• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A novel model of multiple sclerosis and multiple system atrophy that are differentially manifested by the time of abnormal protein expression

Research Project

Project/Area Number 20K20470
Project/Area Number (Other) 19H05562 (2019)
Research Category

Grant-in-Aid for Challenging Research (Pioneering)

Allocation TypeMulti-year Fund (2020)
Single-year Grants (2019)
Review Section Medium-sized Section 52:General internal medicine and related fields
Research InstitutionInternational University of Health and Welfare (2020-2022)
Kyushu University (2019)

Principal Investigator

Kira Jun-ichi  国際医療福祉大学, 医学研究科, 教授 (40183305)

Co-Investigator(Kenkyū-buntansha) 立川 正憲  徳島大学, 大学院医歯薬学研究部(薬学域), 教授 (00401810)
松下 拓也  九州大学, 大学病院, 講師 (00533001)
山口 浩雄  九州大学, 大学病院, 特任講師 (00701830)
松瀬 大  九州大学, 医学研究院, 助教 (70596395)
山崎 亮  九州大学, 医学研究院, 准教授 (10467946)
渡邉 充  九州大学, 大学病院, 助教 (30748009)
Project Period (FY) 2019-06-28 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2021: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2020: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2019: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Keywords神経変性疾患 / 脱髄疾患 / 多系統萎縮症 / 多発性硬化症 / αーシヌクレイン / ミクログリア / アストログリア / 小脳失調 / オリゴデンドログリア / 神経炎症 / α―シヌクレイン / 脱髄 / 神経内科疾患 / シヌクレイン / コネキシン / α-シヌクレイン / グリオパチー / グリア標的治療 / 小脳型多系統萎縮症 / 進行型多発性硬化症 / オリゴデンドロサイト / アストロサイト
Outline of Research at the Start

私たちは中枢脱髄疾患の多発性硬化症(MS)患者が後に小脳/錐体外路等を侵す多系統萎縮症(MSA)を発症する例やMS病巣へのα-シヌクレイン(α-syn)蓄積から、両者共通のグリオパチーへのα-synの関与を考え、A53T変異α-synをTet-off系で任意の期間オリゴデンドログリアに発現できるマウスを樹立した。離乳直後から変異α-synを発現させると脳幹から頚髄の顕著な脱髄を示す進行型MS、成熟期以降に発現させると小脳型MSAを呈した。本研究では①変異α-syn発現時期によりMSとMSAを示す新規モデルを用いたグリオパチー機序の解明、②MSとMSAの髄液網羅的解析と分子病理学的解析による共通病態関連分子の同定、③グリア標的治療開発を行なう。

Outline of Final Research Achievements

We developed a novel multiple system atrophy (MSA) model by oligodendrocyte-specific over-expression of human A53T mutant α-synuclein in adult mice using Tet-Off regulation. Transgenic mice presented rapidly progressive ataxia and prominent demyelination in the brainstem/cerebellum with phosphorylated α-synuclein accumulation and substantial glial activation. With late re-inhibition of α-synuclein production, clinicopathological deterioration persisted despite the resolution of aggregated α-synuclein. Single-cell RNA sequencing of brain CD11b+ cells revealed a unique microglia cluster highly expressing Tlr2, Tgm2, Arg1, Msr1, and inflammatory cytokine genes that surrounded phosphorylated α-synuclein aggregates. Prophylactic administration of a colony-stimulating factor 1 receptor inhibitor increased these α-synuclein-associated microglia and worsened demyelination. Thus, a unique α-synuclein-associated microglia subset engages in progressive demyelination and neurodegeneration.

Academic Significance and Societal Importance of the Research Achievements

多系統萎縮症(MSA)は、小脳/錐体外路/自律神経等を侵す治療法のない神経変性疾患である。一方、多発性硬化症(MS)は代表的な中枢神経脱髄疾患である。MSとMSAで共通性のあるα-synの関与に着目し、凝集性の強い変異α-synA53TをTet-off系で任意の期間オリゴデンドログリアに発現できるマウスを樹立し、世界初のMSA-C(多系統萎縮症小脳型)モデルマウスを確立した。このマウスの解析により病原性の高いα-synucleinopathy-associated microglia (SAM)の同定に成功した。このモデルは、グリア炎症を標的とした新薬の開発に大きく貢献できる。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Annual Research Report
  • Research Products

