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Investigation of the mechanism of development and preventive method for endometriosis-associated ovarian cancer

Research Project

Project/Area Number 20K21665
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Research InstitutionKindai University

Principal Investigator

Matsumura Noriomi  近畿大学, 医学部, 教授 (20452336)

Co-Investigator(Kenkyū-buntansha) 村上 幸祐  近畿大学, 医学部, 講師 (60734671)
高矢 寿光  近畿大学, 医学部, 講師 (60734689)
宮澤 正顯  近畿大学, 医学部, 教授 (60167757)
Project Period (FY) 2020-07-30 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2022: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2020: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords卵巣癌 / 子宮内膜症 / 遺伝子変異 / 内膜症関連卵巣癌 / 遺伝子変異解析 / PIK3CA変異 / 卵巣明細胞癌
Outline of Research at the Start

子宮内膜症に伴って生じる卵巣癌(明細胞癌や類内膜癌)の発生母地として、遺伝子変異を伴う正所性子宮内膜腺由来である可能性を考えた。本研究は、その仮説のもと、内膜症関連卵巣癌において、腫瘍組織、隣接する子宮内膜症、正所性子宮内膜において、同一の遺伝子変異があるかを調べ、内膜症関連卵巣癌の発生母地を探索する。また、卵巣明細胞癌にはAPOBEC3による遺伝子変異が生じており、それが発癌に関与する可能性がある。そのような遺伝子変異が生じる分子メカニズムを調べる。

Outline of Final Research Achievements

We studied endometriosis-associated ovarian cancer (ovarian clear cell carcinoma) with a focus on the mechanism of carcinogenesis. We analysed previously published data and found that the time between the diagnosis of endometriosis and the diagnosis of ovarian cancer was short. This suggests that carcinogenesis from a benign endometriotic cyst is unlikely. In ovarian clear cell carcinoma cases, uterine endometrium and endometriosis were often associated with PIK3CA mutations unrelated to the ovarian tumour, suggesting the presence of abnormal DNA repair mechanisms in the carcinogenesis.

Academic Significance and Societal Importance of the Research Achievements

卵巣癌は予後不良の疾患である。そのなかで明細胞癌は日本で頻度の高い組織型であり、化学療法に抵抗性を示す。卵巣明細胞癌は子宮内膜症と合併することが多く、内膜症関連卵巣癌として知られているが、その発癌メカニズムは明らかになっていない。本研究の成果は、卵巣明細胞癌の発癌メカニズムを明らかにし、その予防や早期発見のための方法を開発するための基礎データとなる。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (29 results)

All 2023 2022 2021 2020

All Journal Article (21 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 21 results,  Open Access: 15 results) Presentation (8 results) (of which Invited: 7 results)

  • [Journal Article] Uterine angioleiomyoma with disseminated intravascular coagulation: a case report2023

    • Author(s)
      Hanako Sato, Kosuke Murakami, Risa Fujishima, Tomoyuki Otani, Kazuko Sakai, Kazuto Nishio, Noriomi Matsumura
    • Journal Title

      BMC Women's Health

      Volume: 23 Issue: 1 Pages: 157-157

    • DOI

      10.1186/s12905-023-02292-5

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synchronous ovarian and uterine mesonephric‐like carcinoma that potentially arose from endometrioid adenofibroma: A case report2023

    • Author(s)
      Ishida Kentaro、Ashihara Takahito、So Makiko、Minamiguchi Sachiko、Matsumura Noriomi、Nonogaki Takafumi
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 49 Issue: 3 Pages: 1052-1056

    • DOI

      10.1111/jog.15539

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic relevance of HRDness gene expression signature in ovarian high-grade serous carcinoma; JGOG3025-TR2 study2023

    • Author(s)
      Takamatsu Shiro、Yoshihara Kosuke、Baba Tsukasa、Shimada Muneaki、Yoshida Hiroshi、Kajiyama Hiroaki、Oda Katsutoshi、Mandai Masaki、Okamoto Aikou、Enomoto Takayuki、Matsumura Noriomi
    • Journal Title

      British Journal of Cancer

      Volume: 128 Issue: 6 Pages: 1095-1104

    • DOI

      10.1038/s41416-022-02122-9

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tubulovillous adenoma with high-grade dysplasia of the vulva harboring high tumor mutational burden and cancer-associated mutations: a case report2022

    • Author(s)
      Sato Hanako、Murakami Kosuke、Otani Tomoyuki、Matsumura Noriomi
    • Journal Title

      Diagnostic Pathology

      Volume: 17 Issue: 1 Pages: 85-85

    • DOI

      10.1186/s13000-022-01268-7

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ovarian teratoid carcinosarcoma with a PIK3CA mutation: a case report and review of the literature.2022

    • Author(s)
      Masato Aoki, Hisamitsu Takaya, Tomoyuki Otani, Hidekatsu Nakai, Kosuke Murakami, Noriomi Matsumura.
    • Journal Title

      Int Cancer Conf J.

