| Budget Amount *help |
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2022: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2021: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Outline of Final Research Achievements |
The molecular mechanism of the synthesis of DL-PGA and L-PGA was elucidated, and a mutant strain with higher productivity was successfully obtained than wild-type PgsA. We also succeeded in creating a strain deficient in the acetoin-acetate synthesis pathway without growth inhibition, which leads to improved PGA productivity, and in developing fibroblasts. We established a screening method for strains with enhanced D-PGA synthesis, but we could not obtain a D-PGA-producing mutant strain. However, we developed a new method to obtain mutant strains of D-PGA synthesis.
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