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Regulation of memory T cell generation and function by fatty acid metabolism

Research Project

Project/Area Number 20K20383
Project/Area Number (Other) 18H05375 (2018-2019)
Research Category

Grant-in-Aid for Challenging Research (Pioneering)

Allocation TypeMulti-year Fund (2020)
Single-year Grants (2018-2019)
Review Section Medium-sized Section 49:Pathology, infection/immunology, and related fields
Research InstitutionChiba University

Principal Investigator

Nakayama Toshinori  千葉大学, その他部局等, 学長 (50237468)

Project Period (FY) 2018-06-29 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2021: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Keywords免疫記憶 / 脂肪酸代謝 / 記憶T細胞 / 喘息 / ACC1 / ACCI
Outline of Research at the Start

生体内で長期間生存する記憶T細胞は免疫記憶の司令塔としての役割を担っているが、その重要性にも拘わらずどのような特徴を示す細胞が、いかなるメカニズムで記憶T細胞として生体内で長期間生存するのかは未だ明らかになっていない。本申請では、脂肪酸代謝に焦点をあて、記憶T細胞の形成を担う分子メカニズムを解明する。具体的には以下の実験を行う。
1)脂肪酸代謝制御による記憶T細胞形成メカニズムの解明、
2)記憶T細胞への運命決定を制御する遺伝子およびマーカーの同定、
3)ヒト記憶T前駆細胞の同定、
4)記憶T細胞形成調節による病態(喘息・がん等)の制御。
本研究は、「免疫記憶を代謝で制御する」という挑戦的な研究である。

Outline of Final Research Achievements

In pathogenic memory Th2 (Tpath2) cells, which are involved in chronic inflammation such as asthma, fatty acid metabolism pathway play an important role. We focused on two molecules that control fatty acid metabolism in Tpath2 cells: Stearoyl-CoA desaturase 2 (Scd2) and acetyl-CoA carboxylase 1 (ACC1). In the present study, we found that Scd2 and ACC1 expressed in Tpath2 cells regulate immune responses via controlling fatty acid metabolites. These findings have been reported in two separated papers. In addition, we published several other papers and had active discussions on the pathogenic T cells at domestic and international congresses. Although it is still debatable whether fatty acid metabolism could be potential therapeutic target, our findings will be helpful for better understanding of the fatty acid metabolism in the pathogenic T cells and chronic inflammation.

Academic Significance and Societal Importance of the Research Achievements

本研究では、総説等で単純化されすぎたモデルが提唱されているT細胞での代謝経路に焦点を当て、「細胞内代謝経路を操作することで免疫細胞の機能を制御できないか?」という仮説の検証を試みた。その結果、従来の単純化モデルでは注目されなかった脂肪酸代謝と記憶T細胞の関連を示唆する、T細胞の代謝モデルを書き換える免疫学上重要な知見が得られた。また、脂肪酸代謝を人工的に操作することで、慢性炎症に関与する病原性記憶T細胞を抑制可能というデータも得られ、「免疫記憶を代謝で制御する」という開始当初の目標に向けて一歩前進し、喘息などの慢性難治性炎症疾患の治療法開発等、将来的に大きな社会的意義をもたらすと考えられる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (103 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (5 results) Journal Article (56 results) (of which Int'l Joint Research: 16 results,  Peer Reviewed: 36 results,  Open Access: 33 results) Presentation (38 results) (of which Int'l Joint Research: 9 results,  Invited: 28 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] NIH/La Jolla Institute for Immunology(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of South Australia/SAHMRI(オーストラリア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Johannes Gutenberg University Mainz/DRFZ(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] National Institutes of Health/Harverd University/La Jolla Institute for Immunology(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of South Australia(オーストラリア)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Nematode ascarosides attenuate mammalian type 2 inflammatory responses2022

    • Author(s)
      Shinoda Kenta、Choe Andrea、Hirahara Kiyoshi、Kiuchi Masahiro、Kokubo Kota、Ichikawa Tomomi、Hoki Jason S.、Suzuki Akane S.、Bose Neelanjan、Appleton Judith A.、Aroian Raffi V.、Schroeder Frank C.、Sternberg Paul W.、Nakayama Toshinori
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 119(9) Issue: 9

    • DOI

      10.1073/pnas.2108686119

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 脂肪酸代謝制御による免疫記憶2022

    • Author(s)
      遠藤 裕介、中山 俊憲
    • Journal Title

      がん免疫ペディア 腫瘍免疫学・がん免疫療法の全てをまるごと理解!

