βグルカンによるDNA２重らせんの裂開メカニズムなど：化学的量子状態間の転移挙動

• Project/Area Number: 20K20449
• Project/Area Number (Other): 19H05531 (2019)
• Research Category: Grant-in-Aid for Challenging Research (Pioneering)
• Allocation Type: Multi-year Fund (2020); Single-year Grants (2019)
• Review Section: Medium-sized Section 35:Polymers, organic materials, and related fields
• Research Institution: The University of Kitakyushu
• Principal Investigator: 櫻井 和朗 北九州市立大学, 環境技術研究所, 教授 (70343431)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000); Fiscal Year 2022: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2021: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2020: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2019: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
• Keywords: 化学的量状態 / 多糖核酸複合体 / 小角X線散乱 / プラトニックミセル / 化学的量子状態

Outline of Research at the Start

ある特定の構造のみが安定な分子集合体では熱による構造揺らぎが極めて小さくなり、化学的な量子状態と言える。このような状態から他の状態への転移では異常な現象が観測される。例えば、我々が発見したプラトニックミセルでは、会合数が１２と２０しか許されないため、１２から２０への転移は長い誘導期とそれに続くシグモイド変化が観測されている。これは会合数が逐次的かつ指数関数的に増加してく通常のミセルの変化とは対照的である。本研究ではこのような化学的量子状態間の転移に関して、その分子論的なメカニズムを解明し、新しいサイエンスの領域を開拓する。

Outline of Annual Research Achievements

本研究は、化学的量子状態間の転移に関する理論と実験の進展を目指すものであった。具体的には、外部要素の変化によって状態Aから状態Bに変化する化学状態の転移を詳細に観察し、そのダイナミクスを理論的に解明することを目指した。本研究では、プラトニックミセルと多糖核酸複合体系を対象とし、これらの化学的量子状態間の転移を詳細に調査した。プラトニックミセルの形成ダイナミクスについては、時間分解放射光X線散乱法を用いて詳細に調査し、ミセル形成の時間依存性を明らかにした。また、塩濃度や温度の変化による影響も観察した。さらには、ミセルの形成過程に関する理論モデルを構築し、ユニマー交換やミセル融合を考慮に入れた動力学モデルを提案した。一方、多糖核酸複合体系についても同様の方法で調査を行い、DNAの２重鎖の鎖交換反応を中心に観察した。その結果、DNAの塩基数に応じて結合する多糖の長さが存在することを発見した。さらに、アクリル酸のラジカル重合において、特殊な溶媒で沈殿重合を行うと、極めて分布がせまい粒子が形成することを見出した。

Research Products

• [Journal Article] Protective effects of alpha-mangostin encapsulated in cyclodextrin-nanoparticle on cerebral ischemia (2023)
  • Author(s): Oka Natsumi、Doan Van Thi Hong、Matsubara Hirofumi、Imai Takahiko、Yoshioka Yukie、Katsuki Jun、Fujii Shota、Nakamura Shinsuke、Shimazawa Masamitsu、Hara Hideaki、Sakurai Kazuo
  • Journal Title: Journal of Controlled Release Volume: 353 Pages: 216-228
  • DOI: 10.1016/j.jconrel.2022.11.030
  • Peer Reviewed
• [Journal Article] Molecular Bottlebrushes for Immunostimulatory CpG ODN Delivery: Relationship among Cation Density, Complex Formation Ability, and Cytotoxicity (2023)
  • Author(s): Takano Shin、Miyashima Yusuke、Fujii Shota、Sakurai Kazuo
  • Journal Title: Biomacromolecules Volume: 24 Issue: 3 Pages: 1299-1309
  • DOI: 10.1021/acs.biomac.2c01348
  • Peer Reviewed
• [Journal Article] A surprisingly narrow particle size distribution for polyacrylic acid nanospheres produced by precipitation polymerization and revealed by small-angle X-ray scattering (2023)
  • Author(s): Takano Shin、Ono Ryohei、Sakurai Kazuo
  • Journal Title: Polymer Journal Volume: 55 Issue: 12 Pages: 1387-1391
  • DOI: 10.1038/s41428-023-00836-y
  • Peer Reviewed
• [Journal Article] Structural analysis of polysaccharide/antisense DNA complexes during cytoplasmic target mRNA hybridization (2023)
  • Author(s): Sumiya Kazuki、Izumi Hiroto、Sakurai Kazuo
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 94 Pages: 129457-129457
  • DOI: 10.1016/j.bmcl.2023.129457
  • Peer Reviewed
• [Journal Article] Enhanced Therapeutic Efficacy of Immunostimulatory CpG-ODN by Silencing SOCS-1 with Polysaccharide/miR-155 Complexes (2023)
  • Author(s): Sumiya Kazuki、Izumi Hiroto、Sakurai Kazuo
  • Journal Title: ACS Applied Bio Materials Volume: 6 Issue: 2 Pages: 774-783
  • DOI: 10.1021/acsabm.2c00963
  • Peer Reviewed
• [Journal Article] Binding assay of human Dectin-1 variants for DNA/ β-glucan complex for active-targeting delivery of antisense DNA: Part II (2023)
  • Author(s): Sumiya Kazuki、Izumi Hiroto、Adachi Yoshiyuki、Mochizuki Shinichi、Sakurai Kazuo
  • Journal Title: Carbohydrate Research Volume: 523 Pages: 108731-108731
  • DOI: 10.1016/j.carres.2022.108731
  • Peer Reviewed / Open Access
• [Journal Article] Correction: Lung disorders induced by respirable organic chemicals [J Occup Health. 2021;63:e12240] (2023)
  • Author(s): Morimoto, Y.; Nishida, C.; Tomonaga, T.; Izumi, H.; Yatera, K.; Sakurai, K.; Kim, Y.
