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Creation of a support system for diagnosis and treatment of oriental medicine using artificial intelligence

Research Project

Project/Area Number 20K21825
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 62:Applied informatics and related fields
Research InstitutionChiba University

Principal Investigator

Tamura Yutaka  千葉大学, 大学院医学研究院, 准教授 (50263174)

Co-Investigator(Kenkyū-buntansha) 菅波 晃子  千葉大学, 大学院医学研究院, 助教 (10527922)
並木 隆雄  千葉大学, 大学院医学研究院, 准教授 (20312001)
Project Period (FY) 2020-07-30 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords人工知能 / 四診 / 漢方薬処方 / 科学知 / 経験知 / 血流量 / 匂い / 証 / 問診 / 望診 / 舌診 / 東洋医学 / 支援システム
Outline of Research at the Start

人工知能による“科学知”に基づく客観的な診断治療基準を活用した漢方専門医による“経験知”に則った“証”の確定と“漢方薬処方”の決定の標準化を支援する「診断・治療支援システム」を創生する,
具体的には,人工知能による統合解析を可能にするために,①“自動問診システム”により取得した「問診情報」の画像化法,②“舌画像撮影システム”により取得した「舌診画像」の特徴抽出法を開発すると共に,③それらを人工知能(主に,ディープラーニングによる画像特徴抽出機能を適応した)により統合解析するためのシステムを独自に開発する.

Outline of Final Research Achievements

In this study, we aimed to establish "evidence" based on the "experienced knowledge" of Chinese herbal medicine experts and standardize "herbal medicine prescriptions" by utilizing objective diagnostic and treatment standards based on "scientific knowledge" using artificial intelligence.
As a result, 1. Accumulation and conversion of information related to "interviews" using the "automated interview system"; 2. It has become possible to collect and analyze information regarding “cutting examination'' using the “blood flow measurement system” and “auscultation'' using the “odor sensing system''.
Furthermore, we created a "Japanese Kampo Medicine Prescription application" for doctors by integrating the information converted from 3. "Automatic interview system" and analysis information from "Blood flow measurement system" and "Odor detection system".

Academic Significance and Societal Importance of the Research Achievements

近年,「ISO/TC249における漢方・鍼灸領域の国際規格策定」に関して東アジアの国際化・標準化の動きが中国を中心として活発化している.また,世界保健機構・国際統計分類第11版(ICD-11)において,伝統医学病名と伝統医学診断が含まれることとなり,伝統医学に関する診療状況が,世界的に共通の言語で取りまとめられる必要に迫られている.
本システムは,機能を拡張整備することで,一般の医師よる利用が可能になると共に,世界保健機構・国際統計分類第11版(ICD-11)に則り多言語・多人種への対応も可能になるため,東洋医学と西洋医学が連携した“統合医療”の国際的展開に貢献する可能性を有している.

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (19 results)

All 2024 2023 2022 2021 2020 Other

All Journal Article (12 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 11 results,  Open Access: 6 results) Presentation (3 results) (of which Invited: 2 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Photodynamic therapy with paclitaxel-encapsulated indocyanine green-modified liposomes for breast cancer2024

    • Author(s)
      Ishizuka Mariko、Kaibori Masaki、Sumiyama Fusao、Okamoto Yoshiharu、Suganami Akiko、Tamura Yutaka、Yoshii Kengo、Sugie Tomoharu、Sekimoto Mitsugu
    • Journal Title

      Frontiers in Oncology

      Volume: 14 Pages: 1-10

    • DOI

      10.3389/fonc.2024.1365305

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of tea, catechins and catechin derivatives on Omicron subvariants of SARS-CoV-22023

    • Author(s)
      Shin-Ya Masaharu、Nakashio Maiko、Ohgitani Eriko、Suganami Akiko、Kawamoto Masaya、Ichitani Masaki、Kobayashi Makoto、Takihara Takanobu、Inaba Tohru、Nukui Yoko、Kinugasa Hitoshi、Ishikura Hiroyasu、Tamura Yutaka、Mazda Osam
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 16577-16577

    • DOI

      10.1038/s41598-023-43563-3

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 人工知能による東洋医学の診断・治療に係る支援システムの創生2022

    • Author(s)
      田村裕, 菅波晃子, 並木隆雄
    • Journal Title

      月刊細胞

      Volume: 54 Pages: 826-828

    • Related Report
      2022 Research-status Report
  • [Journal Article] Indocyanine green conjugated phototheranostic nanoparticle for photodiagnosis and photodynamic therapy2022

    • Author(s)
      Shinoda Kenta、Suganami Akiko、Moriya Yasumitsu、Yamashita Masamichi、Tanaka Tsutomu、Suzuki Akane S.、Suito Hiroshi、Akutsu Yasunori、Saito Kengo、Shinozaki Yoko、Isojima Kazuoki、Nakamura Naohito、Miyauchi Yasushi、Shirasawa Hiroshi、Matsubara Hisahiro、Okamoto Yoshiharu、Nakayama Toshinori、Tamura Yutaka
    • Journal Title

      Photodiagnosis and Photodynamic Therapy

      Volume: 39 Pages: 103041-103041

    • DOI

      10.1016/j.pdpdt.2022.103041

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Outcome of Photodynamic Therapy with Diode Laser and Indocyanine Green Modified Liposome against Animal Spontaneous Occurring Tumors2022

    • Author(s)
      Okamoto Y, Yamashita M, Osaki T, Azuma K, Ito N, Murahata Y, Tsuka T, Imagawa T, Kaibori M, Suganami A and Tamura Y.
    • Journal Title