      Volume: - Pages: 214-216

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy.2021

    • Author(s)
      Takasato Y, Kurashima Y, Kiuchi M, Hirahara K, Murasaki S, Arai F, Izawa K, Kaitani A, Shimada k, Saito Y, Toyoshima S, Nakamura M, Fujisawa K, Okayama Y, Kunisawa J, Kubo M, Takemura N, Uematsu S, Akira S, Kitaura J, Takahashi T, Nakayama T, Kiyono H
    • Journal Title

      Mucosal Immunol

      Volume: 14 Issue: 3 Pages: 640-651

    • DOI

      10.1038/s41385-020-00358-3

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Role of CD4+ Resident Memory T Cells in Local Immunity in the Mucosal Tissue - Protection Versus Pathology -2021

    • Author(s)
      Kiyoshi Hirahara、Kota Kokubo、Ami Aoki、Masahiro Kiuchi、Toshinori Nakayama
    • Journal Title

      Frontiers in Immunology

      Volume: - Pages: 616309-616309

    • DOI

      10.3389/fimmu.2021.616309

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells2021

    • Author(s)
      Onodera Atsushi、Gonzalez-Avalos Edahi、Lio Chan-Wang Jerry、Georges Romain O.、Bellacosa Alfonso、Nakayama Toshinori、Rao Anjana
    • Journal Title

      Genome Biology

      Volume: 22(1) Issue: 1 Pages: 186-186

    • DOI

      10.1186/s13059-021-02384-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells2021

    • Author(s)
      Kanno Toshio、Nakajima Takahiro、Yokoyama Satoru、Asou Hikari K.、Sasamoto Shigemi、Kamii Yasuhiro、Hayashizaki Koji、Ouchi Yasuo、Onodera Taishi、Takahashi Yoshimasa、Ikeda Kazutaka、Hasegawa Yoshinori、Kinjo Yuki、Ohara Osamu、Nakayama Toshinori、Endo Yusuke
    • Journal Title

      Communications Biology

      Volume: 4(1) Issue: 1 Pages: 820-820

    • DOI

      10.1038/s42003-021-02310-y

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells2021

    • Author(s)
      Hosokawa Hiroyuki、Koizumi Maria、Masuhara Kaori、Romero-Wolf Maile、Tanaka Tomoaki、Nakayama Toshinori、Rothenberg Ellen V.
    • Journal Title

      Journal of Experimental Medicine

      Volume: 218(8) Issue: 8 Pages: 1-16

    • DOI

      10.1084/jem.20202648

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Antibody responses to BNT162b2 mRNA COVID-19 vaccine and their predictors among healthcare workers in a tertiary referral hospital in Japan2021

    • Author(s)
      Kageyama Takahiro、Ikeda Kei、Tanaka Shigeru、Taniguchi Toshibumi、Igari Hidetoshi、Onouchi Yoshihiro、Kaneda Atsushi、Matsushita Kazuyuki、Hanaoka Hideki、Nakada Taka-Aki、Ohtori Seiji、Yoshino Ichiro、Matsubara Hisahiro、Nakayama Toshinori、Yokote Koutaro、Nakajima Hiroshi
    • Journal Title

      Clinical Microbiology and Infection

      Volume: 27(12) Issue: 12 Pages: 1861.e1-1861.e5

    • DOI

      10.1016/j.cmi.2021.07.042

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD4+ T cells in inflammatory diseases: pathogenic T-helper cells and the CD69-Myl9 system2021

    • Author(s)
      Nakayama Toshinori、Hirahara Kiyoshi、Kimura Motoko Y、Iwamura Chiaki、Kiuchi Masahiro、Kokubo Kota、Onodera Atsushi、Hashimoto Kahoko、Motohashi Shinichiro
    • Journal Title

      International Immunology

      Volume: 33(12) Issue: 12 Pages: 699-704

    • DOI

      10.1093/intimm/dxab053

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice2021

    • Author(s)
      Nakajima Takahiro、Kanno Toshio、Yokoyama Satoru、Sasamoto Shigemi、Asou Hikari K.、Tumes Damon J.、Ohara Osamu、Nakayama Toshinori、Endo Yusuke
    • Journal Title

      Journal of Experimental Medicine

      Volume: 218(12) Issue: 12

    • DOI

      10.1084/jem.20210639

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue Treg cell homeostasis2021

    • Author(s)
      Kanno Toshio、Nakajima Takahiro、Kawashima Yusuke、Yokoyama Satoru、Asou Hikari K.、Sasamoto Shigemi、Hayashizaki Koji、Kinjo Yuki、Ohara Osamu、Nakayama Toshinori、Endo Yusuke
    • Journal Title