    (40 results)

All 2023 2022 2021 2020 2019

All Journal Article (25 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 25 results,  Open Access: 9 results) Presentation (15 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] High-dose ubiquinol supplementation in multiple-system atrophy : a multicentre, randomised, double-blinded, placebo-controlled phase 2 trial2023

    • Author(s)
      Mitsui J, Matsukawa T, Uemura Y, Kawahara T, Matsuse D, Yamasaki R, Kira J, Tsuji S, et al.
    • Journal Title

      eClinicalMedicine

      Volume: 101920 Pages: 1-13

    • DOI

      10.1016/j.eclinm.2023.101920

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Early and extensive alterations of glial connexins, distal oligodendrogliopathy type demyelination, and nodal/paranodal pathology are characteristic of multiple system atrophy2022

    • Author(s)
      Yuji Nishimura, Katsuhisa Masaki, Dai Matsuse, Hiroo Yamaguchi, Tatsunori Tanaka1, Eriko Matsuo, Shotaro Hayashida, Mitsuru Watanabe, Takuya Matsushita, Shoko Sadashima, Naokazu Sasagasako, Ryo Yamasaki, Noriko Isobe, Toru Iwaki, Jun-ichi Kira
    • Journal Title

      Brain Pathology

      Volume: - Issue: 3 Pages: 1-16

    • DOI

      10.1111/bpa.13131

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brain gray matter astroglia-specific connexin 43 ablation attenuates spinal cord inflammatory demyelination.2021

    • Author(s)
      Une H, Yamasaki R, Nagata S, Yamaguchi H, Nakamuta Y, Indiasari UC, Cui YW, Shinoda K, Masaki K, Gotz M, Kira J:
    • Journal Title

      J Neuroinflammation

      Volume: 18 Issue: 1 Pages: 126-126

    • DOI

      10.1186/s12974-021-02176-1

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oligodendroglial connexin 47 regulates neuroinflammation upon autoimmune demyelination in a novel mouse model of multiple sclerosis2020

    • Author(s)
      Zhao Y, Yamasaki R, Yamaguchi H, Nagata S, Une H, Cui Y, Masaki K, Nakamuta Y, Iinuma K, Watanabe M, Matsushita T, Isobe N, Kira J.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 117 Issue: 4 Pages: 2160-2169

    • DOI

      10.1073/pnas.1901294117

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Contribution of cortical lesions to cognitive impairment in Japanese patients with multiple sclerosis2020

    • Author(s)
      Shinoda K, et al.
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 5228-5228

    • DOI

      10.1038/s41598-020-61012-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Risk HLA-DRB1 alleles differentially influence brain and lesion volumes in Japanese patients with multiple sclerosis2020

    • Author(s)
      Fukumoto S, Nakamura Y, Watanabe M, Isobe N, Matsushita T, Sakoda A, Hiwatashi A, Shinoda K, Yamasaki R, Tsujino A, Kira J.
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 413 Pages: 116768-116768

    • DOI

      10.1016/j.jns.2020.116768

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Environmental risk factors for multiple sclerosis in Japanese people2020

    • Author(s)
      Sakoda A, Matsushita T, Nakamura Y, Watanabe M, Shinoda K, Masaki K, Isobe N, Yamasaki R, Kira J.
    • Journal Title

      Multiple Sclerosis and Related Disorders

      Volume: 38 Pages: 101872-101872

    • DOI

      10.1016/j.msard.2019.101872

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unique HLA haplotype associations in IgG4 anti-neurofascin 155 antibody-positive chronic inflammatory demyelinating polyneuropathy2020

    • Author(s)
      Ogata H, Isobe N, Zhang X, Yamasaki R, Fujii T, Machida A, Morimoto N, Kaida K, Masuda T, Ando Y, Kuwahara M, Kusunoki S, Nakamura Y, Matsushita T, Kira J.
    • Journal Title

      Journal of Neuroimmunology

      Volume: 339 Pages: 577139-577139

    • DOI

      10.1016/j.jneuroim.2019.577139

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Central nervous system-specific antinuclear antibodies in patients with multiple sclerosis2020

    • Author(s)
      Fujii T, Yamasaki R, Miyachi Y, Nagata S, Maimaitijiang G, Nakamura Y, Shinoda K, Matsushita T, Isobe N, Kira J.
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 409 Pages: 116619-116619

