• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

New therapeutic strategy for diabetic kidney disease by inhibiting MGAT

Research Project

Project/Area Number 20K21773
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Research InstitutionKanazawa Medical University

Principal Investigator

古家 大祐  金沢医科大学, 医学部, 客員教授 (70242980)

Co-Investigator(Kenkyū-buntansha) 北田 宗弘  和歌山県立医科大学, 医学部, 博士研究員 (40434469)
Project Period (FY) 2020-07-30 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2020: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords糖尿病 / PKC / MGAT2 / シングルセル解析 / MAPK / HK細胞 / 糖尿病性腎臓病 / SGLT-2阻害薬 / MGAT / DAG
Outline of Research at the Start

顕著な腎線維化を有する2型糖尿病モデル動物CD-1db/dbの腎遺伝子発現アレイ解析にて、異常解糖系遺伝子の変動が明らかとなり、我々はCD1db/dbにおいてBKSdb/dbやCD1db/mに比し有意に増加している遺伝子群の中で、monoacylglycerol Acyltransferase 2 (MGAT2)に注目した。CD1db/db腎にてDAG蓄積によりPKC・MAPK活性が増強されることも確認した。今回、「MGAT2阻害によりPKC活性化の根本であるDAG集積の抑制できればDKDの根本的治療になる」という仮説のもと解析を行うとともに発現責任細部を同定する。

Outline of Annual Research Achievements

db遺伝子を戻し交配にてCD-1に導入し顕著な腎線維化を有する2型糖尿病モデル動物CD-1db/dbの作成に成功した。さらに腎遺伝子発現アレイ解析にて、異常解糖系遺伝子の変動が明らかとなり、我々はCD1db/dbにおいてBKSdb/dbやCD1db/mに比し有意に増加している遺伝子群の中で、monoacylglycerol Acyltransferase 2 (MGAT2)に注目した。CD1 db/dbマウスの腎臓において、PKC-MAPKに活性化とともに、それら活性化がMGAT2阻害薬ととおに、SGLT2阻害薬治療によって改善することが見出された。single cell suspension作成と腎構成細胞の分離同定によって、PKC-MAPK活性化は糸球体構成細胞(上皮細胞、内皮細胞、メサンギウム細胞)および近位尿細管細胞に生じていることが見出された。糸球体構成細胞(上皮細胞、内皮細胞、メサンギウム細胞)の活性増加はMGAT2阻害薬によって、近位尿細管細胞の活性化はMGAT2阻害薬とSGLT2阻害薬によって相乗的に抑制された。

Report

(3 results)
  • 2022 Annual Research Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (49 results)

All 2023 2022 2021 2020 Other

All Journal Article (48 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 48 results,  Open Access: 36 results) Remarks (1 results)

  • [Journal Article] Linagliptin ameliorated cardiac fibrosis and restored cardiomyocyte structure in diabetic mice associated with the suppression of necroptosis2023

    • Author(s)
      Adhikari J, Hirai T, Kawakita E, Iwai K, Koya D, Kanasaki K.
    • Journal Title

      J Diabetes Invetstig

      Volume: Online ahead of print. Issue: 7 Pages: 844-855

    • DOI

      10.1111/jdi.14017

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes According to Baseline HbA1c and Insulin Use: An Analysis From the FIDELIO-DKD Study2022

    • Author(s)
      Rossing P, FIDELIO-DKD Investigators.
    • Journal Title

      Diabetes Care

      Volume: 45 Issue: 4 Pages: 888-897

    • DOI

      10.2337/dc21-1944

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Rationale, design and baseline characteristics of the effect of canagliflozin in patients with type 2 diabetes and microalbuminuria in the Japanese population: The CANPIONE study2022

    • Author(s)
      Miyamoto S, Heerspink HJL, de Zeeuw D, Toyoda M, Suzuki D, Hatanaka T, Nakamura T, Kamei S, Murao S, Hida K, Ando S, Akai H, Takahashi Y, Koya D, Kitada M, Sugano H, Nunoue T, Nakamura A, Sasaki M, Nakatou T, Fujimoto K, Kawanami D, Wada T, Miyatake N, Yoshida M, Shikata K; CANPIONE study Investigators.
    • Journal Title