      Cell Reports

      Volume: 37(6) Issue: 6 Pages: 109921-109921

    • DOI

      10.1016/j.celrep.2021.109921

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epigenetic regulation of inflammation by CxxC domain‐containing proteins2021

    • Author(s)
      Onodera Atsushi、Kiuchi Masahiro、Kokubo Kota、Nakayama Toshinori
    • Journal Title

      Immunological Reviews

      Volume: 305(1) Issue: 1 Pages: 137-151

    • DOI

      10.1111/imr.13056

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 病原性Th2細胞2021

    • Author(s)
      青木 亜美、平原 潔、中山 俊憲
    • Journal Title

      アレルギー

      Volume: 70(2) Pages: 134-135

    • NAID

      130007996948

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 病原性記憶Th細胞による難治性炎症疾患の病態形成機構2021

    • Author(s)
      木内 政宏、平原 潔、中山 俊憲
    • Journal Title

      Annual Review 神経

      Volume: 2021 Pages: 38-44

    • Related Report
      2021 Annual Research Report
  • [Journal Article] マウス気管移植モデルを用いた拒絶反応におけるPD-L1の関連についての検討2021

    • Author(s)
      海寶 大輔、鈴木 秀海、松本 寛樹、豊田 行英、稲毛 輝長、田中 教久、坂入 祐一、中島 崇裕、木内 政宏、本橋 新一郎、中山 俊憲、吉野 一郎
    • Journal Title

      移植

      Volume: 56(1) Pages: 94-94

    • Related Report
      2021 Annual Research Report
  • [Journal Article] CxxCドメインを持つタンパク質によるT細胞および炎症の制御2021

    • Author(s)
      小野寺 淳、木内 政宏、中山 俊憲
    • Journal Title

      アレルギーの臨床

      Volume: 41(10) Pages: 897-901

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 病原性記憶Th2細胞による慢性気道炎症と肺線維化の病態制御2021

    • Author(s)
      岩村 千秋、中山 俊憲
    • Journal Title

      アレルギー

      Volume: 70(10) Pages: 1358-1362

    • NAID

      130008128878

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Trithorax複合体を構成するCxxc1はCD4+T細胞分化におけるepigenetic licensingをつかさどる2021

    • Author(s)
      木内 政宏、平原 潔、中山 俊憲
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 76(6) Pages: 688-693

    • NAID

      40022755458

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Memory-type pathogenic TH2 cells and ILC2s in type 2 allergic inflammation2021

    • Author(s)
      Hirahara Kiyoshi、Aoki Ami、Kiuchi Masahiro、Nakayama Toshinori
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: - Issue: 6 Pages: 2063-2066

    • DOI

      10.1016/j.jaci.2021.02.006

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathogenic helper T cells2021

    • Author(s)
      Hirahara Kiyoshi、Aoki Ami、Nakayama Toshinori
    • Journal Title

      Allergology International

      Volume: 70 Issue: 2 Pages: 169-173

    • DOI

      10.1016/j.alit.2021.02.001

    • NAID

      130008024337

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Myosin Light Chain 9/12 Regulates the Pathogenesis of Inflammatory Bowel Disease2021

    • Author(s)
      Yokoyama Masaya、Kimura Motoko Y.、Ito Toshihiro、Hayashizaki Koji、Endo Yukihiro、Wang Yangsong、Yagi Ryoji、Nakagawa Tomoo、Kato Naoya、Matsubara Hisahiro、Nakayama Toshinori
    • Journal Title

      Frontiers in Immunology

      Volume: 11

    • DOI

      10.3389/fimmu.2020.594297

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation2021

    • Author(s)
      Kiuchi Masahiro、Onodera Atsushi、Kokubo Kota、Ichikawa Tomomi、Morimoto Yuki、Kawakami Eiryo、Takayama Naoya、Eto Koji、Koseki Haruhiko、Hirahara Kiyoshi、Nakayama Toshinori
    • Journal Title

      Journal of Experimental Medicine

      Volume: 218 Issue: 4 Pages: 3-8

    • DOI

      10.1084/jem.20201690

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Eosinophils: Cells known for over 140 years with broad and new functions2021

    • Author(s)
      Aoki Ami、Hirahara Kiyoshi、Kiuchi Masahiro、Nakayama Toshinori
    • Journal Title

      Allergology International

      Volume: 70 Issue: 1 Pages: 3-8

    • DOI

      10.1016/j.alit.2020.09.002

    • NAID

      130007966778

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 病原性Th2細胞2021

    • Author(s)
      青木亜美、平原潔、中山俊憲
    • Journal Title

      アレルギ-

      Volume: 70(2) Pages: 134-135

    • NAID

      130007996948

    • Related Report
      2020 Research-status Report
  • [Journal Article] CD1d expression in glioblastoma is a promising target for NKT cell-based cancer immunotherapy2020

