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Elucidation of mechanisms underlying the link between nutritional modulation of gut microbiota and gut-multiorgan crosstalk that can promote health span extension in the elderly people

Research Project

Project/Area Number 20K20320
Project/Area Number (Other) 18H05299 (2018-2019)
Research Category

Grant-in-Aid for Challenging Research (Pioneering)

Allocation TypeMulti-year Fund (2020)
Single-year Grants (2018-2019)
Review Section Studies on the Super-Aging Society
Research InstitutionSuzuka University of Medical Science

Principal Investigator

TOYODA NAGAYASU  鈴鹿医療科学大学, 公私立大学の部局等, 学長 (40126983)

Co-Investigator(Kenkyū-buntansha) 中東 真紀  鈴鹿医療科学大学, 保健衛生学部, 准教授 (00440785)
川西 正祐  鈴鹿医療科学大学, なし, 客員教授 (10025637)
畠中 泰彦  鈴鹿医療科学大学, 保健衛生学部, 教授 (10309601)
大井 一弥  鈴鹿医療科学大学, 薬学部, 教授 (40406369)
佐藤 英介  鈴鹿医療科学大学, 薬学部, 教授 (60211942)
鈴木 宏治  鈴鹿医療科学大学, 薬学部, 教授 (70077808)
葛原 茂樹  鈴鹿医療科学大学, 看護学部, 教授 (70111383)
郡山 恵樹  鈴鹿医療科学大学, 薬学部, 教授 (70397199)
西田 圭吾  鈴鹿医療科学大学, 薬学部, 教授 (80360618)
栃谷 史郎  鈴鹿医療科学大学, 保健衛生学部, 准教授 (90418591)
Project Period (FY) 2018-06-29 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2020: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2019: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2018: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords健康寿命延伸 / 腸内細菌叢 / 亜鉛 / フレイル / サルコペニア / 腸内細菌 / 健康寿命 / 中鎖脂肪酸 / 認知機能 / 高齢者 / 嚥下 / 皮膚バリア機能
Outline of Research at the Start

高齢になると腸内細菌の種類が変わり、それらが皮膚・筋肉・認知機能の老化促進及び疾病発症につながることが知られてきている。それらを抑制し、健康に近づけるような補助食品やサプリメントを選出することは、ヒトの健康増進に寄与する可能性が考えられる。そこで、本研究では亜鉛や中鎖脂肪酸を高齢者に摂取させ、腸内細菌と皮膚・筋肉・認知機能の関係を調べる。最終的に、特定の栄養改善を施した高齢者の腸内細菌叢のバランス変化と、腸内細菌によって産生される代謝物を明らかとし、健康寿命延伸に寄与する。また、栄養素が腸内細菌叢やその代謝物に与える影響の科学的根拠を導くために、各種モデル動物を用いた実験も平行して実施する。

Outline of Final Research Achievements

This study examined the changes in the balance of the intestinal microbiota in the elderly under specific nutritional improvement treatment and their relationship to frailty status, muscle and skin function, which are common problems in the elderly. An improvement in lower leg circumference was observed in the elderly who took zinc for 8 weeks. Leg circumference is one of the indicators of muscle mass, suggesting that zinc is involved in the maintenance of muscle mass in the elderly. In addition, when we examined the intestinal bacterial species associated with increased muscle mass by zinc improvement, we confirmed that the occupancy of the Rikenellaceae was found to increase with increasing leg circumference. Based on these results, we have identified the intestinal bacterial species that can serve as a new indicator to assess the improvement of the muscle mass in the elderly and found a new approach to preventing frailty in the elderly.