    • DOI

      10.1016/j.jns.2019.116619

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Branchial Myorhythmia in a Case of Systemic Lupus Erythematosus2020

    • Author(s)
      Une H, et al.
    • Journal Title

      J Neurol Sci

      Volume: 408 Pages: 116501-116501

    • DOI

      10.1016/j.jns.2019.116501

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of overlapping adult-onset linear scleroderma and Parry-Romberg syndrome presenting with widespread ipsilateral neurogenic involvement2020

    • Author(s)
      Yamasaki R, et al.
    • Journal Title

      Neuropathology

      Volume: 40 Issue: 1 Pages: 109-115

    • DOI

      10.1111/neup.12614

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum GFAP and neurofilament light as biomarkers of disease activity and disability in NMOSD2019

    • Author(s)
      Watanabe M, Nakamura Y, Michalak Z, Isobe N, Barro C, Leppert D, Matsushita T, Hayashi F, Yamasaki R, Kuhle J, Kira J.
    • Journal Title

      Neurology

      Volume: 93 Issue: 13

    • DOI

      10.1212/wnl.0000000000008160

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Long-term use of interferon-β in multiple sclerosis increases Vδ1(-)Vδ2(-)Vγ9(-) γδ T cells that are associated with a better outcome2019

    • Author(s)
      Maimaitijiang G, Watanabe M, Shinoda K, Isobe N, Nakamura Y, Masaki K, Matsushita T, Yoshikai Y, Kira J.
    • Journal Title

      Journal of Neuroinflammation

      Volume: 16 Issue: 1 Pages: 179-179

    • DOI

      10.1186/s12974-019-1574-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intrathecal cytokine profile in neuropathy with anti‐neurofascin 155 antibody2019

    • Author(s)
      Ogata H, Zhang X, Yamasaki R, Fujii T, Machida A, Morimoto N, Kaida K, Masuda T, Ando Y, Kuwahara M, Kusunoki S, Nakamura Y, Matsushita T, Isobe N, Kira J.
    • Journal Title

      Annals of Clinical and Translational Neurology

      Volume: 6 Issue: 11 Pages: 2304-2316

    • DOI

      10.1002/acn3.50931

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cerebrospinal fluid cytokine/chemokine/growth factor profiles in idiopathic hypertrophic pachymeningitis.2019

    • Author(s)
      Zhang X, et al
    • Journal Title

      J Neuroimmunol.

      Volume: 330 Pages: 38-43

    • DOI

      10.1016/j.jneuroim.2019.01.010

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discriminative clinical and neuroimaging features of motor-predominant hereditary diffuse leukoencephalopathy with axonal spheroids and primary progressive multiple sclerosis: A preliminary cross-sectional study2019

    • Author(s)
      Saitoh B, Yamasaki R, Hiwatashi A, Matsushita T, Hayashi S, Mitsunaga Y, Maeda Y, Isobe N, Yoshida K, Ikeda S, Kira J.
    • Journal Title

      Multiple Sclerosis and Related Disorders

      Volume: 31 Pages: 22-31

    • DOI

      10.1016/j.msard.2019.03.008

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Grand Total EEG Score Can Differentiate Parkinson's Disease From Parkinson-Related Disorders2019

    • Author(s)
      Barcelon Ela Austria、Mukaino Takahiko、Yokoyama Jun、Uehara Taira、Ogata Katsuya、Kira Jun-ichi、Tobimatsu Shozo
    • Journal Title

      Frontiers in Neurology

      Volume: 10 Pages: 398-398

    • DOI

      10.3389/fneur.2019.00398

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Higher postictal parasympathetic activity following greater ictal heart rate increase in right than left-sided seizures2019

    • Author(s)
      Shimmura M, et al.
    • Journal Title

      Epilepsy Behav

      Volume: 97 Pages: 161-168

    • DOI

      10.1016/j.yebeh.2019.05.026

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporal trends in clinical characteristics and door-to-needle time in patients receiving intravenous tissue plasminogen activator: a retrospective study of four hospitals in Japan2019