      Diabetes Obes Metab

      Volume: 24 Issue: 8 Pages: 1429-1438

    • DOI

      10.1111/dom.14731

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity2022

    • Author(s)
      Tsuneki Hiroshi、Maeda Takahiro、Takata Shinjiro、Sugiyama Masanori、Otsuka Koyuki、Ishizuka Hinako、Onogi Yasuhiro、Tokai Emi、Koshida Chiaki、Kon Kanta、Takasaki Ichiro、Hamashima Takeru、Sasahara Masakiyo、Rudich Assaf、Koya Daisuke et al.
    • Journal Title

      Cell Reports

      Volume: 41 Issue: 3 Pages: 111497-111497

    • DOI

      10.1016/j.celrep.2022.111497

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adenosine/adenosine type?1 receptor signaling pathway did not play dominant roles on the influence of sodium?glucose cotransporter?2 inhibitor in the kidney of bovine serum albumin‐overloaded streptozotocin‐induced diabetic mice2022

    • Author(s)
      Shimada Keiji、Kanasaki Keizo、Kato Makoto、Ogura Yoshio、Takagaki Yuta、Monno Itaru、Hirai Taro、Kitada Munehiro、Koya Daisuke
    • Journal Title

      Journal of Diabetes Investigation

      Volume: Online ahead of print Issue: 6 Pages: 955-964

    • DOI

      10.1111/jdi.13760

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dietary intake and physical activity in Japanese patients with type 2 diabetes: the Japan Diabetes Complication and its Prevention prospective study (JDCP study 8)2022

    • Author(s)
      Horikawa C, Tsuda K, Oshida Y, Satoh J, Hayashino Y, Tajima N, Nishimura R, Sone H, JDCP Study Group
    • Journal Title

      Diabetology International

      Volume: 13 Issue: 2 Pages: 344-357

    • DOI

      10.1007/s13340-022-00575-0

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Novel PKD2 Missense Mutation p.Ile424Ser in an Individual with Multiple Hepatic Cysts: A Case Report2022

    • Author(s)
      Miura S, Niida Y, Hashizume C, Fujii A, Takagaki Y, Kusama K, Akazawa S, Minami T, Mukai T, Furuichi K, Tsuchishima M, Ueda N, Takamura H, Koya D, Ito T.
    • Journal Title

      Medicines (Basel)

      Volume: 9 Issue: 4 Pages: 25-25

    • DOI

      10.3390/medicines9040025

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship Between Autophagy and Metabolic Syndrome Characteristics in the Pathogenesis of Atherosclerosis2021

    • Author(s)
      Xu J, Kitada M, Ogura Y, Koya D.
    • Journal Title

      Front Cell Dev Biol.

      Volume: 9 Pages: 641852-641852

    • DOI

      10.3389/fcell.2021.641852

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress.2021

    • Author(s)
      Kitada M, Ogura Y, Monno I, Xu J, Koya D.
    • Journal Title

      Biomedicines.

      Volume: - Issue: 2 Pages: 130-130

    • DOI

      10.3390/biomedicines9020130

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD26/DPP-4: Type 2 Diabetes Drug Target with Potential Influence on Cancer Biology2021

    • Author(s)
      Kawakita Emi、Koya Daisuke、Kanasaki Keizo
    • Journal Title

      Cancers

      Volume: 13 Issue: 9 Pages: 2191-2191

    • DOI

      10.3390/cancers13092191

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney Disease2021

    • Author(s)
      Srivastava Swayam Prakash、Goodwin Julie E.、Tripathi Pratima、Kanasaki Keizo、Koya Daisuke
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 11 Pages: 6027-6027

    • DOI

      10.3390/ijms22116027

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exercise Ameliorates Diabetic Kidney Disease in Type 2 Diabetic Fatty Rats.2021