  • Journal Title: Journal of Occupational Health Volume: 65 Issue: 1 Pages: n/a
  • DOI: 10.1002/1348-9585.12384
  • ISSN: 1341-9145, 1348-9585
  • Peer Reviewed
• [Journal Article] A Thermo-Responsive Polymer Micelle with a Liquid Crystalline Core (2023)
  • Author(s): Mizoue Yoko、Takahashi Rintaro、Sakurai Kazuo、Yusa Shin-ichi
  • Journal Title: Polymers Volume: 15 Issue: 3 Pages: 770-770
  • DOI: 10.3390/polym15030770
  • Peer Reviewed / Open Access
• [Journal Article] β-1,3-d-glucan lentinan/Poly-dA40 triple-helical complex in dilute solutions (2023)
  • Author(s): Matsunaga Takuya、Sumiya Kazuki、Tanaka Motoko、Mochizuki Shinichi、Sakurai Kazuo
  • Journal Title: Polymer Journal Volume: 56 Issue: 1 Pages: 43-54
  • DOI: 10.1038/s41428-023-00839-9
  • Peer Reviewed
• [Journal Article] Determining the critical quality attribute for the delivery of α?mangostin by β?cyclodextrin-based nanoparticles in cancer treatment (2023)
  • Author(s): Doan Van Thi Hong、Katsuki Jun、Takano Shin、Nguyen Phuong Thi Mai、Nguyen Van Anh Thi、Pham Huong Thi Thu、Fujii Shota、Sakurai Kazuo
  • Journal Title: Polymer Journal Volume: 55 Issue: 12 Pages: 1367-1378
  • DOI: 10.1038/s41428-023-00813-5
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dramatically Increased Binding Constant of Water-Soluble Cyclodextrin Hyperbranched Polymers: Explored with Diffusion Ordered NMR Spectroscopy (DOSY) (2022)
  • Author(s): Doan Anh Thi Ngoc、Doan Van Thi Hong、Katsuki Jun、Fujii Shota、Kono Hiroyuki、Sakurai Kazuo
  • Journal Title: ACS Omega Volume: 7 Issue: 13 Pages: 10890-10900
  • DOI: 10.1021/acsomega.1c06194
  • Peer Reviewed
• [Journal Article] Delivery of therapeutic oligonucleotides targeting Dectin-1 using quantized complexes (2022)
  • Author(s): Sumiya Kazuki、Izumi Hiroto、Matsunaga Takuya、Tanaka Motoko、Sakurai Kazuo
  • Journal Title: Polymer Journal Volume: 54 Issue: 4 Pages: 591-601
  • DOI: 10.1038/s41428-021-00595-8
  • Peer Reviewed
• [Journal Article] Impact of Zwitterionic Polymers on the Tumor Permeability of Molecular Bottlebrush-Based Nanoparticles (2022)
  • Author(s): Fujii Shota、Takano Shin、Nakazawa Kohji、Sakurai Kazuo
  • Journal Title: Biomacromolecules Volume: in press Issue: 7 Pages: 2846-2855
  • DOI: 10.1021/acs.biomac.2c00216
  • Peer Reviewed
• [Journal Article] Inflammogenic effect of polyacrylic acid in rat lung following intratracheal instillation (2022)
  • Author(s): Nishida Chinatsu、Tomonaga Taisuke、Izumi Hiroto、Wang Ke-Yong、Higashi Hidenori、Ishidao Toru、Takeshita Jun-ichi、Ono Ryohei、Sumiya Kazuki、Fujii Shota、Mochizuki Shinichi、Sakurai Kazuo、Yamasaki Kei、Yatera Kazuhiro、Morimoto Yasuo
  • Journal Title: Particle and Fibre Toxicology Volume: 19 Issue: 1 Pages: 1-17
  • DOI: 10.1186/s12989-022-00448-z
  • Peer Reviewed
• [Journal Article] Impact of Polyethylene Glycol (PEG) Conformations on the <i>In Vivo</i> Fate and Drug Release Behavior of PEGylated Core-Cross-Linked Polymeric Nanoparticles (2022)
  • Author(s): Kanamaru Takuma、Sakurai Kazuo、Fujii Shota
  • Journal Title: Biomacromolecules Volume: 23 Issue: 9 Pages: 3909-3918
  • DOI: 10.1021/acs.biomac.2c00730
  • Peer Reviewed
• [Journal Article] Zwitterionic Amino Acid Polymer-Grafted Core-Crosslinked Particle toward Tumor Delivery (2022)
  • Author(s): Fujii Shota、Sakurai Kazuo
  • Journal Title: Biomacromolecules Volume: 23 Issue: 9 Pages: 3968-3977
  • DOI: 10.1021/acs.biomac.2c00803
  • Peer Reviewed
• [Journal Article] Effect of Different Molecular Weights of Polyacrylic Acid on Rat Lung Following Intratracheal Instillation (2022)