    • Author(s)
      Hara Ayaka、Koyama-Nasu Ryo、Takami Mariko、Toyoda Takahide、Aoki Takahiro、Ihara Fumie、Kobayashi Masayoshi、Hirono Seiichiro、Matsutani Tomoo、Nakayama Toshinori、Iwadate Yasuo、Motohashi Shinichiro
    • Journal Title

      Cancer Immunology, Immunotherapy

      Volume: - Issue: 5 Pages: 1239-1254

    • DOI

      10.1007/s00262-020-02742-1

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation2020

    • Author(s)
      Suzuki Akane S.、Yagi Ryoji、Kimura Motoko Y.、Iwamura Chiaki、Shinoda Kenta、Onodera Atsushi、Hirahara Kiyoshi、Tumes Damon J.、Koyama-Nasu Ryo、Iismaa Siiri E.、Graham Robert M.、Motohashi Shinichiro、Nakayama Toshinori
    • Journal Title

      Frontiers in Immunology

      Volume: 11 Pages: 1536-1536

    • DOI

      10.3389/fimmu.2020.01536

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activated invariant natural killer T cells directly recognize leukemia cells in a CD1d‐independent manner2020

    • Author(s)
      Aoki Takahiro、Takami Mariko、Takatani Tomozumi、Motoyoshi Kiwamu、Ishii Ayana、Hara Ayaka、Toyoda Takahide、Okada Reona、Hino Moeko、Koyama‐Nasu Ryo、Kiuchi Masahiro、Hirahara Kiyoshi、Kimura Motoko Y.、Nakayama Toshinori、Shimojo Naoki、Motohashi Shinichiro
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 7 Pages: 2223-2233

    • DOI

      10.1111/cas.14428

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation2020

    • Author(s)
      Nakayama Yukiteru、Fujiu Katsuhito、Yuki Ryuzaburo、Oishi Yumiko、Morioka Masaki Suimye、Isagawa Takayuki、Matsuda Jun、Oshima Tsukasa、Matsubara Takumi、Sugita Junichi、Kudo Fujimi、Kaneda Atsushi、Endo Yusuke、Nakayama Toshinori、Nagai Ryozo、Komuro Issei、Manabe Ichiro
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 117 Issue: 25 Pages: 14365-14375

    • DOI

      10.1073/pnas.2005924117

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 繊維化を誘導するCD4+組織常在性記憶T細胞のエピジェネティクス2020

    • Author(s)
      平原潔、木内政宏、中山俊憲
    • Journal Title

      医学のあゆみ

      Volume: 275(1) Pages: 133-137

    • Related Report
      2020 Research-status Report
  • [Journal Article] T細胞性免疫のエフェクタ-機能のメカニズム 生体防御におけるT細胞の機能2020

    • Author(s)
      中山俊憲、木村元子、八木良二
    • Journal Title

      基礎免疫学 原著第6版ー免疫系の機能とその異常

      Volume: - Pages: 111-127

    • Related Report
      2020 Research-status Report
  • [Journal Article] CD103highTreg細胞による肺繊維化抑制2020

    • Author(s)
      小久保幸太、平原潔、中山俊憲
    • Journal Title

      臨床免疫・アレルギ-科

      Volume: 74(2) Pages: 180-184

    • Related Report
      2020 Research-status Report
  • [Journal Article] 肺の組織線維化をひき起こす新たな細胞集団の同定2020

    • Author(s)
      青木亜美、平原潔、中山俊憲
    • Journal Title

      臨床免疫・アレルギ-科

      Volume: 73(6) Pages: 652-657

    • NAID

      40022265221

    • Related Report
      2020 Research-status Report
  • [Journal Article] AID (Activation-induced cytidine deaminase)2020

    • Author(s)
      木内政宏、中山俊憲
    • Journal Title

      アレルギ-用語解説シリ-ズ

      Volume: 69(3) Pages: 222-223

    • NAID

      130007845012

    • Related Report
      2020 Research-status Report
  • [Journal Article] 記憶型病原性Th2細胞とアレルギ- -好酸球浸潤から繊維化反応まで2020

    • Author(s)
      平原潔、中山俊憲
    • Journal Title

      あたらしい眼科

      Volume: 37(4) Pages: 59-59

    • Related Report
      2020 Research-status Report
  • [Journal Article] 肺における組織常在性病原性記憶T細胞と制御性T細胞2020

