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An exploration for biomarkers for predicting heart failure prognosis by the human olfactory-based odor analysis technology

Research Project

Project/Area Number 20K21893
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionOsaka University

Principal Investigator

Koseki Masahiro  大阪大学, 大学院医学系研究科, 助教 (10467582)

Co-Investigator(Kenkyū-buntansha) 黒田 俊一  大阪大学, 産業科学研究所, 教授 (60263406)
Project Period (FY) 2020-07-30 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2022: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2021: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords心不全 / 匂いセンサー / 予後予測バイオマーカー / 尿 / 終末期 / ヒト嗅覚受容体センサー
Outline of Research at the Start

心不全の予後を、血清や尿中の単一の代謝物質の測定で、簡便に予測することは難しかった。本研究では心不全患者の匂いに着目し、終末期に近い入院中あるいは在宅医療を実施中の心不全患者から、呼気、尿、皮脂より遊離するガスを収集し、大阪大学産業科学研究所黒田俊一教授らが独自に開発した、網羅的匂い解析装置「ヒト嗅覚受容体センサー」により解析する。本装置では、ヒトが感じる匂い分子のみをヒト嗅覚と同等に検知し、単一の匂い分子のみならず複数の匂い分子を組み合わせとしてパターン認識が可能であり、予後予測に有用なヒト嗅覚受容体を数個特定し、これに対応した患者由来匂い成分を心不全予後予測バイオマーカーとして同定する。

Outline of Final Research Achievements

In this study, we aim to develop a highly portable testing device using odor for end-stage heart failure. The odor samples were collected from patients with heart failure and analyzed using the "human olfactory receptor sensor," a comprehensive odor analysis device originally developed by Professor Shunichi Kuroda and his colleagues at the SANKEN, Osaka University.
In a preliminary study, urine was chosen as the method for collecting odorants because it is easy to transport and store samples, and the concentration of odorants was assumed to be relatively high. While an unspecified number of odorant substances were detected, the analysis of a large number of clinical specimens became difficult due to the spread of COVID-19 infection throughout the study period, and analysis by machine learning and other methods was also difficult, so identification of specific substances could not be achieved.

Academic Significance and Societal Importance of the Research Achievements

本研究では、終末期心不全におけるポータビリティの高い検査機器の開発を目指して、心不全患者から得た匂いサンプルを、大阪大学黒田俊一教授らが独自に開発した網羅的匂い解析装置により解析した。検体は、呼気、皮膚ガス、尿のうち輸送、保存が容易な尿とし、臨床研究計画を立案し、倫理委員会にて承認済を得て、各群5例の尿サンプルを得て解析したところ、不特定多数のにおい物質が検出された。検体数を増やし、多数の検体を解析し、機械学習等で解析する予定であったが、研究期間を通じてCOVID-19感染症が遷延し、多数の検体の収集が困難であったため、機械学習も実施できす、特定の物質の同定には至らなかった。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (109 results)

All 2023 2022 2021 2020

All Journal Article (17 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 15 results,  Open Access: 15 results) Presentation (91 results) (of which Int'l Joint Research: 42 results,  Invited: 14 results) Book (1 results)

  • [Journal Article] Anti-GPIHBP1 Antibody-Positive Autoimmune Hyperchylomicronemia and Immune Thrombocytopenia2023

    • Author(s)
      Tanaka Katsunao、Koseki Masahiro、Kato Hisashi、Miyashita Kazuya、Okada Takeshi、Kanno Kotaro、Saga Ayami、Chang Jiuyang、Omatsu Takashi、Inui Hiroyasu、Ohama Tohru、Nishida Makoto、Yamashita Shizuya、Sakata Yasushi
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 30 Issue: 1 Pages: 100-104

    • DOI

      10.5551/jat.63348

    • NAID

      130008161257

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2023-01-01
    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] XCR1+ conventional dendritic cell-induced CD4+ T helper 1 cell activation exacerbates cardiac remodeling after ischemic myocardial injury2023

    • Author(s)
      Inui H, Nishida M, Ichii M, Nakaoka H, Asaji M, Ide S, Saito S, Saga A, Omatsu T, Tanaka K, Kanno K, Chang J, Zhu Y, Okada T, Okuzaki D, Matsui T, Ohama T, Koseki M, Morii E, Hosen N, Yamashita S, Sakata Y.
    • Journal Title

      Journal of Molecular and Cellular Cardiology

      Volume: 176 Pages: 68-83

    • DOI

      10.1016/j.yjmcc.2023.01.011

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] HDLコレステロール値異常の鑑別と対応2023

    • Author(s)
      小関正博
    • Journal Title

      Medical Practice

      Volume: 40 Pages: 57-64

    • Related Report
      2022 Annual Research Report
  • [Journal Article] A Resuscitated Case of Acute Myocardial Infarction with both Familial Hypercholesterolemia Phenotype Caused by Possibly Oligogenic Variants of the <i>PCSK9</i> and <i>ABCG5</i> Genes and Type I CD36 Deficiency2022

    • Author(s)
      Nishikawa Ryo、Furuhashi Masato、Hori Mika、Ogura Masatsune、Harada-Shiba Mariko、Okada Takeshi、Koseki Masahiro、Kujiraoka Takeshi、Hattori Hiroaki、Ito Ryosuke、Muranaka Atsuko、Kokubu Nobuaki、Miura Tetsuji
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 29 Issue: 4 Pages: 551-557

    • DOI

      10.5551/jat.58909

    • NAID

      130007992205

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2022-04-01
    • Related Report
      2022 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Dietary Oxysterol, 7-Ketocholesterol, Exacerbates Imiquimod-Induced Psoriasis-like Dermatitis in Steatohepatitic Mice2022

    • Author(s)
      Saga Ayami、Koseki Masahiro、Kanno Kotaro、Chang Jiuyang、Higo Tomoaki、Yamashita Shizuya、Sakata Yasushi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 24 Pages: 15855-15855

    • DOI

      10.3390/ijms232415855

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of Nutrient Intake in Biopsy-Confirmed NAFLD Patients2022

