| Budget Amount *help |
¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2023: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2022: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2021: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2020: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
At Risk Mental State (ARMS) is a group of individuals who are at high risk of developing psychosis before the onset of illness. People with ARMS often exhibit subtle symptoms such as changes in thinking, mood, and behavior that precede full-blown psychosis. Identifying these individuals early can be crucial for preventive interventions as about 30% of ARMS patients transition to psychosis (mainly schizophrenia). There was no accurate early diagnosis of "transitioners," leading to delays in treatment and worse prognosis. However, current diagnostic methods lack the precision needed to distinguish between those who will develop psychosis and those who will not. This study demonstrates the feasibility of a study to predict transition to psychosis based on the amount and distribution of AMPA receptors. The findings of this study could pave the way for future research into other biomarkers and risk factors associated with the transition to psychosis.
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