    • Author(s)
      Monno I, Ogura Y, Xu J, Koya D, Kitada M.
    • Journal Title

      Antioxidants

      Volume: 10 Issue: 11 Pages: 1754-1754

    • DOI

      10.3390/antiox10111754

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dapagliflozin Restores Impaired Autophagy and Suppresses Inflammation in High Glucose-Treated HK-2 Cells2021

    • Author(s)
      Xu J, Kitada M, Ogura Y, Liu H, Koya D.
    • Journal Title

      Cells

      Volume: 10 Issue: 6 Pages: 1457-1457

    • DOI

      10.3390/cells10061457

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dietary Magnesium Insufficiency Induces Salt-Sensitive Hypertension in Mice Associated With Reduced Kidney Catechol-O-Methyl Transferase Activity2021

    • Author(s)
      Kumagai Asako、Takeda Satoru、Sohara Eisei、Uchida Shinichi、Iijima Hiroshi、Itakura Astuo、Koya Daisuke、Kanasaki Keizo
    • Journal Title

      Hypertension

      Volume: - Issue: 1 Pages: 138-150

    • DOI

      10.1161/hypertensionaha.120.16377

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of SGLT2 Inhibitors on Atherosclerosis: Lessons from Cardiovascular Clinical Outcomes in Type 2 Diabetic Patients and Basic Researches2021

    • Author(s)
      Xu J, Hirai T, Koya D, Kitada M.
    • Journal Title

      J Clin Med.

      Volume: 11 Issue: 1 Pages: 137-137

    • DOI

      10.3390/jcm11010137

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Randomized trial of an intensified, multifactorial intervention in patients with advanced-stage diabetic kidney disease: Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT-Japan)2021

    • Author(s)
      Shikata K, Haneda M, Ninomiya T, Koya D, Suzuki Y, Suzuki D, Ishida H, Akai H, Tomino Y, Uzu T, Nishimura M, Maeda S, Ogawa D, Miyamoto S, Makino H; Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT-Japan) collaborative group.
    • Journal Title

      J Diabetes Investig.

      Volume: 12 Issue: 2 Pages: 207-216

    • DOI

      10.1111/jdi.13339

    • NAID

      120006880216

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sodium-glucose cotransporter 2 inhibitors in type 2 diabetes patients with renal function impairment slow the annual renal function decline, in a real clinical practice2021

    • Author(s)
      Hirai T, Kitada M, Monno I, Oda E, Hayashi Y, Shimada K, Takagaki Y, Ogura Y, Fujii M, Konishi K, Sakurai M, Nakagawa A, Koya D.
    • Journal Title

      J Diabetes Investig.

      Volume: 12 Issue: 9 Pages: 1577-1585

    • DOI

      10.1111/jdi.13502

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical and histological features in pediatric and adolescent/young adult patients with renal disease: a cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR)2021

    • Author(s)
      Urushihara M, Sato H, Shimizu A, Sugiyama H, Yokoyama H, Hataya H, Matsuoka K, Okamoto T, Ogino D, Miura K, Hamada R, Hibino S, Shima Y, Yamamura T, Kitamoto K, Ishihara M, Konomoto T, Hattori M; the Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 25 Issue: 9 Pages: 1018

    • DOI

      10.1007/s10157-021-02077-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes.2021

    • Author(s)
      Pitt B, Filippatos G, Agarwal R, Anker SD, Bakris GL, Rossing P, Joseph A, Kolkhof P, Nowack C, Schloemer P, Ruilope LM; FIGARO-DKD Investigators.
    • Journal Title

      N Engl J Med.

      Volume: 385 Issue: 24 Pages: 2252-2263

    • DOI

      10.1056/nejmoa2110956

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Autophagy in metabolic disease and ageing.2021

    • Author(s)
      Kitada M, Koya D.
    • Journal Title

      Nat Rev Endocrinol.

      Volume: 11 Issue: 11 Pages: 647-461

    • DOI

      10.1038/s41574-021-00551-9

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy.2021

    • Author(s)
      Srivastava SP, Zhou H, Setia O, Liu B, Kanasaki K, Koya D, Dardik A, Fernandez-Hernando C, Goodwin J.
    • Journal Title

      Nat Commun.