    • Author(s)
      Kamada Y, Takahashi H, Ogawa Y, Hyogo H, Nakamura K, Yada T, Asada N, Bando T, Sawano H, Hatanaka M, Tosa T, Ando M, Hikita E, Yoshida K, Koseki M, Sumida Y, Maeda K, Fujii M, Aishima S, Hayakawa M, Nakajima A.
    • Journal Title

      Nutrients

      Volume: 14 Issue: 17 Pages: 3453-3453

    • DOI

      10.3390/nu14173453

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pemafibrate suppresses NLRP3 inflammasome activation in the liver and heart in a novel mouse model of steatohepatitis-related cardiomyopathy2022

    • Author(s)
      Kanno Kotaro、Koseki Masahiro、Chang Jiuyang、Saga Ayami、Inui Hiroyasu、Okada Takeshi、Tanaka Katsunao、Asaji Masumi、Zhu Yinghong、Ide Seiko、Saito Shigeyoshi、Higo Tomoaki、Okuzaki Daisuke、Ohama Tohru、Nishida Makoto、Kamada Yoshihiro、Ono Masafumi、Saibara Toshiji、Yamashita Shizuya、Sakata Yasushi
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 2996-2996

    • DOI

      10.1038/s41598-022-06542-8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Current Diagnosis and Management of Tangier Disease2021

    • Author(s)
      Koseki Masahiro、Yamashita Shizuya、Ogura Masatsune、Ishigaki Yasushi、Ono Koh、Tsukamoto Kazuhisa、Hori Mika、Matsuki Kota、Yokoyama Shinji、Harada-Shiba Mariko
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 28 Issue: 8 Pages: 802-810

    • DOI

      10.5551/jat.RV17053

    • NAID

      130008070332

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2021-08-01
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development and Clinical Application of an Enzyme-Linked Immunosorbent Assay for Oxidized High-Density Lipoprotein2021

    • Author(s)
      Okada Takeshi、Sumida Mizuki、Ohama Tohru、Katayama Yuki、Saga Ayami、Inui Hiroyasu、Kanno Kotaro、Masuda Daisaku、Koseki Masahiro、Nishida Makoto、Sakata Yasushi、Yamashita Shizuya
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 28 Issue: 7 Pages: 703-715

    • DOI

      10.5551/jat.56887

    • NAID

      130008060163

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2021-07-01
    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] MAFLD better predicts the progression of atherosclerotic cardiovascular risk than NAFLD: Generalized estimating equation approach2021

    • Author(s)
      Tsutsumi Tsubasa、Eslam Mohammed、Kawaguchi Takumi、Yamamura Sakura、Kawaguchi Atsushi、Nakano Dan、Koseki Masahiro、Yoshinaga Shinobu、Takahashi Hirokazu、Anzai Keizo、George Jacob、Torimura Takuji
    • Journal Title

      Hepatology Research

      Volume: 51 Issue: 11 Pages: 1115-1128

    • DOI

      10.1111/hepr.13685

    • Related Report
      2021 Research-status Report
  • [Journal Article] Dietary oxysterol, 7-Ketocholesterol accelerates hepatic lipid accumulation and macrophage infiltration in obese Mice2021

    • Author(s)
      J. Chang, M. oseki, A. Saga, K. Kanno, T. Higo, D. Okuzaki, T. Okada, H. Inui, K. Tanaka, M. Asaji, Y. Zhu, K. Yamada, M. Ono, T. Saibara, I Ichi, T. Ohama, M. Nishida, S. Yamashita, Y. Sakata
    • Journal Title

      Front Endocrinol (Lausanne)

      Volume: 11 Pages: 614692-614692

    • DOI

      10.3389/fendo.2020.614692

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] FIB-4 First in the Diagnostic Algorithm of Metabolic-Dysfunction-Associated Fatty Liver Disease in the Era of the Global Metabodemic2021

    • Author(s)
      Sumida Y, Yoneda M, Tokushige K, Kawanaka M, Fujii H, Yoneda M, Imajo K, Takahashi H, Eguchi Y, Ono M, Nozaki Y, Hyogo H, Koseki M, Yoshida Y, Kawaguchi T, Kamada Y, Okanoue T, Nakajima A, Japan Study Group of NAFLD (JSG-NAFLD)
    • Journal Title

      Life

      Volume: 11 Issue: 2 Pages: 143-143

    • DOI

      10.3390/life11020143

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Marked effects of novel selective peroxisome proliferator-activated receptor α modulator, pemafibrate in severe hypertriglyceridemia: preliminary report2020

    • Author(s)
      Iitake Chie、Masuda Daisaku、Koseki Masahiro、Yamashita Shizuya
    • Journal Title

      Cardiovascular Diabetology

      Volume: 19 Issue: 1 Pages: 201-206

    • DOI

      10.1186/s12933-020-01172-8

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evinacumab for Homozygous Familial Hypercholesterolemia2020

    • Author(s)
      Raal FJ, Kawashiri M, et al.
    • Journal Title

      N Engl J Med.

      Volume: 383 Issue: 8 Pages: 711-720

    • DOI

      10.1056/nejmoa2004215

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serum Mac-2 Binding Protein Levels Associate with Metabolic Parameters and Predict Liver Fibrosis Progression in Subjects with Fatty Liver Disease: A 7-Year Longitudinal Study2020

    • Author(s)
      Kamada Yoshihiro、Morishita Koichi、Koseki Masahiro、Nishida Mayu、Asuka Tatsuya、Naito Yukiko、Yamada Makoto、Takamatsu Shinji、Sakata Yasushi、Takehara Tetsuo、Miyoshi Eiji
    • Journal Title

      Nutrients

      Volume: 12 Issue: 6 Pages: 1770-1770

    • DOI

      10.3390/nu12061770

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of core fucosylation reduces low-density lipoprotein receptor expression in hepatocytes by inducing PCSK9 production2020

