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Verification of gut microbial pathogenesis in Inflammatory Bowel Disease

Research Project

Project/Area Number 20K21530
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 49:Pathology, infection/immunology, and related fields
Research InstitutionKeio University

Principal Investigator

Kim Yun-Gi  慶應義塾大学, 薬学部(芝共立), 教授 (00620220)

Project Period (FY) 2020-07-30 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2021: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2020: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords腸内細菌 / 炎症性腸疾患 / 遺伝子 / 疾患感受性
Outline of Research at the Start

炎症性腸疾患 (IBD: Inflammatory bowel disease) は、腸管における慢性的な炎症により、下痢・便秘・血便・発熱などを引き起こす疾患である。IBDは、遺伝学的・環境要因が関与する疾患であると言われているが詳細な発症メカニズムについては不明である。近年、IBDの発症に腸内細菌が関与している可能性が示唆されている。そこで本研究は、IBD疾患モデルマウスを用いることで、腸炎惹起に関わる腸内細菌を同定し、その作用メカニズムを解明することを目的とする。

Outline of Final Research Achievements

Inflammatory bowel disease (IBD) is an inflammatory disorder of the gastrointestinal tract. Although the etiology of IBD is unknown, gut microbiota alteration is considered a novel factor involved in the pathogenesis of IBD. In this study, we were able to identify a group of gut microbiota that increase the susceptibility to experimental colitis, and obtained the data that can be used as a stepping stone to identify the gut microbiota-related genes involved in inducing experimental colitis.

Academic Significance and Societal Importance of the Research Achievements

IBDの発症や病態変化に腸内細菌が関与していることが示唆されているが、実際に特定の腸内細菌が腸炎を惹起しているのか、また、その場合にどのようなメカニズムを介しているのか、については未だ不明である。本研究では実験的腸炎の感受性を高める腸内細菌を同定し、遺伝子レベルでの解析を行うことができた。この腸炎惹起にかかわる腸内細菌由来の遺伝子の機能を同定できれば、腸内細菌が腸炎を引き起こす新たな作用メカニズムを明らかにすることができ、IBDの病因を理解する上で重要な知見が得られると期待している。

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • Research Products

    (22 results)

All 2022 2021 2020

All Journal Article (12 results) (of which Int'l Joint Research: 12 results,  Peer Reviewed: 12 results,  Open Access: 11 results) Presentation (8 results) (of which Invited: 7 results) Book (2 results)

  • [Journal Article] A randomized placebo-controlled trial of combination therapy with post-triple-antibiotic-therapy fecal microbiota transplantation and alginate for ulcerative colitis (FLAG): protocol2022

    • Author(s)
      Ishikawa D., Zhang X., Nomura K., Seki N., Haraikawa M., Haga K., Shibuya T., Kim Y.G., Nagahara A.
    • Journal Title

      Front. Med.

      Volume: 9 Pages: 779205-779205

    • DOI

      10.3389/fmed.2022.779205

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gut Microbiota Reinforces Host Antioxidant Capacity via the Generation of Reactive Sulfur Species2022

    • Author(s)
      Uchiyama J. , Akiyama M., Hase K., Kumagai Y., Kim Y.G.
    • Journal Title

      Cell Reports

      Volume: 38(10) Issue: 10 Pages: 110479-110479

    • DOI

      10.1016/j.celrep.2022.110479

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Potentiation of methylmercury toxicity by combined metal exposure: in vitro and in vivo models of a restricted metal exposome2022

    • Author(s)
      Akiyama M., Shinkai Y., Yamakawa H., Kim Y.G., Kumagai Y.
    • Journal Title

      Chemosphere

      Volume: - Pages: 134374-134374

    • DOI

      10.1016/j.chemosphere.2022.134374

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Amino acid-based diet prevents lethal infectious diarrhea by maintaining body water balance in a murine citrobacter rodentium infection model2021

    • Author(s)
      Kimizuka T., Seki N., Yamaguchi G., Akiyama M., Higashi S., Hase K., Kim Y.G.
    • Journal Title

      Nutirents

      Volume: 13(6) Issue: 6 Pages: 1896-1896

    • DOI

      10.3390/nu13061896

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gut microbiota prevents sugar alcohol-induced diarrhea2021

    • Author(s)
      Hattori K., Akiyama M., Seki N., Yakabe K., Hase K., Kim Y.G.
    • Journal Title

      Nutrients

      Volume: 13(6) Issue: 6 Pages: 2029-2029

    • DOI

      10.3390/nu13062029

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Macropinocytosis and SARS-CoV-2 cell entry2021

    • Author(s)
      Sun X., Zheng W., Hua R., Liu Y., Wang L., Kim Y.G. , Liu X., Mimuro H., Shen Z., Li L., Yoshida S.
    • Journal Title

