| Project/Area Number |
20K20203
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 90120:Biomaterials-related
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| Research Institution | Kumamoto University |
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Principal Investigator |
Lee Ruda 熊本大学, 産業ナノマテリアル研究所, 准教授 (00802050)
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | Multi-drug resistance / Breast cancer / Biomimetic nanoparticles / Cell membrane / Multidrug resistance / cell membrane / Cell line / Receptor / nano constructs |
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| Outline of Research at the Start |
Breast cancer is the most common and lethal cancer type in women worldwide. Yet, inherent and acquired multidrug resistance (MDR) to chemotherapeutic drugs remains a major obstacle in effective breast cancer treatments. In this study, modification of cell membrane on the nanoparticles provides a new strategy in biomimetic platforms for overcoming MDR.
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| Outline of Final Research Achievements |
This study aimed to develop a drug delivery system to increase the treatment efficiency of breast cancer that has developed resistance to anticancer drugs. So, the nanoparticles were protected using the red blood cells membrane, which allows them to evade immune cells and increase the delivery efficiency using the cell membrane with the properties of resistant cancer cells. This experiment has evaluated its effectiveness under similar conditions to the human body with a three-dimensional MDR cell structure.
As a result of the two-year study confirmed that the nanoparticles developed in this study avoid phagocytosis and deliver a more significant amount of drug into the MDR cancer cell. This research is the first study using a hybrid type of red blood cells and resistant cancer cell membranes, unlike previous studies using a kind of membrane. Its efficiency is also significant in proving that it is more efficient than drug-sensitive cancer cell membranes.
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| Academic Significance and Societal Importance of the Research Achievements |
This research is the first study using a hybrid type of red blood cells and resistant cancer cell membranes. The developed NPs have the potential to reduce treatment cost. It can be an asset to the Japanese economy as it provides a proprietary market in competition with other countries.
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