      Volume: 11 Issue: 4 Pages: 231-237

    • DOI

      10.1007/s13691-022-00571-w

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic host immunity and PD-L1/PD-1 blockade efficacy: developments after “IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer”2022

    • Author(s)
      Abiko Kaoru、Hamanishi Junzo、Matsumura Noriomi、Mandai Masaki
    • Journal Title

      British Journal of Cancer

      Volume: 128 Issue: 3 Pages: 461-467

    • DOI

      10.1038/s41416-022-01960-x

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peritoneal dissemination of high-grade serous ovarian cancer: pivotal roles of chromosomal instability and epigenetic dynamics2022

    • Author(s)
      Konishi I, Abiko K, Hayashi T, Yamanoi K, Murakami R, Yamaguchi K, Hamanishi J, Baba T, Matsumura N, Mandai M; Kyoto Study Group for Ovarian Cancer Research.
    • Journal Title

      J Gynecol Oncol

      Volume: 33(5) Issue: 5

    • DOI

      10.3802/jgo.2022.33.e83

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CXCL13-producing CD4+ T cells accumulate in the early phase of tertiary lymphoid structures in ovarian cancer2022

    • Author(s)
      Ukita Masayo、Hamanishi Junzo、Yoshitomi Hiroyuki、Yamanoi Koji、Takamatsu Shiro、Ueda Akihiko、Suzuki Haruka、Hosoe Yuko、Furutake Yoko、Taki Mana、Abiko Kaoru、Yamaguchi Ken、Nakai Hidekatsu、Baba Tsukasa、Matsumura Noriomi、Yoshizawa Akihiko、Ueno Hideki、Mandai Masaki
    • Journal Title

      JCI Insight

      Volume: 7 Issue: 12 Pages: 157215-157215

    • DOI

      10.1172/jci.insight.157215

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The roles and limitations of bevacizumab in the treatment of ovarian cancer.2022

    • Author(s)
      Hidekatsu Nakai, Noriomi Matsumura.
    • Journal Title

      Int J Clin Oncol.

      Volume: 27 Issue: 7 Pages: 1120-1126

    • DOI

      10.1007/s10147-022-02169-x

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Individualization in the first-line treatment of advanced ovarian cancer based on the mechanism of action of molecularly targeted drugs.2022

    • Author(s)
      Hidekatsu Nakai, Noriomi Matsuymura.
    • Journal Title

      Int J Clin Oncol.

      Volume: 27 Issue: 6 Pages: 1001-1012

    • DOI

      10.1007/s10147-022-02163-3

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] B7-H3 Suppresses Antitumor Immunity via the CCL2-CCR2-M2 Macrophage Axis and Contributes to Ovarian Cancer Progression2022

    • Author(s)
      Miyamoto T, Murakami R, Hamanishi J, Tanigaki K, Hosoe Y, Mise N, Takamatsu S, Mise Y, Ukita M, Taki M, Yamanoi K, Horikawa N, Abiko K, Yamaguchi K, Baba T, Matsumura N, Mandai M.
    • Journal Title

      Cancer Immunol Res .

      Volume: 10 Issue: 1 Pages: 56-69

    • DOI

      10.1158/2326-6066.cir-21-0407

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of patients that can continue conservative treatment for adenomyosis2021

    • Author(s)
      Miyagawa Chiho、Murakami Kosuke、Tobiume Takako、Nonogaki Takafumi、Matsumura Noriomi
    • Journal Title

      BMC Women's Health

      Volume: 21 Issue: 1 Pages: 431-431

    • DOI

      10.1186/s12905-021-01577-x

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] PDK2 leads to cisplatin resistance through suppression of mitochondrial function in ovarian clear cell carcinoma2021

    • Author(s)
      Kitamura S, Yamaguchi K, Murakami R, Furutake Y, Higasa K, Abiko K, Hamanishi J, Baba T, Matsumura N, Mandai M.
    • Journal Title

      Cancer Sci.

      Volume: 112 Issue: 11 Pages: 4627-4640

    • DOI

      10.1111/cas.15125

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Frequent PIK3CA mutations in eutopic endometrium of patients with ovarian clear cell carcinoma2021

    • Author(s)
      Murakami Kosuke、Kanto Akiko、Sakai Kazuko、Miyagawa Chiho、Takaya Hisamitsu、Nakai Hidekatsu、Kotani Yasushi、Nishio Kazuto、Matsumura Noriomi
    • Journal Title

      Modern Pathology

      Volume: 34 Issue: 11 Pages: 2071-2079

    • DOI

      10.1038/s41379-021-00861-3

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combination of gene set signatures correlates with response to nivolumab in platinum-resistant ovarian cancer2021

    • Author(s)
      Murakami R, Hamanishi J, Brown JB, Abiko K, Yamanoi K, Taki M, Hosoe Y, Yamaguchi K, Baba T, Matsumura N, Konishi I, Mandai M.
    • Journal Title

      Sci Rep .

