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Development of drug delivery carriers for photodynamic therapy using peptides exhibiting photoresponsive reversible self-aggregation

Research Project

Project/Area Number 20K20202
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 90120:Biomaterials-related
Research InstitutionKyushu University

Principal Investigator

Suyama Keitaro  九州大学, 基幹教育院, 助教 (60707222)

Project Period (FY) 2020-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsエラスチン様ペプチド / 温度応答性分子 / 光応答性分子 / 自己集合能 / 温度応答性 / 光応答性ペプチド / コアセルベーション / 薬物送達システム / 光線力学的療法
Outline of Research at the Start

本研究では、凝集・溶解状態を何度でも切り替えることができ、生体への安全性も高いペプチド・ELPを母体として、光線力学的療法に利用可能なペプチド性医療材料を開発する。ELPは温度変化等の刺激によって凝集体を形成することで、がん組織に薬剤を選択的に輸送可能な素材である。このELPをもとにして、光照射によって凝集・活性化するペプチドを合成し、有効成分のがん組織への輸送能力と、光によるがん細胞選択的な傷害活性を合わせ持つ薬物輸送担体を開発するのが目的である。開発したペプチドを用いて、光を照射するだけで周囲の正常組織を傷つけることなく、がん細胞を選択的に破壊することのできる医療素材への応用を目指す。

Outline of Final Research Achievements

ELPs (elastin-like peptides) are synthetic peptide derived from elastin and possess excellent biodegradability and biocompatibility because they consist of natural amino acids. ELPs exhibit temperature-dependent reversible self-assembly (coacervation) characteristics. The aim of this study was to develop peptide-based biomaterials applicable to cancer therapy, especially photodynamic therapy. We have previously reported the ELPs that exhibits temperature responsiveness with small molecular weight. In this stugy, we attempted to develop the ELP analogs that combined with light-responsive cancer cell injury activity with the ability to deliver drugs to cancer cells by combining molecules that exhibit structural changes in response to light.

Academic Significance and Societal Importance of the Research Achievements

光線力学療法は、侵襲性が非常に低い、腫瘍周辺の臓器機能の温存を可能とする先端治療法であり、麻酔を安全に施すことができない等の手術が困難な場合や、臓器温存が必要な場合に必要となる。一方で、ELPは生体や環境にやさしい生体分子素材であり、その温度依存的な自己集合特性を利用し、薬物輸送担体としての応用が期待されている。本研究では、温度と光で自己集合を制御可能な新しい薬物輸送担体を開発し、光線力学療法に適用可能な新しい生体分子素材の開発を目標として行った。

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • Research Products

    (23 results)

All 2022 2021 2020

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 5 results) Presentation (12 results) (of which Invited: 1 results)

  • [Journal Article] Metal ion scavenging activity of elastin-like peptide analogues containing a cadmium ion binding sequence2022

    • Author(s)
      Sumiyoshi Shogo、Suyama Keitaro、Tatsubo Daiki、Tanaka Naoki、Tomohara Keisuke、Taniguchi Suguru、Maeda Iori、Nose Takeru
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 1861-1861

    • DOI

      10.1038/s41598-022-05695-w

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of temperature-responsive short-chain peptide analogues based on elastin-like peptide FPGVG2022

    • Author(s)
      Suyama Keitaro、Sumiyoshi Shogo、Tanaka Naoki、Ando Takumi、Nagata Akihiko、Tomohara Keisuke、Taniguchi Suguru、Maeda Iori、Nose Takeru
    • Journal Title

      Peptide Science 2021

      Volume: - Pages: 141-142

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of temperature-responsive peptides by EDTA-mediated multimerization of short (FPGVG)n chains2022

    • Author(s)
      Tanaka Naoki、Suyama Keitaro、Tomohara Keisuke、Maeda Iori、Nose Takeru
    • Journal Title

      Peptide Science 2021

      Volume: - Pages: 83-84

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Bisphenol A derivatives act as novel coactivator-binding inhibitors for estrogen receptor β2021

    • Author(s)
      Iwamoto Masaki、Masuya Takahiro、Hosose Mari、Tagawa Koki、Ishibashi Tomoka、Suyama Keitaro、Nose Takeru、Yoshihara Eiji、Downes Michael、Evans Ronald M.、Matsushima Ayami
    • Journal Title

      Journal of Biological Chemistry

      Volume: 297 Issue: 5 Pages: 101173-101173

    • DOI

      10.1016/j.jbc.2021.101173

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Simple Regulation of the Self-Assembling Ability by Multimerization of Elastin-Derived Peptide (FPGVG)n Using Nitrilotriacetic Acid as a Building Block2021

    • Author(s)
      Keitaro Suyama, Mika Mawatari, Daiki Tatsubo, Iori Maeda, and Takeru Nose
    • Journal Title

      ACS Omega

      Volume: 6(8) Issue: 8 Pages: 5705-5716

    • DOI

      10.1021/acsomega.0c06140

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bisphenol-C is the strongest bifunctional ERα-agonist and ERβ-antagonist due to magnified halogen bonding2021

    • Author(s)
      Liu Xiaohui、Suyama Keitaro、Nose Takeru、Shimohigashi Miki、Shimohigashi Yasuyuki
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 2 Pages: e0246583-e0246583

    • DOI

      10.1371/journal.pone.0246583

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of Pheresidues in elastin-like peptide (FPGVG)5 on self-assembly properties2021