  • Author(s): Nishida Chinatsu、Izumi Hiroto、Tomonaga Taisuke、Wang Ke-Yong、Higashi Hidenori、Takeshita Jun-Ichi、Ono Ryohei、Sumiya Kazuki、Fujii Shota、Hata Yuki、Sakurai Kazuo、Higashi Yasuyuki、Yamasaki Kei、Yatera Kazuhiro、Morimoto Yasuo
  • Journal Title: International Journal of Molecular Sciences Volume: 23 Issue: 18 Pages: 10345-10345
  • DOI: 10.3390/ijms231810345
  • Peer Reviewed / Open Access
• [Journal Article] Crosslinked Structure of Polyacrylic Acid Affects Pulmonary Fibrogenicity in Rats (2022)
  • Author(s): Tomonaga Taisuke、Nishida Chinatsu、Izumi Hiroto、Kawai Naoki、Wang Ke-Yong、Higashi Hidenori、Takeshita Jun-Ichi、Ono Ryohei、Sumiya Kazuki、Fujii Shota、Hata Yuki、Sakurai Kazuo、Morimoto Toshiki、Higashi Yasuyuki、Yamasaki Kei、Yatera Kazuhiro、Morimoto Yasuo
  • Journal Title: International Journal of Molecular Sciences Volume: 23 Issue: 22 Pages: 13870-13870
  • DOI: 10.3390/ijms232213870
  • Peer Reviewed / Open Access
• [Journal Article] Antisense DNA cocktail therapy using short ?-1,3-glucan/oligonucleotide complexes (2022)
  • Author(s): Hata Yuki、Sumiya Kazuki、Izumi Hiroto、Sakurai Kazuo
  • Journal Title: Polymer Journal Volume: 55 Issue: 3 Pages: 283-288
  • DOI: 10.1038/s41428-022-00720-1
  • Peer Reviewed
• [Journal Article] Enhanced In-vitro Efficacy of Antisense Delivery by Use of Low-molecular Weight Polysaccharide/DNA Complex (2021)
  • Author(s): Sumiya Kazuki、Izumi Hiroto、Mochizuki Shinichi、Sakurai Kazuo
  • Journal Title: Chemistry Letters Volume: 50 Issue: 6 Pages: 1191-1193
  • DOI: 10.1246/cl.210058
  • NAID: 130008053413
  • Peer Reviewed
• [Journal Article] First Observation of the Hydration Layer around Polymer Chain by Scattering and Its Relationship to Thromboresistance: Dilute Solution Properties of PMEA in THF/Water (2021)
  • Author(s): Kanamaru Takuma、Araki Masataka、Takahashi Rintaro、Fujii Shota、Shikata Toshiyuki、Murakami Daiki、Tanaka Masaru、Sakurai Kazuo
  • Journal Title: The Journal of Physical Chemistry B Volume: 125 Issue: 26 Pages: 7251-7261
  • DOI: 10.1021/acs.jpcb.1c01864
  • Peer Reviewed / Open Access
• [Journal Article] Weak Interplay between Hydrophobic Part of Water-soluble Polymers and Serum Protein (2021)
  • Author(s): Takano Shin、Islam Waliul、Fujii Shota、Maeda Hiroshi、Sakurai Kazuo
  • Journal Title: Chemistry Letters Volume: 50 Issue: 7 Pages: 1392-1393
  • DOI: 10.1246/cl.210156
  • NAID: 130008065522
  • Peer Reviewed
• [Journal Article] Binding assay of human Dectin-1 variants to DNA/β-glucan complex for active-targeting delivery of antisense DNA (2021)
  • Author(s): Fujiwara Nobuaki、Izumi Hiroto、Kira Ryoma、Morimoto Yasuo、Mochizuki Shinichi、Sakurai Kazuo
  • Journal Title: Carbohydrate Research Volume: 500 Pages: 108219-108219
  • DOI: 10.1016/j.carres.2020.108219
  • Peer Reviewed
• [Journal Article] Characterizing block-copolymer micelles used in nanomedicines via solution static scattering techniques (2021)
  • Author(s): Akiba Isamu、Sakurai Kazuo
  • Journal Title: Polymer Journal Volume: 53 Issue: 9 Pages: 951-973
  • DOI: 10.1038/s41428-021-00489-9
  • Peer Reviewed
• [Journal Article] Polymer Micelles Composed of Molecular‐Bottlebrush‐Based Surfactants: Precisely Controlling Aggregation Number Corresponding to Polyhedral Structures (2021)
  • Author(s): Fujii Shota、Eichhorn Jonas、Schacher Felix H.、Brendel Johannes C.、Sakurai Kazuo
  • Journal Title: Macromolecular Rapid Communications Volume: 42 Issue: 16 Pages: 2100285-2100285
  • DOI: 10.1002/marc.202100285
  • Peer Reviewed
• [Journal Article] Manipulating the Morphology of Amphiphilic Graft-Copolymer Assemblies by Adjusting the Flexibility of the Main Chain (2021)