    • Author(s)
      Tanaka K, et al.
    • Journal Title

      J Stroke and Cerebrovascular Dis

      Volume: 28 Issue: 11 Pages: 104305-104305

    • DOI

      10.1016/j.jstrokecerebrovasdis.2019.104305

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MOG antibody disease manifesting as progressive cognitive deterioration and behavioral changes with primary central nervous system vasculitis2019

    • Author(s)
      Baba T, et al.
    • Journal Title

      Mult Scler Relat Disord

      Volume: 30 Pages: 48-50

    • DOI

      10.1016/j.msard.2019.01.053

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intractable axonal neuropathy with multifocal peripheral nerve swelling in neuromyelitis optica spectrum disorders: a case report2019

    • Author(s)
      Mizuno Y, et al.
    • Journal Title

      Mult Scler Relat Disord

      Volume: 35 Pages: 16-18

    • DOI

      10.1016/j.msard.2019.06.033

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toxic myopathy with multiple deletions in mitochondrial DNA associated with long‐term use of oral anti‐viral drugs for hepatitis B: A case study2019

    • Author(s)
      Fujii Takayuki、Takase Kei‐ichiro、Honda Hiroyuki、Kawamura Nobutoshi、Yamasaki Ryo、Urata Michiyo、Uchiumi Takeshi、Iwaki Toru、Kira Jun‐ichi
    • Journal Title

      Neuropathology

      Volume: 39 Issue: 2 Pages: 162-167

    • DOI

      10.1111/neup.12548

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Creutzfeldt-Jakob disease-like diffusion-weighted imaging hyperintensity paralleled with neuropsychiatric symptoms in a patient with limbic encephalitis associated with anti-voltage-gated potassium channel complex antibodies2019

    • Author(s)
      Okadome T, et al.
    • Journal Title

      Clin Exp Neuroimmunol

      Volume: 10 Issue: 3 Pages: 204-206

    • DOI

      10.1111/cen3.12525

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brainstem posterior reversible encephalopathy syndrome in a case with Guillain-Barre syndrome2019

    • Author(s)
      Yokoyama J, et al.
    • Journal Title

      Clin Exp Neuroimmunol

      Volume: 10 Issue: 4 Pages: 267-271

    • DOI

      10.1111/cen3.12530

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spinal cord involvement by atrophy and associations with disability are different between multiple sclerosis and neuromyelitis optica spectrum disorder2019

    • Author(s)
      Nakamura Y, Liu Z, Fukumoto S, Shinoda K, Sakoda A, Matsushita T, Hayashida S, Isobe N, Watanabe M, Hiwatashi A, Yamasaki R, Kira J.
    • Journal Title

      European Journal of Neurology

      Volume: 27 Issue: 1 Pages: 92-99

    • DOI

      10.1111/ene.14038

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] A population of inflammatory microglia exacerbates a novel mouse model of multiple system atrophy.2022

    • Author(s)
      Dai Matsuse, Hiroo Yamaguchi, Katsuhisa Masaki, Yuji Nishimura, Tatsunori Tanaka, Toru Saiga, Kenji Tanaka, Ryo Yamasaki, Noriko Isobe, Jun-ichi Kira.
    • Organizer
      第63回日本神経学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Synucleinopathy-associated microglia uncovered by a novel multiple system atrophy-cerebellar type (MSA-C) mouse model.2022

    • Author(s)
      Jun-ichi Kira, Hiroo Yamaguchi, Yuji Nishimura, Dai Matsuse, Katsuhisa Masaki, Ryo Yamasaki, Noriko Isobe.
    • Organizer
      The 147th Annual Meeting of the American Neurological Association
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] .Identification of synucleinopathy associated microglia in a novel mouse model of multiple system atrophy (MSA)-cerebellar type2022

    • Author(s)
      Hiroo Yamaguchi, Yuji Nishimura, Dai Matsuse, Katsuhisa Masaki, Tatsunori Tanaka, Toru Saiga, Masaya Harada, Kenji Tanaka, Ryo Yamasaki, Noriko lsobe, Jun-ichi Kira.
    • Organizer
      Neuroscience 2022 (San Diego, USA)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新規小脳型多系統萎縮症モデルのCSF-1R阻害剤治療.2021