Academic Significance and Societal Importance of the Research Achievements

本邦の高齢者における低栄養状態は年齢が上がるとともに悪化し、低栄養は、認知症・サルコペニア・フレイルと深く関連している。本研究では、高齢者を対象とし、特定の栄養改善を施した際に観察される腸内細菌叢のバランス変化、産生される腸内細菌由来代謝物の同定することで、高齢者の低栄養問題を改善するための新たなアプローチを見出すことを目的とした。結果、栄養素の一つである亜鉛が高齢者の筋肉量維持に関わっていることを示し、特定の腸内細菌種と関連性を示唆した。今回の知見により、高齢者の栄養改善と疾病予防を広く提案でき、各個人の腸内細菌叢の個別診断が高齢者フレイル予防の指標となりうることを示した。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (66 results)

All 2022 2021 2020 2019 2018

All Journal Article (33 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 31 results,  Open Access: 24 results) Presentation (28 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results) Book (5 results)

  • [Journal Article] Taurine: A Maternally Derived Nutrient Linking Mother and Offspring2022

    • Author(s)
      Tochitani Shiro
    • Journal Title

      Metabolites

      Volume: 12 Issue: 3 Pages: 228-228

    • DOI

      10.3390/metabo12030228

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between Whole Blood Manganese and Dry Skin in Hemodialysis Patients2021

    • Author(s)
      Deguchi Masataka、Machida Hirofumi、Yasui Hiroyuki、Hiraoka Jun、Nishida Keigo、Hiramoto Keiichi、Jose Hidehiko、Takeuchi Misao、Ooi Kazuya
    • Journal Title

      BPB Reports

      Volume: 4 Issue: 4 Pages: 124-129

    • DOI

      10.1248/bpbreports.4.4_124

    • NAID

      130008075971

    • ISSN
      2434-432X
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elevated Hydrostatic Pressure Causes Retinal Degeneration Through Upregulating Lipocalin-22021

    • Author(s)
      Yoneshige Azusa、Hagiyama Man、Takashima Yasutoshi、Ueno Satoru、Inoue Takao、Kimura Ryuichiro、Koriyama Yoshiki、Ito Akihiko
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 9 Pages: 664327-664327

    • DOI

      10.3389/fcell.2021.664327

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] グリセルアルデヒド由来終末糖化産物起因性のアルツハイマー病発症機序の解明2021

    • Author(s)
      那須隆斗, 古川絢子, 竹内正義, 郡山恵樹
    • Journal Title

      アグリバイオ

      Volume: 5 Pages: 64-67

    • NAID

      40022735522

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glycyrrhizin Attenuates Carcinogenesis by Inhibiting the Inflammatory Response in a Murine Model of Colorectal Cancer2021

    • Author(s)
      Wang Guifeng、Hiramoto Keiichi、Ma Ning、Yoshikawa Nobuji、Ohnishi Shiho、Murata Mariko、Kawanishi Shosuke
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 5 Pages: 2609-2609

    • DOI

      10.3390/ijms22052609

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intracellular Toxic AGEs (TAGE) Triggers Numerous Types of Cell Damage.2021

    • Author(s)
      Takeuchi M, Sakasai-Sakai A, Takata T, Takino JI, Koriyama Y, Kikuchi C, Furukawa A, Nagamine K, Hori T, Matsunaga T.
    • Journal Title

      Biomolecules.

      Volume: 11 Issue: 3 Pages: 387-387

    • DOI

      10.3390/biom11030387

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mushroom <i>Sparassis crispa</i> (Hanabiratake) Fermented with Lactic Acid Bacteria Significantly Enhances Innate Immunity of Mice2020

    • Author(s)
      Nishioka Junji、Hiramoto Keiichi、Suzuki Koji
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 43 Issue: 4 Pages: 629-638

    • DOI

      10.1248/bpb.b19-00724

    • NAID

      130007825344

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2020-04-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transepidermal Water Loss (TEWL)-decreasing Effect by Administration of Zinc in the Elderly People2020

    • Author(s)
      1.Masataka Deguchi , Hidehiko Jose , Keigo Nishida , Kazuya Ooi
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 140 Issue: 2 Pages: 313-318

    • DOI

      10.1248/yakushi.19-00198

    • NAID

      130007793399

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2020-02-01
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of 5-Hydroxymethylfurfural (5-HMF) as an Active Component Citrus Jabara That Suppresses FcεRI-Mediated Mast Cell Activation2020

    • Author(s)
      Uchida Ryota、Kato Michiko、Hattori Yuka、Kikuchi Hiroko、Watanabe Emi、Kobayashi Katsuumi、Nishida Keigo
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 7 Pages: 2472-2472

    • DOI

      10.3390/ijms21072472

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 亜鉛/亜鉛トランスポーターによる皮膚創傷治癒の制御機構2020

    • Author(s)
      西田 圭吾
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 73 Pages: 500-505

    • Related Report
      2020 Research-status Report
  • [Journal Article] Innate immune activation and antitumor effects of Lactobacillus-fermented Sparassis crispa extract in mice2020

    • Author(s)
      Hiramoto Keiichi、Nishioka Junji、Suzuki Koji
    • Journal Title

      Journal of Functional Foods

      Volume: 75 Pages: 104215-104215

    • DOI

      10.1016/j.jff.2020.104215

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of thrombomodulin mutation causing defective thrombin binding with absence of protein C and TAFI activation2020

    • Author(s)
      Okada Masahiko、Tominaga Norio、Honda Goichi、Nishioka Junji、Akita Nobuyuki、Hayashi Tatsuya、Suzuki Koji、Moriuchi Hiroyuki
    • Journal Title

      Blood Advances

      Volume: 4 Issue: 12 Pages: 2631-2639

    • DOI

      10.1182/bloodadvances.2019001155

    • NAID

      120006988143

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vertical transmission of gut microbiota: Points of action of environmental factors influencing brain development2020

    • Author(s)
      Tochitani Shiro
    • Journal Title

      Neuroscience Research

      Volume: 印刷中 Pages: 83-94

    • DOI

      10.1016/j.neures.2020.11.006

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 母と子を結びつける周産期母体腸内細菌叢と児の脳発達ー動物モデルを用いた研究成果からの示唆ー2020

    • Author(s)
      栃谷 史郎
    • Journal Title

      児童青年精神医学とその近接領域

      Volume: 61 Pages: 99-104

    • Related Report
      2020 Research-status Report
  • [Journal Article] TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron‐autonomous manner2020

    • Author(s)
      Koinuma Shingo、Negishi Ryota、Nomura Riko、Sato Kazuki、Kojima Takuya、Segi‐Nishida Eri、Goitsuka Ryo、Iwakura Yoichiro、Wada Naoyuki、Koriyama Yoshiki、Kiryu‐Seo Sumiko、Kiyama Hiroshi、Nakamura Takeshi
    • Journal Title

      Journal of Neurochemistry

      Volume: - Issue: 4 Pages: 1196-1206

    • DOI

      10.1111/jnc.15235

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Effect of Glyceraldehyde-Derived Advanced Glycation End Products on β-Tubulin-Inhibited Neurite Outgrowth in SH-SY5Y Human Neuroblastoma Cells2020

    • Author(s)
      Nasu R, Furukawa A, Suzuki K, Takeuchi M, Koriyama Y.
    • Journal Title

      Nutrients

      Volume: 12 Issue: 10 Pages: 2958-2958

    • DOI

      10.3390/nu12102958

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] DNA demethylation increases NETosis2020

    • Author(s)
      Yasuda Hiroyuki、Takishita Yutaka、Morita Akihiro、Tsutsumi Tomonari、Tsuchiya Masahiko、Sato Eisuke F.
    • Journal Title

      Archives of Biochemistry and Biophysics

      Volume: 689 Pages: 108465-108465

    • DOI

      10.1016/j.abb.2020.108465

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A new zinc chelator, IPZ-010 ameliorates postoperative ileus2020