    • Author(s)
      平原潔、中山俊憲
    • Journal Title

      感染・炎症・免疫

      Volume: 50(1) Pages: 24-34

    • Related Report
      2020 Research-status Report
  • [Journal Article] 気管支喘息と自然炎症~病原性CD4陽性T細胞を起点とした気管支喘息重症化機構~2020

    • Author(s)
      平原潔、中山俊憲
    • Journal Title

      炎症と免疫

      Volume: 28 Pages: 77-80

    • Related Report
      2019 Annual Research Report
  • [Journal Article] CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells2019

    • Author(s)
      Ichikawa, T.*, Hirahara, K.*, Kokubo, K.*, Kiuchi, M., Aoki, A., Morimoto, Y., Kumagai, J., Onodera, A., Mato, N., Tumes, D., Goto, Y., Hagiwara, K., Inagaki, Y., Sparwasser, T., Tobe, K., and Nakayama, T.
    • Journal Title

      Nature Immunology

      Volume: 20 Issue: 11 Pages: 1469-1480

    • DOI

      10.1038/s41590-019-0494-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The immunopathology of lung fibrosis: amphiregulin-producing pathogenic memory T helper-2 cells control the airway fibrotic responses by inducing eosinophils to secrete osteopontin.2019

    • Author(s)
      Hirahara, K, Aoki, A, Morimoto, Y, Kiuchi, M, Okano, M, Nakayama, T
    • Journal Title

      Semin. Immunopathol.

      Volume: 41(3) Issue: 3 Pages: 339-348

    • DOI

      10.1007/s00281-019-00735-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)2019

    • Author(s)
      Cossarizza A,…150 authors…,Wing, JB….16 authors… Zychlinsky A
    • Journal Title

      European Journal of Immunology

      Volume: 49 Issue: 10 Pages: 1457-1973

    • DOI

      10.1002/eji.201970107

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ezh2 controls development of natural killer T cells, which cause spontaneous asthma-like pathology2019

    • Author(s)
      Tumes, D., Hirahara, K., Papadopoulos, M., Shinoda, K., Onodera, A., Kumagai, J., Yip, KH., Pant, H., Kokubo, K., Masahiro, K., Aoki, A., Obata-Ninomiya, K., Yokoyoda, K., Endo, Y., Kimura, MY., Nakayama, T.
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 0091-6749(19) Issue: 2 Pages: 30340-9

    • DOI

      10.1016/j.jaci.2019.02.024

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A new therapeutic target: the CD69-Myl9 system in immune responses2019

    • Author(s)
      Kimura Motoko Y.、Koyama-Nasu Ryo、Yagi Ryoji、Nakayama Toshinori
    • Journal Title

      Seminars in Immunopathology

      Volume: - Issue: 3 Pages: 349-358

    • DOI

      10.1007/s00281-019-00734-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 【サイトカインのすべて】免疫病とサイトカイン 各種サイトカインで誘導される2型免疫応答による組織線維化のしくみ2019

    • Author(s)
      平原 潔、中山 俊憲
    • Journal Title

      医学のあゆみ

      Volume: 271 Pages: 486-490

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 【アレルギーの分子細胞機構】エフェクター、メモリーTh2細胞の誘導と維持のエピジェネティクス2019

    • Author(s)
      小久保 幸太、小野寺 淳、中山 俊憲
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 72 Pages: 117-121

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 【新時代が始まった-アレルギー疾患研究 疾患多様性を理解し病態の層別化に基づく治療を実現する】(第1章)アレルギーのメカニズム研究 免疫細胞とサイトカインなど アレルギー性気道炎症の病態形成におけるPathogenic Th2細胞の多様な役割2019

    • Author(s)
      青木 亜美、平原 潔、中山 俊憲
    • Journal Title

      実験医学

      Volume: 37 Pages: 1561-1566

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 専門医のためのアレルギー学講座 免疫学における基礎と新たな展開 病原性Th細胞2019

    • Author(s)
      森本 侑樹、平原 潔、中山 俊憲
    • Journal Title

      アレルギー

      Volume: 68 Pages: 138-143

    • Related Report
      2019 Annual Research Report
  • [Journal Article] ACC1 determines memory potential of individual CD4+ T cells by regulating de novo fatty acid biosynthesis2019

    • Author(s)
      Yusuke Endo, Atsushi Onodera, Kazushige Obata-Ninomiya, Ryo Koyama-Nasu, Hikari K. Asou, Toshihiro Ito, Takeshi Yamamoto, Toshio Kanno, Takahiro Nakajima, Kenji Ishiwata, Hirotaka Kanuka, Damon J. Tumes, Toshinori Nakayama
    • Journal Title