  • Author(s): Nishimura Tomoki、Fujii Shota、Sakurai Kazuo、Sasaki Yoshihiro、Akiyoshi Kazunari
  • Journal Title: Macromolecules Volume: 54 Issue: 14 Pages: 7003-7009
  • DOI: 10.1021/acs.macromol.1c01030
  • Peer Reviewed
• [Journal Article] Structural Analysis of an Octameric Resorcinarene Self-Assembly in Toluene and its Morphological Transition by Temperature (2021)
  • Author(s): Fujii Shota、Sakurai Kazuo
  • Journal Title: The Journal of Physical Chemistry Letters Volume: 12 Issue: 28 Pages: 6464-6468
  • DOI: 10.1021/acs.jpclett.1c01978
  • Peer Reviewed
• [Journal Article] β-1.3 Glucan Complex Drastically Suppresses Kidney Clearance of siRNA (2021)
  • Author(s): Uno Atsushi、Arima Kenji、Ushida Maki、Katayama Yuka、Shimazaki Masako、Amano Kanako、Namikawa Reiko、Sakurai Kazuo
  • Journal Title: Chemistry Letters Volume: 50 Issue: 10 Pages: 1778-1780
  • DOI: 10.1246/cl.210334
  • NAID: 130008101944
  • Peer Reviewed
• [Journal Article] A novel β-glucan?oligonucleotide complex selectively delivers siRNA to APCs via Dectin-1 (2021)
  • Author(s): Uno Atsushi、Arima Kenji、Shimazaki Masako、Ushida Maki、Amano Kanako、Namikawa Reiko、Sakurai Kazuo
  • Journal Title: Journal of Controlled Release Volume: 338 Pages: 792-803
  • DOI: 10.1016/j.jconrel.2021.09.011
  • Peer Reviewed
• [Journal Article] Internalization into cancer cells of zwitterionic amino acid polymers <i>via</i> amino acid transporter recognition (2021)
  • Author(s): Takano Shin、Sakurai Kazuo、Fujii Shota
  • Journal Title: Polymer Chemistry Volume: 12 Issue: 42 Pages: 6083-6087
  • DOI: 10.1039/d1py01010g
  • Peer Reviewed
• [Journal Article] Unraveling Decisive Structural Parameters for the Self-Assembly of Supramolecular Polymer Bottlebrushes Based on Benzene Trisureas (2020)
  • Author(s): Gruschwitz Franka V.、Fu Mao-Chun、Klein Tobias、Takahashi Rintaro、Higashihara Tomoya、Hoeppener Stephanie、Nischang Ivo、Sakurai Kazuo、Brendel Johannes C.
  • Journal Title: Macromolecules Volume: 53 Issue: 17 Pages: 7552-7560
  • DOI: 10.1021/acs.macromol.0c01361
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Induction of potent cell growth inhibition by schizophyllan/K-ras antisense complex in combination with gemcitabine (2020)
  • Author(s): Sasaki Shogo、Izumi Hiroto、Morimoto Yasuo、Sakurai Kazuo、Mochizuki Shinichi
  • Journal Title: Bioorganic & Medicinal Chemistry Volume: 28 Issue: 18 Pages: 115668-115668
  • DOI: 10.1016/j.bmc.2020.115668
  • Peer Reviewed
• [Journal Article] Scattering Form Factor of Block Copolymer Micelles with Corona Chains Discretely Distributed on the Core Surface (2020)
  • Author(s): Takahashi Rintaro、Fujii Shota、Akiba Isamu、Sakurai Kazuo
  • Journal Title: The Journal of Physical Chemistry B Volume: 124 Issue: 28 Pages: 6140-6146
  • DOI: 10.1021/acs.jpcb.0c04120
  • Peer Reviewed
• [Journal Article] Monodisperse Micelles with Aggregation Numbers Related to Platonic Solids (2020)
  • Author(s): Lee Ji Ha、Fujii Shota、Takahashi Rintaro、Sakurai Kazuo
  • Journal Title: Macromolecular Rapid Communications Volume: 41 Issue: 18 Pages: 2000227-2000227
  • DOI: 10.1002/marc.202000227
  • Peer Reviewed
• [Journal Article] Synthesis and characterization of nanoemulsion-mediated core crosslinked nanoparticles, and in vivo pharmacokinetics depending on the structural characteristics (2020)
  • Author(s): Matsuno Jun、Kanamaru Takuma、Arai Koichi、Tanaka Rena、Lee Ji Ha、Takahashi Rintaro、Sakurai Kazuo、Fujii Shota
  • Journal Title: Journal of Controlled Release Volume: 324 Pages: 405-412
  • DOI: 10.1016/j.jconrel.2020.05.035
  • Peer Reviewed