    • Author(s)
      Kimura Hitomi、Yoneya Yutaka、Mikawa Shoma、Kaji Noriyuki、Ito Hiroki、Tsuchida Yasuaki、Komatsu Hirotsugu、Murata Takahisa、Ozaki Hiroshi、Uchida Ryota、Nishida Keigo、Hori Masatoshi
    • Journal Title

      Biomedicine & Pharmacotherapy

      Volume: 123 Pages: 109773-109773

    • DOI

      10.1016/j.biopha.2019.109773

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formation of neutrophil extracellular traps in mitochondrial DNA-deficient cells2020

    • Author(s)
      Takishita Yutaka、Yasuda Hiroyuki、Shimizu Mio、Matsuo Akane、Morita Akihiro、Tsutsumi Tomonari、Tsuchiya Masahiko、Sato Eisuke F.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 66 Issue: 1 Pages: 15-23

    • DOI

      10.3164/jcbn.19-77

    • NAID

      130007779236

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological Activities of Rhamnan Sulfate Extract from the Green Algae Monostroma nitidum (Hitoegusa)2020

    • Author(s)
      Suzuki Koji、Terasawa Masahiro
    • Journal Title

      Marine Drugs

      Volume: 18 Issue: 4 Pages: 228-228

    • DOI

      10.3390/md18040228

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical evaluation of Emblica Officinalis Gatertn (Amla) in healthy human subjects: Health benefits and safety results from a randomized, double-blind, crossover placebo-controlled study2020

    • Author(s)
      Kapoor Mahendra Parkash、Suzuki Koji、Derek Timm、Ozeki Makoto、Okubo Tsutomu
    • Journal Title

      Contemporary Clinical Trials Communications

      Volume: 17 Pages: 100499-100499

    • DOI

      10.1016/j.conctc.2019.100499

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] L-Type Calcium Channel-Mediated Zinc Wave Is Involved in the Regulation of IL-6 by Stimulating Non-IgE with LPS and IL-33 in Mast Cells and Dendritic Cells2019

    • Author(s)
      Uchida Ryota、Xiang Huihui、Arai Hiroya、Kitamura Hidemitsu、Nishida Keigo
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 1 Pages: 87-93

    • DOI

      10.1248/bpb.b18-00565

    • NAID

      130007542207

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-01-01
    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis2019

    • Author(s)
      Nishida K, Hasegawa A, Yamasaki S, Uchida R, Ohashi W, Kurashima Y, Kunisawa J, Kimura S, Iwanaga T, Watarai H, Hase K, Ogura H, Nakayama M, Kashiwakura J, Okayama Y, Kubo M, Ohara O, Kiyono H, Koseki H, Murakami M, Hirano T
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 10842-10842

    • DOI

      10.1038/s41598-019-47132-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rhamnan sulfate extracted from Monostroma nitidum attenuates blood coagulation and inflammation of vascular endothelial cells2019

    • Author(s)
      Okamoto Takayuki、Akita Nobuyuki、Terasawa Masahiro、Hayashi Tatsuya、Suzuki Koji
    • Journal Title

      Journal of Natural Medicines

      Volume: 印刷中 Issue: 3 Pages: 614-619

    • DOI

      10.1007/s11418-019-01289-5

    • NAID

      40021912735

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk factor analysis of the decrease in gait speed among Japanese older outpatients with polypharmacy2019

    • Author(s)
      Deguchi Masataka、Nishida Keigo、Enokiya Tomoyuki、Ooi Kazuya
    • Journal Title

      Journal of Pharmaceutical Health Care and Sciences

      Volume: 5 Issue: 1 Pages: 23-23

    • DOI

      10.1186/s40780-019-0152-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of the minimal region of peptide derived from ADP-ribosylation factor1 (ARF1) that inhibits IgE-mediated mast cell activation2019