      Nature Metabolism

      Volume: 1(2) Issue: 2 Pages: 261-275

    • DOI

      10.1038/s42255-018-0025-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] An Optimized protocol for the analysis of House dust mites (Dermatophagoides farinae) induced neutrophil-dominant airway inflammation with fibrosis2019

    • Author(s)
      Wada, T., Hirahara, K., Aoki, A., Morimoto, Y., Kiuchi, M., Kumagai, J., Okano, M., Kokubo, K., Kato, M., Fukano, C., Ohashi-Doi, K., and Nakayama, T.
    • Journal Title

      J. Immunol. Methods

      Volume: 465 Pages: 53-60

    • DOI

      10.1016/j.jim.2018.12.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic and Transcriptional Regulation in the Induction, Maintenance, Heterogeneity, and Recall-Response of Effector and Memory Th2 Cells2018

    • Author(s)
      Onodera A, Kokubo K, Nakayama T
    • Journal Title

      Front Immunol.

      Volume: 9 Pages: 2929-2929

    • DOI

      10.3389/fimmu.2018.02929

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crucial role of CD69 in anti-tumor immunity through regulating the exhaustion of tumor-infiltrating T cells2018

    • Author(s)
      Mita Y, Kimura MY, Hayashizaki K, Koyama-Nasu R, Ito T, Motohashi S, Okamoto Y & Nakayama T
    • Journal Title

      International Immunology

      Volume: 30 Issue: 12 Pages: 559-567

    • DOI

      10.1093/intimm/dxy050

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells2018

    • Author(s)
      Yamamoto, T., Endo, Y., Onodera, A., Hirahara, K., Asou, H., Nakajima, T., Kanno, T., Ouchi, Y., Uematsu, S., Nishimasu, H., Nureki, O., Tumes, D. J., Shimojo, N., and Nakayama, T.
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 4231-4231

    • DOI

      10.1038/s41467-018-06468-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CXCR6+ST2+ memory T helper 2 cells induced the expression of major basic protein in eosinophils to reduce the fecundity of helminth2018

    • Author(s)
      Obata-Ninomiya, K., Ishiwata, K., Nakano, H., Endo, Y., Ichikawa, T., Onodera, A., Hirahara, K., Okamoto, Y., Kanuka, H., Nakayama, T.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 115 Issue: 42

    • DOI

      10.1073/pnas.1714731115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Maintenance of memory-type pathogenic Th2 cells in the pathophysiology of chronic inflammation2018

    • Author(s)
      Hirahara, K., Shinoda, K., Endo, Y., Ichikawa, T., and Nakayama, T
    • Journal Title

      Inflammation and Regeneration

      Volume: 38 Issue: 1 Pages: 10-10

    • DOI

      10.1186/s41232-018-0067-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The pathogenicity of IL-33 on steroid-resistant eosinophilic inflammation via the activation of memory-type ST2+CD4+ T cells.2018

    • Author(s)
      Hirahara K*, Mato N*, Hagiwara K, Nakayama T. (*: These authors are equally contributed.)
    • Journal Title

      Journal of Leukocyte Biology

      Volume: 104 Issue: 5 Pages: 895-901

    • DOI

      10.1002/jlb.mr1117-456r

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD69 prevents PLZFhi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation2018

    • Author(s)
      Kimura Motoko Y.、Igi Akemi、Hayashizaki Koji、Mita Yukiyoshi、Shinzawa Miho、Kadakia Tejas、Endo Yukihiro、Ogawa Satomi、Yagi Ryoji、Motohashi Shinichiro、Singer Alfred、Nakayama Toshinori
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 3749-3749

    • DOI

      10.1038/s41467-018-06283-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of CD1d- and MR1-Restricted T Cells in Asthma2018

    • Author(s)
      Iwamura Chiaki、Nakayama Toshinori
    • Journal Title

      Frontiers in Immunology

      Volume: 9 Pages: 1942-1942

    • DOI

      10.3389/fimmu.2018.01942

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Amphiregulin-Producing Pathogenic Memory T Helper 2 Cells Instruct Eosinophils to Secrete Osteopontin and Facilitate Airway Fibrosis2018

    • Author(s)
      Morimoto, Y., Hirahara, K., Kiuchi, M., Wada, T., Ichikawa, T., Kanno, T., Okano, M., Kokubo, K., Onodera, A., Sakurai, D., Okamoto, Y., Nakayama, T.
    • Journal Title