    • Author(s)
      Kamada Yoshihiro、Yamamoto Akiko、Fujiyoshi Anna、Koseki Masahiro、Morishita Koichi、Asuka Tatsuya、Takamatsu Shinji、Sakata Yasushi、Takehara Tetsuo、Taniguchi Naoyuki、Miyoshi Eiji
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 527 Issue: 3 Pages: 682-688

    • DOI

      10.1016/j.bbrc.2020.05.019

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antidiabetic Therapy in the Treatment of Nonalcoholic Steatohepatitis2020

    • Author(s)
      Sumida Yoshio、Yoneda Masashi、Tokushige Katsutoshi、Kawanaka Miwa、Fujii Hideki、Yoneda Masato
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 6 Pages: 1907-1907

    • DOI

      10.3390/ijms21061907

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 動脈硬化性疾患ハイリスク因子としてのNAFLD/NASH ~NAFLD/NASHに合併した糖尿病・脂質異常症にどうアプローチするか~2023

    • Author(s)
      小関正博
    • Organizer
      第23回動脈硬化教育フォーラム
    • Related Report
      2022 Annual Research Report
  • [Presentation] Beyond LDL:動脈硬化性疾患の残余リスクと戦う! 7-ketocholesterol as a risk for steatohepatitis, psoriasis and cardiovascular disease2023

    • Author(s)
      Koseki M, Saga A, Chang J, Sakata Y.
    • Organizer
      第87回日本循環器学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] The Genetic and Clinical Analysis of Six Patients with Sitosterolemia2023

    • Author(s)
      Omatsu T, Koseki M, Okada T, Nishihara S, Tanaka K, Saga A, Inui H, Ohama T, Ito K, Ishikawa M, Kujiraoka T, Nshida M, Yamashita S, Sakata Y.
    • Organizer
      第87回日本循環器学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] XCR1+ Conventional Dendritic Cell-Induced CD4+ T Helper 1 Cell Activation Exacerbates Cardiac Remodeling after Ischemic Myocardial Injury2023

    • Author(s)
      乾洋勉, 西田誠, 一井倫子, 朝治真澄, 井手盛子, 嵯峨礼美, 尾松卓, 田中克尚, 岡田健志, 大濱透, 小関正博, 山下静也, 坂田泰史
    • Organizer
      第87回日本循環器学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 一卵性双生児を対象としたLDL-C変動要因の解析2023

    • Author(s)
      西原紗恵, 小関正博, 田中克尚, 尾松卓, 岡田健志, 嵯峨礼美, 朝治真澄, 乾洋勉, 大濱透, 西田誠, 坂田泰史, 渡邉幹夫, 大阪ツインリサーチグループ
    • Organizer
      第87回日本循環器学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 脂質の質と脂肪肝、動脈硬化2022

    • Author(s)
      小関正博
    • Organizer
      第58回日本肝臓学会総会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 脂質異常症と脂肪肝のクロストーク2022

    • Author(s)
      小関正博
    • Organizer
      第54回日本動脈硬化学会総会・学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] LC-MS/MSを用いた酸化ステロール・植物ステロールの測定について2022

    • Author(s)
      伊藤香緒里、小関正博
    • Organizer
      第54回日本動脈硬化学会総会・学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Appropriate Treatment of Familial Hypercholesterolemia Based on Genetic Diagnosis2022

    • Author(s)
      Koseki M, Okada T, Nishida M, Saga A, Tanaka K, Omatsu T, Inui H, Nishihara S, Ohama T, Kujiraoka T, Ishihara M, Hattori H, Masuda D, Yamashita S, Sakata Y.
    • Organizer
      第54回日本動脈硬化学会総会・学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] スタチンとペマフィブラートの併用療法による肝臓内脂質および炎症に及ぼす影響の検討2022

    • Author(s)
      田中克尚、小関正博、岡田健志、冠野昂太郎、常久洋、嵯峨礼美、尾松卓、乾洋勉、大濱透、西田誠、山下静也、坂田泰史
    • Organizer
      第54回日本動脈硬化学会総会・学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] LDLコレステロール100mg/dl未満の管理下で経皮的冠動脈インターベンションを施行された慢性冠症候群患者の予後と非絶食non HDLコレステロールの関連の検証2022

    • Author(s)
      北尾隆、小関正博、白記達也、岡田健志、溝手勇、大谷朋仁、彦惣俊吾、中谷大作、坂田泰史
    • Organizer
      第54回日本動脈硬化学会総会・学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] XCR1+Conventional Dendritic Cell Th1 Activation Exacerbates Cardiac Remodeling after Myocardial Infarction2022

    • Author(s)
      乾洋勉、西田誠、朝治真澄、嵯峨礼美、冠野昂太郎、岡田健志、田中克尚、大濱透、小関正博、山下静也、坂田泰史
    • Organizer
      第54回日本動脈硬化学会総会・学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] シトステロール血症6例の症状に関する検討2022

    • Author(s)
      尾松卓、小関正博、岡田健志、田中克尚、冠野昂太郎、嵯峨礼美、乾洋勉、大濱透、伊藤香緒里、石原光昭、鯨岡健、服部浩明、西田誠、山下静也、坂田泰史
    • Organizer
      第54回日本動脈硬化学会総会・学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 動脈硬化と関連疾患_脂肪肝・脂肪肝炎2022

    • Author(s)
      小関正博
    • Organizer
      第54回日本動脈硬化学会総会・学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 妊娠希望、妊娠・授乳期間中のFH患者のLDL-C値管理におけるコレスチミドの有用性と課題の検討2022

    • Author(s)
      田中克尚、小関正博、岡田健志、冠野昂太郎、常久洋、尾松卓、乾洋勉、大濱透、西田誠、山下静也、坂田泰史
    • Organizer
      第54回日本動脈硬化学会総会・学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 一卵性双生児におけるLDL-C変動要因の検討2022

    • Author(s)
      西原紗恵、小関正博、田中克尚、尾松卓、冠野昂太郎、岡田健志、嵯峨礼美、朝治真澄、乾洋勉、大濱透、西田誠、坂田泰史、渡邉幹夫、大阪 ツインリサーチグループ
    • Organizer
      第54回日本動脈硬化学会総会・学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ANGPTL3とHoFH2022

