| Budget Amount *help |
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2020: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
During the developmental processes, complex tissues of the embryo are formed by secreted proteins such as morphogen. Morphogens are secreted by the producing cells and diffuse through the extracellular space, forming a concentration gradient. It is known that cells differentiate into various tissues depending on local morphogen concentration. In this study, we have developed a novel method for spatiotemporal regulation of morphogen distribution in the embryo by light stimulation. Furthermore, we found that perturbation of morphogen distribution disrupts pattern formation. We think that this method will be a powerful tool for understanding the interactive mechanisms of morphogen dynamics and tissue patterning.
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