      Volume: 12 Issue: 1 Pages: 2368-2368

    • DOI

      10.1038/s41467-021-22617-y

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The PKM2 activator TEPP-46 suppresses kidney fibrosis via inhibition of the EMT program and aberrant glycolysis associated with suppression of HIF-1α accumulation.2021

    • Author(s)
      Liu H, Takagaki Y, Kumagai A, Kanasaki K, Koya D.
    • Journal Title

      J Diabetes Investig

      Volume: 12 Issue: 5 Pages: 697-709

    • DOI

      10.1111/jdi.13478

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sirtuins and Renal Oxidative Stress.2021

    • Author(s)
      Ogura Y, Kitada M, Koya D.
    • Journal Title

      Antioxidants

      Volume: 10 Issue: 8 Pages: 1198-1198

    • DOI

      10.3390/antiox10081198

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] NAD+ Homeostasis in Diabetic Kidney Disease.2021

    • Author(s)
      Xu J, Kitada M, Koya D.
    • Journal Title

      Front Med (Lausanne).

      Volume: 8 Pages: 703076-703076

    • DOI

      10.3389/fmed.2021.703076

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneys.2021

    • Author(s)
      Srivastava SP, Li J, Takagaki Y, Kitada M, Goodwin JE, Kanasaki K, Koya D.
    • Journal Title

      iScience

      Volume: - Issue: 5 Pages: 102390-102390

    • DOI

      10.1016/j.isci.2021.102390

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anterior pituitary function in Rathke’s cleft cysts <i>versus</i> nonfunctioning pituitary adenomas2021

    • Author(s)
      Fujii M, Nakagawa A, Tachibana O, Iizuka H, Koya D.
    • Journal Title

      Endocrine Journal

      Volume: 68 Issue: 8 Pages: 943-952

    • DOI

      10.1507/endocrj.EJ21-0050

    • NAID

      130008079314

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metformin Mitigates DPP-4 Inhibitor-Induced Breast Cancer Metastasis via Suppression of mTOR Signaling2020

    • Author(s)
      Kawakita Emi、Yang Fan、Kumagai Asako、Takagaki Yuta、Kitada Munehiro、Yoshitomi Yasuo、Ikeda Takayuki、Nakamura Yuka、Ishigaki Yasuhito、Kanasaki Keizo、Koya Daisuke
    • Journal Title

      Molecular Cancer Research

      Volume: 19 Issue: 1 Pages: 61-73

    • DOI

      10.1158/1541-7786.mcr-20-0115

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes.2020

    • Author(s)
      Bakris GL, Agarwal R, Anker SD, Pitt B, Ruilope LM, Rossing P, Kolkhof P, Nowack C, Schloemer P, Joseph A, Filippatos G; FIDELIO-DKD Investigators.
    • Journal Title

      N Engl J Med.

      Volume: 3893 Issue: 23 Pages: 2219-2229

    • DOI

      10.1056/nejmoa2025845

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Renal protective effects of empagliflozin via inhibition of EMT and aberrant glycolysis in proximal tubules2020

    • Author(s)
      Li J, Liu H, Takagi S, Nitta K, Kitada M, Srivastava SP, Kanasaki K et al.
    • Journal Title

      JCI Insight.

      Volume: 5 Issue: 6 Pages: 6-6

    • DOI

      10.1172/jci.insight.129034

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Endothelial autophagy deficiency induces IL6 - dependent endothelial mesenchymal transition and organ fibrosis.2020

    • Author(s)
      Takagaki Y, Lee SM, Dongqing Z, Kitada M, Kanasaki K, Koya D
    • Journal Title

      Autophagy.

      Volume: - Issue: 10 Pages: 1-10

    • DOI

      10.1080/15548627.2020.1713641

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] The impact of mitochondrial quality control by Sirtuins on the treatment of type 2 diabetes and diabetic kidney disease2020

    • Author(s)
      Xu J, Kitada M, Koya D.
    • Journal Title

      Biochim Biophys Acta Mol Basis Dis

      Volume: 1866 Issue: 6 Pages: 165756-165756

    • DOI

      10.1016/j.bbadis.2020.165756

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD +/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats2020

    • Author(s)
      Ogura Y, Kitada M, Xu J, Monno I, Koya D.
    • Journal Title

      Aging (Albany NY) .

