| Budget Amount *help |
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2022: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2021: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
Temperature (heat) is an ambiguous physical quantity in life science, and the purpose of this project is to understand temperature in life. The nucleus has a higher temperature than the cytoplasm, which leads to the following questions: (1) How is this temperature difference created by suppressing thermal diffusion? (2) What is the purpose of creating this temperature difference? For (1), we developed a novel fluorescent protein probe for temperature measurement and measured the thermal conductivity of the cytoplasm to understand the behavior of heat in the cell. For (2), we focused on the heat shock factor (HSF) and generated medaka KO to investigate the difference in degrees of latitude between proteins and nucleic acids with respect to temperature. Subsequently, we cloned HSF1s from various species, including flatfish, and are now analyzing heat properties.
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