      Journal of Biomedical Science and Research

      Volume: 4 Issue: 1 Pages: 1-4

    • DOI

      10.36266/jbsr/157

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] The differential functional coupling of phosphodiesterase 4 to human DP and EP2 prostanoid receptors stimulated with PGD2 or PGE22021

    • Author(s)
      Okura Iori、Hasuoka Nanae、Senoo Kanaho、Suganami Akiko、Fukushima Keijo、Regan John W.、Mashimo Masato、Murayama Toshihiko、Tamura Yutaka、Fujino Hiromichi
    • Journal Title

      Pharmacological Reports

      Volume: - Issue: 3 Pages: 946-953

    • DOI

      10.1007/s43440-021-00247-x

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Role of Blood Stasis Syndrome of Kampo Medicine in the Early Pathogenic Stage of Atherosclerosis: A Retrospective Cross-Sectional Study2021

    • Author(s)
      Morita A, Namiki T, Nakaguchi T, Murai K, Watanabe Y, Nakamura M, Kawasaki Y, Shiko Y, Tamura Y, Suganami A, Murakami A, Yagi A, Okamoto H, Hirasaki Y.
    • Journal Title

      Evid Based Complement Alternat Med .

      Volume: - Pages: 1-9

    • DOI

      10.1155/2021/5557392

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] CCL299, a Benzimidazole Derivative Induces G1 Phase Arrest and Apoptosis in Cancer Cells2021

    • Author(s)
      OHNO YOSHIFUMI、YI RUIRONG、SUGANAMI AKIKO、TAMURA YUTAKA、MATSUMOTO AKIO、MATSUMOTO SHOJI、SAITO KENGO、SHIRASAWA HIROSHI
    • Journal Title

      Anticancer Research

      Volume: 41 Issue: 2 Pages: 699-706

    • DOI

      10.21873/anticanres.14821

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 15-Keto-PGE2 acts as a biased/partial agonist to terminate PGE2-evoked signaling2020

    • Author(s)
      Endo Suzu、Suganami Akiko、Fukushima Keijo、Senoo Kanaho、Araki Yumi、Regan John W.、Mashimo Masato、Tamura Yutaka、Fujino Hiromichi
    • Journal Title

      Journal of Biological Chemistry

      Volume: 295 Issue: 38 Pages: 13338-13352

    • DOI

      10.1074/jbc.ra120.013988

    • NAID

      120007182108

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Photohyperthermal therapy using liposomally formulated indocyanine green for feline nasal lymphoma: A case report2020

    • Author(s)
      Yamashita Masamichi、Mayama Mayumi、Suganami Akiko、Azuma Kazuo、Tsuka Takeshi、Ito Norihiko、Imagawa Tomohiro、Tamura Yutaka、Okamoto Yoshiharu
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 13

    • DOI

      10.3892/mco.2020.2107

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] CCL113, a novel sulfonamide, induces selective mitotic arrest and apoptosis in HeLa and HepG2 cells2020

    • Author(s)
      Yi Ruirong、Ohno Yoshifumi、Tian Zheng、Guo Shuhan、Chen Weiwei、Ma Xue、Win Nan、Li Qisen、Vahed Majid、Saito Kengo、Nakamoto Shingo、Suganami Akiko、Isegawa Naohisa、Yoshida Keisuke、Harada Shinji、Tamura Yutaka、Nishida Atsushi、Shirasawa Hiroshi
    • Journal Title

      Oncology Reports

      Volume: 44 Issue: 6 Pages: 2770-2782

    • DOI

      10.3892/or.2020.7805

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Total synthesis of lindbladione, a Hes1 dimerization inhibitor and neural stem cell activator isolated from Lindbladia tubulina2020

    • Author(s)
      Arai Midori A.、Makita Yuna、Yamaguchi Yumi、Kawano Haruka、Suganami Akiko、Tamura Yutaka、Ishibashi Masami
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 21433-21433

    • DOI

      10.1038/s41598-020-78524-7

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] がん光免疫治療の創生2024

    • Author(s)
      菅波晃子,田村 裕
    • Organizer
      第57回ISLISシンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] AWG治療による血流量変動等に関する臨床研究2023

    • Author(s)
      菅波晃子,田村 裕
    • Organizer
      第1回痛み医療開発研究会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 蛍光性色素が有する光応答性を利用したがん光免疫治療の創生2023

    • Author(s)
      菅波晃子,田村 裕
    • Organizer
      第17回日本臨床ストレス応答学会
    • Related Report
      2023 Annual Research Report
  • [Book] 術中蛍光イメージング実践ガイド2020

    • Author(s)
      日本蛍光ガイド手術研究会
    • Total Pages
      354
    • Publisher
      メジカルビュー社
    • ISBN
      9784758315371
    • Related Report
      2020 Research-status Report
  • [Remarks] 千葉大学大学院生命情報科学

    • URL

      http://www.m.chiba-u.ac.jp/class/bioinfor/

    • Related Report
      2022 Research-status Report
  • [Remarks] 千葉大学大学院医学研究院生命情報科学

    • URL

      https://www.m.chiba-u.ac.jp/class/bioinfor/

    • Related Report
      2021 Research-status Report
  • [Remarks] 千葉大学大学院医学研究院 生命情報科学

    • URL

      https://www.m.chiba-u.ac.jp/class/bioinfor/index.html

    • Related Report
      2020 Research-status Report

URL: 

Published: 2020-08-03   Modified: 2025-01-30  

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