    • Author(s)
      松瀬大, 山口浩雄, 眞﨑勝久, 西村由宇慈, 田中辰典, 雑賀徹, 田中謙二, 山﨑亮, 吉良潤一, 磯部紀子
    • Organizer
      第15回パーキンソン病・運動障害疾患コングレス
    • Related Report
      2021 Research-status Report
  • [Presentation] 新規小脳型多系統萎縮症モデルによる脱髄・神経細胞障害機序とグリア制御による新規治療法開発の試み2020

    • Author(s)
      西村由宇慈, 眞﨑勝久, 松瀬大, 山口浩雄, 雑賀徹, 田中辰典, 田中謙二, 山﨑亮, 岩城徹, 吉良潤一.
    • Organizer
      第32回日本神経免疫学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] オリゴデンドロサイト特異的αシヌクレイン蓄積による小脳型多系統萎縮症モデルの樹立2020

    • Author(s)
      松瀬大, 山口浩雄, 眞﨑勝久, 西村由宇慈, 田中辰典, 雑賀徹, 田中謙二, 山﨑亮, 吉良潤一
    • Organizer
      第14回日本パーキンソン病・運動障害疾患学会(Movement Disorder Society-Japan)
    • Related Report
      2020 Research-status Report
  • [Presentation] Therapeutic drug search using model mice for multiple system atrophy and primary progressive multiple sclerosis2020

    • Author(s)
      Tatsunori Tanaka, Yuji Nishimura, Katsuhisa Masaki, Dai Matsuse, Hiroo Yamaguchi, Toru Saiga, Mitsuru Watanabe, Ryo Yamasaki, Kenji Tanaka and Jun-ichi Kira
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Gene expression profile of multiple system atrophy/primary progressive multiple sclerosis mice model2020

    • Author(s)
      Hiroo Yamaguchi, Tasunori Tanaka, Dai Mtasuse, Yuji Nishimura, Katsuhisa Masaki, Toru Saiga, Mitsuru Watanabe, Ryo Yamasaki, Kenji Tanaka, Jun-ichi Kira
    • Organizer
      61st Annual Meeting of the Japanese Society of Neurology
    • Related Report
      2020 Research-status Report
  • [Presentation] Drug targets for multiple system atrophy and primary progressive multiple sclerosis by a novel model2020

    • Author(s)
      Yuji Nishimura, Katsuhisa Masaki, Dai Matsuse, Hiroo Yamaguchi, Toru Saiga, Tatsunori Tanaka, Mitsuru Watanabe, Ryo Yamasaki, Kenji Tanaka, Jun-ichi Kira
    • Organizer
      61st Annual Meeting of the Japanese Society of Neurology
    • Related Report
      2020 Research-status Report
  • [Presentation] Early decrease of peripheral blood intermediate monocytes in multiple system atrophy cerebellar-type2020

    • Author(s)
      Dai Matsuse, Ryo Yamasaki, Maimaitjiang Guzailiayi, Hiroo Yamaguchi, Jun-ichi Kira
    • Organizer
      61st Annual Meeting of the Japanese Society of Neurology
    • Related Report
      2020 Research-status Report
  • [Presentation] A novel model of multiple system atrophy-cerebellar type and primary progressive mutliple sclerosis2019

    • Author(s)
      Masaki K, et al.
    • Organizer
      The 24th Annual Meeting of the Japan Glia
    • Related Report
      2019 Annual Research Report
  • [Presentation] Expression of mutant α-synucelin in oligodendrocytes during myelination period induces remarkable glial inflammation and demyelination in the spinal cord and brainstem/cerebellar white matter: a novel model of multiple system atrophy-cerebellar type and primary progressive mutliple sclerosis2019

    • Author(s)
      Yamaguchi H, et al.
    • Organizer
      Neuroscience 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel model of primary progressive multiple sclerosis by oligodendroglial mutant alpha-synuclein2019

    • Author(s)
      Saiga T, et al.
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A novel mice model of PPMS/MSA by oligodendroglial overexpression of mutant alpha-synuclein.2019

    • Author(s)
      Matsuse D, et al.
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] オリゴデンドロサイト特異的αシヌクレイン蓄積による小脳型多系統萎縮症・一次進行型多発性硬化症モデル.2019

    • Author(s)
      眞﨑勝久ら
    • Organizer
      第31回日本神経免疫学会学術集会
    • Related Report
      2019 Annual Research Report

URL: 

Published: 2019-07-04   Modified: 2024-03-26  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi