| Project/Area Number |
20K22175
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0108:Sociology and related fields
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
Zhang Shu 国立研究開発法人国立長寿医療研究センター, 老年学・社会科学研究センター, 研究員 (00874471)
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| Project Period (FY) |
2020-09-11 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | Japanese diet / MRI / brain atrophy / hippocampus / transverse temporal / Japanese Diet Index / cohort / atrophy / Green tea / Gray matter / White matter / Hippocampus / Atrophy / Cohort |
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| Outline of Research at the Start |
The present study uses the 3-day dietary record data and the 3D brain magnetic resonance imaging images during a 10-year follow-up to elucidate (1) whether Japanese diet suppresses the total brain atrophy in cognitively normal individuals, and (2) which part(s) of the brain is affected.
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| Outline of Final Research Achievements |
The present study uses the 3-day dietary record(3DR) data and the 3D brain magnetic resonance imaging (MRI) images during a 10-year follow-up to elucidate (1) whether Japanese diet suppresses the total brain atrophy in cognitively normal individuals, and (2) which part(s) of the brain is affected.
The results of the study (with 2-years follow-up) showed that green tea, one of the important components of the Japanese diet, exhibited an inhibitory effect on hippocampal atrophy. In addition, we observed a negative association between Japanese dietary pattern evaluated using a 9-component weighted Japanese Diet Index score and annual change ratio of transverse temporal. These findings suggest that the Japanese diet may have a positive effect in inhibiting brain atrophy in middle-aged and elderly Japanese community-dwellers.
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| Academic Significance and Societal Importance of the Research Achievements |
By using 2-years' follow-up data, the present study elucidated the impact of Japanese diet on brain atrophy at an earlier disease stage of dementia, suggesting the possibility of preventing dementia by improving diet in daily life.
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