IPMN as a risk factor for pancreatic ductal adenocarcinoma; challenge for early diagnosis of pancreatic cancer by the assessment of clonal expansion
| Project/Area Number |
20K21633
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
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| Research Institution | Kagoshima University |
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Principal Investigator |
Ohtsuka Takao 鹿児島大学, 医歯学域医学系, 教授 (20372766)
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| Co-Investigator(Kenkyū-buntansha) |
山口 浩 東京医科大学, 医学部, 兼任准教授 (20510697)
三森 功士 九州大学, 大学病院, 教授 (50322748)
又木 雄弘 鹿児島大学, 鹿児島大学病院, 特任講師 (10444902)
蔵原 弘 鹿児島大学, 医歯学域医学系, 准教授 (70464469)
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| Project Period (FY) |
2020-07-30 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2021: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2020: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 膵癌 / IPMN / ゲノム / 予防 / ゲノム医療 / クローン拡大 / 早期診断 |
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| Outline of Research at the Start |
膵癌の危険因子である膵管内乳頭粘液性腫瘍(IPMN; Intraductal Papillary Mucinous Neoplasm)に注目し、同一膵内に膵癌と膵IPMNが発症する機序を遺伝子解析に基づくクローン拡大（慢性刺激→共通のドライバー遺伝子変異による臓器全体の遺伝子変異と前癌病変の蓄積→別のドライバー遺伝子変異による膵癌とIPMNの選択と拡大）から解明し、膵癌早期診断に有用なバイオマーカーを探索する事を目的とする。本研究は、膵癌発癌過程の機序を一気に解明する学問的意義のみならず、内視鏡で癌の早期診断を得意とする本邦の技術を世界へ向けて発信し社会的意義も有する極めて挑戦的な研究である。
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| Outline of Final Research Achievements |
We found the driver gene mutation namely XXX (unpublished data) which lead sustained benign intraductal papillary mucinous neoplasm (IPMN). The preliminary experiments demonstrated that this mutation was observed only in IPMN having concomitant pancreatic ductal adenocarcinoma (PDAC), but not in IPMN without PDAC. This finding indicates that there possibly exists the clonal expansion in whole pancreatic parenchyma having IPMN with concomitant PDAC.
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| Academic Significance and Societal Importance of the Research Achievements |
危険因子を有する膵癌発癌過程の機序を解明する学問的意義のみならず、膵癌早期診断法の技術を世界へ向けて発信し、広く世界人類の健康に大きく寄与する社会的意義も有する
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] FoundationOne CDx gene profiling in Japanese pancreatic ductal adenocarcinoma patients: a single-institution experience2020
Author(s)
Kimura R, Ohtsuka T, Kubo M, Kajihara A, Fujii A, Watanabe Y, Mori Y, Ikenaga N, Nakata K, Shindo K, Ohuchida K,Nakamura M
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Journal Title
Surgery Today
Volume: 51
Issue: 4
Pages: 619-626
DOI
Related Report
Peer Reviewed
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[Journal Article] Concomitant intraductal papillary mucinous neoplasm in pancreatic ductal adenocarcinoma is an independent predictive factor for the occurrence of new cancer in the remnant pancreas.2020
Author(s)
Matsuda R, Miyasaka Y, Ohishi Y, Yamamoto T, Saeki K, Mochidome N, Abe A, Ozono K, Shindo K, Ohtsuka T, Kanetake C, Nakamura M, Oda Y.
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Journal Title
Annals of Surgery
Volume: 271
Issue: 5
Pages: 941-948
DOI
Related Report
Peer Reviewed
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