    • Author(s)
      小関正博
    • Organizer
      第70回日本心臓病学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Recent evidence between CVD & NAFLD/NASH in Japan2022

    • Author(s)
      Koseki M
    • Organizer
      ICoLA 2022 (The 11th International Congress on Lipid & Atherosclerosis with Asian-Pacific Society of Atherosclerosis and Vascular Disease)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The Hepatic Lipid Type And Content Had An Impact On Hepatic Inflammation And Fibrosis In Streptozotocin-induced Diabetic Mice2022

    • Author(s)
      Masahiro Koseki, Jiuyang Chang, Ayami Saga, Kotara Kanno, Katsunao Tanaka, Takashi Omatsu, Takeshi Okada, Hiroyasu lnui, Tohru Ohama, Makoto Nishida, Yasushi Sakata
    • Organizer
      AHA 2022 (American Heart Association Scientific Sessions 2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synergistic Effects of Pitavastatin and Pemafibrate on Hepatic Steatosis and Inflammation in Ldlr+/- Mice Fed Fat Diet2022

    • Author(s)
      Tanaka K, Koseki M, Ohyama H, Okada T, Kanno K, Inui H, Chang J, Omatsu T, Saga A, Ohama T, Nishida M, Sakata Y
    • Organizer
      AHA 2022 (American Heart Association Scientific Sessions 2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Stronger Positive Correlation Between Left Ventricular Mass Index And E/e’ In Patients With Diabetes Compared To Non-diabetic Subjects2022

    • Author(s)
      Miura H, Koseki M, Ide S, Saga A, Morita Y, Ohta Y, Fukuda T, Tanaka K, Okada T, Omatsu T, Sakata Y, Noguchi T
    • Organizer
      AHA 2022 (American Heart Association Scientific Sessions 2022)
    • Related Report
      2022 Annual Research Report
  • [Presentation] 心血管疾患の背景因子としての、NAFLD/NASHの重要性2022

    • Author(s)
      小関正博、冠野昂太郎、常久洋、嵯峨礼美、岡田健志、田中克尚、尾松卓、乾洋勉、大濵透、西田誠、坂田泰史
    • Organizer
      第55回日本成人病(生活習慣病)学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 吹田研究における虚血性心疾患因子としてのFib-4 indexの検討2022

    • Author(s)
      小関正博、小久保喜弘、冠野昂太郎、常久洋、嵯峨礼美、岡田健志、乾洋勉、大濵透、西田誠、東山綾、宮本恵宏、坂田泰史
    • Organizer
      第55回日本成人病(生活習慣病)学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 非絶食非高密度リポ蛋白コレステロールと経皮的冠動脈形成術後患者の予後の関連の検証2022

    • Author(s)
      北尾隆、小関正博、白記達也、岡田健志、溝手勇、大谷朋仁、彦惣俊吾、中谷大作、坂田泰史
    • Organizer
      第55回日本成人病(生活習慣病)学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 冠動脈硬化症を認めた脳腱黄色腫の一例2022

    • Author(s)
      尾松卓、小関正博、岡田健志、田中克尚、冠野昂太郎、嵯峨礼美、乾洋勉、大濵透、西田誠、坂田泰史
    • Organizer
      第55回日本成人病(生活習慣病)学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 40年以上通院加療中の家族性コレステロール血症ホモ接合体の一例2022

    • Author(s)
      岡田健志、小関正博、西田誠、尾松卓、田中克尚、乾洋勉、冠野昂太郎、嵯峨礼美、大濵透、山下静也、坂田泰史
    • Organizer
      第55回日本成人病(生活習慣病)学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] ITPに対するステロイド中止を契機に判明した自己免疫性高カイロミクロン血症の一例2022

    • Author(s)
      田中克尚、小関正博、加藤恒、宮下かずや、常久洋、冠野昂太郎、岡田健志、乾洋勉、大濵透、西田誠、山下静也、坂田泰史
    • Organizer
      第55回日本成人病(生活習慣病)学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 巨大血小板性血小板減少症と両側肘部黄色腫を機に診断されたシトステロール血症の1例2022

    • Author(s)
      岡田健志、小関正博、尾松卓、田中克尚、乾洋勉、冠野昂太郎、嵯峨礼美、大濵透、西田誠、石原光昭、鯨岡健、服部浩明、山下静也、坂田泰史
    • Organizer
      第55回日本成人病(生活習慣病)学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] The Time to Pay Attention to NASH as a Risk of Cardiovascular Diseases2022

    • Author(s)
      小関正博、冠野昂太郎、坂田泰史
    • Organizer
      第86回日本循環器学会学術集会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Examination of the Combination Therapy of Pemafibrate and Statins to Serum Lipid and Hepatic Lipid Contents in Ldlr+/- Mice(FH Model)2022

    • Author(s)
      田中克尚、小関正博、大山文哉、岡田健志、冠野昂太郎、乾洋勉、常久洋、尾松卓、嵯峨礼美、大濵透、西田誠、坂田泰史
    • Organizer
      第86回日本循環器学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Pemafibrate Suppresses NLRP3 Inflammasome Activation in a Novel Model of Cholesterolinduced, Steatohepatitis-related Cardiomyopathy2022

    • Author(s)
      冠野昂太郎、小関正博、常久洋、嵯峨礼美、乾洋勉、岡田健志、田中克尚、朝治真澄、朱穎竑、井手盛子、肥後友彰、斎藤茂芳、奥崎大介、大濵透、西田誠、鎌田佳宏、小野正文、西原利治、山下静也、坂田泰史
    • Organizer
      第86回日本循環器学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Cholesterol-dominant Diet Activates Nlrp3 and Causes Steatohepatitis-related Cardiomyopathy2022

    • Author(s)
      Kanno K、Koseki M、Omatsu T、Tanaka K、Inui H、Okada T、Ohama T、Nishida M、Yamashita S、Sakata Y
    • Organizer
      第86回日本循環器学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] XCR1+ Dendritic Cell-Induced CD4 T Helper-1 Activation Leads to Exacerbation of Remodeling after Myocardial Infarction2022