    • Author(s)
      Uchida Ryota、Egawa Tomonori、Fujita Yoshio、Furuta Kazuyuki、Taguchi Hiroaki、Tanaka Satoshi、Nishida Keigo
    • Journal Title

      Molecular Immunology

      Volume: 105 Pages: 32-37

    • DOI

      10.1016/j.molimm.2018.11.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 17-β-estradiol enhances neutrophil extracellular trap formation by interaction with estrogen membrane receptor2019

    • Author(s)
      Yasuda Hiroyuki、Sonoda Annri、Yamamoto Maki、Kawashima Yuna、Takishita Yutaka、Morita Akihiro、Tsutsumi Tomonari、Tsuchiya Masahiko、Sato Eisuke F.
    • Journal Title

      Archives of Biochemistry and Biophysics

      Volume: 663 Pages: 64-70

    • DOI

      10.1016/j.abb.2018.12.028

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Zinc Signaling in the Regulation of Mast Cell-, Basophil-, and T Cell-Mediated Allergic Responses2018

    • Author(s)
      Nishida Keigo、Uchida Ryota
    • Journal Title

      Journal of Immunology Research

      Volume: 2018 Pages: 1-9

    • DOI

      10.1155/2018/5749120

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Talaumidin promotes neurite outgrowth of staurosporine-differentiated RGC-5 cells through PI3K/Akt-dependent pathway2018

    • Author(s)
      Y. Koriyama, A. Furukawa, K. Sugitani, M. Kubo, K. Harada, Y. Fukuyama
    • Journal Title

      Adv. Exp. Med. Biol

      Volume: 1074 Pages: 649-653

    • DOI

      10.1007/978-3-319-75402-4_79

    • ISBN
      9783319754017, 9783319754024
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Alternative Splicing for Activation of Coagulation Factor XIII-A in the Fish Retina After Optic Nerve Injury.2018

    • Author(s)
      Sugitani K, Koriyama Y, Ogai K, Furukawa A, Kato S.
    • Journal Title

      Adv Exp Med Biol.

      Volume: 1074 Pages: 387-393

    • DOI

      10.1007/978-3-319-75402-4_48

    • ISBN
      9783319754017, 9783319754024
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Protein carbonylation-dependent photoreceptor cell death induced by N-methyl-N-nitrosourea in mice.2018

    • Author(s)
      Furukawa A, Sugitani K, and Koriyama Y
    • Journal Title

      Adv. Exp. Med. Biol.

      Volume: 1074 Pages: 297-302

    • DOI

      10.1007/978-3-319-75402-4_36

    • ISBN
      9783319754017, 9783319754024
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Role of mast cells in the induction of dry skin in a mouse model of rheumatoid arthritis.2018

    • Author(s)
      Goto K, Hiramoto K, Kita H, Ooi K.
    • Journal Title

      Cutan Ocul Toxicol.

      Volume: 37 Issue: 1 Pages: 61-70

    • DOI

      10.1080/15569527.2017.1337784

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The influence of reactive oxygen species and glucocorticoids on dry skin in a mouse model of Arthritis.2018

    • Author(s)
      Goto K, Hiramoto K, Kawakita M, Yamaoka M, Ooi K.
    • Journal Title

      Skin Pharmacol Physiol.

      Volume: 31 Issue: 4 Pages: 188-197

    • DOI

      10.1159/000488250

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 亜鉛の大腸がんモデルマウスにおける腫瘍抑制効果2022

    • Author(s)
      中川直也、前田菜々子、市原武、沈輝棟、王向東、北村秀光、西田圭吾
    • Organizer
      日本薬学会 第142年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] AGEs阻害剤はβ-チューブリンのTAGE化を介した神経軸索伸長抑制を軽減する2022

    • Author(s)
      那須 隆斗、古川 絢子、竹内 正義、郡山 恵樹
    • Organizer
      日本薬学会 第142年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 生活習慣病における新たな概念Toxic AGEs (TAGE)2022