• [Journal Article] Structural Polymorphism of Resorcinarene Assemblies (2020)
  • Author(s): Fujii Shota、Miyake Rika、Campo Liliana de、Lee Ji Ha、Takahashi Rintaro、Sakurai Kazuo
  • Journal Title: Langmuir Volume: in press Issue: 22 Pages: 6222-6227
  • DOI: 10.1021/acs.langmuir.0c00861
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Bundling Process of Citrulline Polypeptides upon UCST-Type Phase Separation (2020)
  • Author(s): Fujii Shota、Kuroyanagi Sotaro、Shimada Naohiko、Matsuno Jun、Lee Ji Ha、Takahashi Rintaro、Maruyama Atsushi、Sakurai Kazuo
  • Journal Title: The Journal of Physical Chemistry B Volume: 124 Issue: 20 Pages: 4036-4043
  • DOI: 10.1021/acs.jpcb.0c00934
  • Peer Reviewed
• [Journal Article] Furry nanoparticles: synthesis and characterization of nanoemulsion-mediated core crosslinked nanoparticles and their robust stability in vivo (2020)
  • Author(s): Tanaka Rena、Arai Koichi、Matsuno Jun、Soejima Miyo、Lee Ji Ha、Takahashi Rintaro、Sakurai Kazuo、Fujii Shota
  • Journal Title: Polymer Chemistry Volume: 11 Issue: 27 Pages: 4408-4416
  • DOI: 10.1039/d0py00610f
  • Peer Reviewed
• [Journal Article] Enhanced Binding Constant of Cyclodextrin to Alpha-mangostin in Hyperbranched Polymers (2020)
  • Author(s): Van Doan Thi Hong、Anh Doan Thi Ngoc、Fujii Shota、Sakurai Kazuo
  • Journal Title: Chemistry Letters Volume: 49 Issue: 10 Pages: 1144-1146
  • DOI: 10.1246/cl.200210
  • NAID: 130007923149
  • Peer Reviewed
• [Journal Article] Polymersome formation induced by encapsulation of water-insoluble molecules within ABC triblock terpolymers (2020)
  • Author(s): Takahashi Rintaro、Miwa Shotaro、Rossel Carsten、Fujii Shota、Lee Ji Ha、Schacher Felix H.、Sakurai Kazuo
  • Journal Title: Polymer Chemistry Volume: 11 Issue: 20 Pages: 3446-3452
  • DOI: 10.1039/d0py00426j
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Synthesis and Dilute Solution Properties of <i>N</i>-(2-Hydroxypropyl) methacrylamide-Based Copolymers (2020)
  • Author(s): Doi Kiyomasa、Takahashi Rintaro、Fujii Shota、Sakurai Kazuo
  • Journal Title: Journal of Fiber Science and Technology Volume: 76 Issue: 9 Pages: 305-309
  • DOI: 10.2115/fiberst.2020-0033
  • NAID: 130007922388
  • Peer Reviewed
• [Journal Article] Flower Necklaces of Controllable Length Formed From N-(2-Hydroxypropyl) Methacrylamide-Based Amphiphilic Statistical Copolymers (2020)
  • Author(s): Takahashi Rintaro、Doi Kiyomasa、Fujii Shota、Sakurai Kazuo
  • Journal Title: Langmuir Volume: 36 Issue: 39 Pages: 11556-11563
  • DOI: 10.1021/acs.langmuir.0c02032
  • Peer Reviewed
• [Journal Article] Characterizing an siRNA-Containing Lipid-Nanoparticle Prepared by a Microfluidic Reactor: Small-Angle X-ray Scattering and Cryotransmission Electron Microscopic Studies (2020)
  • Author(s): Aburai Kenichi、Hatanaka Kentaro、Takano Shin、Fujii Shota、Sakurai Kazuo
  • Journal Title: Langmuir Volume: 36 Issue: 42 Pages: 12545-12554
  • DOI: 10.1021/acs.langmuir.0c01079
  • Peer Reviewed
• [Journal Article] Oligo-DNA Stoichiometrically Binds β-1,3-Glucan with the Best Fit Length (2020)
  • Author(s): Sumiya Kazuki、Matsunaga Takuya、Tanaka Motoko、Mochizuki Shinichi、Sakurai Kazuo
  • Journal Title: Biomacromolecules Volume: 21 Issue: 12 Pages: 4823-4834
  • DOI: 10.1021/acs.biomac.0c01038
  • Peer Reviewed
• [Journal Article] Overcoming the Necessity of a Lateral Aggregation in the Formation of Supramolecular Polymer Bottlebrushes in Water (2020)
  • Author(s): Klein Tobias、Ulrich Hans F.、Gruschwitz Franka V.、Kuchenbrod Maren T.、Takahashi Rintaro、Hoeppener Stephanie、Nischang Ivo、Sakurai Kazuo、Brendel Johannes C.