    • Author(s)
      Inui H、Nshida M、Asaji M、Ide S、Saito S、Okuzaki D、Matsui T、 Ichii M、Saga A、Kanno K、Okada T、Koseki M、Ohama T、Yamashita S、 Sakata Y
    • Organizer
      第86回日本循環器学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Evinacumab in Japanese Patients with Homozygous Familial Hypercholesterolemia: Long-term Efficacy and Safety2022

    • Author(s)
      Koseki M、Raal F、Gaudet D、 Fujii N、 Kawashiri M、Otsubo Y、Yanagi K、Ali S、Banerjee P、Chan K、Khilla N、Pordy R、Zhang Y、Harada-Shiba M
    • Organizer
      第86回日本循環器学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Non-fasting Non-HDL-cholesterol is Independently Associated with Prognosis in Patients with Coronary Artery Disease Following Percutaneous Coronary Intervention2022

    • Author(s)
      Kitao T、Koseki M、Shiraki T、Okada T、Mizote I、Ohtani T、Hikosoh S、Nakatani D、Sakata Y
    • Organizer
      第86回日本循環器学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Recent Advances in LDL-C Lowering Therapy in Familial Hypercholisterolemia2021

    • Author(s)
      Koseki M
    • Organizer
      SICEM 2021 (The 9th Seoul International Congress of Endocrinology and Metabolism)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Steatohepatitis-related Atherosclerosis and/or Cardiomyopathy in a Rodent Model2021

    • Author(s)
      Koseki M, Kanno K, Chang J, Saga A, Okada T, Inui H, Tanaka K, Omatsu T, Higo T, Ide S, Saito S, Kamada Y, Ohama T, Nishida M, Yamashita S, Sakata Y
    • Organizer
      ISA2021(国際動脈硬化学会) The 19th International Symposium on Atherosclerosis
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Long-term efficacy and safety of evinacumab in Japanese patients with homozygous familial hypercholesterolemia2021

    • Author(s)
      Koseki M, Raal F, Gaudet D, Fujii N, Kawashiri M, Otsubo Y, Yanagi K, Ali S, Banerjee P, Cha K, Khilla N, Pordy R, Zhang Y, Harada-Shiba M
    • Organizer
      ISA2021(国際動脈硬化学会) The 19th International Symposium on Atherosclerosis
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Xcr1+ Dendritic Cell-Induced Cd4+ T Helper-1 Activation Leads to Exacerbation of Remodeling After Myocardial Infarction2021

    • Author(s)
      Inui H, Nishida M, Asaji M, Saga A, Kanno K, Jiuyang C, Zhu Y, Okada T, Tanaka K, Ohama T, Koseki M, Yamashita S, Sakata Y
    • Organizer
      AHA2021 (American Heart Association)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 7-ketocholesterol exacerbates psoriasis-like dermatitis in diet-induced steatosis mice2021

    • Author(s)
      Saga A, Koseki M, Kanno K, Chang J, Tanaka K, Omatsu T, Nishihara S, Asaji M, Okada T, Kamada Y, Zhu Y, Inui H, Ohama T, Nishida M, Yamashita S, Sakata Y
    • Organizer
      ISA2021(国際動脈硬化学会) The 19th International Symposium on Atherosclerosis
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] A case of anti-GPIHBP1 antibody positive hyperchylomicronemia accompanied with idiopathic thrombocytopenic purpura2021

    • Author(s)
      Tanaka K, Koseki M, Kato H, Chang J, Okada T, Kanno K, Inui H, Zhu Y, Ohama T, Nishida M, Miyashita K, Yamashita S, Sakata Y
    • Organizer
      ISA2021(国際動脈硬化学会) The 19th International Symposium on Atherosclerosis
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] A Case with Sitosterolemia Accompanied with Macrothrombocytopenia and Bilateral Elbow Tuberous Xanthomas2021

    • Author(s)
      Okada T, Koseki M, Kato H, Tomita K, Matsui T, Tanaka K, Chang J, Inui H, Kanno K, Saga A, Ohama T, Ishihara M, Kujiraoka T, Hattori H, Nishida M, Yamashita S, Sakata Y
    • Organizer
      ISA2021(国際動脈硬化学会) The 19th International Symposium on Atherosclerosis
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Targeted Exon Sequencing of 36 Lipid-Related Genes in Patients with Clinically Diagnosed Familial Hypercholesterolemia2021

    • Author(s)
      Okada T, Koseki M, Nishida M, Omatsu T, Tanaka K, Inui H, Chang J, Kanno K, Saga A, Ohama T, Ishihara M, Kujiraoka T, Hattori H, Masuda D, Yamashita S, Sakata Y
    • Organizer
      ISA2021(国際動脈硬化学会) The 19th International Symposium on Atherosclerosis
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Usefulness of apolipoprotein B-48 concentration measurement in ischemic heart disease screening for cases without classical coronary risk factors2021

    • Author(s)
      Masuda D, Yamashita S, Tanaka K, Okada T, Koseki M, Nishida M, Mori K, Ishida T, Hirata K
    • Organizer
      ISA2021(国際動脈硬化学会) The 19th International Symposium on Atherosclerosis
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 小児期より腱黄色腫、皮膚黄色腫を発症したシトステロール血症の4例2021

    • Author(s)
      小関正博
    • Organizer
      第35回日本小児脂質研究会 2021年11月20日
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 次世代シーケンサーを用いた家族性高コレステロール血症患者における脂質関連36遺伝子の遺伝子変異解析2021

    • Author(s)
      岡田健志, 小関正博, 西田誠, 尾松卓, 田中克尚, 乾洋勉, 冠野昂太郎, 嵯峨礼美, 大濱透, 石原光昭, 鯨岡健, 服部浩明, 増田大作, 山下静也, 坂田泰史
    • Organizer
      第53回日本動脈硬化学会総会・学術集会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 動脈硬化惹起食によって発症する脂肪肝炎関連心筋症のメカニズムの解明2021

    • Author(s)
      冠野昂太郎, 小関正博, 嵯峨礼美, 常久洋, 尾松卓, 田中克尚, 乾洋勉, 西原紗恵, 朝治真澄, 岡田健志, 大濱透, 西田誠, 鎌田佳宏, 山下静也, 坂田泰史
    • Organizer
      第53回日本動脈硬化学会総会・学術集会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 40年以上通院加療中の家族性コレステロール血症ホモ接合体の一例2021

    • Author(s)
      岡田健志, 小関正博, 西田誠, 尾松卓, 田中克尚, 乾洋勉, 冠野昂太郎, 嵯峨礼美, 大濱透, 山下静也, 坂田泰史
    • Organizer
      第53回日本動脈硬化学会総会・学術集会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 家族性高コレステロール血症ホモ接合体の日本人患者におけるエビナクマブの長期安全性と有効性の検討2021

    • Author(s)
      小関正博, Frederick Raal, Daniel Gaudet, 藤井直彦, 川尻剛照, 大坪義彦, 柳光司, Shazia Ali, Poulabi Banerjee, Kuo-Chen Chan, Nagwa Khilla, Robert Pordy, Yi Zhang, 斯波真理子
    • Organizer
      第53回日本動脈硬化学会総会・学術集会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 7-ketocholesterolは食餌誘導性脂肪肝炎モデルマウスにおいて乾癬様皮膚炎を促進させる2021

    • Author(s)
      嵯峨礼美, 小関正博, 冠野昂太郎, 常久洋, 田中克尚, 尾松卓, 朝治真澄, 岡田健志, 鎌田佳宏, 乾洋勉, 朱穎こう, 大濱透, 西田誠, 山下静也, 坂田泰史
    • Organizer
      第53回日本動脈硬化学会総会・学術集会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 古典的冠疾患リスク因子を有さない症例に対する虚血性心疾患スクリーニングにおけるアポリポタンパク質B-48濃度測定の有用性2021

    • Author(s)
      増田大作, 山下静也, 田中克尚, 岡田健志, 小関正博, 西田誠, 森健太, 石田達郎, 平田健一
    • Organizer
      第53回日本動脈硬化学会総会・学術集会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 巨大血小板性血小板減少症と両側肘部黄色腫を契機に診断されたシトステロール血症の1例2021

    • Author(s)
      岡田健志, 小関正博, 加藤恒, 冨田興一, 松井崇浩, 田中克尚, 乾洋勉, 冠野昂太郎, 大濱透, 西田誠, 石原光昭, 鯨岡健, 服部浩明, 山下静也, 坂田泰史
    • Organizer
      第53回日本動脈硬化学会総会・学術集会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 全身性に著明な腱黄色腫を認めた脳腱黄色腫症の一例2021

    • Author(s)
      尾松卓, 小関正博, 岡田健志, 田中克尚, 冠野昴太郎, 嵯峨礼美, 乾洋勉, 常久洋, 大濱透, 石原光昭, 鯨岡健, 服部浩明, 西田誠, 山下静也, 坂田泰史
    • Organizer
      第53回日本動脈硬化学会総会・学術集会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 特発性血小板減少性紫斑病を伴う抗GPIHBP1抗体陽性自己免疫性高カイロミクロン血症の1例2021

    • Author(s)
      田中克尚, 小関正博, 加藤恒, 岡田健志, 嵯峨礼美, 冠野昴太郎, 常久洋, 乾洋勉, 朱頴こう, 大濱透, 西田誠, 宮下かずや, 山下静也, 坂田泰史
    • Organizer
      第53回日本動脈硬化学会総会・学術集会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 心筋梗塞後に活性化したXCR1+樹状細胞によるTh1の誘導がリモデリングの増悪につながる2021

    • Author(s)
      乾洋勉, 西田誠, 朝治真澄, 嵯峨礼美, 冠野昂太郎, 常久洋, 朱頴広, 岡田健志, 田中克尚, 大濱透, 小関正博, 山下静也, 坂田泰史
    • Organizer
      第53回日本動脈硬化学会総会・学術集会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 学会企画 来たれ迷える大学院生 最新研究TECH Seminar 22021

    • Author(s)
      小関正博
    • Organizer
      第53回日本動脈硬化学会総会・学術集会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] JCNA 薬局・薬剤師活動委員会による「薬局薬剤師のための食事・栄養に関するガイダンス」作成の試み2021

    • Author(s)
      望月眞弓, 富永佳子, 池末文, 石村智加子, 上野美晴, 大舘夕, 小関正博, 菅原正勝, 土橋愛美, 松島照彦, 三橋清治, 盛岡正博, 山本晃平
    • Organizer
      第43回日本臨床栄養学会総会・第42回日本臨床栄養協会総会 2021年10月1日
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 家族性高コレステロール血症ホモ接合体の日本人患者におけるエビナクマブの長期安全性と有効性の検討2021

    • Author(s)
      小関正博, Frederick J Raal, Daniel Gaudet, 藤井直彦, 川尻剛照, 大坪義彦, 柳光司, Shazia Ali, Poulabi Banerjee, Kuo-Chen Chan
    • Organizer
      第69回 日本心臓病学会学術集会 2021年9月18日
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Current & future treatment for HeFH & HoFH2021

    • Author(s)
      Koseki M
    • Organizer
      ICoLA2021(韓国脂質動脈硬化学会)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] NAFLD, NASH & cardiovascular disease2021

    • Author(s)
      Koseki M
    • Organizer
      ICoLA2021(韓国脂質動脈硬化学会)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 原発性脂質異常症とNAFLD/NASH2021

    • Author(s)
      小関正博
    • Organizer
      第57回 日本肝臓学会総会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] PGRMC1(Progesterone receptor membrane associated component 1)ノックダウンマウスにおける脂肪肝の検討2021

    • Author(s)
      田中克尚, 小関正博, 嵯峨礼美, 朝治真澄, 常久洋, 乾洋勉, 冠野昂太郎, 朱穎竑, 岡田健志, 加部泰明, 末松誠, 大濱透, 西田誠, 坂田泰史
    • Organizer
      第63回 日本脂質生化学会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 健診受信者おける血清7-ketocholesterol濃度と肝機能検査値の相関2021

    • Author(s)
      小関正博, 鎌田佳宏, 冠野昂太郎, 常久洋, 嵯峨礼美, 岡田健志, 乾洋勉, 大濱透, 西田誠, 三善英知, 山下静也, 坂田泰史
    • Organizer
      第63回 日本脂質生化学会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 食餌由来7-ketocholesterolはイミキモド誘導乾癬様皮膚炎を憎悪させる2021

    • Author(s)
      嵯峨礼美, 小関正博, 冠野昂太郎, 常久洋, 田中克尚, 朝治真澄, 岡田健志, 鎌田佳宏, 乾洋勉, 朱穎竑, 大濱透, 西田誠, 山下静也, 坂田泰史
    • Organizer
      第63回 日本脂質生化学会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] The Dietary 7-Ketocholesterol Induces Steatohepatitis and Cardiac Inflammation in STZ-Induced Diabetic Mice2021

    • Author(s)
      Chang J, Koseki M, Kanno K, Saga A, Inui H, Okada T, Saito S, Higo T, Tanaka K, Asaji M, Zhu Y, Ohama T, Nishida M, Yamashita S, Sakata Y
    • Organizer
      第63回 日本脂質生化学会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Diet-induced Hepatic Steatosis and Fibrosis were Improved by a Selective PPARa Modulator, Pemafibrate, in STZ-induced Diabetic Mice2021

    • Author(s)
      Chang J, Koseki M, Kanno K, Saga A, Okada T, Tanaka K, Kamada Y, Higo T, Okuzaki D, Inui H, Asaji M, Zhu Y, Ohama T, Nishida M, Yamashita S, Sakata Y
    • Organizer
      EAS Congress 2021(欧州動脈硬化学会)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] A Case with Sitosterolemia Accompanied with Macrothrombocytopenia and Bilateral Elbow Tuberous Xanthomas2021

    • Author(s)
      Okada T, Koseki M, Kato H, Tomita K, Tanaka K, Chang J, Inui H, Kanno K, Saga A, Ohama T, Kujiraoka T, Hattori H, Nishida M, Yamashita S, Sakata Y
    • Organizer
      EAS Congress 2021(欧州動脈硬化学会)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脂肪肝炎惹起食により誘導した脂肪肝炎モデルにおける心筋症の合併と、脂肪肝炎/心筋障害に対するぺまフィブラートの有効性2021

    • Author(s)
      小関正博
    • Organizer
      第7回 肝臓と糖尿病 代謝研究会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 心筋梗塞モデルへのFeature trackingを用いたMRストレイン解析の適用2021

    • Author(s)
      大西隆太郎, 林菜緒, 上田淳平, 井手盛子, 小関正博, 坂田泰史, 齋藤茂芳
    • Organizer
      第77回日本放射線技術学会総会学術大会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cardiac inflammation and dysfunction were accompanied with cholesterol-dominant steatohepatitis induced by atherogenic-diet2021

    • Author(s)
      Kanno K, Koseki M, Sakata Y
    • Organizer
      Cardiovascular and Metabolic Week 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] High Fat Diet Containing 7-Ketocholesterol Induces Steatohepatitis and Cardiac Inflammation in STZ-Induced Diabetic Mice2021

    • Author(s)
      Koseki M, Chang J, Kanno K, Saga A, Inui H, Okada T, Saito S, Higo T, Ide S, Tanaka K, Zhu Y, Ohama T, Nishida M, Yamashita S, Sakata Y
    • Organizer
      第85回日本循環器学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Progranulin Deficiency Leads to Enhanced Age-related Cardiac Hypertrophy through Complement C1q-induced Beta-catenin Activation2021

    • Author(s)
      Zhu Y, Ohama T, Tanaka K, Kanno K, Chang J, Inui H, Okada T, Koseki M, Nishida M, Yamashita S, Sakata Y
    • Organizer
      第85回日本循環器学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] A dietary oxysterol, 7-ketocholesterol, exacerbates imiquimod-induced psoriasis-like dermatitis in steatohepatitis mice2020

    • Author(s)
      Saga A, Koseki M, Kanno K, Chang J, Asaji M, Okada T, Inui H, Zhu Y, Ohama T, Nishida M, Yamashita S, Sakata Y.
    • Organizer
      日本研究皮膚科学会 第45回年次学術大会・総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Pemafibrate Suppresses Liver Inflammation Caused by Atherogenic Diet and Improves Cardiac Function.2020

    • Author(s)
      Kanno K, Koseki M, Saga A, Chang J, Okada T, Inui H, Asaji M, Zhu Y, Ohama T, Nishida M, Yamashita S, Sakata Y.
    • Organizer
      American Heart Association Scientific Sessions 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Targeted Exon Sequencing of Lipid-Related Genes in Patients with Clinically Diagnosed Familial Hypercholesterolemia2020

    • Author(s)
      Okada T, Koseki M, Nishida M, Tanaka K, Inui H, Kanno K, Saga A, Ohama T, Kujiraoka T, Hattori H, Yamashita S, Sakata Y.
    • Organizer
      American Heart Association Scientific Sessions 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Immunometabolic Disorder in Cardiovascular System and Liver Mediated by Long-term Exposure to Dietderived Oxidized Cholesterol, 7-Ketocholesterol2020

    • Author(s)
      Koseki M, Kanno K, Saga A, Chang J, Inui H, Okada T, Ohama T, Nishida M, Kamada Y, Miyoshi E, Yamashita S, Sakata Y.
    • Organizer
      88th European Atherosclerosis Congress (EAS)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prevalence of Coronary Artery Disease and Achievement of Low-density Lipoprotein Cholesterol Management Targets in Familial Hypercholesterolemia Patients at Osaka University Hospital2020