    • Author(s)
      竹内 正義、逆井(坂井) 亜紀子、高田 尊信、瀧野 純一、郡山 恵樹、古川 絢子、那須 隆斗、菊池 千草、長嶺 憲太郎、堀 隆光、松永 民秀
    • Organizer
      日本薬学会 第142年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 亜鉛摂取による腸内細菌叢の変化2021

    • Author(s)
      田中崇之、中上雄太、中川直也、栃谷史郎、西田圭吾
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] 褥瘡患者における血清亜鉛値と肉芽組織中のサイトカイン転写量の関係2021

    • Author(s)
      中川直也、西田圭吾
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] 亜鉛の大腸がん抑制効果に関する研究2021

    • Author(s)
      中川直也、前田菜々子、沈輝棟、王向東、北村秀光、西田圭吾
    • Organizer
      第67回 日本薬学会東海支部総会・大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] タミバロテン(Am80)による中枢神経再生作用とその作用機序解明について2021

    • Author(s)
      朝倉 彩絵、郡山 恵樹
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] HSP70を標的とした網膜色素変性症の新たな治療薬の可能性2021

    • Author(s)
      西村 飛由馬、郡山 恵樹
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] 毒性終末糖化産物(TAGE)によるアルツハイマー尿神経原線維変化の可能性について2021

    • Author(s)
      那須 隆斗、古川 絢子、竹内 正義、郡山 恵樹
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] グリセル-AGEs依存性β-チューブリン異常凝集による神経軸索伸長抑制効果2021

    • Author(s)
      那須 隆斗、古川 絢子、竹内 正義、郡山 恵樹
    • Organizer
      日本薬理学会 第94回年
    • Related Report
      2021 Annual Research Report 2020 Research-status Report
  • [Presentation] 糖尿病由来アルツハイマー病発症における毒性終末糖化産物(TAGE)関与の可能性2021

    • Author(s)
      那須 隆斗、古川 絢子、竹内 正義、郡山 恵樹
    • Organizer
      日本薬学会第141年会
    • Related Report
      2020 Research-status Report
  • [Presentation] 細胞内Toxic AGEs (TAGE) の生成・蓄積は各種細胞障害のトリガーとなる2021

    • Author(s)
      竹内 正義、逆井(坂井) 亜紀子、高田 尊信、瀧野 純一、郡山 恵樹、菊池 千草、古川 絢子、長嶺 憲太郎、堀 隆光、松永 民秀
    • Organizer
      日本薬学会第141年会
    • Related Report
      2020 Research-status Report
  • [Presentation] Heat Shock Factor 1は魚類視神経再生初期においてHeat Shock Proteinsの発現誘導と同様に cellular Factor XIII-A の活性化にも重要である2021

    • Author(s)
      杉谷加代、大貝和裕、郡山 恵樹
    • Organizer
      第98回 日本生理学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] フルボキサミンの Sigma-1受容体刺激を介した神経栄養因子様作用2020

    • Author(s)
      那須隆斗、郡山恵樹
    • Organizer
      日本薬学会第140年会
    • Related Report
      2020 Research-status Report
  • [Presentation] グリセルアルデヒド由来Toxic AGEs化βチュブリン由来の神経軸索伸長阻害について2020

    • Author(s)
      郡山恵樹、古川絢子、那須隆斗、竹内正義
    • Organizer
      日本薬学会第140年会
    • Related Report
      2020 Research-status Report
  • [Presentation] 必須微量元素である亜鉛は乾燥皮膚や皮膚バリア機能に関与する2019

    • Author(s)
      西田 圭吾、内田 亮太、古川 絢子
    • Organizer
      第42回 基礎老化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Zinc plays roles in the inflammatory phase of wound healing through the GPR39/IL-6 axis2019

    • Author(s)
      Nishida Keigo, Uchida Ryota
    • Organizer
      The 6th Meeting of International Society for Zinc Biology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 亜鉛による疾病予防、創傷治癒との関わり合い2019