  • Journal Title: Macromolecular Rapid Communications Volume: 42 Issue: 8 Pages: 2000585-2000585
  • DOI: 10.1002/marc.202000585
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Topical Therapy with Antisense Tumor Necrosis Factor Alpha Using Novel β-Glucan-Based Drug Delivery System Ameliorates Intestinal Inflammation (2020)
  • Author(s): Sakisaka Hideto、Takedatsu Hidetoshi、Mitsuyama Keiichi、Mochizuki Shinichi、Sakurai Kazuo、Sakisaka Shotaro、Hirai Fumihito
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 2 Pages: 683-683
  • DOI: 10.3390/ijms21020683
  • Peer Reviewed
• [Journal Article] Monodisperse micelles composed of poly(ethylene glycol) attached surfactants: platonic nature in a macromolecular aggregate (2019)
  • Author(s): Lee Ji Ha、Matsumoto Hayata、Fujii Shota、Takahashi Rintaro、Sakurai Kazuo
  • Journal Title: Soft Matter Volume: 15 Issue: 27 Pages: 5371-5374
  • DOI: 10.1039/c9sm00943d
  • Peer Reviewed
• [Journal Article] Observing the Kinetic Pathway of Nanotube Formation from Bolaamphiphiles by Time-Resolved Small-Angle X-ray Scattering (2019)
  • Author(s): Takahashi Rintaro、Kawauchi Hiroki、Kameta Naohiro、Lee Ji Ha、Fujii Shota、Shimizu Toshimi、Sakurai Kazuo
  • Journal Title: The Journal of Physical Chemistry B Volume: 123 Issue: 19 Pages: 4340-4345
  • DOI: 10.1021/acs.jpcb.9b01746
  • Peer Reviewed
• [Journal Article] Non-dependence of dodecamer structures on alkyl chain length in Platonic micelles (2019)
  • Author(s): Araki Masataka、Fujii Shota、Lee Ji Ha、Takahashi Rintaro、Sakurai Kazuo
  • Journal Title: Soft Matter Volume: 15 Issue: 17 Pages: 3515-3519
  • DOI: 10.1039/c9sm00076c
  • Peer Reviewed
• [Journal Article] Structural analysis of a calix[4]arene-based Platonic Micelle (2019)
  • Author(s): Mylonas Efstratios、Yagi Naoto、Fujii Shota、Ikesue Kodai、Ueda Tomoya、Moriyama Hideaki、Sanada Yusuke、Uezu Kazuya、Sakurai Kazuo、Okobira Tadashi
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 1982-1982
  • DOI: 10.1038/s41598-018-38280-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Encapsulation of Albumin in Organic Nanotube Channel: Structural Investigation by Small-Angle X-ray Scattering (2019)
  • Author(s): Kawauchi Hiroki、Takahashi Rintaro、Kameta Naohiro、Fujii Shota、Lee Ji Ha、Shimizu Toshimi、Sakurai Kazuo
  • Journal Title: ACS Applied Bio Materials Volume: 2 Issue: 4 Pages: 1652-1659
  • DOI: 10.1021/acsabm.9b00047
  • Peer Reviewed
• [Journal Article] Preparation of a Series of Photoresponsive Polymersomes Bearing Photocleavable a 2-nitrobenzyl Group at the Hydrophobic/Hydrophilic Interfaces and Their Payload Releasing Behaviors (2019)
  • Author(s): Yamamoto、Yamada、Kubo、Sakurai、Yamaguchi、Nakanishi
  • Journal Title: Polymers Volume: 11 Issue: 8 Pages: 1254-1254
  • DOI: 10.3390/polym11081254
  • Peer Reviewed / Open Access
• [Journal Article] Discrete and Discontinuous Increase in the Micellar Aggregation Number: Effects of the Alkyl Chain Length on Platonic Micelles (2019)
  • Author(s): Fujii Shota、Yamada Shimpei、Araki Masataka、Lee Ji Ha、Takahashi Rintaro、Sakurai Kazuo
  • Journal Title: Langmuir Volume: 35 Issue: 8 Pages: 3156-3161
  • DOI: 10.1021/acs.langmuir.8b04204
  • Peer Reviewed
• [Journal Article] Tuning of the aggregation number of Platonic micelles with a binary mixture of calix[4]arene surfactants (2019)
  • Author(s): Lee Ji Ha、Fujii Shota、Takahashi Rintaro、Sakurai Kazuo
  • Journal Title: Chemical Communications Volume: 55 Issue: 9 Pages: 1303-1305
  • DOI: 10.1039/c8cc09621j
  • Peer Reviewed
• [Journal Article] Dual and multiple stimuli-responsive platonic micelles bearing disaccharides (2019)
  • Author(s): Miyake Rika、Fujii Shota、Lee Ji Ha、Takahashi Rintaro、Sakurai Kazuo
