| Project/Area Number |
20K21708
|
|---|
| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Medium-sized Section 58:Society medicine, nursing, and related fields
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
橋本 和宜 名城大学, 薬学部, 助教 (10816242)
杉本 賢文 名古屋大学, 医学部附属病院, 助教 (30759668)
|
|---|
| Project Period (FY) |
2020-07-30 – 2023-03-31
|
| Project Status |
Completed (Fiscal Year 2022)
|
| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2022: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2021: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 平衡感覚障害 / 有害元素 / 前庭 / 内耳 |
|---|
| Outline of Research at the Start |
有害元素の曝露は難聴（内耳のコルチ器の障害）のリスクを増大させる事が報告されているが、平衡感覚 (内耳の前庭)への影響は不明な点が多い。本研究は、疫学研究と前庭の機能解析や元素イメージング等で評価する実験研究の融合により、ヒトとマウスで平衡感覚障害を誘発する有害元素を特定し、予防法を提案する。
|
| Outline of Final Research Achievements |
This study investigated toxic elements that induce balance impairments in humans and mice. Associations of scores of posturography and salivary elements were determined in healthy subjects. There was a tendency of correlation between element X level and scores of posturography were correlated. Future study is needed to investigate the association of balance with element X levels contained in nails and hair samples, which are known as an index of chronic exposure status. In an experimental study, mice were exposed to element A in drinking water and balance was evaluated by rotarod. No significant difference was observed between the exposed group and the non-exposed group. Further study is needed to evaluate balance in exposed mice with other evaluations.
|
| Academic Significance and Societal Importance of the Research Achievements |
平衡感覚障害は転倒転落事故に直結する為、危険因子の特定は急務である。これまでに我々はヒ素などの有害元素の飲水曝露は難聴 (内耳のコルチ器) のリスクを増大させる事を報告してきたが、平衡感覚 (内耳の前庭) への影響は全く分かっていない。本研究により、ヒトで平衡感覚と関連する元素が明らかになりつつあるので、今後、動物実験でメカニズムを解析し予防法を開発する事により、社会的に意義のある成果が得られる事が期待される。
|