      Volume: 12 Issue: 12 Pages: 11325-11336

    • DOI

      10.18632/aging.103410

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Manganese Superoxide Dismutase Dysfunction and the Pathogenesis of Kidney Disease2020

    • Author(s)
      Kitada M, Xu J, Ogura Y, Monno I, Koya D.
    • Journal Title

      Front Physiol .

      Volume: 11 Pages: 755-755

    • DOI

      10.3389/fphys.2020.00755

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanism of Activation of Mechanistic Target of Rapamycin Complex 1 by Methionine2020

    • Author(s)
      Kitada M, Xu J, Ogura Y, Monno I, Koya D.
    • Journal Title

      Front Cell Dev Biol .

      Volume: 8 Pages: 715-715

    • DOI

      10.3389/fcell.2020.00715

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent Insights Into SREBP as a Direct Mediator of Kidney Fibrosis via Lipid-Independent Pathways2020

    • Author(s)
      Dorotea D, Koya D, Ha H.
    • Journal Title

      Front Pharmacol .

      Volume: 11 Pages: 265-265

    • DOI

      10.3389/fphar.2020.00265

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Metabolic reprogramming by N-acetyl-seryl-aspartyl-lysyl-proline protects against diabetic kidney disease2020

    • Author(s)
      Srivastava SP, Goodwin JE, Kanasaki K, Koya D.
    • Journal Title

      Br J Pharmacol.

      Volume: - Issue: 16 Pages: 3691-3711

    • DOI

      10.1111/bph.15087

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Significance of SGLT2 inhibitors: lessons from renal clinical outcomes in patients with type 2 diabetes and basic researches2020

    • Author(s)
      Kitada M, Hirai T, Koya D.
    • Journal Title

      Diabetol Int.

      Volume: 11 Issue: 3 Pages: 245-251

    • DOI

      10.1007/s13340-020-00444-8

    • NAID

      40022307347

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Medical nutrition therapy and dietary counseling for patients with diabetes-energy, carbohydrates, protein intake and dietary counseling2020

    • Author(s)
      Yamauchi Toshimasa、Kamiya Hideki、Utsunomiya Kazunori、Watada Hirotaka、Kawanami Daiji、Sato Junko、Kitada Munehiro、Koya Daisuke、Harada Norio、Shide Kenichiro、Joo Erina、Suzuki Ryo、Bouchi Ryotaro、Ohta Yasuharu、Kondo Tatsuya
    • Journal Title

      Diabetology International

      Volume: 11 Issue: 3 Pages: 224-239

    • DOI

      10.1007/s13340-020-00437-7

    • NAID

      130007821841

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of Angiotensin-Converting Enzyme Ameliorates Renal Fibrosis by Mitigating DPP-4 Level and Restoring Antifibrotic MicroRNAs2020

    • Author(s)
      Srivastava SP, Goodwin JE, Kanasaki K, Koya D.
    • Journal Title

      Genes

      Volume: 11 Issue: 2 Pages: 2-2

    • DOI

      10.3390/genes11020211

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD‐1db/db mice: a novel type 2 diabetic mouse model with progressive kidney fibrosis2020

    • Author(s)
      Mizunuma Yuiko、Kanasaki Keizo、Nitta Kyoko、Nakamura Yuka、Ishigaki Yasuhito、Takagaki Yuta、Kitada Munehiro、Li Shaolan、Liu Haijie、Li Jinpeng、Usui Isao、Aso Yoshimasa、Koya Daisuke
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 10.1111/jdi.13311 Issue: 6 Pages: 1-23

    • DOI

      10.1111/jdi.13311

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deficiency in Dipeptidyl Peptidase-4 Promotes Chemoresistance through the CXCL12/CXCR4/mTOR/TGFbeta Signaling Pathway in Breast Cancer Cells.2020

    • Author(s)
      Li S, Fan Y, Kumagai A, Kawakita E, Kitada M, Kanasaki K, et al.
    • Journal Title

      Int J Mol Sci.

