| Budget Amount *help |
¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2023: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2022: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2021: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2020: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
In this study, we attempted to establish a precision molecular design system tailored to target information at the peptide and protein level, and to explore molecular design technology by combining it with structural analysis of target proteins as well. Consequently, we have succeeded in isolating and producing highly functional molecules and elucidating their mechanisms of action by designing them based on the structural information of prefusion and postfusion structures of viral membrane fusion proteins, and specific inhibitory molecules, peptides, and antibodies against viral glycoproteins related to cell entry.
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