  • Journal Title: Journal of Colloid and Interface Science Volume: 535 Pages: 8-15
  • DOI: 10.1016/j.jcis.2018.09.044
  • Peer Reviewed
• [Presentation] Discovery of a Novel β-(1,3)-Glucan/DNA Complex and its Application to Targeting Delivery of Therapeutic Oligonucleotides (2023)
  • Author(s): Kazuo Sakurai
  • Organizer: East Tennessee State University Seminar
  • Int'l Joint Research / Invited
• [Presentation] Polyacrylic acid has a long history, but still shows eye-opening surprises (2023)
  • Author(s): Kazuo Sakurai
  • Organizer: University of Massachusetts Amherst Seminar
  • Int'l Joint Research / Invited
• [Presentation] Polyacrylic acid has a long history, but still shows eye-opening surprises (2023)
  • Author(s): Kazuo Sakurai
  • Organizer: オスロ大学セミナー
  • Int'l Joint Research / Invited
• [Presentation] Polyacrylic acid has a long history, but still shows eye-opening surprises (2023)
  • Author(s): Kazuo Sakurai
  • Organizer: フリードリヒ・シラー大学イエーナ（ドイツ）セミナー
  • Int'l Joint Research / Invited
• [Presentation] X線小角散乱を用いた水溶液中のナノ粒子の構造解析 (2023)
  • Author(s): 櫻井 和朗
  • Organizer: 第35回 散乱研究会
  • Invited
• [Presentation] 夢を実現するには：How to make your dream come true (2023)
  • Author(s): 櫻井 和朗
  • Organizer: 日本バイオマテリアル学会 2023 年度九州ブロック研究発表会
  • Invited
• [Presentation] Characterizing Self-Assembled Nanoparticles for Drug Delivery by Use of Solution Scattering (2023)
  • Author(s): Kazuo Sakurai
  • Organizer: The 47th PST Annual Meeting
  • Int'l Joint Research / Invited
• [Presentation] CMC の観点から見た溶液中のナノメディシンの特性評価： X 線小角散乱を中心にして (2023)
  • Author(s): 櫻井 和朗
  • Organizer: 日本薬剤学会 物性FGセミナー2023
  • Invited
• [Presentation] Characterizing Self-Assembled Nanoparticles of Drug Delivery by use of Solution Scattering (2023)
  • Author(s): Kazuo Sakurai
  • Organizer: Pusan National University Seminar
  • Int'l Joint Research / Invited
• [Presentation] 多糖核酸複合体におけるホスホロチオエート核酸の実用的役割と生命起源への想像 (2023)
  • Author(s): 櫻井 和朗
  • Organizer: 日本薬学会第143年会
  • Invited
• [Presentation] Discovery of a Novel β-(1,3)-Glucan/DNA Complex and its Application to Targeting Delivery of Therapeutic Oligonucleotides (2022)
  • Author(s): Kazuo Sakurai
  • Organizer: Exeter University Seminar
  • Int'l Joint Research / Invited
• [Presentation] Solution properties of monodisperse cross-linked poly (acrylic acid) particles made by radical precipitation polymerization (2022)
  • Author(s): Kazuo Sakurai
  • Organizer: ACS Fall 2022 NATIONAL MEETING & EXPOSITION
  • Int'l Joint Research
• [Presentation] Microphase separation induced by the segregation of side chains in styrene-acrylic-acid alternating copolymers (2022)
  • Author(s): Kazuo Sakurai
  • Organizer: ACS Fall 2022 NATIONAL MEETING & EXPOSITION
  • Int'l Joint Research
• [Presentation] Therapeutic efficacy of microRNA and immunoadjuvant combination therapy for tumors (2022)
  • Author(s): Kazuo Sakurai
  • Organizer: 18th Annual Meeting of the Oligonucleotide Therapeutics Society
  • Int'l Joint Research
• [Presentation] DDSナノ粒子の構造解析 (2022)
  • Author(s): 櫻井 和朗
  • Organizer: 軟X線共鳴散乱・反射率/Resonant Soft X-ray Scattering and Reflectivity
  • Invited
• [Presentation] 日本発の核酸医薬の実用化を目指して (2022)
  • Author(s): 櫻井 和朗
  • Organizer: 岐阜大学公開講座 先端を行く連合創薬医療情報研究科 次世代創薬を支えるモダリティー
  • Invited
• [Presentation] 溶液中のバイオナノ粒子からのX線小角散乱 (2022)
  • Author(s): 櫻井 和朗
  • Organizer: 東京都産業技術研究センターヘルスケア関連セミナー
  • Invited
• [Presentation] 数学上の未解決問題とせっけんの化学の関連：ミセルの集合問題 (2022)
  • Author(s): 櫻井 和朗
  • Organizer: 計測自動制御学会九州支部学術講演会
  • Invited
• [Presentation] DNA を２分子含む多糖核酸複合体からの X 線小角散乱 (2021)
  • Author(s): 櫻井 和朗
  • Organizer: 第70回高分子年次大会
• [Presentation] Me散乱を用いたサブから数十ミクロン粒子を含む溶液の解析 (2021)
  • Author(s): 櫻井 和朗
