Constructing a Disease-Related Microbiome Atlas for Advancing Understanding of Microbial Functionality
Project/Area Number |
20K21832
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Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 62:Applied informatics and related fields
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Research Institution | Nagoya University |
Principal Investigator |
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Project Period (FY) |
2020-07-30 – 2023-03-31
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Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | メタゲノム / マルチオミクス解析 / ベイズモデリング / トピックモデル / 因子分解モデル / 深層生成モデル |
Outline of Research at the Start |
本研究課題では、最先端のオミクス計測技術とベイズ推論による最新の解析技術を駆使し、様々な疾患の原因となる細菌叢を効率的に探索するための「疾患関連細菌叢アトラス」を創出する。本研究で行うユニークなモデリング技術の開発とそれによる斬新なデータベースの構築により、細菌叢の大海原で研究者が遭難しないように「予測地図」を提供することが主たる目的である。細菌叢の機能解析への障壁を取り去り、我が国の強みを生かした研究を推進することで国際産業競争力を強化するとともに、国民のQOL、細菌叢を利用した健康・医療産業の活性化にも大きく貢献することが期待される。
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Outline of Final Research Achievements |
In this study, we utilize Bayesian modeling techniques, previously developed by the applicant, as the technical cornerstone to address challenges in microbiome analysis such as the management of infrequently occurring microbial species and the consideration of inter-individual variability. Targeting the human microbiota, we develop Bayesian modeling techniques aimed at elucidating the functionalities of the microbiota and its correlation with health and disease. Concurrently, we construct a suite of analytical tools enabling the analysis of microbiome data from public disease-related cohort studies, and integrate these into a comprehensive database, the 'Disease-Related Microbiome Atlas'.
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Academic Significance and Societal Importance of the Research Achievements |
本研究課題は、世界中に登録された公共の膨大なコホート研究の細菌叢データ(衛星地図)と最先端のベイズモデリング技術(GPS)の2つの強力なツールを駆使することによって、細菌叢の大海原で研究者が遭難しないように「予測地図」を提供することが主たる目的である。本研究の活用により、細菌叢の機能解析への障壁を取り去り、国民のQOL、細菌叢を利用した健康・医療産業の活性化にも大きく貢献することが期待される。
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma2023
Author(s)
Kitagawa A, Osawa T,Noda M,Kobayashi Y, Aki S,Nakano Y,Saito T,Shimizu D,Komatsu H,Sugaya M,Takahashi J,...Mimori K.
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Journal Title
Br J Cancer
Volume: -
Issue: 12
Pages: 2206-2217
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer.2023
Author(s)
Ozato Y, Kojima Y, Kobayashi Y, Hisamatsu Y, Toshima T, Yonemura Y, Masuda T, Kagawa K, Goto Y, Utou M, Fukunaga M,... Mimori K.
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Journal Title
Cell Rep
Volume: 42(1)
Issue: 1
Pages: 111929-111929
DOI
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Peer Reviewed / Open Access
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[Journal Article] Metabolome and transcriptome analysis on muscle of sporadic inclusion body myositis.2022
Author(s)
Murakami, A., Noda, S., Kazuta, T., Hirano, S., Kimura, S., Nakanishi, H., Matsuo, K., Tsujikawa, K., Iida, M., Koike, H., Sakamoto, K., Hara, Y., Kuru, S., Kadomatsu, K., Shimamura, T., Ogi, T., Katsuno, M.
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Journal Title
Ann Clin Transl Neurol.
Volume: 9
Issue: 10
Pages: 1602-1615
DOI
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Peer Reviewed / Open Access
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[Journal Article] An analysis modality for vascular structures combining tissue-clearing technology and topological data analysis2022
Author(s)
Takahashi K, Abe K, Kubota SI, Fukatsu N, Morishita Y, Yoshimatsu Y, Satoshi Hirakawa, Yoshiaki Kubota, Tetsuro Watabe, Shogo Ehata, Hiroki R. Ueda, Teppei Shimamura, Kohei Miyazono
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Journal Title
Nature Communiactions
Volume: 13
Issue: 1
Pages: 5239-5239
DOI
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Peer Reviewed / Open Access
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[Journal Article] A bifurcation concept for B-lymphoid/plasmacytoid dendritic cells with largely fluctuating transcriptome dynamics.2022
Author(s)
Nagaharu K, Kojima Y, Hirose H, Minoura K, Hinohara K, Minami H, Kageyama Y, Sugimoto Y, Masuya M, Nii S, Seki M, Suzuki Y, Tawara I, Shimamura T, Katayama N, Nishikawa H, Ohishi K.
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Journal Title
Cell Rep.
Volume: 40
Issue: 9
Pages: 111260-111260
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Peer Reviewed / Open Access
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[Journal Article] Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets.2020
Author(s)
Sekiguchi M, Seki M, Kawai T, Yoshida K, Yoshida M, Isobe T, Hoshino N, Shirai R, Tanaka M, Souzaki R, Watanabe K, Arakawa Y, Nannya Y, Suzuki H, Fujii Y, Kataoka K, Shiraishi Y, Chiba K, Tanaka H, Shimamura T, Sato Y, Sato-Otsubo A, Kimura S, Kubota Y, Hiwatari M, et al
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Journal Title
NPJ Precis Oncol.
Volume: Jul 7;4:20.
Issue: 1
Pages: 20-20
DOI
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Peer Reviewed / Open Access
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[Journal Article] Meta‐Analysis of Gut Dysbiosis in Parkinson's Disease2020
Author(s)
Nishiwaki Hiroshi、Ito Mikako、Ishida Tomohiro、Hamaguchi Tomonari、Maeda Tetsuya、Kashihara Kenichi、Tsuboi Yoshio、Ueyama Jun、Shimamura Teppei、Mori Hiroshi、Kurokawa Ken、Katsuno Masahisa、Hirayama Masaaki、Ohno Kinji
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Journal Title
Movement Disorders
Volume: 35
Issue: 9
Pages: 1626-1635
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] EXOSC9 depletion attenuates P-body formation, stress resistance, and tumorigenicity of cancer cells.2020
Author(s)
Yoshino S, Matsui Y, Fukui Y, Seki M, Yamaguchi K, Kanamori A, Saitoh Y, Shimamura T, Suzuki Y, Furukawa Y, Kaneko S, Seiki M, Murakami Y, Inoue JI, Sakamoto T.
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Journal Title
Sci Rep
Volume: 10
Issue: 1
Pages: 9275-9275
DOI
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Peer Reviewed / Open Access
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[Journal Article] Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells2020
Author(s)
Higashijima Y, Matsui Y, Shimamura T, Nakaki R, Nagai N, Tsutsumi S, Abe Y, Link VM, Osaka M, Yoshida M, Watanabe R, Tanaka T, Taguchi A, Miura M, Ruan X, Li G, Inoue T, Nangaku M, Kimura H, Furukawa T, Aburatani H, Wada Y, Ruan Y, Glass CK, Kanki Y
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Journal Title
The EMBO Journal
Volume: 39
Issue: 7
Pages: 1-1
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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