    • Author(s)
      Suyama Keitaro, Shimizu Marin, Maeda Iori, Nose Takeru
    • Journal Title

      Peptide Science 2021

      Volume: -

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of self-aggregating elastin-like peptide analogs with a metal-binding sequence2021

    • Author(s)
      Sumiyoshi Shogo, Suyama Keitaro, Nose Takeru
    • Journal Title

      Peptide Science 2021

      Volume: -

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fractionation of water-soluble elastin from pigaorta by coacervation method2021

    • Author(s)
      Maeda Iori, Taniguchi Suguru, Moriuchi Yumi, Sawa Naruhiko, Inoue Asako, Usa Tomoyuki, Watanabe Noriko, Suyama Keitaro, Nose Takeru
    • Journal Title

      Peptide Science 2021

      Volume: -

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of a universal coactivator peptide binding to the estrogen receptor and NURR12021

    • Author(s)
      Tagawa Koki , Suyama Keitaro, Kesamaru Hitoshi, Masuya Takahiro, Nose Takeru, Matsushima Ayami
    • Journal Title

      Peptide Science 2021

      Volume: -

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Simple, Low Cost, Sensitive, and Portable Electrochemical Immunochromatography Sensing Device to Measure Estrone-3-Sulfate2020

    • Author(s)
      Iwasaki Wataru、Kataoka Chiwa、Sawadaishi Kazuyuki、Suyama Keitaro、Morita Nobutomo、Miyazaki Masaya
    • Journal Title

      Sensors

      Volume: 20 Issue: 17 Pages: 4781-4781

    • DOI

      10.3390/s20174781

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] エラスチンのアミノ酸配列を母体とした温度応答性ペプチド・(FPGVG)nアナログの自己集合能と分子構造に関する研究2021

    • Author(s)
      巣山慶太郎
    • Organizer
      令和3年度日本生化学会 九州支部例会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 金属結合性配列を導入した短鎖エラスチン様ペプチドアナログの金属結合性2021

    • Author(s)
      田中尚輝、住吉勝伍、巣山慶太郎、友原啓介、前田衣織、野瀬 健
    • Organizer
      令和3年度日本生化学会 九州支部例会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 有害環境化学物質ビスフェノールC構造に基づく新規なエストロゲン受容体阻害剤2021

    • Author(s)
      岩本雅輝、巣山慶太郎、野瀬 健、松島綾美
    • Organizer
      令和3年度日本生化学会 九州支部例会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 短鎖エラスチン由来ペプチド(FPGVG)nの多量体化による温度応答性を有する機能性分子素材の開発2021

    • Author(s)
      巣山慶太郎、馬渡弥佳、前田衣織、野瀬 健
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ビスフェノール構造に基づくエストロゲン受容体の新規アンタゴニストの系統的合成2021

    • Author(s)
      岩本雅輝、巣山慶太郎、野瀬健、松島綾美
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Development of temperature-responsive short-chain peptide analogues based on elastin-like peptide FPGVG2021

    • Author(s)
      Keitaro Suyama, Shogo Sumiyoshi, Naoki Tanaka, Takumi Ando, Akihiko Nagata, Keisuke Tomohara, Suguru Taniguchi, Iori Maeda, Takeru Nose
    • Organizer
      第58回ペプチド討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Development of temperature-responsive peptides by EDTA-mediated multimerization of short (FPGVG) n chains2021

    • Author(s)
      Naoki Tanaka, Keitaro Suyama, Keisuke Tomohara, Iori Maeda, Takeru Nose
    • Organizer
      第58回ペプチド討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 温度応答性ペプチド・(FPGVG)5のフェニルアラニン残基置換による自己集合特性への影響2020

    • Author(s)
      巣山慶太郎、清水真凜、谷口 卓、前田衣織、野瀬 健
    • Organizer
      令和2年度日本生化学会九州支部例会
    • Related Report
      2020 Research-status Report
  • [Presentation] Role of Pheresidues in elastin-like peptide (FPGVG)5 on self-assembly properties2020

    • Author(s)
      Suyama Keitaro, Shimizu Marin, Maeda Iori, Nose Takeru
    • Organizer
      第57回ペプチド討論会
    • Related Report
      2020 Research-status Report
  • [Presentation] Development of self-aggregating elastin-like peptide analogs with a metal-binding sequence2020

    • Author(s)
      Sumiyoshi Shogo, Suyama Keitaro, Nose Takeru
    • Organizer
      第57回ペプチド討論会
    • Related Report
      2020 Research-status Report
  • [Presentation] Fractionation of water-soluble elastin from pigaorta by coacervation method2020

    • Author(s)
      Maeda Iori, Taniguchi Suguru, Moriuchi Yumi, Sawa Naruhiko, Inoue Asako, Usa Tomoyuki, Watanabe Noriko, Suyama Keitaro, Nose Takeru
    • Organizer
      第57回ペプチド討論会
    • Related Report
      2020 Research-status Report
  • [Presentation] Design and synthesis of a universal coactivator peptide binding to the estrogen receptor and NURR12020

    • Author(s)
      Tagawa Koki , Suyama Keitaro, Kesamaru Hitoshi, Masuya Takahiro, Nose Takeru, Matsushima Ayami
    • Organizer
      第57回ペプチド討論会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2023-01-30  

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