  • Organizer: 第70回高分子年次大会
• [Presentation] 小角X線散乱法で計測したナノ粒子製剤 (2021)
  • Author(s): 櫻井 和朗
  • Organizer: SPring-8ユーザー協同体（SPRUC）研究会「小角散乱とナノ粒子製剤のCMC」
  • Invited
• [Presentation] An alternating copolymer exhibiting the microphase-structure transition fromultrathin plate to unimeric sphere (2021)
  • Author(s): Kazuo Sakurai
  • Organizer: ACS Spring2022 NATIONAL MEETING & EXPOSITION
  • Int'l Joint Research
• [Presentation] Novel cyclodextrin-based nanoparticle delivering alpha mangostin to treat brainischemia (2021)
  • Author(s): Kazuo Sakurai
  • Organizer: ACS Spring2022 NATIONAL MEETING & EXPOSITION
  • Int'l Joint Research
• [Presentation] 多糖核酸複合体を用いた核酸医薬のDDS (2021)
  • Author(s): 櫻井 和朗
  • Organizer: 日本化学会第101春季年会
  • Invited
• [Presentation] ナノメディシンのレギュラトリーサイエンスにおける散乱法と電子顕微鏡の補完的役割 (2020)
  • Author(s): 櫻井 和朗
  • Organizer: ソフトマテリアル研究拠点キックオフ・セミナー
  • Invited
• [Presentation] 多糖拡散複合体を用いた核酸医薬の免疫系細胞への選択的デリバリー (2020)
  • Author(s): 櫻井 和朗
  • Organizer: 第36回日本DDS学会学術集会
  • Invited
• [Presentation] 多糖核酸複合体を用いた核酸医薬の免疫系細胞への選択的デリバリー (2020)
  • Author(s): 櫻井 和朗
  • Organizer: 令和2年度 岐阜大学 赤尾研究室セミナー
  • Invited
• [Presentation] Characterizing Self-Assembled Nanoparticles of Drug Delivery by use of Solution Scattering Techniques (2020)
  • Author(s): Kazuo Sakurai
  • Organizer: 高分子学会 関東支部企画 GPS-K2020
  • Int'l Joint Research / Invited
• [Presentation] レギュラトリーサイエンスから見た溶液中のナノ粒子の特性評価 (2020)
  • Author(s): 櫻井 和朗
  • Organizer: フロンティアソフトマター開発専用ビームライン産学連合体（FSBL）第10回研究発表会
  • Invited
• [Presentation] Polysaccharide/DNA Complexes to Deliver Therapeutic Oligonucleotides to Immunocytes (2019)
  • Author(s): Kazuo Sakurai
  • Organizer: 韓国高分子学会2019春季学術大会
  • Int'l Joint Research / Invited
• [Presentation] Polysaccharide/DNA Complexes to Deliver Therapeutic Oligonucleotides to Immunocytes (2019)
  • Author(s): Kazuo Sakurai
  • Organizer: 19th Symposium for Gene &middot; Design and delivery
  • Int'l Joint Research / Invited
• [Presentation] Polysaccharide/DNA Complexes to Deliver Therapeutic Oligonucleotides to Immunocytes (2019)
  • Author(s): Kazuo Sakurai
  • Organizer: Vietnam National University Seminar
  • Int'l Joint Research / Invited
• [Presentation] Polysaccharide/DNA Complexes to Deliver Therapeutic Oligonucleotides to Immunocytes (2019)
  • Author(s): Kazuo Sakurai
  • Organizer: 12nd East Asian Symposium on Polymers for Advanced Technologies (EASPAT2019)
  • Int'l Joint Research / Invited
• [Presentation] 放射光を用いたソフトマテリアルの時間空間に渡る精密構造解析 (2019)
  • Author(s): 櫻井 和朗
  • Organizer: ポリマーフロンティア21 放射光を利用した高分子材料開発の最前線
  • Invited
• [Presentation] Monodisperse micelles with the aggregation numbers corresponding to platonic solids: structures and dynamics (2019)
  • Author(s): Kazuo Sakurai
  • Organizer: 37th Australasian Polymer symposium
  • Int'l Joint Research / Invited
• [Presentation] Discovery of the platonic micelles and their potential applications (2019)
  • Author(s): Kazuo Sakurai
  • Organizer: International workshop on Bioiontronics
  • Int'l Joint Research / Invited
• [Presentation] 多糖核酸複合体の発見から臨床試験まで：レギュラトリーサイエンスにおける基礎研究の重要性 (2019)
  • Author(s): 櫻井 和朗
  • Organizer: 第9回日本バイオマテリアル学会九州ブロック講演会
  • Invited
• [Presentation] 多糖核酸複合体を用いた核酸医薬の免疫細胞への選択的デリバリー (2019)
  • Author(s): 櫻井 和朗
  • Organizer: 第54回薬効解析学研究室セミナー
  • Invited
• [Remarks] 櫻井研究室ホームページ
  • URL: https://www.sakurai-lab-kitakyushu.com/
• [Remarks] 櫻井・望月研究室
  • URL: http://www.sakurai-lab.jp/index.php/member/
• [Patent(Industrial Property Rights)] 粒子および粒子の製造方法、ならびに薬剤、薬剤の製造方法、抗がん剤 (2020)
  • Inventor(s): 櫻井和朗、他
  • Industrial Property Rights Holder: 北九州市立大学、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2020
  • Acquisition Date: 2021
  • Overseas