      Volume: 11 Issue: 1 Pages: 11427-11427

    • DOI

      10.1038/s41598-021-91012-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tumor Immune Microenvironment during Epithelial-Mesenchymal Transition.2021

    • Author(s)
      Taki M, Abiko K, Ukita M, Murakami R, Yamanoi K, Yamaguchi K, Hamanishi J, Baba T, Matsumura N, Mandai M.
    • Journal Title

      Clin Cancer Res

      Volume: - Issue: 17 Pages: 4459-4459

    • DOI

      10.1158/1078-0432.ccr-20-4459

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case report of bladder and intestinal endometriosis, and the relationship between sex hormone receptor expression and PIK3CA mutation analysis.2021

    • Author(s)
      Kanto A, Kotani Y, Murakami K, Miyagawa C, Nakai H, Matsumura N.
    • Journal Title

      BMC Womens Health

      Volume: 21 Issue: 1 Pages: 118-118

    • DOI

      10.1186/s12905-021-01269-6

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Novel Malignant Peritoneal Mesothelioma with STRN Exon 2 and ALK Exon 20: A Case Report and Literature Review.2021

    • Author(s)
      Miyagawa C, Takaya H, Sakai K, Nishio K, Konishi M, Minamiguchi S, Shimada T, Matsumura N.
    • Journal Title

      Oncologist

      Volume: - Issue: 5 Pages: 356-361

    • DOI

      10.1002/onco.13714

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunogenomic landscape of gynecologic carcinosarcoma2021

    • Author(s)
      Gotoh Osamu、Kiyotani Kazuma、Chiba Tomohiro、Sugiyama Yuko、Takazawa Yutaka、Nemoto Kensaku、Kato Kazuyoshi、Tanaka Norio、Nomura Hidetaka、Hasegawa Kosei、Fujiwara Keiichi、Takamatsu Shiro、Matsumura Noriomi、Noda Tetsuo、Mori Seiichi
    • Journal Title

      Gynecologic Oncology

      Volume: 160 Issue: 2 Pages: 547-556

    • DOI

      10.1016/j.ygyno.2020.11.030

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Targeting Dormant Ovarian Cancer Cells In Vitro and in an In Vivo Mouse Model of Platinum Resistance2020

    • Author(s)
      Huang Zhiqing、Kondoh Eiji、Visco Zachary R.、Baba Tsukasa、Matsumura Noriomi、Dolan Emma、Whitaker Regina S.、Konishi Ikuo、Fujii Shingo、Berchuck Andrew、Murphy Susan K.
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: 20 Issue: 1 Pages: 85-95

    • DOI

      10.1158/1535-7163.mct-20-0119

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Endometriosis-Associated Ovarian Cancer: The Origin and Targeted Therapy.2020

    • Author(s)
      Murakami K, Kotani Y, Nakai H, Matsumura N.
    • Journal Title

      Cancers

      Volume: 12 Issue: 6 Pages: 1676-1676

    • DOI

      10.3390/cancers12061676

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 内膜症の癌化とは何を意味しているのか?2022

    • Author(s)
      松村謙臣
    • Organizer
      堺産婦人科医会学術講演会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 子宮内膜症の発生機序から癌化リスクを考える2022

    • Author(s)
      松村謙臣
    • Organizer
      第74回日本産科婦人科学会学術講演会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 婦人科悪性腫瘍のトランスレーショナルリサーチ2022

    • Author(s)
      松村謙臣
    • Organizer
      日本婦人科腫瘍学会教育セミナー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 婦人科がんのゲノムと分子標的治療2022

    • Author(s)
      松村謙臣
    • Organizer
      第96回日本病理学会近畿支部学術集会
    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Invited
  • [Presentation] 子宮内膜症関連卵巣癌の発生母地は?2022

    • Author(s)
      松村謙臣
    • Organizer
      第43回日本エンドメトリオーシス学会学術講演会
    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Invited
  • [Presentation] 卵巣がん薬物療法における 真の個別化医療 ~PARP阻害剤とVEGF阻害剤の使い分け~2021

    • Author(s)
      松村謙臣
    • Organizer
      姫路産婦人科医会学術講演会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Frequency of homologous recombination deficiency in high-grade serous ovarian cancer in Japan; JGOG3025-TR22021

    • Author(s)
      Noriomi Matsumura, Shiro Takamatsu, Kosuke Yoshihara, Tsukasa Baba, Muneaki Shimada, Hiroshi Yoshida, Aikou Okamoto, Hiroaki Kajiyama, Katsutoshi Oda, Takayuki Enomoto
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 卵巣がんの予防2021

    • Author(s)
      松村謙臣
    • Organizer
      第63 回日本婦人科腫瘍学会学術講演会
    • Related Report
      2021 Research-status Report
    • Invited

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Published: 2020-08-03   Modified: 2024-01-30  

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