| Budget Amount *help |
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2023: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2022: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2021: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2020: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
This study utilized advanced methodologies such as trans-synaptic labeling and transcriptome analysis at a single-cell resolution to investigate the neural circuitry underlying animal social behaviors. Our findings revealed dynamic changes in the inputs to oxytocin neurons in the paraventricular nucleus (PVH) during paternal life-stage transitions, along with specific neural circuit reorganization occurring during pregnancy in female mice. Additionally, we identified the selective vulnerability of PVH parvocellular oxytocin neurons as a crucial factor in social dysfunction and developed a therapeutic approach based on this discovery. Moreover, we identified two distinct transcriptome profiles in spinal sympathetic preganglionic neurons; one negatively regulating the gastrointestinal tract and the other positively regulating the adrenal glands.
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