    • Author(s)
      西田 圭吾、内田 亮太
    • Organizer
      フォーラム2019 衛生薬学・環境トキシコロジー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] A mouse model useful in studying the function of the gut microbiota in the development of offspring based on mother-infant interactions2019

    • Author(s)
      Shiro Tochitani
    • Organizer
      Cell Symposia Neuro-Immune Axis
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A preclinical mouse model inheriting perturbed maternal gut microbiota to screen for intervention materials to promote brain development of offspring2019

    • Author(s)
      Shiro Tochitani
    • Organizer
      World of Microbiome
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] グリセルアルデヒド由来のAGEs化βチュブリンの異常重合と軸索伸長阻害について2019

    • Author(s)
      郡山 恵樹、古川 絢子、那須 隆斗、竹内 正義
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] TLRおよびサイトカイン受容体シグナル経路における亜鉛ウェーブの役割2018

    • Author(s)
      西田圭吾、内田亮太
    • Organizer
      第6回 メタロミクス研究フォーラム プラズマ分光分析研究会 第104回講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 亜鉛は亜鉛受容体GPR39を介してサイトカイン産生を促すはたらきを持つ2018

    • Author(s)
      内田亮太、西田圭吾
    • Organizer
      第64回 日本薬学会東海支部会総会 大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Toll様受容体およびサイトカイン受容体のシグナル経路における亜鉛ウェーブの役割2018

    • Author(s)
      内田亮太、新井裕也、西田圭吾
    • Organizer
      日本薬学会第138年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] S-ニトロシル化のエピジェネティック制御による中枢神経再生制御機構2018

    • Author(s)
      郡山 恵樹
    • Organizer
      第34回日本ストレス学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 海藻アオサ(ヒトエグサ)由来ラムナン硫酸の抗血栓・血管内皮保護・抗腫瘍作用の検討2018

    • Author(s)
      鈴木宏治、秋田展幸、岡本貴行、西岡淳二、林辰弥
    • Organizer
      第40回日本血栓止血学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 炎症性血管内皮障害に対するアオサ由来ラムナン硫酸の効果2018

    • Author(s)
      寺澤匡博、岡本貴行、秋田展幸、西岡淳二、林辰弥、鈴木宏治
    • Organizer
      第16回日本機能性食品医用学会年次総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 海藻アオサに含まれる成分の生理活性2018

    • Author(s)
      鈴木宏治
    • Organizer
      第5回日本薬膳学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Book] 食と医療 16号 WINTERーSPRING2021

    • Author(s)
      西田圭吾、中川直也、北村秀光
    • Total Pages
      82
    • Publisher
      講談社
    • ISBN
      9784065224854
    • Related Report
      2020 Research-status Report
  • [Book] 腸内微生物叢最前線 内藤 裕二 編集2021

    • Author(s)
      栃谷 史郎
    • Total Pages
      5
    • Publisher
      診断と治療社
    • Related Report
      2020 Research-status Report
  • [Book] 海藻(ラムナン)で健康寿命を延ばす!2020

    • Author(s)
      鈴木 宏治
    • Total Pages
      162
    • Publisher
      産学社
    • ISBN
      9784782535561
    • Related Report
      2020 Research-status Report
  • [Book] ヒトマイクロバイオーム Vol.2  ~解析技術の進展とデータ駆動型・ターゲット機能型研究最前線~ 服部 正平監修2020

    • Author(s)
      栃谷 史郎
    • Total Pages
      10
    • Publisher
      (株)エヌ・ティー・エス
    • Related Report
      2020 Research-status Report
  • [Book] Zinc signaling2019

    • Author(s)
      Nishida Keigo, Kato Michiko, Uchida Ryota
    • Total Pages
      413
    • Publisher
      Springer
    • Related Report
      2019 Annual Research Report

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Published: 2018-07-20   Modified: 2024-03-26  

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