    • Author(s)
      Okada T, Koseki M, Inui H, Kanno K, Saga A, Ohama T, Nishida M, Yamashita S, Sakata Y.
    • Organizer
      88th European Atherosclerosis Congress (EAS)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] A Selective PPARα Modulator, Pemafibrate Reduced Hepatic Fibrosis and Cardiac Inflammation in Cholesterol-Dominant, Atherogenic-Diet Induced Steatohepatitis Model in STZ Induced Diabetic Mice.2020

    • Author(s)
      Chang J, Koseki M, Saga A, Kanno K, Okada T, Saito S, Kamada Y, Inui H, Asaji M, Zhu Y, Ohama T, Nishida M, Yamashita S, Sakata Y.
    • Organizer
      第4回日本循環器学会基礎研究フォーラム(BCVR)
    • Related Report
      2020 Research-status Report
  • [Presentation] Pemafibrate Improves Steatohepatitis and Cardiac Function in Atherogenic-diet Mice Model2020

    • Author(s)
      Kanno K, Koseki M, Saga A, Chang J, Okada T, Tanaka K, Inui H, Asaji M, Zhu Y, Ohama T, Nishida M, Yamashita S, Sakata Y.
    • Organizer
      第4回日本循環器学会基礎研究フォーラム(BCVR)
    • Related Report
      2020 Research-status Report
  • [Presentation] 食餌誘導性肝線維化モデルにおけるペマフィブラートの肝臓、心臓への作用メカニズムの解明2020

    • Author(s)
      小関正博、冠野昂太郎、常久洋、嵯峨礼美、岡田健志、乾洋勉、齋藤茂芳、鎌田佳宏、山下静也、坂田泰史
    • Organizer
      第56回日本肝臓学会総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 食事由来酸化ステロール蓄積のNAFLD、動脈硬化の進展における影響2020

    • Author(s)
      小関正博、三善英知、西原利治
    • Organizer
      第56回日本肝臓学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] The dietary 7-Ketocholesterol accelerated steatohepatitis in ob/ob mice by suppressing autophagy2020

    • Author(s)
      常久洋、Koseki M, 嵯峨礼美
    • Organizer
      第56回日本肝臓学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] イミキモド誘導乾癬モデルマウスにおける食事誘導脂肪肝炎の影響2020

    • Author(s)
      嵯峨礼美、常久洋、小関正博
    • Organizer
      第56回日本肝臓学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] The Role of Th1 and Th17 During Myocardial Infarction and Inhibitory Effect of Probucol on Th1 in SR-BI KO/ApoeR61h/h Mice2020

    • Author(s)
      Inui H, Nishida M, Asaji M, Saga A, Kanno K, Okada T, Koseki M, Chang J, Zhu Y, Ohama T, Yamashita S, Sakata Y.
    • Organizer
      第84回日本循環器学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] A selective PPARα modulator, pemafibrate reduced hepatic cholesterol accumulation and inflammatory cell infiltration in atherogenic-diet induced steatohepatitis mouse model2020

    • Author(s)
      冠野昂太郎、小関正博、嵯峨礼美、常久洋、岡田健志、乾洋勉、朝治真澄、朱穎竑、大濱透、西田誠、山下静也、坂田泰史
    • Organizer
      第84回日本循環器学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] The Current Status of Achievement of Low-density Lipoprotein Cholesterol Management Targets in Familial Hypercholesterolemia Patients in Osaka University Hospital2020

    • Author(s)
      Okada T, Koseki M, Inui H, Kanno K, Chang J, Zhu Y, Saga A, Asaji M, Ohama T, Nishida M, Yamashita S, Sakata Y.
    • Organizer
      第84回日本循環器学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 動脈硬化惹起食誘導脂肪肝炎モデルにおける、ペマフィブラートの抗脂肪肝炎、抗心筋炎症作用の解明2020

    • Author(s)
      小関正博、冠野昂太郎、常久洋、嵯峨礼美、岡田健志、鎌田佳宏、山下静也、坂田泰史
    • Organizer
      第52回日本動脈硬化学会総会・学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] NAFLD/NASH、動脈硬化進展における外因性酸化ステロール7-ketocholesterolの影響2020

    • Author(s)
      小関正博、冠野昂太郎、常久洋、嵯峨礼美、岡田健志、乾洋勉、鎌田佳宏、山下静也、坂田泰史
    • Organizer
      第52回日本動脈硬化学会総会・学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 食餌誘発性脂肪肝炎マウスモデルにおいて7-ketocholesterolはイミキモド誘導乾癬様皮膚炎を増悪させる2020

    • Author(s)
      嵯峨礼美、小関正博、冠野昂太郎、常久洋、朝治真澄、岡田健志、鎌田佳宏、乾洋勉、朱穎竑、大濵透、西田誠、山下静也、坂田泰史
    • Organizer
      第52回日本動脈硬化学会総会・学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] The Dietary 7-ketocholesterol Accelerated Steatohepatitis in STZ Induced Diabetic Mice2020

    • Author(s)
      Chang J, Koseki M, Saga A, Kanno K, Okada T, Saito S, Kamada Y, Inui H, Asaji M, Zhu Y, Ohama T, Nishida M, Yamashita S, Sakata Y.
    • Organizer
      第52回日本動脈硬化学会総会・学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Progranulin deficiency leads to enhanced age-related cardiac hypertrophy through Clq-induced β-catenin activation2020

    • Author(s)
      朱穎竑、大濵透、常久洋、乾洋勉、冠野昂太郎、岡田健志、小関正博、西田誠、坂田泰史、山下静也
    • Organizer
      第52回日本動脈硬化学会総会・学術集会
    • Related Report
      2020 Research-status Report
  • [Book] CARDIO-HEPATOLOGY Connections Between Hepatic and Cardiovascular Disease2023

    • Author(s)
      Tanighchi T. Koseki M. et al.
    • Total Pages
      360
    • Publisher
      Elsevier
    • ISBN
      9780128173947
    • Related Report
      2022 Annual Research Report

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Published: 2020-08-03   Modified: 2024-01-30  

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