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Development of a non-invasive method for measuring oxygen uptake of active muscle using optical technology and elucidation of training effects

Research Project

Project/Area Number 20K21772
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Research InstitutionMeiji University

Principal Investigator

Ichinose Masashi  明治大学, 経営学部, 専任教授 (10551476)

Co-Investigator(Kenkyū-buntansha) 小野 弓絵  明治大学, 理工学部, 専任教授 (10360207)
Project Period (FY) 2020-07-30 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywordsスポーツ生理学 / 生体医工学 / 有酸素性エネルギー代謝 / 末梢循環 / 光技術
Outline of Research at the Start

光技術を用いた骨格筋酸素摂取量の非侵襲連続測定法を開発し,運動時における活動筋酸素摂取量の動態と最大値を計測すること,およびそれらに対するトレーニング効果を解明することを目的とする。具体的には,申請者らが独自に開発した拡散相関分光法による活動筋血流計測と近赤外分光法による組織酸素抽出量測定の同時計測を実現し,それらの積から活動筋酸素摂取量を算出する。この新法を用いて,動的運動時における活動筋酸素摂取動態およびその最大値を測定し,さらに,トレーニング効果について検討する。

Outline of Final Research Achievements

In this study, to solve the problems of conventional measurement technique that have been a barrier to research on oxygen uptake in active muscles in humans, we developed a noninvasive continuous measurement technique of skeletal muscle tissue oxygen uptake employing diffusion correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) and investigated its utility. The DCS-NIRS simultaneous measurement system developed in this study was shown to be capable of noninvasively and continuously measuring changes in oxygen uptake in active muscle. Furthermore, we confirmed that the DCS-NIRS simultaneous measurement system can clearly detect the temporal changes in active muscle oxygen uptake in response to voluntary exercise and involuntary exercise induced by electrical muscle stimulation and showed that the system can be applied to various studies in the field of sports physiology, exercise training and rehabilitation.

Academic Significance and Societal Importance of the Research Achievements

本研究において開発に成功したDCS-NIRS同時計測システムにより,これまで検出することが困難であった,活動筋における酸素供給および酸素消費の動態を非侵襲かつ連続的に測定することが可能となった。本研究の成果は,運動能力に直接影響する活動筋の酸素摂取量の動態や最大値を規定するメカニズムの解明に資するものである。さらに,トレーニングやリハビリテーションの効果の評価,運動不足,加齢,生活習慣病などの影響の検討,疾病の早期発見・予防・治療などへの応用などスポーツ生理学分野に留まらない広範な波及効果が期待できる。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (28 results)

All 2022 2021 2020

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (22 results) (of which Int'l Joint Research: 6 results,  Invited: 5 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Evaluation of Local Skeletal Muscle Blood Flow in Manipulative Therapy by Diffuse Correlation Spectroscopy2022

    • Author(s)
      Matsuda Yasuhiro、Nakabayashi Mikie、Suzuki Tatsuya、Zhang Sinan、Ichinose Masashi、Ono Yumie
    • Journal Title

      Frontiers in Bioengineering and Biotechnology

      Volume: 9 Pages: 800051-800051

    • DOI

      10.3389/fbioe.2021.800051

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diffuse Optics for Probing Oxygen Metabolism of Active Muscles2021

    • Author(s)
      Ono Yumie、Nakabayashi Mikie、Ichinose Masashi
    • Journal Title

      2021 IEEE Photonics Conference (IPC)

      Volume: 2021 Pages: 1-2

    • DOI

      10.1109/ipc48725.2021.9592861

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Muscle Blood Flow Improvement in Manipulative Therapy by Diffuse Correlation Spectroscopy2021

    • Author(s)
      Matsuda Yasuhiro、Nakabayashi Mikie、Ono Yumie
    • Journal Title

      Biophotonics Congress 2021 OSA Technical Digest

      Volume: 2021 Pages: JTu4A.8-JTu4A.8

    • DOI

      10.1364/boda.2021.jtu4a.8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dual-channel Diffuse Correlation Spectroscopy for Simultaneous Blood Flow Measurement of Multiple Muscles2021

    • Author(s)
      Tsuchiya Tomohiro、Yamamoto Yukihiko、Nakabayashi Mikie、Ichinose Masashi、Ono Yumie
    • Journal Title

      Biophotonics Congress 2021 OSA Technical Digest

      Volume: 2021 Pages: JTu4A.7-JTu4A.7

    • DOI

      10.1364/boda.2021.jtu4a.7

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rapid vasodilation within contracted skeletal muscle in humans: new insight from concurrent use of diffuse correlation spectroscopy and Doppler ultrasound2021

    • Author(s)
      M Ichinose, M Nakabayashi, Y Ono
    • Journal Title

      American Journal of Physiology-Heart and Circulatory Physiology

      Volume: 320 Issue: 2 Pages: H654-H667

    • DOI

      10.1152/ajpheart.00761.2020

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 骨格筋における代謝性血管拡張‐導管動脈と微小循環での血流反応の違い‐2022

    • Author(s)
      一之瀬 真志,中林 実輝絵,小野 弓絵
    • Organizer
      第77回日本体力医学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 拡散相関分光法による組織血流イメージング:原理と応用2022

    • Author(s)
      小野弓絵
    • Organizer
      第61回日本生体医工学会大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 拡散相関分光法を用いた血液透析中の下肢筋血流動態の計測2022

    • Author(s)
      土屋智裕, 中林実輝絵, 髙山卓, 藤島理恵, 小島茂樹, 櫻田勉, 柴垣有吾, 一之瀬真志, 小野弓絵
    • Organizer
      第61回日本生体医工学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 筋電気刺激による筋運動と随意筋運動における骨格筋血流動態の比較2022

