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Is there any biomarker for Grit?

Research Project

Project/Area Number 20K20838
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 9:Education and related fields
Research InstitutionKyushu Institute of Technology

Principal Investigator

Natsume Kiyohisa  九州工業大学, 大学院生命体工学研究科, 教授 (30231492)

Project Period (FY) 2020-07-30 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsやり抜く力Grit / 勤勉性学習 / カイニン酸少量投与モデル / やりぬく力Grit / オープンフィールド試験 / 高架式十字迷路実験 / 新規物体課題 / カイニン酸モデル / カイニン酸投与 / 回し車走行試験 / 無力感学習 / 高架十字迷路試験 / やりぬく力 / Grit / バイオマーカー / ドパミン / 脳波
Outline of Research at the Start

問題解決に重要な「やり抜く力」Gritに影響を与える要因に、「学習性勤勉性」と「学習性無力感」がある。前者は努力を学習し他の困難な事にも取り組むようになる事であり、後者は努力をしても駄目だと思い何もしなくなる事である。このように努力は学習により獲得したり喪失する。「勤勉性」、「無力感」の学習時の脳内変化は調べられていない。そこで本研究では、ラットに勤勉性と無力感を学習させ、その時の脳内変化バイオマーカを明らかにする。こようなGritバイオマーカが明らかになれば、学習者に応じた学習カリキュラム・学習教材の作成が可能になり、カスタムメイド教育・教授法開発が可能となる。

Outline of Final Research Achievements

We attempted to create a diligent rat model (DRM) to determine a Grit behavioral index for rats. First, we examined the behavior of rats given three small doses of kainic acid (KA). The total distance traveled increased in the open field task. Anxious feelings were also decreased, suggesting that the DRM is a model of industriousness. In addition, rats treated with two doses of kainic acid (KA) were subjected to a novel object recognition task. The results showed that the rats stayed longer at the novel object before the administration. After the administration, the rats in the control group approached the familiar object, but the rats in the KA group maintained the tendency to stay at the novel object. This indicates that the control group showed a simple presentation effect by the familiar object, but the KA group did not. Furthermore, hippocampal dopamine levels in the KA group were higher than in the control group. These results suggest that a small dose of KA can create DRM.

Academic Significance and Societal Importance of the Research Achievements

本研究では、通常では外部刺激による単純呈示効果を起こすラットが、カイニン酸少量投与すると内発的動機づけが高くなり、単純呈示効果を抑制し勤勉性が上がる事を明らかにした。本研究ではこれまで得られてこなかった勤勉性ラットモデルが得られた可能性がありその学術的意義は大きい。またモデル内海馬ドパミン濃度は高かった。ドパミンは報酬系に関連する脳内物質なので脳内ドパミン濃度が勤勉性の一つのバイオマーカとなる可能性がある。ただ「やり抜く力」(Grit)は勤勉性が持続する事である。今回は一つの学習課題のみで勤勉性を調べたが、今後は他の学習課題でも勤勉に学習するのか調べる予定である。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (14 results)

All 2023 2022 2021 2020

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (9 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Multi-view image-based behavior classification of wet-dog shake in Kainate rat model2023

    • Author(s)
      Negrete Salvador Blanco、Arai Hirofumi、Natsume Kiyohisa、Shibata Tomohiro
    • Journal Title

      Frontiers in Behavioral Neuroscience

      Volume: 17 Pages: 1-12

    • DOI

      10.3389/fnbeh.2023.1148549

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of the change in characteristics of self-grooming by the neural network in the latent period of the Rat Kainate Epilepsy model2022

    • Author(s)
      Arai Hirofumi、Shigemoto Masaya、Natsume Kiyohisa
    • Journal Title

      SICE Journal of Control, Measurement, and System Integration

      Volume: 15 Issue: 2 Pages: 64-70

    • DOI

      10.1080/18824889.2022.2079327

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability2021

    • Author(s)
      Nagayoshi Y.、Chujo T.、Hirata S.、Nakatsuka H.、Chen C.-W.、Takakura M.、Miyauchi K.、Ikeuchi Y.、Carlyle B. C.、Kitchen R. R.、Suzuki T.、Katsuoka F.、Yamamoto M.、Goto Y.、Tanaka M.、Natsume K.、Nairn A. C.、Suzuki T.、Tomizawa K.、Wei F.-Y.
    • Journal Title

      Science Advances

      Volume: 7 Issue: 13

    • DOI

      10.1126/sciadv.abf3072

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diurnal rhythm regulates the frequency of carbachol-induced beta oscillation via inhibitory neural system in rat hippocampus2021

    • Author(s)
      Shigemoto, M., Nakatsuka, H., Ohtubo, Y., Natsume, K.
    • Journal Title

      Cognitive Neurodynamics

      Volume: - Issue: 3 Pages: 507-518

    • DOI

      10.1007/s11571-021-09736-4

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] てんかんモデル動物海馬スライスにおける脳波とNMDA受容体の関与2020

    • Author(s)
      新井博文, Blanco Negrete Salvador, Rollyn Labuguen, 柴田智広, 夏目季代久
    • Journal Title

      信学技報

      Volume: 120 Pages: 9-14

    • Related Report
      2020 Research-status Report
  • [Presentation] カイニン酸少量投与ラットモデルの新規物体認識2023

    • Author(s)
      Yang Jie、夏目季代久
    • Organizer
      第31回 電子情報通信学会九州支部 学生会講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] The involvement of oxytocin receptor activation in the change in self-grooming at the latent period in rat kainate model of epilepsy2022

    • Author(s)
      H. Arai, and K. Natsume
    • Organizer
      Neuro2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] The carbachol-induced beta oscillation causes the decrease in frequency by disinhibition at the midnight phase2021

    • Author(s)
      M. Shigemoto, Y. Ohtubo, K. Natsume
    • Organizer
      Neuro2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Spontaneous activity of rat hippocampal slices during latent period in kainate model rat for epilepsy2021

    • Author(s)
      H. Arai, and K. Natsume
    • Organizer
      Neuro2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] The relationship between generation of Carbachol induced β oscillation and high frequency oscillation in rat hippocampal slices2021

    • Author(s)
      R. Maeda, T. Sawada, and K. Natsume
    • Organizer
      Neuro2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neural network based time zone classification allows circadian rhythm analysis2021

    • Author(s)
      Shigemoto, Masaya, Natsume, Kiyohisa
    • Organizer
      SICE2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Behavior and Emotional Modification at Latent Period of Rat Epilepsy Model2021

    • Author(s)
      Arai, Hirofumi;Negrete, Salvador Blanco;Labuguen, Rollyn Tiu;Shibata, Tomohiro;Natsume, Kiyohisa
    • Organizer
      SICE2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] カイニン酸誘導てんかんモデルラット潜伏期における行動変容、及び海馬CA3領域における神経回路変化2021

    • Author(s)
      新井博文、夏目季代久
    • Organizer
      非線形問題研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] てんかんモデル動物海馬スライスにおける脳波とNMDA受容体の関与2020

    • Author(s)
      新井博文, Blanco Negrete Salvador, Rollyn Labuguen, 柴田智広, 夏目季代久
    • Organizer
      非線形問題研究会
    • Related Report
      2020 Research-status Report

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Published: 2020-08-03   Modified: 2025-01-30  

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