      日本臨床バイオメカニクス学会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2023-01-30  

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