    • Author(s)
      片桐誠, 中林美輝絵, 松田康宏, 一之瀬真志, 小野弓絵
    • Organizer
      第61回日本生体医工学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 拡散相関分光法と近赤外分光法の同時計測による局所筋の血流動態と酸素動態の評価2022

    • Author(s)
      中林実輝絵,一之瀬真志,小野弓絵
    • Organizer
      第61回日本生体医工学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 筋電気刺激は同等の強度の随意運動と比較して局所的な酸素代謝および血流を促進する2022

    • Author(s)
      片桐誠、中林美輝絵、松田康宏、一之瀬真志、小野弓絵
    • Organizer
      生体医工学シンポジウム2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] 拡散相関分光法を用いた血液透析による血圧低下の早期検出の検討2022

    • Author(s)
      土屋智裕
    • Organizer
      明治大学・聖マリアンナ医科大学共同研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 運動開始時の微小循環レベル酸素消費量~拡散相関分光法とNIRS法の併用~2022

    • Author(s)
      古賀俊策、中林実輝絵、廣田俊作、一之瀬真志、奥島 大、小野弓絵
    • Organizer
      呼吸研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Sensing your mind by wearable devices: a challenge of Neuroengineering for human well-being2022

    • Author(s)
      Y Ono
    • Organizer
      IEEE-NEMS2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 筋血流・脳血流計測による手技療法効果の客観的評価に関する検討2022

    • Author(s)
      松田康宏,中林実輝絵,鈴木達也,小野弓絵
    • Organizer
      第33回実社会におけるマルチモーダル脳情報応用技術研究会
    • Related Report
      2021 Research-status Report
  • [Presentation] Evaluation of Muscle Blood Flow Improvement in Manipulative Therapy by Diffuse Correlation Spectroscopy2021

    • Author(s)
      Matsuda Y, Nakabayashi M, Ono Y
    • Organizer
      OSA Biophotonics Congress: Optics in the Life Sciences
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dual-channel Diffuse Correlation Spectroscopy for Simultaneous Blood Flow Measurement of Multiple Muscles2021

    • Author(s)
      T Tsuchiya, Y Yamamoto, M Nakabayashi, M Ichinose, Y Ono
    • Organizer
      OSA Biophotonics Congress: Optics in the Life Sciences
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Diffuse optics for probing oxygen metabolism of active muscles2021

    • Author(s)
      Ono Y, Nakabayashi M, Ichinose M
    • Organizer
      IEEE Photonics Conference
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 拡散相関分光法を用いた局所筋血流計測による手技療法の評価2021

    • Author(s)
      松田康宏,中林実輝絵,鈴木達也,章斯楠,一之瀬真志,小野弓絵
    • Organizer
      第27回医用近赤外線分光法研究会, 第25回酸素ダイナミクス研究会
    • Related Report
      2021 Research-status Report
  • [Presentation] 拡散相関分光法と近赤外分光法を組み合わせた局所筋の酸素代謝率検出に関する検討2021

    • Author(s)
      中林実輝絵,一之瀬 真志,小野弓絵
    • Organizer
      第27回医用近赤外線分光法研究会, 第25回酸素ダイナミクス研究会
    • Related Report
      2021 Research-status Report
  • [Presentation] 筋収縮が誘起する迅速な骨格筋血流増加反応‐導管動脈と骨格筋微小循環での血流反応の違い‐2020

    • Author(s)
      一之瀬 真志,中林 実輝絵,小野 弓絵
    • Organizer
      第75回日本体力医学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Evaluation of Functional Sympatholysis Occurring Within Contracting Skeletal Muscle Microvasculature in Humans2020

    • Author(s)
      M Ichinose, M Nakabayashi, K Nozaki, S Sasaki, Y Ono.
    • Organizer
      American College of Sports Medicine 67th Annual Meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Detection of tissue metabolic rate of oxygen: a combined near-infrared spectroscopy and diffuse correlation spectroscopy study2020

    • Author(s)
      Y Ono, M Nakabayashi, M Kono, M Ichinose
    • Organizer
      International Conference on Complex Medical and Engineering 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 拡散相関分光法を用いた自転車運動中筋血流動態の計測2020

    • Author(s)
      野崎 寛一郎 , 中林 実輝絵, 一之瀬 真志, 小野 弓絵
    • Organizer
      第59回 日本生体医工学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Beat-by-beat blood flow change during handgrip exercise using diffuse correlation spectroscopy2020

    • Author(s)
      M Nakabayashi, M Ichinose, Y Ono
    • Organizer
      第59回 日本生体医工学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 腎低酸素バイオマーカーとしての尿中L型脂肪酸結合タンパク(L-FABP)の可能性2020

    • Author(s)
      田邉淳,小野弓絵,中林実輝絵,菅谷健,大畑敬一,市川大介,星野誠子,木村健二郎,柴垣有吾,池森敦子
    • Organizer
      第63回 日本腎臓学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 拡散相関分光法とNIRSによる組織循環・代謝機能の評価2020

    • Author(s)
      小野 弓絵,中林 実輝絵,一之瀬 真志
    • Organizer
      日本光学会年次学術講演会(OPJ2020)
    • Related Report
      2020 Research-status Report
    • Invited
  • [Patent(Industrial Property Rights)] 計測装置、計測方法及びプログラム2022

    • Inventor(s)
      小野弓絵,中林実輝絵
    • Industrial Property Rights Holder
      小野弓絵,中林実輝絵
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Related Report
      2022 Annual Research Report

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Published: 2020-08-03   Modified: 2024-01-30  

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