      Immunity

      Volume: 49 Issue: 1 Pages: 134-150

    • DOI

      10.1016/j.immuni.2018.04.023

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 病原性Th2細胞による慢性アレルギ-性気道炎症の病態形成と制御2021

    • Author(s)
      中山 俊憲
    • Organizer
      千里ライフサイエンスセミナ-SO 獲得免疫と自然免疫の双方から捉える新しいアレルギ-学
    • Related Report
      2021 Annual Research Report
  • [Presentation] Memory-type pathogenic Th2 (Tpath2) cells in airway inflammation2021

    • Author(s)
      Nakayama Toshinori
    • Organizer
      5th Symposium of the International Immunological Memory and Vaccine Forum, Educating the immune system: good and bad memory
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Trithorax Cxxc1-directed epigenetic machinery licensing CD4+ T cell differentiation2021

    • Author(s)
      Kiuchi Masahiro, Onodera Atsushi, Kokubo Kota, Ichikawa Tomomi, Kawakami Eiryo, Takayama Naoya, Eto Koji, Koseki Haruhiko, Hirahara Kiyoshi, Nakayama Toshinori
    • Organizer
      第85回 日本インターフェロン・サイトカイン学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 病原性記憶Th2細胞による慢性炎症の病態形成と制御2021

    • Author(s)
      中山 俊憲
    • Organizer
      第32回日本生体防御学会学術総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Memory-type pathogenic Th2 (Tpath2) cells in the pathogenesis of chronic airway inflammation2021

    • Author(s)
      Nakayama Toshinori
    • Organizer
      第19回あわじ感染と免疫国際フォ-ラム
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 病原性Th2細胞による難治性アレルギ-性気道炎症の病態制御2021

    • Author(s)
      中山 俊憲、市川 智巳、小久保 幸太、木内 政宏、青木 亜美、平原 潔
    • Organizer
      第70回日本アレルギ-学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 病原性ヘルパー細胞によるアレルギ-性炎症の難治性病態形成機構について2021

    • Author(s)
      平原 潔、中山 俊憲
    • Organizer
      第70回日本アレルギ-学会学術大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 慢性アレルギ-性結膜炎におけるIL-33-ST2-CGRP経路を介した記憶型Th2細胞の役割2021

    • Author(s)
      横山 美樹子、尾上 美樹、木内 政宏、平原 潔、池原 譲、海老原 伸行、中山 俊憲
    • Organizer
      第70回日本アレルギ-学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ベンラリズマブによる好酸球性炎症組織局所での抗体依存性細胞傷害活性についての検討2021

    • Author(s)
      青木 亜美、辻 香織、小久保 幸太、木内 政宏、平原 潔、中山 俊憲
    • Organizer
      第70回日本アレルギ-学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Memory-type pathogenic Th2 (Tpath2) cells in airway inflammation2021

    • Author(s)
      Nakayama Toshinori
    • Organizer
      FIMSA 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation2021

    • Author(s)
      Kiuchi Masahiro, Onodera Atsushi, Kokubo Kota, Kawakami Eiryo, Koseki Haruhiko, Hirahara Kiyoshi, Nakayama Toshinori
    • Organizer
      第50回 日本免疫学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 病原性ヘルパ-T細胞による慢性炎症の病態形成2021

    • Author(s)
      中山俊憲
    • Organizer
      第1433回千葉医学会例会 千葉大学大学院医学研究院 消化器内科学例会 WEB開催
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 病原性Th2細胞による慢性気道炎症と肺線維化の病態制御2020

    • Author(s)
      中山俊憲
    • Organizer
      第69回日本アレルギ-学会学術大会 WEB開催
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 病原性Th2細胞による慢性難治性気道炎症の病態形成と制御2020

    • Author(s)
      中山俊憲
    • Organizer
      千里ライフサイエンス新適塾「難病への挑戦」第43回会合
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 病原性Th2細胞によるアレルギー性気道炎症の病態形成と制御2020

    • Author(s)
      中山俊憲
    • Organizer
      第3回日本アレルギー学会関東地方会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Th2細胞とアレルギー2020

    • Author(s)
      中山俊憲
    • Organizer
      第6回アレルギー講習会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Memory-type pathogenic Th2 (Tpath2) cells in airway inflammation2019

    • Author(s)
      Nakayama T
    • Organizer
      48th Annual Scientific Meeting of The Australian and New Zealand Society for Immunology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 病原性Th2細胞による喘息の発症と線維化の最新知見2019

    • Author(s)
      中山俊憲
    • Organizer
      第15回山梨アレルギー研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 病原性Th2細胞によるアレルギー性炎症発症とその制御2019