      Blood and Genomics

      Volume: 5(1) Pages: 1-12

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Seaweed dietary fiber sodium alginate suppresses the migration of colonic inflammatory monocytes and diet-induced metabolic syndrome via the gut microbiota2021

    • Author(s)
      Ejima R., Akiyama M., Sato H., Tomioka S., Yakabe K., Kimizuka T., Seki N., Fujimura Y., Hirayama A., Fukuda S., Hase K., Kim Y.G.
    • Journal Title

      Nutrients

      Volume: 13(8) Issue: 8 Pages: 2812-2812

    • DOI

      10.3390/nu13082812

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Commensal microbe-derived acetate suppresses NAFLD/NASH development via hepatic FFAR2 signalling in mice2021

    • Author(s)
      Aoki R., Onuki M., Hattori K., Ito M., Yamada T., Kamikado K., Kim Y.G., Nakamoto N., Kimura I., Clarke J.M., Kanai T, Hase K.
    • Journal Title

      Microbiome

      Volume: 9(1) Issue: 1 Pages: 188-188

    • DOI

      10.1186/s40168-021-01125-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Specific adsorption of a β-lactam antibiotic: In vivo by an anion-exchange resin for protection of the intestinal microbiota2021

    • Author(s)
      Li S., Yakabe K., Zai K., Liu Y., Kishimura A., Hase K., Kim Y.G., Mori T., Katayama Y.
    • Journal Title

      Biomaterials Science

      Volume: 9(21) Issue: 21 Pages: 7219-7227

    • DOI

      10.1039/d1bm00958c

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation2021

    • Author(s)
      Kurashima Yosuke、Kigoshi Takaaki、Murasaki Sayuri、Arai Fujimi、Shimada Kaoru、Seki Natsumi、Kim Yun-Gi、Hase Koji、Ohno Hiroshi、Kawano Kazuya、Ashida Hiroshi、Suzuki Toshihiko、Morimoto Masako、Saito Yukari、Sasou Ai、Goda Yuki、Yuki Yoshikazu、Inagaki Yutaka、Iijima Hideki、Suda Wataru、Hattori Masahira
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 1067-1067

    • DOI

      10.1038/s41467-021-21277-2

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adverse effects of methylmercury on gut bacteria and accelerated accumulation of mercury in organs due to disruption of gut microbiota2021

    • Author(s)
      Seki N, Akiyama M, Yamakawa H, Hase K, Kumagai Y, Kim YG
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 46 Issue: 2 Pages: 91-97

    • DOI

      10.2131/jts.46.91

    • NAID

      130007980544

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Understanding Host Immunity and the Gut Microbiota Inspires the New Development of Vaccines and Adjuvants2021

    • Author(s)
      Yakabe K, Uchiyama J, Akiyama M, Kim YG
    • Journal Title

      Pharmaceutics

      Volume: 13(2) Issue: 2 Pages: 163-163

    • DOI

      10.3390/pharmaceutics13020163

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 腸内環境制御によるサクセスフルエイジングの実現2021

    • Author(s)
      金 倫基
    • Organizer
      第2回PAC国際シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] 腸内細菌の創薬応用2020

    • Author(s)
      金 倫基
    • Organizer
      腸内デザイン学会(招待講演)
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 抗肥満作用を発揮する腸内細菌関連代謝物の探索2020

    • Author(s)
      金 倫基
    • Organizer
      第20回日本抗加齢医学会総会(招待講演)
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 抗肥満作用を発揮する腸内細菌由来代謝物の探索2020

    • Author(s)
      金 倫基
    • Organizer
      第32回微生物シンポジウム(招待講演)
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 腸内細菌と肥満2020

    • Author(s)
      金 倫基
    • Organizer
      第64回日本薬学会関東支部大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 腸内微生物を対象とした Live Biotherapeutic Productsの開発の現状2020

    • Author(s)
      金 倫基
    • Organizer
      第23回日本臨床腸内微生物学会総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 腸内細菌の宿主生理機能や疾患に与える影響2020

    • Author(s)
      金 倫基
    • Organizer
      LO皮膚科学研究会(スカイクラブ)夏季プログラム
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 抗肥満作用を発揮する腸内細菌由来代謝物の探索2020

    • Author(s)
      金 倫基
    • Organizer
      第93回日本内分泌学会学術総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Book] 腸内細菌叢の変動因子と生活習慣病2022

    • Author(s)
      山口 元輝, 秋山 雅博, 金 倫基
    • Total Pages
      6
    • Publisher
      機能性食品と薬理栄養
    • Related Report
      2021 Annual Research Report
  • [Book] 炎症性腸疾患をターゲットにした腸内細菌製剤の開発と現状2021

    • Author(s)
      矢加部 恭輔, 金 倫基
    • Total Pages
      6
    • Publisher
      Medical Science Digest
    • Related Report
      2021 Annual Research Report

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Published: 2020-08-03   Modified: 2023-01-30  

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