| Budget Amount *help |
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2022: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2021: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2020: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2019: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Outline of Final Research Achievements |
The microRNA miR-142 is involved in lipid metabolism and is associated with aging. The dysfunction of miR-142 has been suggested to affect lifespan, but the molecular mechanism is unknown. We examined mitochondria derived from miR-142 knockout (KO) mouse liver using a focused ion beam/scanning electron microscope. We found that the KO mice had morphological abnormalities. In addition to these morphological abnormalities, the miR-142 KO liver-derived mitochondria showed an increase in beta-oxidation (hyperactivation of lipid metabolism). As a result, the development of age-related fatty liver was suppressed in miR-142 KO mice. These findings suggest that the cause of the shortened lifespan in miR-142 KO mice is mild chronic mitochondrial dysfunction in the liver.
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