    • Author(s)
      中山俊憲
    • Organizer
      第2回日本眼科アレルギ-学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 病原性Th2細胞によるアレルギー性炎症誘導とその制御2019

    • Author(s)
      中山俊憲
    • Organizer
      第17回高知眼炎症研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Pathogenic Th2 (Tpath2) cells in airway inflammation: Fibrosis inducing Tpath2 cells2019

    • Author(s)
      Nakayama T
    • Organizer
      6th Pediatric Allergy and Asthma Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pathogenic tissue resident CD4 T cells in lung fibrosis2019

    • Author(s)
      Nakayama T
    • Organizer
      9th International Conference on Autoimmunity
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 記憶型病原性Th2細胞によるアレルギー性気道炎症制御2019

    • Author(s)
      中山俊憲
    • Organizer
      アレルギー・好酸球研究会2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 病原性記憶Th細胞による難治性炎症疾患の病態制御2019

    • Author(s)
      中山俊憲
    • Organizer
      第31回日本神経免疫学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] IL-25, 33, TSLP2019

    • Author(s)
      中山俊憲
    • Organizer
      第39回六甲カンファレンス
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 病原性Th2細胞による慢性炎症制御2019

    • Author(s)
      中山俊憲
    • Organizer
      第43回日本小児皮膚科学会学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 記憶型病原性Th2細胞によるアレルギ-性気道炎症の発症と線維化誘導2019

    • Author(s)
      中山俊憲
    • Organizer
      第40回日本炎症・再生医学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 病原性Th2細胞による喘息の発症と線維化の最新知見2019

    • Author(s)
      中山俊憲
    • Organizer
      Asthma Seminar for emerging talents
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Pathogenic Th2 (Tpath2) Cells in Airway Inflammation: Fibrosis-Inducing Tpath2 Cells.2019

    • Author(s)
      Nakayama, T
    • Organizer
      Origins of Allergic Disease: Microbial, Epithelial and Immune Interactions, Keystone Symposia on Molecular and Cellular Biology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 病原性Th細胞 講義 ~Total Allergistをめざして~2018

    • Author(s)
      中山俊憲
    • Organizer
      第5回総合アレルギ-講習会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Epigenetics in the induction and maintenance of effector and memory Th2 cells.2018

    • Author(s)
      中山俊憲
    • Organizer
      第47回日本免疫学会総会・学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 病原性T細胞による慢性気道炎症制御2018

    • Author(s)
      中山俊憲
    • Organizer
      骨・免疫・内分泌代謝 Expert Meeting
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 感染症とアレルギ-疾患の病態制御2018

    • Author(s)
      中山俊憲
    • Organizer
      第50回日本小児感染症学会総会・学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Pathogenic Th2 (Tpath2) cells in airway inflammation: Fibrosis inducing Tpath2 cells.2018

    • Author(s)
      Nakayama, T
    • Organizer
      32nd Symposium of the Collegium Internationale Allergologium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アレルギ-病態と病原性記憶Th2細胞2018

    • Author(s)
      中山俊憲
    • Organizer
      第1回日本眼科アレルギ-学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] アレルギ-性気道炎症とiBALT2018

    • Author(s)
      中山俊憲
    • Organizer
      第39回日本炎症・再生医学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 自然免疫と獲得免疫:アレルギ-性気道炎症の病態制御機構2018

    • Author(s)
      中山俊憲
    • Organizer
      第39回日本炎症・再生医学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Pathogenic Th2 (Tpath2) cells in airway inflammation: Fibrosis inducing Tpath2 cells.2018

    • Author(s)
      Nakayama, T
    • Organizer
      Immunochemistry and Immunobiology Gordon Research Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Remarks] 千葉大学大学院医学研究院 免疫発生学HP

    • URL

      https://www.m.chiba-u.ac.jp/class/meneki/jisseki/index.html

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
  • [Remarks] 千葉大学大学院医学研究院 免疫発生学

    • URL

      https://www.m.chiba-u.ac.jp/class/meneki/jisseki/index.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 千葉大学大学院医学研究院 免疫発生学ホームページ

    • URL

      http://www.m.chiba-u.ac.jp/class/meneki/member/member_nakayama_more.html

    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] COVID-19に罹患しているか、もしくはCOVID-19に罹患しているリスクがあるかを検出するための方法、又は重症化を判定するための方法2021

    • Inventor(s)
      中山俊憲、平原潔、木村元子、岩村千秋
    • Industrial Property Rights Holder
      千葉大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-098843
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report

URL: 

Published: 2018-07-20   Modified: 2024-03-26  

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