      Volume: 21 Issue: 3 Pages: 3-3

    • DOI

      10.3390/ijms21030805

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pro-inflammatory macrophages coupled with glycolysis remodel adipose vasculature by producing platelet-derived growth factor-B in obesity2020

    • Author(s)
      Onogi Yasuhiro、Wada Tsutomu、Okekawa Akira、Matsuzawa Takatoshi、Watanabe Eri、Ikeda Keisuke、Nakano Minoru、Kitada Munehiro、Koya Daisuke、Tsuneki Hiroshi、Sasaoka Toshiyasu
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 670-670

    • DOI

      10.1038/s41598-019-57368-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Supplementation with Red Wine Extract Increases Insulin Sensitivity and Peripheral Blood Mononuclear Sirt1 Expression in Nondiabetic Humans2020

    • Author(s)
      Kitada M, Ogura Y, Monno I, Koya D.
    • Journal Title

      Nutrients .

      Volume: 12 Issue: 10 Pages: 3108-3108

    • DOI

      10.3390/nu12103108

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endothelial FGFR1 (Fibroblast Growth Factor Receptor 1) Deficiency Contributes Differential Fibrogenic Effects in Kidney and Heart of Diabetic Mice2020

    • Author(s)
      Li J, Liu H, Srivastava SP, Hu Q, Gao R, Li S, Kitada M, Wu G, Koya D, Kanasaki K.
    • Journal Title

      Hypertension .

      Volume: 76 Issue: 6 Pages: 1935-1944

    • DOI

      10.1161/hypertensionaha.120.15587

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Methionine Abrogates the Renoprotective Effect of a Low-Protein Diet Against Diabetic Kidney Disease in Obese Rats With Type 2 Diabetes2020

    • Author(s)
      Kitada M, Ogura Y, Monno I, Xu J, Koya D.
    • Journal Title

      Aging (Albany NY)

      Volume: 12 Issue: 5 Pages: 4489-4505

    • DOI

      10.18632/aging.102902

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stromal cell-derived factor 1 (SDF1) attenuates platelet-derived growth factor-B (PDGF-B)-induced vascular remodeling for adipose tissue expansion in obesity2020

    • Author(s)
      Watanabe E, Wada T, Okekawa A, Kitamura F, Komatsu G, Onogi Y, Yamamoto S, Sasahara M, Kitada M, Koya D, Tsuneki H, Sasaoka T.
    • Journal Title

      Angiogenesis .

      Volume: 23 Issue: 4 Pages: 667-684

    • DOI

      10.1007/s10456-020-09738-6

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence of albuminuria and renal dysfunction, and related clinical factors in Japanese patients with diabetes: The Japan Diabetes Complication and its Prevention prospective study 52020

    • Author(s)
      Shikata K, Kodera R, Utsunomiya K, Koya D, Nishimura R, Miyamoto S, Tajima N; JDCP study group.
    • Journal Title

      J Diabetes Investig .

      Volume: 11 Issue: 2 Pages: 325-332

    • DOI

      10.1111/jdi.13116

    • NAID

      120007004813

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Case report of superior mesenteric artery syndrome that developed in a lean type 2 diabetes patient and was associated with rapid body weight loss after sodium-glucose cotransporter 2 inhibitor administration2020

    • Author(s)
      Hirai T, Kitada M, Hayashi Y, Monno I, Takagaki Y, Shimada K, Ogura Y, Fujii M, Konishi K, Nakagawa A, Koya D.
    • Journal Title

      J Diabetes Investig .

      Volume: 11 Issue: 5 Pages: 1359-1362

    • DOI

      10.1111/jdi.13228

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Remarks] 金沢医科大学 糖尿病・内分泌内科学

    • URL

      http://www.kanazawa-med.ac.jp/~endocrin/

    • Related Report
      2020 Research-status Report

URL: 

Published: 2020-08-03   Modified: 2023-12-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi