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Optical control of intercellular and inter-tissue information using animal opsins

Research Project

Project/Area Number 20K21434
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
Research InstitutionOsaka Metropolitan University (2022)
Osaka City University (2020-2021)

Principal Investigator

Terakita Akihisa  大阪公立大学, 大学院理学研究科, 教授 (30212062)

Project Period (FY) 2020-07-30 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2022: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2021: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords光遺伝学 / 動物オプシン / ロドプシン / 光操作 / エクソソーム
Outline of Research at the Start

エクソソーム放出制御に関与するGタンパク質共役型受容体(GPCR)が知られている。しかし、GPCRによるエクソソーム放出制御のメカニズムの全容は明らかではない。光感受性GPCRである動物のオプシンの中には、眼以外の組織に発現している非視覚オプシンがあり、それらはGPCRの光遺伝学ツールとして優れていると考えられる。そこで、本研究では、非視覚オプシンを用いて、GPCR によるエクソソーム放出の制御機構について、オプシンが共役するGタンパク質および調節する二次メッセンジャーとの関係から解明するとともに、その知見に基づいて、非視覚オプシンを利用したエクソソームの放出制御ツールの開発を目指す。

Outline of Final Research Achievements

We attempted to develop a light manipulation method for the secretion of exosomes and release of neurotransmitters by utilizing opsin, a light-sensitive G-protein coupled receptor (GPCR) in animals. Through analyzing the control of exosome release by light irradiation in cultured cells expressing various opsins, it was suggested that the amount of exosome secretion is controlled by the type of G-protein activated by the opsins, rather than second messengers. We introduced Parapinopsin into motor neurons of c elegans and conducted behavioral analysis. As a result, we successfully halted the movement with violet light irradiation and resumed the movement with green light irradiation, highlighting Parapinopsin as a promising neuronal control tool for neurotransmitters.

Academic Significance and Societal Importance of the Research Achievements

光遺伝学は、標的とする細胞に光受容タンパク質を遺伝学的に導入し、その細胞の活動や活性を光で操作する方法であり、最近の神経科学や細胞生物学の発展に大きく寄与している。本研究の成果により、細胞間連絡のシステムの中で、代表的である神経伝達物質の光制御と、まだ未知な点が多いエクソソームの分泌の光制御についての方法を確立することは、神経科学や細胞生物学の発を加速すると期待される。さらに、エクソソームの分泌メカニズムの詳細の解析に貢献し、まだ不明な点多いエクソソームの分泌メカニズムや機能の解明に貢献すると期待される。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (79 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (10 results) Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 8 results) Presentation (59 results) (of which Int'l Joint Research: 7 results,  Invited: 6 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] The University of Manchester(英国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Paul Scherrer Institut(スイス)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Sorbonne Universite(フランス)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] University of Louvain - UCLouvain(ベルギー)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Paul Scherrer Institut(スイス)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] The University of Manchester(英国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] Sorbonne Universite(フランス)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] Paul Scherrer Institut(スイス)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] The University of Manchester(英国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Universite Catholique de Louvain(ベルギー)

    • Related Report
      2020 Research-status Report
  • [Journal Article] Multiple opsins in a reef-building coral, Acropora millepora2023

    • Author(s)
      Benjamin M. Mason, Mitsumasa Koyanagi, Tomohiro Sugihara, Makoto Iwasaki, Vladlen Slepak, David J. Miller, Yusuke Sakai, Akihisa Terakita
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 1628-1628

    • DOI

      10.1038/s41598-023-28476-5

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Whale shark rhodopsin adapted to deep-sea lifestyle by a substitution associated with human disease2023

    • Author(s)
      Kazuaki Yamaguchi, Mitsumasa Koyanagi, Keiichi Sato, Akihisa Terakita, Shigehiro Kuraku
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 120(13) Issue: 13 Pages: 13-13

    • DOI

      10.1073/pnas.2220728120

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of a homologue of a vertebrate non-visual opsin Opn3 in the insect photoreceptors2022

    • Author(s)
      Mitsumasa Koyanagi, Hayato Honda, Hirohisa Yokono, Ryu Sato, Takashi Nagata, Akihisa Terakita
    • Journal Title

      Philosophical transactions of the Royal Society of London. Series B

      Volume: 377(1862) Issue: 1862 Pages: 20210274-20210274

    • DOI

      10.1098/rstb.2021.0274

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-performance optical control of GPCR signaling by bistable animal opsins MosOpn3 and LamPP in a molecular property?dependent manner2022

    • Author(s)
      Koyanagi Mitsumasa、Shen Baoguo、Nagata Takashi、Sun Lanfang、Wada Seiji、Kamimura Satomi、Kage-Nakadai Eriko、Terakita Akihisa
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 119 Issue: 48

    • DOI

      10.1073/pnas.2204341119

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Insights into the evolutionary origin of the pineal color discrimination mechanism from the river lamprey2021

    • Author(s)
      Wada Seiji、Kawano-Yamashita Emi、Sugihara Tomohiro、Tamotsu Satoshi、Koyanagi Mitsumasa、Terakita Akihisa
    • Journal Title

      BMC Biology

      Volume: 19 Issue: 1 Pages: 188

    • DOI

      10.1186/s12915-021-01121-1

    • NAID

      120007149260

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019688

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional identification of an opsin kinase underlying inactivation of the pineal bistable opsin parapinopsin in zebrafish2021

    • Author(s)
      Baoguo Shen, Seiji Wada, Haruka Nishioka, Takashi Nagata, Emi Kawano-Yamashita, Mitsumasa Koyanagi, Akihisa Terakita
    • Journal Title

      Zoological letters

      Volume: 7(1) Issue: 1 Pages: 1-1

    • DOI

      10.1186/s40851-021-00171-1

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The non-visual opsins expressed in deep brain neurons projecting to the retina in lampreys2020

    • Author(s)
      Emi Kawano-Yamashita, Mitsumasa Koyanagi, Seiji Wada, Tomoka Saito, Tomohiro Sugihara, Satoshi Tamotsu, Akihisa Terakita
    • Journal Title

      Scientific reports

      Volume: 10 Issue: 1 Pages: 9669

    • DOI

      10.1038/s41598-020-66679-2

    • NAID

      120006866803

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2020480

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] From extraocular photoreception to pigment movement regulation: a new control mechanism of the lanternshark luminescence2020

    • Author(s)
      Laurent Duchatelet, Tomohiro Sugihara, Jerome Delroisse, Mitsumasa Koyanagi, Rene Rezsohazy, Akihisa Terakita, Jerome Mallefet
    • Journal Title

      Scientific reports

      Volume: 10 Issue: 1 Pages: 10195

    • DOI

      10.1038/s41598-020-67287-w

    • NAID

      120006866802

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2020481

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] ゼブラフィッシュを用いた松果体光情報が伝達される脳領域の解析2022

    • Author(s)
      和田清二、小柳光正、寺北明久
    • Organizer
      日本動物学会近畿支部研究発表会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 造礁サンゴで発現する花虫綱特異的オプシンの分子特性解析2022

    • Author(s)
      酒井祐輔、小柳光正、寺北明久
    • Organizer
      日本動物学会近畿支部研究発表会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 平板動物のGPCRの解析によるオプシンの起源の探求2022

    • Author(s)
      髙橋 直樹、寺北 明久、小柳光正
    • Organizer
      日本進化学会第24回沼津大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 非視覚オプシンの機能解明のための「発光遺伝学」的解析法の開発の試み2022

    • Author(s)
      岩崎誠、和田清二、永田崇、杉原智博、小柳光正、寺北明久
    • Organizer
      第22回日本光生物学協会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 動物の光受容の分子基盤の多様性と機能の解明2022

    • Author(s)
      寺北明久
    • Organizer
      第22回日本光生物学協会年会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 造礁サンゴで発現する花虫綱特異的オプシンの吸収波長特性2022

    • Author(s)
      酒井祐輔、小柳光正、寺北明久
    • Organizer
      第22回日本光生物学協会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ゼブラフィッシュを用いた松果体オプシンの関わる光依存的行動の解析2022

    • Author(s)
      和田清二、小柳光正、寺北明久
    • Organizer
      第22回日本光生物学協会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 造礁サンゴで発現する花虫綱特異的オプシンにおける吸収スペクトルの制御メカニズムの解析2022

    • Author(s)
      酒井祐輔、小柳光正、寺北明久
    • Organizer
      日本動物学会第93回早稲田大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ハエトリグモのピンぼけ像にもとづく奥行き知覚を支えるロドプシンの吸収極大波長制御メカニズムの解析2022

    • Author(s)
      佐藤龍、永田崇、寺北明久、小柳光正
    • Organizer
      日本動物学会第93回早稲田大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 松果体オプシン欠損個体を用いたゼブラフィッシュの光依存的行動の解析2022

    • Author(s)
      和田清二、小柳光正、寺北明久
    • Organizer
      日本動物学会第93回早稲田大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 造礁サンゴの花虫綱特異的オプシンが駆動するシグナル伝達特性に関する解析2022

    • Author(s)
      岩崎誠、酒井祐輔、小柳光正、寺北明久
    • Organizer
      日本動物学会第93回早稲田大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 視覚ロドプシンとは逆向きの異性化反応を示すハエトリグモペロプシンの光異性化機構解析2022

    • Author(s)
      犬飼 紫乃、片山 耕大、杉原 智博、小柳 光正、寺北 明久、神取 秀樹
    • Organizer
      第16回分子科学討論会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Investigation of spectral properties and spectral tuning mechanisms of anthozoan-specific opsins from a reef-building coral.2022

    • Author(s)
      Yusuke Sakai、Mitsumasa Koyanagi、Akihisa Terakita
    • Organizer
      第60回日本生物物理学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Development of bistable optical control tools based on a Gs-coupled opsin2022

    • Author(s)
      Akinari Sakayori, Yusuke Sakai, Mitsumasa Koyanagi, Akihisa Terakita, Hisao Tsukamoto
    • Organizer
      第60回日本生物物理学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Spectroscopic study of photoisomerization mechanism of Jellyfish Opsin having counterion at different position2022

    • Author(s)
      Shino Inukai, Kota Katayama, Mitsumasa Koyanagi, Akihisa Tereakita, Hideki Kandori
    • Organizer
      第60回日本生物物理学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Analysis of light-dependent behaviors with a pineal opsin, parapinopsin-mutant zebrafish2022

    • Author(s)
      Yuki Yamamoto、Tomoka Saito、Seiji Wada、Mitsumasa Koyanagi, Akihisa Tereakita
    • Organizer
      日本比較生理生化学会第44回高知大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Analyses of light-dependent behavior involving pineal photoreceptions using zebrafish larvae.2022

    • Author(s)
      Seiji Wada, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第44回高知大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Investigation of spectroscopic properties and spectral tuning of anthozoan opsins in a reef-building coral2022

    • Author(s)
      Yusuke Sakai, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第44回高知大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Analyses of light-dependent bInvestigation of neural activity changes derived from extraocular photoreception in the whole brain of larval zebrafish by calcium imaging.ehavior involving pineal photoreceptions using zebrafish larvae.2022

    • Author(s)
      Yuya Namikoshi, Seiji Wada, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第44回高知大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Spectroscopic and immunohistochemical characterization of a mammalian non-visual opsin Opn32022

    • Author(s)
      Daigo Takakusa, Tomohiro Sugihara, Hiroshi Kiyonari, Akihisa Terakita, Mitsumasa Koyanagi
    • Organizer
      日本比較生理生化学会第44回高知大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Reproduction of early processes in the evolution of photosensory system by short-term selection of C. elegans optogenetically rendered photosensitive2022

    • Author(s)
      Ryu Sato, Takashi Nagata, Taizo Kawano, Shinichi Miyazaki, Yu Hayashi, Akihisa Terakita, Mitsumasa Koyanagi
    • Organizer
      日本比較生理生化学会第44回高知大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Visualization of neural pathways based on the molecular property of a pineal opsin and its contribution to light-dependent behavior using zebrafish larvae2022

    • Author(s)
      Seiji Wada, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      19th International Conference on Retinal Proteins
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Investigation of bioluminescence-based opsin activation for analyzing biological function of non-visual opsins2022

    • Author(s)
      Makoto Iwasaki, Seiji Wada, Takashi Nagata, Tomohiro Sugihara, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      19th International Conference on Retinal Proteins
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigation of spectroscopic properties and spectral tuning of anthozoan opsins in a reef-building coral.2022

    • Author(s)
      Yusuke Sakai, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      19th International Conference on Retinal Proteins
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Investigation of neural activity changes derived from extraocular photoreception in the whole brain of larval zebrafish by calcium imaging.2022

    • Author(s)
      Yuya Namikoshi, Seiji Wada, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      19th International Conference on Retinal Proteins
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigation of the spectral tuning of the jumping spider rhodopsin that underlies the depth perception from image defocus2022

    • Author(s)
      Ryu Sato, Takashi Nagata, Akihisa Terakita, Mitsumasa Koyanagi
    • Organizer
      19th International Conference on Retinal Proteins
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 造礁サンゴがもつ多様なオプシン類の光受容特性の解析2021

    • Author(s)
      酒井 祐輔、小柳 光正、寺北 明久
    • Organizer
      日本動物学会 近畿支部 研究発表会
    • Related Report
      2021 Research-status Report
  • [Presentation] 非視覚オプシンの解析のための選択的活性化法の開発2021

    • Author(s)
      岩崎 誠、和田 清二、永田 崇、杉原 智博、小柳 光正、寺北 明久
    • Organizer
      日本動物学会 近畿支部 研究発表会
    • Related Report
      2021 Research-status Report
  • [Presentation] 深海での光受容に特化したジンベエザメの視覚2021

    • Author(s)
      山口和晃、小柳光正、佐藤圭一、寺北明久、工樂樹洋
    • Organizer
      日本動物学会第92回オンライン米子大会
    • Related Report
      2021 Research-status Report
  • [Presentation] オプシン欠損変異体を用いたゼブラフィッシュ松果体光応答の解析2021

    • Author(s)
      和田清二、小柳光正、寺北明久
    • Organizer
      日本動物学会第92回オンライン米子大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 原始的な多細胞動物に存在するオプシン様GPCRの解析2021

    • Author(s)
      髙橋 直樹、寺北 明久、小柳光正
    • Organizer
      日本動物学会第92回オンライン米子大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 非視覚オプシンゼブラフィッシュOpn3のGタンパク質活性化能の解析2021

    • Author(s)
      白田泰士、杉原智博、永田崇、小柳光正、寺北明久
    • Organizer
      日本動物学会第92回オンライン米子大会
    • Related Report
      2021 Research-status Report
  • [Presentation] ゼブラフィッシュ網膜におけるメラノプシン発現水平細胞の光に対する応答の解析2021

    • Author(s)
      真野桃歌、和田清二、小柳光正、寺北明久
    • Organizer
      日本動物学会第92回オンライン米子大会
    • Related Report
      2021 Research-status Report
  • [Presentation] ハエトリグモのユニークな奥行き知覚メカニズムを支えるロドプシンの吸収極大波長制御機構の解析2021

    • Author(s)
      佐藤龍、永田崇、寺北明久、小柳光正
    • Organizer
      日本動物学会第92回オンライン米子大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 哺乳類の非視覚オプシンOpn3の分子特性の解析2021

    • Author(s)
      高草大悟、杉原智博、寺北明久、小柳光正
    • Organizer
      日本動物学会第92回オンライン米子大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 松果体オプシン、パラピノプシン変異ゼブラフィッシュを用いた光依存的な行動の解析2021

    • Author(s)
      山本悠貴、斉藤智香、和田清二、小柳光正、寺北明久
    • Organizer
      日本動物学会第92回オンライン米子大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 造礁性のウスエダミドリイシがもつ多様なオプシン類の光受容特性の解析2021

    • Author(s)
      酒井祐輔、塚本寿夫、小柳光正、寺北明久
    • Organizer
      日本動物学会第92回オンライン米子大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Five opsins sensitive to blue to green lights are co-expressed in the eye photoreceptors of the terrestrial slug Limax2021

    • Author(s)
      Ryota Matsuo, Mitsumasa Koyanagi, Tomohiro Sugihara, Yuko Matsuo, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第43回札幌大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Transmission of light information generated in the pineal organ to the midbrain in zebrafish.2021

    • Author(s)
      Seiji Wada, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第43回札幌大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Molecular roperties of opsin-like GPCRs identified in a primitive multicellular animal2021

    • Author(s)
      Naoki Takahashi, Akihisa Terakita, Mitsumasa Koyanagi
    • Organizer
      日本比較生理生化学会第43回札幌大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Comparative investigation of G protein activation ability of a non-visual opsin, zebrafish Opn32021

    • Author(s)
      Taishi Shirata, Tomohiro Sugihara, Takashi Nagata, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第43回札幌大会
    • Related Report
      2021 Research-status Report
  • [Presentation] A possible regulation of cone light responses by melanopsin distributed to horizontal cells in the larval zebrafish2021

    • Author(s)
      Momoka Mano, Seiji Wada, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第43回札幌大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Toward detection of neural activity changes in the zebrafish brain derived from extraocular photoreceptions.2021

    • Author(s)
      波越裕也、和田清二、小柳光正、寺北明久
    • Organizer
      日本比較生理生化学会第43回札幌大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Spectroscopic characterization of anthozoa-specific opsins found in a reef-building coral.2021

    • Author(s)
      Y. Sakai, M. Koyanagi, A. Terakita.
    • Organizer
      日本比較生理生化学会第43回札幌大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Optogenetic potentials of animal bistable opsins2021

    • Author(s)
      Akihisa Terakita
    • Organizer
      Fourth ERNEST Meeting: Insights from structures of signalling complexes and computational modelling on GPCR function
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular properties and optogenetic potentials of animal bistable opsins2021

    • Author(s)
      Akihisa Terakita
    • Organizer
      Pacifichem 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 奥行き知覚を支えるハエトリグモ視物質の特徴的な吸収スペクトルの獲得2020

    • Author(s)
      小柳光正、永田崇、寺北明久
    • Organizer
      日本動物学会第91回大会
    • Related Report
      2020 Research-status Report
  • [Presentation] ゼブラフィッシュにおける松果体光情報の処理に関わる脳部位候補の解析2020

    • Author(s)
      和田清二、小柳光正、寺北明久
    • Organizer
      日本動物学会第91回大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] ゼブラフィッシュにおける松果体光応答:「色検出」とその脳投射2020

    • Author(s)
      和田清二、沈宝國、山下(川野)絵美、永田崇、日比正彦、保智己、小柳光正、寺北明久
    • Organizer
      日本動物学会第91回大会
    • Related Report
      2020 Research-status Report
  • [Presentation] ゼブラフィッシュ松果体の色検出を担う光受容タンパク質の不活性化機構の解析2020

    • Author(s)
      沈宝国,和田清二,西岡春香,杉原智博,永田崇,橘木修志,山下(川野)絵美, 小柳光正,寺北明久
    • Organizer
      日本動物学会第91回大会
    • Related Report
      2020 Research-status Report
  • [Presentation] ゼブラフィッシュ網膜におけるメラノプシンの視覚への関与に関する解析2020

    • Author(s)
      真野桃歌、和田清二、小柳光正、寺北明久
    • Organizer
      日本動物学会第91回大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Investigation of opsins in the reef-building coral, Acropora tenuis, exhibiting a light-response behavior at the larval stage2020

    • Author(s)
      Yusuke Sakai, Hisao Tsukamoto, Naoto Ueno, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第42回山形大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Functional analysis of melaonpsin expressed in retinal horizontal cells of zebrafish2020

    • Author(s)
      真野桃歌、和田清二、小柳光正、寺北明久
    • Organizer
      日本比較生理生化学会第42回山形大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Investigation of opsin-like GPCRs identified in a primitive multicellular animal.2020

    • Author(s)
      _橋直樹、小柳光正、寺北明久
    • Organizer
      日本比較生理生化学会第42回山形大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Comparative investigation of G protein activation ability of members of a non-visual opsin, Opsin3 group.2020

    • Author(s)
      Taishi Shirata, Tomohiro Sugihara, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第42回山形大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Toward a new method for selective activation of a non-visual opsin2020

    • Author(s)
      Makoto Iwasaki, Tomohiro Sugihara, Seiji Wada, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      42nd Annual Meeting of The Japanese Society for Comparative Physiology and Biochemistry
    • Related Report
      2020 Research-status Report
  • [Presentation] Histological investigation of deep brain photoreceptors in the larval and adult lampreys2020

    • Author(s)
      Emi Kawano-Yamashita, Nanaho Yura, Mitsumasa Koyanagi, Seiji Wada, Akihisa Terakita, Satoshi Tamotsu
    • Organizer
      日本比較生理生化学会第42回大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 奥行き知覚を支えるハエトリグモのロドプシンの分子進化2020

    • Author(s)
      小柳光正、永田崇、寺北明久
    • Organizer
      日本進化学会第22回大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 造礁サンゴAcropora tenuisの幼生における光応答的な遊泳行動と成体の分布パターンへの影響2020

    • Author(s)
      酒井祐輔、加藤輝、小山宏史、Alyson Kuba、高橋弘樹、藤森俊彦、服田昌之、Andrew Negri、Andrew Baird、上野直人
    • Organizer
      日本進化学会第22回大会
    • Related Report
      2020 Research-status Report
  • [Book] Biomedical and Life Sciences (AEMB, volume 1293), Optogenetics2021

    • Author(s)
      Koyanagi M, Saito T, Wada S, Nagata T, Kawano-Yamashita E, Terakita A.
    • Total Pages
      279
    • Publisher
      Springer, Singapore
    • ISBN
      9789811587627
    • Related Report
      2020 Research-status Report
  • [Remarks] 大阪市立大学大学院理学研究科生物地球系専攻生体高分子機能学II研究室

    • URL

      http://www.sci.osaka-cu.ac.jp/biol/mphys/index.html

    • Related Report
      2020 Research-status Report

URL: 

Published: 2020-08-03   Modified: 2024-01-30  

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